-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

705.O3.6 705. Cellular Immunotherapies: Late Phase and Commercially Available Therapies: Prediction and Management of CAR-T Cell Related Toxicity Clinically Relevant Abstract

Symposia: Cellular Immunotherapies: Late Phase and Commercially Available Therapies Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, clinical trials, real-world evidence, registries
Saturday, December 9, 2023: 4:00 PM-5:30 PM
Room 6B (San Diego Convention Center)
Moderators:
Roberta Di Blasi, MD, PhD, Assistance Publique Hôpitaux de Paris - Hôpital Saint-Louis, University of Paris and Gurbakhash Kaur, MD, MA, Montefiore Medical Center
Disclosures:
Di Blasi: Pfizer: Honoraria; BMS: Consultancy; Kite Gilead: Consultancy, Honoraria; abbvie: Honoraria; Incyte: Honoraria; Novartis: Consultancy, Honoraria; Janssen: Consultancy. Kaur: BMS: Consultancy, Research Funding; Abbvie: Research Funding; Arcellx: Consultancy, Research Funding; Sanofi: Consultancy; Janssen: Consultancy, Research Funding; Pfizer: Consultancy; Kedrion: Consultancy; Cellectar: Consultancy.
This session contains prospective and retrospective data that pertains to prediction and management of CAR T-cell related toxicity.  It is focused on cytokine release syndrome, immune effector cell associated neurotoxicity syndrome, hematologic toxicity and infections.
4:00 PM

Roni Shouval, MD, PhD1*, Christopher Strouse, MD2, Soyoung Kim, PhD3,4*, Temitope Oloyede, MPH4*, Sairah Ahmed, MD5, Farrukh T. Awan, MD6, Veronika Bachanova, MD, PhD7, Talha Badar, MD8, Pere Barba, MD9, Amer M. Beitinjaneh, MD, MS10*, Amanda F Cashen11, Bhagirathbhai Dholaria, MBBS12, Mahmoud Elsawy, MD, MSc13*, Siddhartha Ganguly, MD14, Praveen Ramakrishnan Geethakumari, MD, MS15, Uri Greenbaum, MD16, Hamza Hashmi, MD17*, Laquisa C. Hill, BS, MD18*, Michael D. Jain, MD, PhD19, Tania Jain, MD20, Partow Kebriaei, MD21, Adam S Kittai, MD22, Frederick L. Locke, MD19, Premal D. Lulla, MBBS23, Elena Mead, MD24*, Joseph P McGuirk, DO25, Alberto Mussetti26*, Taiga Nishihori, MD19, Amanda L. Olson, MD21, Martina Pennisi27*, Miguel-Angel Perales, MD28, Peter A. Riedell, MD29, Wael Saber, MD, MS30, Sayeef Mirza, MD, MPH19, Margarida Magalhaes-Silverman, MD31, Elizabeth J. Shpall, MD21, Mohamed Sorror, MD, MSc32,33, Kitsada Wudhikarn, MD34, Cameron J. Turtle, MBBS, PhD32,35*, Marcelo Pasquini, MD, MS36,37 and Amy Moskop, MD38,39*

1Adult BMT Service, Memorial Sloan Kettering Cancer Center, New York, NY
2Division of Hematology, Oncology and Blood & Marrow Transplantation, Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA
3Division of Biostatistics, Institute for Health and Equity, Medical College of Wisconsin, Milwaukee, WI
4CIBMTR® (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
5Department of Lymphoma/Myeloma and Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX
6Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX
7Bone and Marrow Transplant Program, University of Minnesota Medical Center, Minneapolis, MN
8Division of Hematology-Oncology, Blood and Marrow Transplantation Program, Mayo Clinic, Jacksonville, FL
9Deparment of Hematology, Vall Hebron Institute of Oncology (VHIO), Hospital Universitari Vall D'Hebron, La Garriga, Barcelona, Spain
10Division of Transplantation and Cellular Therapy, University of Miami Hospital and Clinics, Sylvester Comprehensive Cancer Center, Miami, FL
11Washington University School of Medicine in St. Louis, St Louis, MO
12Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN
13Division of Hematology, Department of Medicine, Dalhousie University, Halifax, Canada
14Houston Methodist Hospital and Neal Cancer Center, Houston, TX
15Section of Hematological Malignancies and Cellular Therapy, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX
16Soroka University Medical Center, Beer Sheva, Israel
17Medical University of South Carolina, Charleston, SC
18Baylor College of Medicine, Center for Cell and Gene Therapy, Houston, TX
19Department of Blood and Marrow Transplantation and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL
20Johns Hopkins University, Baltimore, MD
21Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
22Division of Hematology, The Ohio State University, Columbus, OH
23Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital, Texas Children's Hospital, Houston, TX
24Cellular Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY
25University of Kansas Medical Center, Westwood, KS
26Clinical Hematology Department, Institut Català d’Oncologia-Hospitalet, IDIBELL, Barcelona, Spain
27Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
28Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
29Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL
30Medical College of Wisconsin, Milwaukee, WI
31Holden Comprehensive Cancer Center, University of Iowa Hospital and Clinics, Iowa City, IA
32Fred Hutchinson Cancer Center, Seattle, WA
33University of Washington School of Medicine, Seattle, WA
34Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand
35Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia
36Froedtert & The Medical College Cancer Ctr., Milwaukee, WI
37Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI
38Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
39Division of Pediatric Hematology/Oncology/Blood and Marrow Transplant, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI

4:15 PM

Matthew J. Frigault, MD, MS1, Richard T Maziarz, MD2, Jae H. Park, MD3, Aleksandr Lazaryan, MD, MPH, PhD4, Nirav N. Shah, MD5, Jakub Svoboda6*, Lazaros J. Lekakis7*, Ran Reshef, MD8*, Christine L Phillips, MD9, Lea M Burke, MS10*, Jing Lei11*, Rodica Morariu-Zamfir10* and John F. DiPersio, MD, PhD12

1Massachusetts General Hospital, Dorchester, MA
2Knight Cancer Institute, Oregon Health & Science University, Portland, OR
3Memorial Sloan Kettering Cancer Center, New York, NY
4Department of Blood and Marrow Transplantation and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL
5Medical College of Wisconsin, Milwaukee, WI
6University of Pennsylvania, Philadelphia, PA
7University of Miami, Miami, FL
8Columbia University Herbert Irving Comprehensive Cancer Center, New York, NY
9Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
10Incyte Corporation, Wilmington, DE
11Incyte, Wilmington, DE
12Washington University School of Medicine, Saint Louis, MO

4:30 PM

Karthik Nath, MBBS, PhD1, Sean M. Devlin, PhD2*, Craig S Sauter, MD3,4, Maria Lia Palomba, MD1,5,6, Gunjan L. Shah7,8,9, Parastoo Bahrami Dahi, MD1,8,9*, Richard J. Lin, MD, PhD8,9,10, Michael Scordo10,11,12, Miguel-Angel Perales, MD1,8,13, Lori A. Leslie, MD14, Roni Shouval, MD, PhD8,10,12, Sara Bekele9*, Elizabeth Cathcart1*, Elena Mead, MD1,15*, Bianca Santomasso, MD, PhD1,16*, Andrei Holodny17*, Renier Brentjens, MD PhD4,18, Isabelle Riviere19,20*, Michel Sadelain, MD PhD21 and Jae H. Park, MD7,8,22

1Cellular Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY
2Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY
3Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
4Center for Cell Engineering, Sloan Kettering Institute, New York, NY
5Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York
6Department of Medicine, Weill Cornell Medical College, New York
7Memorial Sloan Kettering Cancer Center, New York, NY
8Department of Medicine, Weill Cornell Medicine, New York, NY
9Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY
10Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
11Department of Medicine, Weill Cornell Medical College, New York, NY
12Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
13Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
14Lymphoma Division, John Theurer Cancer Center, Hackensack Meridian School of Medicine, Hackensack, NJ
15Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
16Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY
17Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY
18Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
19Michael G. Harris Cell Therapy and Cell Engineering Facility, Memorial Sloan Kettering Cancer Center, New York, NY
20Takeda Development Center Americas, Inc., Lexington, MA
21Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY
22Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY

4:45 PM

Zimu Gong, MD, PhD1, Godsfavour Umoru, PharmD2*, Jorge Monge3*, Nishi Shah, MBBS, MPH4, Ghulam Rehman Mohyuddin, MD5, Sabarinath Radhakrishnan6*, Rajshekhar Chakraborty, MD7, Carolina Schinke, MD8, Anita D'Souza, MD, MS9 and Meera Mohan, MD10

1Cancer Center, Houston Methodist Hospital, Houston, TX
2Houston Methodist Hospital, Houston, TX
3Weill Cornell Medicine, New York
4Department of Oncology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY
5Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
6Medical college of Wisconsin, Milwaukee, WI
7Columbia University Medical Center, New York, NY
8Myeloma Center, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR
9Medical College of Wisconsin, Milwaukee, WI
10BMT and Cellular Therapy Program, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI

5:00 PM

Kai Rejeski, MD1,2, Doris K. Hansen, MD3*, Yucai Wang, MD, PhD4, Gloria Iacoboni, MD5*, Emmanuel Bachy, MD, PhD6*, Radhika Bansal, MBBS7*, Olaf Penack, MD8*, Fabian Mueller, MD9*, Wolfgang Andreas Bethge, MD10*, Javier L. Munoz11, Razan Mohty, MD3, Veit L. Buecklein, MD12*, Pere Barba, MD13, Frederick L. Locke, MD14, Yi Lin, MD, PhD7, Michael D. Jain, MD, PhD14 and Marion Subklewe, MD15,16

1LMU University Hospital, Munich, Germany
2Bavarian Cancer Research Center (BZKF), Munich, Germany
3H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
4Division of Hematology, Mayo Clinic, Rochester, MN
5Hospital Universitari Vall d’Hebron-Universitat Autónoma de Barcelona, Barcelona, Spain
6Clinical Hematology, Hospices Civils de Lyon and Claude Bernard Lyon 1 University, Lyon, France
7Mayo Clinic Cancer Center, Rochester, MN
8Department of Hematology, Oncology, and Cancer Immunology, Charité Universitätsmedizin Berlin, Campus Virchow Klinik, Berlin, Germany
9Department of Internal Medicine 5, Hematology and Oncology, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Bavaria, Germany
10University Hospital Tübingen, Tübingen, Germany
11Department of Hematology, Mayo Clinic, Phoenix, AZ
12Department of Medicine III, University Hospital, LMU Munich, Munich, Germany
13Deparment of Hematology, Vall Hebron Institute of Oncology (VHIO), Hospital Universitari Vall D'Hebron, La Garriga, Barcelona, Spain
14Department of Blood and Marrow Transplantation and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL
15Department of Medicine III, LMU University Hospital, LMU Munich, Muenchen, Bavaria, Germany
16Bavarian Cancer Research Center (BZKF), R/R ALL Study Group, Bavaria, Germany

5:15 PM

Mark P. Hamilton, MD1, Brian J. Sworder, MD, PhD2,3, Stefan K. Alig, MD4, Zinaida Good, PhD5, Jan Boegeholz, MD6, Joseph Schroers-Martin, MD6*, John Tamaresis, PhD7*, Mohammad Shahrokh Esfahani, PhD4*, Ying Lu, PhD7*, Mari Olsen4*, Chih Long Liu4*, Zachary Ehlinger8*, Moksha Desai8*, Felicia Liu-Fei9*, Lori S. Muffly, MD10, Robert S. Negrin, MD11, Sally Arai, MD12, Laura Johnston13, Robert Lowsky, MD14*, Everett H. Meyer, MD, PhD15, Andrew R. Rezvani, MD, BA16*, Judith Shizuru, MD, PhD17*, Wen-Kai Weng, MD, PhD18, Parveen Shiraz, MD13*, Surbhi Sidana, MD13, Sushma Bharadwaj, MD, MS18, Melody Smith, MD, MS19, Saurabh Dahiya18*, Bita Sahaf, PhD, MSc20*, Maximilian Diehn, MD, PhD21*, Matthew J. Frank, MD, PhD18, Crystal L. Mackall, MD22, David M. Kurtz, MD, PhD4, David B. Miklos, MD, PhD18,22 and Ash A. Alizadeh, MD, PhD4,23

1Division of Hematology and Oncology, Stanford University, Palo Alto, CA
2Division of Oncology, Department of Medicine, Stanford University, Irvine, CA
3University of California, Irvine, Irvine, CA
4Department of Medicine, Divisions of Oncology and Hematology, Stanford University, Stanford, CA
5Division of Blood and Marrow Transplantation, Stanford University School of Medicine, Palo Alto, CA
6Divisions of Hematology and Oncology, Stanford University, Stanford, CA
7Department of Biomedical Data Science, Stanford University, Stanford, CA
8Center for Cancer Cell Therapy, Stanford University, Stanford, CA
9Stanford University, Stanford
10Division of Blood and Marrow Transplantation & Cellular Therapy, Stanford University School of Medicine, Palo Alto, CA
11Department of Medicine, Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University School of Medicine, Stanford, CA
12Stanford University Medical Center, Palo Alto, CA
13Stanford University, Stanford, CA
14Stanford Univ. Med. Ctr., Stanford, CA
15Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University Medical Center, Stanford, CA
16Stanford University Cancer Institute, Palo Alto, CA
17Stanford U Med Ctr, Stanford, CA
18Division of Blood and Marrow Transplantation & Cellular Therapy, Stanford University, Palo Alto, CA
19Division of Blood and Marrow Transplantation & Cellular Therapy, Stanford University, Stanford, CA
20Cancer Correlative Science Unit, Stanford University, Palo Alto, CA
21Department of Radiation Oncology, Stanford University, Stanford, CA
22Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA
23Stanford Cancer Institute, Stanford University, Stanford, CA

*signifies non-member of ASH