Esperanza Martín-Sánchez^1*, Camila Guerrero, MSc^2*, Luis-Esteban Tamariz-Amador, MD^2*, Anastasiia Zherniakova, MD^2*, Aintzane Zabaleta^1*, Catarina Maia, PhD^2*, Laura Blanco^1*, Maria-Antonia Fortuño, PhD^2*, Carlos Grande, MD, PhD^2*, Andrea Manubens, MD^2*, Jose Maria Arguiñano, MD^3*, Clara Gomez, MD^4*, Ernesto Perez-Persona, MD^5*, Iñigo Olazabal, MD^6*, Itziar Oiartzabal, MD^7*, Carlos Panizo, MD, PhD^2,6*, Felipe Prosper, MD, PhD², Jesús San Miguel, MD, PhD^2*, Paula Rodriguez Otero, MD, PhD^8*, Bruno Paiva^9* and Basque-Navarre Association of Hematology and Hemotherapy Asovasna^10*

¹CIMA (Pamplona)Cancer Center Clinica Universidad de Navarra (CCUN), Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), CIBER-ONC numbers CB16/12/00369 and CB16/12/00489, Pamplona, Spain
²Cancer Center Clinica Universidad de Navarra (CCUN), Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), CIBER-ONC numbers CB16/12/00369 and CB16/12/00489, Pamplona, Spain
³Hospital Universitario de Navarra, IdiSNA, Pamplona, Spain
⁴Hospital Universitario de Galdakao, Galdakano, Spain
⁵Hospital Universitario de Araba – Txagorritxu, Vitoria-Gasteiz, Spain
⁶Hospital Universitario de Donostia, San Sebastian, Spain
⁷Hospital Universitario de Cruces, Bilbao, Spain
⁸Cancer Center Clínica Universidad de Navarra (CCUN), CIMA, CIBERONC, IDISNA, Pamplona, Spain
⁹Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), IDISNA, CIBER-ONC number CB16/12/00369 and CB16/12/00489, Pamplona, Spain
¹⁰Basque-Navarre association of Hematology and Hemotherapy (ASOVASNA), Bilbao, Spain

Gaurav Agarwal, MD^1*, Mohammad Kazeroun^2*, Mirian Salazar^3*, Khrystal McBean^4*, Lisa Ferguson^4*, Jemma Larham^4*, Jaimal Kothari^2,4*, Naser Ansari-Pour, PhD^2*, Sally Moore^5*, Eileen Boyle, MBChB, PhD⁶, Udo Oppermann, PhD^2*, Karthik Ramasamy^2,4, Angela Hamblin, MD, PhD^2,7*, Anjan Thakurta, PhD² and Sarah Gooding^2,3,4*

¹MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Wraysbury, ENG, United Kingdom
²Oxford Translational Myeloma Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, United Kingdom
³MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
⁴Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
⁵Department of Haematology, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, United Kingdom
⁶Department of Hematology, UCL Cancer Institute, London, United Kingdom
⁷Cancer and Haematology Centre, The Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom

Noemi Puig, MD, PhD¹, Cristina Agullo^2*, Teresa Contreras^2*, Bruno Paiva^3,4,5*, Maria Teresa Cedena Romero, MD, PhD^6*, José Juan Pérez^1*, Irene Aires^7*, Joaquin Martinez-Lopez, MD, PhD^8*, Paula Rodriguez Otero, MD, PhD^5,9,10*, Veronica Gonzalez-Calle, MD, PhD^11*, Marta Sonia Gonzalez Perez^12*, Norma C. Gutierrez^13*, Albert Oriol Rocafiguera, MD^14*, Rafael Ríos, MD, PhD^15*, Laura Rosiñol, MD, PhD^16,17*, Miguel Angel Alvarez Rivas^18*, Maria Jose Calasanz, PhD^5*, Bargay Joan^19*, Ramon Garcia-Sanz, MD, PhD^20*, Ana Pilar Gonzalez^21*, Adrián Alegre, MD, MPH^22*, Fernando Escalante^23*, Rafael Martínez^24*, Javier De La Rubia^25,26*, Ana Isabel Teruel, MD^27*, Felipe De Arriba, MD, PhD^28*, Luis Palomera, MD, PhD^29*, Sergio Castro^1*, Miguel Teodoro Hernández Garcia, MD, PhD^30*, Javier López^31*, Aránzazu García Mateo, PhD^32*, Enrique M Ocio, MD, PhD³³, Joan Bladé, MD, PhD^34*, Juan Jose Lahuerta Palacios^6*, Jesús San Miguel, MD, PhD^9,10,35* and Maria Victoria Mateos, MD, PhD^1,7,10,36

¹Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca (IBSAL), University of Salamanca, Salamanca, Spain
²Biochemistry Department, University Hospital of Salamanca, Salamanca, ESP
³Flow Cytometry Core, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain
⁴Cancer Center Universidad de Navarra (CCUN)., Pamplona, Spain
⁵Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), IDISNA, CIBER-ONC number CB16/12/00369 and CB16/12/00489, Pamplona, Spain
⁶Hospital Universitario 12 de Octubre, CIBER-ONC CB16/12/00369, CNIO, Madrid, Spain
⁷University Hospital of Salamanca, Salamanca, Spain
⁸Department of Hematology, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Complutense University, CNIO, CIBERONC, Madrid, Spain
⁹Cancer Center Clínica Universidad de Navarra (CCUN), CIMA, CIBERONC, IDISNA, Pamplona, Spain
¹⁰Centro de Investigacion Biomedica en Red de Cancer (CIBERONC)., Madrid, Spain
¹¹University Hospital of Salamanca/IBSAL/Cancer Research Center-IBMCC (USAL-CSIC), CIBERONC, Salamanca, Salamanca, ESP
¹²University Hospital of Santiago de Compostela, Santiago de Compostela, Spain
¹³Hospital Universitario De Salamanca, Salamanca, ESP
¹⁴Institut Català d'Oncologia and Institut Josep Carreras, Hospital Germans Trias i Pujol, Barcelona, Spain
¹⁵Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
¹⁶Amyloidosis and Myeloma Unit, Hospital Clinic, IDIBAPS, Barcelona, Spain
¹⁷Amyloidosis and Multiple Myeloma Unit, Department of Hematology, IDIBAPS, Hospital Clinic, Barcelona, Spain
¹⁸Hospital General Cordoba, Cordoba, ESP
¹⁹Hospital Son Llazter, Palma de Mallorca, Spain
²⁰Hospital Universitario de Salamanca (HUSAL), IBSAL, IBMCC (USAL-CSIC), CIBERONC, Salamanca, Spain
²¹Hospital Universitario Central de Asturias, Oviedo, Spain
²²Hospital Universitario Quirón Salud, Madrid, Spain
²³Hospital Universitario de Leon, Leon, Spain
²⁴Hospital Clínico Universitario San Carlos, Madrid, Spain
²⁵University Hospital La Fe, Valencia, Spain
²⁶Hospital Universitario y Politécnico La Fe, Valencia, Spain
²⁷Department of Hematology, Hospital Clínico Universitario-INCLIVA, Valencia, Spain
²⁸Hospital Morales Meseguer, IMIB-Arrixaca, Universidad de Murcia, Murcia, Spain
²⁹Hospital Clinico Universitario Lozano Blesa, Instituto Investigacion Sanitaria Aragon, Zaragoza, Spain
³⁰Universidad de La Laguna, Tenerife, Spain
³¹University Hospital Ramón y Cajal, Madrid, Spain
³²Hospital General de Segovia, Segovia, ESP
³³Hospital Universitario Marques de Valdecilla, IDIVAL, Santander, Spain
³⁴Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain
³⁵Hemato-Oncology Program. Cima Universidad de Navarra. IdiSNA., Pamplona, Spain
³⁶Institute of Cancer Molecular and Cellular Biology, University Hospital of Salamanca, Salamanca, Spain

Juan-José Garcés, PhD^1,2*, Rosalinda Termini^3*, Esperanza Martín-Sánchez^4*, Marta Lasa, PhD^5*, Jose J Perez^6*, Norma C. Gutierrez^7*, Manuela Fernández^8*, Maria Jose Calasanz, PhD^9*, Laura Rosiñol, MD, PhD^10*, Miguel Teodoro Hernández Garcia, MD, PhD^11*, Albert Oriol^12*, Anna Maria Sureda Balari, MD, PhD¹³, Albert Perez Montaña, MD^14*, Enrique M Ocio, MD, PhD¹⁵, Maria Casanova Espinosa^16*, Felipe Prosper, MD, PhD⁹, Joaquin Martinez-Lopez, MD, PhD^17*, Jorge Labrador^18*, Esther Gonzalez Garcia, MD^19*, Rafael Ríos, MD, PhD^20*, Fernando Escalante^21*, Joan Bargay^22*, Elena Cabezudo^23*, Valentín Cabañas^24*, Niels Weinhold, PhD^25*, Aldo Roccaro, MD, PhD²⁶, Herve Avet-Loiseau, MD, PhD^27*, Alberto Orfao, MD, PhD^28*, Joan Blade Creixenti^29*, Maria Victoria Mateos, MD, PhD³⁰, Juan Jose Lahuerta Palacios^31*, Jesus San-Miguel, MD, PhD⁴, María T Cedena^32*, Noemi Puig, MD, PhD³⁰ and Bruno Paiva^9*

¹Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain
²Division of Myeloma, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
³Cancer Center Clinica Universidad de Navarra (CCUN), Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), CIBER-ONC numbers CB16/12/00369 and CB16/12/00489, Madrid, Spain, Pamplona, Spain
⁴CIMA (Pamplona)Cancer Center Clinica Universidad de Navarra (CCUN), Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), CIBER-ONC numbers CB16/12/00369 and CB16/12/00489, Pamplona, Spain
⁵Cancer Center Clinica Universidad de Navarra (CCUN), Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), CIBER-ONC numbers CB16/12/00369 and CB16/12/00489, Pamplona, Spain
⁶Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca, Salamanca, Spain
⁷Hospital Universitario De Salamanca, Salamanca, ESP
⁸Hospital Universitario 12 De Octubre, Universidad Complutense, CNIO Madrid, Madrid, Spain
⁹Cancer Center Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), IDISNA, CIBER-ONC number CB16/12/00369 and CB16/12/00489, Pamplona, Spain
¹⁰Hospital Clinic de Barcelona, IDIBAPS, Barcelona, Spain
¹¹Hospital Universitario de Canarias, Tenerife, Spain
¹²Catalan Institute of Oncology and Josep Carreras Institute, Hospital Germans Trias i Pujol, Badalona, Spain
¹³Institut Català d’Oncologia, Hospital Duran i Reynals, IDIBELL, Universitat de Barcelona, L’Hospitalet de Llobregat, Barcelona, Spain
¹⁴Hospital Universitario Son Espases, Palma, Spain
¹⁵Hospital Universitario Marques de Valdecilla, IDIVAL, Santander, Spain
¹⁶Hematology, Hospital Costa del Sol, Malaga, Spain
¹⁷Department of Hematology, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Complutense University, CNIO, CIBERONC, Madrid, Spain
¹⁸Hospital Universitario de Burgos, Universidad Isabel I, Burgos, ESP
¹⁹University Hospital Cabueñes, Gijón, Spain
²⁰Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
²¹Hospital Universitario de Leon, Leon, Spain
²²Hospital Universitario Son Llàtzer. IdIsBa., Palma de Mallorca, Spain
²³Hospital De Sant Joan Despí Moisès Broggi, Sant Joan Despí, Barcelona, ESP
²⁴Hospital Universitario Virgen de la Arrixaca., Murcia, Spain
²⁵Heidelberg Myeloma Center, Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany
²⁶Clinical Trial Center, Translational Research and Phase I Unit, ASST Spedali Civili di Brescia, Brescia, BS, Italy
²⁷Institut universitaire du cancer de Toulouse Oncopole, Toulouse, France
²⁸Cancer Research Center (IBMCC-CSIC/USAL-IBSAL), Cytometry Service (NUCLEUS) and Department of Medicine, University of Salamanca, Salamanca, Spain
²⁹Amyloidosis and Myeloma Unit, Department of Hematology, Hospital Clínic de Barcelona, IDIBAPS, Barcelona, Spain
³⁰Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca (IBSAL), University of Salamanca, Salamanca, Spain
³¹Hospital Universitario 12 de Octubre, CIBER-ONC CB16/12/00369, CNIO, Madrid, Spain
³²University Hospital 12 de octubre, Madrid, Spain

Nisha S. Joseph, MD¹, Jonathan L. Kaufman, MD², Sara Dicamillo^3*, Danielle Roberts^3*, Vikas A. Gupta, MD, PhD³, Craig C. Hofmeister, MD³, Madhav V. Dhodapkar, MD, PhD³, Lawrence H. Boise³, Sagar Lonial, MD^2* and Ajay K. Nooka, MD, MPH²

¹Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Louisville, KY
²Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA
³Winship Cancer Institute of Emory University, Atlanta

Yered Pita-Juarez, PhD^1*, Dimitra Karagkouni^2*, Edgar Gonzalez-Kozlova^3*, Yuling Ma^4*, Lijun Yao^5*, William Pilcher^6*, Beena Thomas, PhD^7,8*, Alessandro Lagana, PhD⁹, Sarthak Satpathy^10*, Swati Bhasin, PhD^7,8, Yizhe Song¹¹, Ravi Vij, MD, MBA¹², Darwin D'Souza^13*, Travis Dawson, PHD^13*, Geoffrey Kelly^13*, Jessica Wendy Schulman, BSc^14*, Shaji Kunnathu Kumar, MD¹⁵, David Avigan, MD¹⁶, Seunghee Kim-Schulze, PhD^17*, Li Ding, PhD^18*, Hearn Jay Cho, MD¹⁹, Taxiarchis Kourelis, MD¹⁵, Eva Lepisto, MSc, MA^14*, Manoj Bhasin, PhD^6,10, April Cook^14*, Mark Hamilton, PhD^20*, George Mulligan, PhD¹⁴, Immune Network^21*, Ioannis Vlachos, PhD^4* and Sacha Gnjatic^22*

¹Pathology, Beth Israel Deaconess Medical Center, Boston, MA
²Broad Institute of MIT and Harvard, Cambridge, MA
³MSSM, New York
⁴Department of Pathology, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
⁵WUSTL, Saint Louis
⁶Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA
⁷Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA
⁸Department of Pediatrics, Emory University, Atlanta, GA
⁹Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York
¹⁰Department of Biomedical Informatics, Emory University, Atlanta, GA
¹¹WUSTL, St Louis, MO
¹²Division of Oncology, Washington University School of Medicine, Saint Louis, MO
¹³Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY
¹⁴MMRF, Norwalk, CT
¹⁵Division of Hematology, Mayo Clinic, Rochester, MN
¹⁶Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
¹⁷Department of Immunology & Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY
¹⁸WUSTL, St Louis
¹⁹Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Tisch Cancer Institute, New York, NY
²⁰Multiple Myeloma Research Foundation, Norwalk, CT
²¹MMRF, Norwalk
²²Icahn School of Medicine at Mount Sinai, New York, NY