65th ASH Annual Meeting & Exposition: 631. Myeloproliferative Syndromes and Chronic Myeloid Leukemia: Basic and Translational: Stromal-Immune and Signaling Context

Symposia: Myeloproliferative Syndromes and Chronic Myeloid Leukemia: Basic and Translational Oral and Poster Abstracts
Oral

Research, Fundamental Science, MDS, Translational Research, MPN, CML, Chronic Myeloid Malignancies, CMML, drug development, Diseases, Therapies, Myeloid Malignancies

Ballroom 20AB (San Diego Convention Center)

Moderators:

Jonas S. Jutzi, MD, PhD, Brigham and Women's Hospital, Harvard Medical School and Simona Soverini, PhD, University of Bologna School of Medicine

Disclosures:

No relevant conflicts of interest to declare.

Abstracts cover cell-extrinsic mediators of MPN pathobiology and the efficacy of anti-inflammatory therapies.

10:30 AM

739

Genetic Deletion or Pharmacologic Inhibition of PTPN11 Impedes the Development and Progression of Myeloproliferative Neoplasms Induced By JAK2V617F and MPLW515L Mutants

Golam Mohi, PhD, Yue Yang, PhD^*, Mohammad A. Sayem, PhD^*, Bao T. Le, PhD^*, Fahim Ather, MSc^*, Avik Dutta, PhD^* and Salar Abbas, PhD^*

University of Virginia, Charlottesville, VA

10:45 AM

740

Interaction between JAK2-Mutated Neutrophils and Platelets Initiates Thrombosis Via Neutrophil Extracellular Traps

Koki Ueda, MD, PhD¹, Saori Miura, PhD²^*, Tomofumi Misaka, MD, PhD³^*, Keiji Minakawa²^*, Yuka Sato, PhD²^*, Yasuchika Takeishi, MD, PhD³^* and Kazuhiko Ikeda, MD, PhD²

¹Department of Blood Transfusion and Transplantation Immunology, School of Medicine, Fukushima Medical University, Fukushima, FKS, Japan
²Department of Blood Transfusion and Transplantation Immunology, School of Medicine, Fukushima Medical University, Fukushima, Japan
³Department of Cardiovascular Medicine, School of Medicine, Fukushima Medical University, Fukushima, Japan

11:00 AM

741

Preclinical Studies Demonstrating Efficacy of Tasquinimod in Models of Advanced Myeloproliferative Neoplasm (MPN) in Blastic Phase

Warren C. Fiskus, BSc, PhD¹, Lucia Masarova, MD², Christopher Peter Mill, PhD, BA³, Christine Birdwell, PhD³, Kaberi Das¹^*, John Davis³^*, Hanxi Hou⁴^*, Noor Alhamadani⁴^*, Kevin Philip⁴^*, Alicia Matthews⁴^*, Taghi Manshouri, PhD¹^*, Tapan M. Kadia, MD², Courtney D. DiNardo, MD, MSc², Prithviraj Bose, MD⁴, Naveen Pemmaraju, MD², Sanam Loghavi, MD⁵, Marie Törngren, PhD⁶^* and Kapil N. Bhalla, MD²

¹UT MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³MD Anderson Cancer Center, Houston, TX
⁴The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Hematopathology, MD Anderson Cancer Center, Houston, TX
⁶Active Biotech, Lund, Sweden

11:15 AM

742

Interferon-Alpha Impairs Neoplastic Vasculogenesis in a 3D iPSC-Based Model of JAK2V617F+ Myeloproliferative Neoplasms

Madeline J. Caduc, MD^1,2^*, Martin Grasshoff, MSc³^*, Sabrina Ernst, PhD⁴^*, Gerhard Müller-Newen, PhD⁴^*, Jörg Eschweiler, PhD⁵^*, Ivan G. Costa, PhD³^*, Tim H. Brümmendorf^1,2, Steffen Koschmieder^1,2,6 and Marcelo Szymanski de Toledo^1,2,6^*

¹Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany
²Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany
³Institute for Computational Genomics, RWTH Aachen University Medical School, Aachen, Germany
⁴Confocal Microscopy Facility, Interdisciplinary Center for Clinical Research IZKF, RWTH Aachen University, Aachen, Germany
⁵Department of Orthopaedics, Trauma and Reconstructive Surgery, Medical Faculty, RWTH Aachen University, Aachen, Germany
⁶Shared senior autorship, Aachen, Germany

11:30 AM

743

MSC Reprogramming and Aberrant Inflammatory Signaling in Myelofibrosis: Insights from Single-Cell RNA-Sequencing of Trephine Bone Marrow Cells

Naseer J Basma, PhD¹^*, Alexia J Strickson²^*, Kristian Gurashi, PhD³^*, Maria Kleppe, PhD, RPh⁴^*, Hugh Young Rienhoff Jr. Jr., MD⁴ and Tim CP Somervaille, PhD FRCP FRCPath²

¹Cancer Research UK Manchester Institute, Manchester, ENG, United Kingdom
²Cancer Research UK Manchester Institute, Manchester, United Kingdom
³The University of Manchester, Manchester, United Kingdom
⁴Imago BioSciences, Inc., a subsidiary of Merck & Co., Inc., Rahway, NJ

11:45 AM

744

TGFβ1 Secretion in Megakaryocytes Is Autophagy-Dependent and Its Inhibition Ameliorates Myelofibrosis in Mice

Isabelle C. Becker, PhD^1,2, Maria N. Barrachina, PhD^1,2, Virginia Camacho, PhD^1,2, Harvey G. Roweth, PhD, BSc^2,3, Julia Tilburg, PhD^1,2, Bernadette Chua, PhD⁴^*, Zoltan Nagy, PhD⁵^*, Maximilian Englert⁵^*, Kellie R. Machlus, PhD^1,6, Robert Signer, PhD⁴, Bernhard Nieswandt, PhD⁵^* and Joseph E. Italiano, PhD^1,2

¹Boston Children's Hospital, Boston, MA
²Harvard Medical School, Boston, MA
³Brigham and Women's Hospital, Boston, MA
⁴University of California San Diego, La Jolla, CA
⁵Institute of Experimental Biomedicine, University Hospital Würzburg, Würzburg, Germany
⁶Boston Children's Hospital and Harvard Medical School, Boston, MA

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^*signifies non-member of ASH

631.O3.6 631. Myeloproliferative Syndromes and Chronic Myeloid Leukemia: Basic and Translational: Stromal-Immune and Signaling Context