65th ASH Annual Meeting & Exposition: 701. Experimental Transplantation: Basic and Translational: T Cells in GVHD, Thymus Regeneration, and Immune Reconstitution

Symposia: Experimental Transplantation: Basic and Translational Oral and Poster Abstracts
Oral

Research, Fundamental Science, Translational Research

Room 6B (San Diego Convention Center)

Moderators:

Susan DeWolf, MD, Memorial Sloan Kettering Cancer Center and Craig Byersdorfer, MD, University of Pittsburgh

Disclosures:

No relevant conflicts of interest to declare.

9:30 AM

457

Recirculating Regulatory T Cells Mediate Thymic Regeneration in a ZFP36L1 and Amphiregulin Dependent Manner

Andri Leo L Lemarquis, MD, PhD¹^*, Anastasia Kousa, PhD¹^*, Kimon V Argyropoulos, MD PhD²^*, Lorenz Jahn, PhD¹^*, Brianna Gipson, BSc¹^*, Lucia Serrano-Marin, MSc¹^*, Hana Andrlova, MD¹^*, Jennifer Tsai, MD, PhD¹^*, Jarrod A Dudakov, PhD³, Susan DeWolf, MD⁴ and Marcel R.M. van den Brink^5,6,7

¹Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
³Program in Immunology, Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA
⁴Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Weill Cornell Medical College, New York, NY
⁶Department of Medicine, Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁷Department of Immunology, Sloan Kettering Institute, New York, NY

9:45 AM

458

TCF-1is Required By CD8⁺ T Cells for the Maintenance of Alloimmune Responses in Graft-Vs-Host Disease

Kevin Quann, MD, PhD¹, Faruk Sacirbegovic, PhD²^*, Sarah Rosenberger, MS¹^*, Emily McFerran, BS¹^*, Kentin Codispot, BS³^* and Warren Shlomchik, MD¹^*

¹Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, PA
²Department of Surgery, University of Pittsburgh, Pittsburgh, PA
³Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh

10:00 AM

459

Mitochondrial Pyruvate Carrier Inhibition Mitigates Murine Chronic Graft Versus Host Disease By Attenuating the Germinal Center Reaction

Fathima A Mohamed, BA, BS¹, Stephanie Y Rhee, PhD¹^*, Joanna Ly¹^*, Ethan G Aguilar, PhD¹^*, Haley Melin¹^*, Peter T Sage, PhD²^*, Tanner Schumacher³^*, Govindarajan Thangavelu, PhD¹^*, Michael C Zaiken, PhD¹^*, Juan Liu, PhD⁴^*, Venkatram Mereddy, PhD³^*, Jason W Locasale, PhD⁴^* and Bruce R Blazar, MD¹

¹Division of Pediatric Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN
²Transplantation Research Center Renal Division, Brigham and Women's Hospital, Boston, MA
³Department of Pharmacy Practice & Pharmaceutical Sciences, University of Minnesota Duluth, Duluth, MN
⁴Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC

10:15 AM

460

Accelerating Immune Reconstitution in HSCT Patients through iPSC-Derived Thymic Epithelial Cells

Abdulvasey Mohammed, BS¹^*, Hanh Dan Nguyen, BS¹^*, Kelsea Hubka, PhD²^*, Wenqing Wang, PhD³, Priscila Slepicka, Phd⁴^*, Ben Solomon, MD PhD¹^*, Martin Arreola, BS⁴^*, Zihao Zheng¹^*, Andrew Gentles⁵^* and Katja G. Weinacht, MD, PhD⁴

¹Department of Pediatrics, Stanford School of Medicine, Stanford, CA
²Department of Pediatrics, Stanford School of Medicine, Stanford
³Department of Pediactrics, Stanford University School of Medicine, Stanford, CA
⁴Department of Pediatrics, Stanford University School of Medicine, Stanford, CA
⁵Department of Pathology, Stanford School of Medicine, Stanford, CA

10:30 AM

461

Hematopoietic Stem Cell Transplantation (HCT) Conditioning Leads to NK Cell Cytotoxicity Limiting Endogenous Thymus Regeneration

David Granadier, BS^1,2^*, Kirsten Cooper³^*, Dante Dennis Acenas II, BA^4,5, Lorenzo Iovino, MD, PhD¹, Paul Deroos³^*, Vanessa A Hernandez³^* and Jarrod A Dudakov, PhD⁶

¹Fred Hutchinson Cancer Center, Seattle, WA
²MCB, University of Washington, Seattle, WA
³Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
⁴University of Washington, Seattle, WA
⁵Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA
⁶Program in Immunology, Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA

10:45 AM

462

AMPK Controls Glycolytic Compensation in Gvhd-Causing T Cells

Archana Ramgopal, DO, Erica Braverman, MD, Lee-Kai Sun, BSc^*, Darlene Monlish, Ph.D.^*, Christopher Wittmann^*, Manda Ramsey^*, Richard Caitley^*, William Hawse, Ph.D.^* and Craig Byersdorfer, MD

UPMC, Department of Pediatrics, Division of Blood and Marrow Transplantation and Cellular Therapies, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA

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^*signifies non-member of ASH

701.O2.6 701. Experimental Transplantation: Basic and Translational: T Cells in GVHD, Thymus Regeneration, and Immune Reconstitution