65th ASH Annual Meeting & Exposition: 621. Lymphomas: Translational – Molecular and Genetic: Signaling Pathways and MRD in Lymphoma

Symposia: Lymphomas: Translational—Molecular and Genetic Oral and Poster Abstracts
Oral

Research, Fundamental Science, Translational Research

Harbor Ballroom (Manchester Grand Hyatt San Diego)

Moderators:

Russell J. H. Ryan, MD, Massachusetts General Hospital and Florence Nguyen-Khac, MD, PhD,

Disclosures:

No relevant conflicts of interest to declare.

12:00 PM

523

BTG2 Super-Enhancer Mutations Disrupt TFAP4 Binding and Deregulate BTG2 Expression in Diffuse Large B-Cell Lymphoma

Pantaleo De Simone, MD¹^*, Elodie Bal, PhD¹^*, Antony Holmes, PhD, BSc, MSc¹^*, Laura Hilton, PhD²^*, Katia Basso, PhD^1,3^*, Rajesh K Soni, PhD⁴^*, Ryan Morin, PhD², Riccardo Dalla-Favera, MD^1,3,5,6,7^* and Laura Pasqualucci, MD^1,3,7^*

¹Institute for Cancer Genetics, Columbia University, New York, NY
²Genome Sciences Center, BC Cancer Research Institute, Vancouver, BC, Canada
³Department of Pathology & Cell Biology, Columbia University, New York, NY
⁴Proteomics and Macromolecular Crystallography Shared Resource, Columbia University, New York, NY
⁵Department of Genetics & Development, Columbia University, New York, NY
⁶Department of Microbiology and Immunology, Columbia University, New York, NY
⁷Herbert Irving Comprehensive Cancer Center, Columbia University Columbia University, New York, NY

12:15 PM

524

CD58 Genetic Alterations and Its Contribution to Upregulation of PD-L1 and IDO Via LYN/CD22/SHP1 Axis in DLBCL

Xiyue Xu¹^*, Qingpei Guan¹^*, Lanfang Li¹^*, Lihua Qiu¹^*, Zhengzi Qian¹^*, Shiyong Zhou¹^*, Yixin Yao, PhD², Xianhuo Wang¹^* and Huilai Zhang¹^*

¹Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
²Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX

12:30 PM

525

An In Vivo PiggyBac Insertional Mutagenesis Screen Reveals Oncogenic Lesions Cooperating with Myd88^L265P

Svenja Höfmann¹^*, Ruth Flümann²^*, Julia Hansen²^*, Sebastian Klein³^*, Jörn Meinel⁴^*, Pauline Pfeiffer²^*, Hannah Goldfarb-Wittkopf²^*, Anna Lütz²^*, Jessica Wirtz²^*, Michael Möllmann³^*, Tanja Zhou³^*, Areya Tabatabai³^*, Tim Lohmann²^*, Filippo Beleggia²^*, Benedikt Pelzer, MD⁵^*, Fabian Ullrich, MD³, Aastha Arora³^*, Thorsten Persigehl⁶^*, Reinhard Büttner⁴^*, Bastian von Tresckow, MD³, Ron Jachimowicz²^*, Gero Knittel, PhD³^* and Hans Christian Reinhardt, MD³

¹Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany
²Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne, Cologne, NRW, Germany
³Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, NRW, Germany
⁴Faculty of Medicine and University Hospital Cologne, Institute of Pathology, University of Cologne, Cologne, NRW, Germany
⁵Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY
⁶Faculty of Medicine and University Hospital Cologne, Department of Radiology and Interventional Radiology, University of Cologne, Cologne, NRW, Germany

12:45 PM

526

Role of the S1P Signaling Pathway in the Pathogenesis of Angioimmunoblastic T-Cell Lymphoma

Wen-Hsuan Wendy Lin, MD, PhD¹, Jose Rodriguez Cortes, PhD²^*, Mick Aitken³^*, Clara Reglero, PhD²^*, Anouchka Laurent, PhD², Anisha Cooke²^*, Laura Belver, PhD²^*, Govind Bhagat, MD⁴, Raul Rabadan, PhD³^*, Adolfo A. Ferrando, MD, PhD²^* and Teresa Palomero, PhD^1,2

¹Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY
²Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY
³Department of Systems Biology, Columbia University Medical Center, New York, NY
⁴Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York

1:00 PM

527

A Personalized Whole Genome-Informed Assay Targeting Single Mutant in Circulating Tumor DNA Can Identify MRD and Predict Relapse in DLBCL

Reid W. Merryman, MD¹, Justin Rhoades²^*, Kan Xiong²^*, Katherine Antel, MD, PhD^3,4, Hyun Hwan An⁵^*, Robert A. Redd, MS⁶^*, Mikaela M. McDonough, BS⁵^*, Lillian Guerrero³^*, Andela Crnjac²^*, Sainetra Sridhar²^*, Timothy Blewett²^*, Ju Chen²^*, Parastoo B. Dahi, MD⁷^*, Yago Nieto, MD, PhD⁸, Yi-Bin Chen, MD, MS⁹, Alex F. Herrera, MD⁹, Robin M. Joyce, MD¹⁰^*, Philippe Armand, MD, PhD¹¹, Mark Alan Murakami, MD, MA, MMSc⁵ and Viktor Adalsteinsson²^*

¹Brigham and Women's Hospital, Boston, MA
²Broad Institute, Boston, MA
³Dana-Farber Cancer Institute, BOSTON, MA
⁴Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
⁵Dana-Farber Cancer Institute, Boston, MA
⁶Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
⁷Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁸Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
⁹City of Hope, Duarte, CA
¹⁰Massachusetts General Hospital, Boston, MA
¹¹Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

1:15 PM

528

Longitudinal Noninvasive Surveillance & Fragmentomic Characterization of Follicular Lymphoma

Joseph G Schroers-Martin, MD¹, Jurik A Mutter, PhD²^*, Mohammad Shahrokh Esfahani, PhD²^*, Florian Scherer, MD³, Joanne Soo, MD⁴^*, Stefan K. Alig, MD⁵, David M. Kurtz, MD, PhD², Takeshi Sugio, MD, PhD⁶^*, Cédric Rossi, MD, PhD⁴, Benoit Tessoulin⁷^*, Mari Olsen²^*, Chih Long Liu²^*, Maximilian Diehn, MD, PhD⁸^* and Ash A. Alizadeh, MD, PhD²

¹Stanford University, Menlo Park, CA
²Department of Medicine, Divisions of Oncology and Hematology, Stanford University, Stanford, CA
³Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University of Freiburg, Freiburg, Germany
⁴Stanford University, Stanford, CA
⁵Divisions of Oncology and Hematology, Stanford University School of Medicine, Stanford, CA
⁶Divisions of Oncology and Hematology, Stanford University, Washington, MD
⁷Hematology Department, CHU Nantes, Nantes, France
⁸Department of Radiation Oncology, Stanford University, Stanford, CA

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^*signifies non-member of ASH

621A.O1.6 621. Lymphomas: Translational – Molecular and Genetic: Signaling Pathways and MRD in Lymphoma