Sandra Huber, PhD^*, Constance Regina Baer, PhD, Stephan Hutter, PhD^*, Frank Dicker, PhD, Irene Fuhrmann^*, Manja Meggendorfer, PhD, Christian Pohlkamp, MD^*, Wolfgang Kern, MD, Torsten Haferlach, MD, PhD, Claudia Haferlach, MD and Gregor Hoermann, MD, PhD

MLL Munich Leukemia Laboratory, Munich, Germany

Alberto Hernández Sánchez, MD^1,2*, Javier Martínez Elicegui^2*, Marta Sobas, MD, PhD^3*, Eric Sträng^4*, Axel Benner^5*, María Abáigar, PhD^2,6*, Gastone Castellani, PhD^7*, Laura Tur^8*, Peter J. M. Valk, PhD⁹, Angela Villaverde Ramiro^10*, Klaus H Metzeler, MD¹¹, Raúl Azibeiro Melchor^1,2*, Jurjen Versluis, MD, PhD^12*, Daniele Dall'Olio, PhD^7*, Teresa González, PhD^6*, Jesse M. Tettero, MD^13,14,15*, Joaquin Martinez-Lopez, MD, PhD^16*, Helena Fidalgo^2*, Jorge Sierra, MD^17*, Frederik Damm^4*, Ken I Mills, BSc, PhD, FRCPath¹⁸, Soren Lehmann, MD, PhD^19*, Ian Thomas^20*, Jiří Mayer, MD^21,22, Christian Thiede, MD²³, Maria Teresa Voso, MD²⁴, Guillermo Sanz, MD, PhD^25,26*, Konstanze Döhner²⁷, Michael Heuser, MD²⁸, Torsten Haferlach, MD, PhD²⁹, Amin T. Turki, MD^30,31*, Dirk Reinhardt, MD, PhD^30*, Michel van Speybroeck^32*, Renate Schulze-Rath, MD, MSc^33*, Martje Barbus, PhD^34*, John E Butler, PhD^35*, Jesús María Hernández-Rivas, PhD^2,6,36, Brian Huntly, PhD^37*, Gert Ossenkoppele, MD, PhD^13,15,38, Hartmut Döhner, MD²⁷ and Lars Bullinger⁴

¹University Hospital of Salamanca, Salamanca, Spain
²Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain
³Wroclaw Medical University, Wroclaw, Poland
⁴Charité Universitätsmedizin Berlin, Berlin, Germany
⁵Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
⁶Cancer Research Center of Salamanca (USAL-CSIC), Salamanca, Spain
⁷University of Bologna, Bologna, Italy
⁸GMV Innovating Solutions, Valencia, Spain
⁹Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, Netherlands
¹⁰University of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, Department of Hematology - Hospital Universitario de Salamanca, Salamanca, Spain
¹¹University of Leipzig, Leipzig, Germany
¹²Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of Hematology, Rotterdam, Netherlands
¹³Amsterdam University Medical Center, Amsterdam, Netherlands
¹⁴Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands
¹⁵VU University Medical Center, Amsterdam, Netherlands
¹⁶Hospital 12 de Octubre, Madrid, Spain
¹⁷Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
¹⁸Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, NI, United Kingdom
¹⁹Department of Medical Sciences, Hematology, Uppsala University, University Hospital Uppsala, Uppsala, Sweden
²⁰Cardiff University, Cardiff, United Kingdom
²¹Masaryk University, Brno, Czech Republic
²²University Hospital Brnoand, University Hospital Brnoand, Czech Republic
²³Department of Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany
²⁴University of Rome “Cattolica S. Cuore”, Rome, Italy
²⁵Hospital Universitario y Politécnico e Instituto de Investigación Sanitaria La Fe, Valencia, Spain
²⁶CIBERONC, Instituto de Salud Carlos III, Valencia, Spain
²⁷Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
²⁸Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
²⁹MLL Munich Leukemia Laboratory, Munich, Germany
³⁰Essen University Hospital, Essen, Germany
³¹West-German Cancer Center, Essen, Germany
³²Janssen Pharmaceutica NV, Beerse, Belgium
³³Bayer AG, Berlin, Germany
³⁴AbbVie Germany GmbH & Co. KG, Wiesbaden, Germany
³⁵Bayer Innovation GmbH, Duesseldorf, Germany
³⁶Servicio de Hematología, Hospital Universita­rio de Salamanca, Universidad de Salamanca, Salamanca, Spain
³⁷Wellcome - MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom
³⁸Cancer Center Amsterdam, Amsterdam, Netherlands

Adriane Halik, MD^1*, Marlon Tilgner^1*, Patricia Silva^1*, Natalia Estrada-Barreras^1*, Robert Altwasser^1*, Ekaterina Jahn, MD^2*, Michael Heuser, MD³, Hsin-An Hou, M.D.; Ph.D.⁴, Marta Pratcorona^5*, Robert Kerrin Hills^6*, Klaus H Metzeler, MD⁷, Laurène Fenwarth, MD, MSc^8*, Anna Dolnik^1*, Christine Terré^9*, Klara Kopp^1*, Martin Szyska^1*, Jan Krönke, MD^1*, Loïc Vasseur^10*, Bob Lowenberg, MD, PhD¹¹, Jordi Esteve, MD, PhD¹², Peter J. M. Valk, PhD¹³, Matthieu Duchmann, M.D. / Ph.D.^14*, Wen-Chien Chou, MD, PhD⁴, David C. Linch, MD^15*, Hartmut Döhner, MD², Rosemary E. Gale^15*, Konstanze Döhner², Lars Bullinger^16,17, Kenichi Yoshida, MD, PhD¹⁸ and Frederik Damm, MD^1,16*

¹Department of Hematology, Oncology, and Cancer Immunology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
²Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
³Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
⁴Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
⁵Institut d’investigació Biomèdica Sant Pau (IIB SANT PAU) Department of Medicine, Hospital de la Santa Creu i Sant Pau, Barcelona, ESP
⁶Nuffield Department of Population Health, University of Oxford, Oxford, UK., Oxford, United Kingdom
⁷Department of Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, University Leipzig Medical Center, Leipzig, NA, Germany
⁸Hematology Laboratory, CHU Lille, Lille, France
⁹Laboratoire de Cytogénétique, Centre hospitalier de Versailles, Chesnay-Roquencourt, France
¹⁰Biostatistics and Medical Information Department, Saint Louis University Hospital, AP-HP, Université Paris Cité, Paris, France
¹¹Erasmus University Medical Center Cancer Institute, Rotterdam, Netherlands
¹²Hematology Department, Hospital Clínic Barcelona, Barcelona, Spain
¹³Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, Netherlands
¹⁴Institut de Recherche Saint-Louis (IRSL), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Université Paris Cité, Paris, France
¹⁵Department of Haematology, Royal Free and University College London Medical School, London, United Kingdom
¹⁶German Cancer Consortium (Deutsches Konsortium für Translationale Krebsforschung, DKTK), Berlin, Germany
¹⁷Department of Hematology, Oncology, and Cancer Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany
¹⁸Division of Cancer Evolution, National Cancer Center Research Institute, Tokyo, Japan

Poonam N Desai¹, Bofei Wang, Ph.D.^1*, Patrick K Reville, MD, MPH¹, Fatima Z Jelloul^2*, Pamella Borges^1*, Jayastu Senapati, MD, MBBS, DM¹, Micah Castillo^3*, Preethi Gunaratne^3*, Naveen Pemmaraju, MD¹, Tapan M. Kadia, MD¹, Farhad Ravandi, MD, MBBS¹, Guillermo Garcia-Manero, MD¹, Naval Daver, MD¹ and Hussein A Abbas, MD, PhD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Biology and Biochemistry, University of Houston, Houston, TX

Sander Lambo, PhD^1*, Diane L. Trinh^2*, Rhonda E Ries, MA^3*, Dan Jin^2*, Audi Setiadi^4*, Michelle Ng^5*, Veronique G. Leblanc^2*, Suzanne Vercauteren, MD, PhD, FRCPC⁶, Soheil Meshinchi, MD, PhD⁷ and Marco Marra, PhD⁸

¹Canada's Michael Smith Genome Sciences Centre, BC Cancer, Boston, MA
²Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada
³Translational Sciences and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
⁴BC Children & Women's Hospital, Vancouver, BC, CAN
⁵Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, Canada
⁶British Columbia Children’s Hospital Research Institute, Vancouver, BC, CAN
⁷Translational Sciences and Therapeutics, Fred Hutchinson Cancer Research Center, Seattle, WA
⁸British Columbia Cancer Agency, Vancouver, BC, CAN

Hanna Duàn, M.Sc.^1,2,3*, Olli Dufva, M.D., Ph.D.^1,2,3*, Emmi Jokinen^1,2,3*, Hanna Lähteenmäki^1,2*, Jay Klievink, M.Sc.^1,2*, Jonas Bouhlal^1,2,3*, Jason Theodoropoulos^1,2,3*, Heikki Kuusanmäki, PhD^4,5,6*, Tanja Ruokoranta, MSc^5*, Pauliina Rumm^1,2*, Dean Anthony Lee, MD, PhD⁷, Esa Pitkänen, PhD^3,5,8*, Tomi P Mäkelä, MD, PhD^3,9*, Kimmo Porkka, MD, PhD^1,2,3,10, Oscar Brück, MD, PhD^11* and Satu Mustjoki, MD, PhD^3,12,13

¹Translational Immunology Research Program, University of Helsinki, Helsinki, Finland
²Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
³ICAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland
⁴Biotech Research & Innovation Centre (BRIC) and Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen, Denmark
⁵Institute for molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland
⁶Foundation for the Finnish Cancer Institute, Helsinki, Finland
⁷Hem/Onc/BMT, Nationwide Children’s Hospital, Columbus, OH
⁸Applied Tumor Genomics Research Program, University of Helsinki, Helsinki, Finland
⁹HiLIFE-Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland
¹⁰Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
¹¹Hematoscope Lab, Comprehensive Cancer Center & Center of Diagnostics, Helsinki University Hospital & University of Helsinki, Helsinki, Finland
¹²Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
¹³Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland