Danielle C Kirkey, MD^1,2, Leila Robinson^1*, Derek Janssens, PhD^3*, Margaret G Hines^4*, Tiffany Hylkema, BS^5*, Makia K Manselle^1*, Rhonda E Ries, MA^5*, Jack H Peplinski, BS^5*, Logan K Wallace^1*, Dominik Otto, PhD^3*, Katherine Tarlock, MD^1,6, Steven Henikoff, PhD^3*, Wei Li, PhD^4* and Soheil Meshinchi, MD, PhD⁷

¹Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
²Division of Pediatric Hematology/Oncology, Seattle Children's Hospital, Seattle, WA
³Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA
⁴Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA
⁵Translational Sciences and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
⁶Division of Pediatric Hematology, Oncology, Bone Marrow Transplant & Cellular Therapy, Seattle Children's Hospital, Seattle, WA
⁷Translational Sciences and Therapeutics, Fred Hutchinson Cancer Research Center, Seattle, WA

Jayakumar Vadakekolathu, PhD^1*, Heidi Altmann, PhD^2*, Manja Wobus^2*, Malte von Bonin, MD^2*, Marc Schmitz, MD^3,4*, Gustavo B. Baretton, MD^5*, Robert Zeiser, MD⁶, Martin Bornhäuser, MD^7,8* and Sergio Rutella, MD, PhD, FRCPath¹

¹John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, United Kingdom
²Department of Internal Medicine I, University Hospital, TU Dresden, Dresden, Germany
³Institute for Immunology, University Hospital, TU Dresden, Dresden, Germany
⁴National Center for Tumor Diseases (NCT/UCC) Dresden, TU Dresden, Dresden, Germany
⁵Institute for Pathology, University Hospital, TU Dresden, Dresden, Germany
⁶Department of Medicine I, Medical Center University of Freiburg, Freiburg, Germany
⁷Department of Internal Medicine 1, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
⁸National Center for Tumor Diseases (NCT/UCC) Dresden, Technical University Dresden, Dresden, Germany

Bettina Nadorp, PhD^1,2,3*, Audrey Lasry, PhD^2,3*, Sanam Loghavi, MD⁴, Ravi Patel^5*, Ben Kelly^6*, Christopher J. Walker, PhD^7,8*, Stephanie LaHaye^9*, Jill Buss, BS^8,10, Isaiah Boateng^8*, Karen Nahmod, MD, PhD^11*, Adrienne Heyrosa^8*, Helee Desai^8*, Andrea Langanson^8*, Hasan Abaza^8*, Linda Procell^2*, Tejas Patel^2*, Benjamin Kaffenberger^8*, Saranga Wijeratne^12*, Maria Guillamot Ruano, PhD, PharmD^2*, Anna Yeaton, PhD^2*, Geraldine Cayanan, PhD^2*, Maria Velegraki^13*, Zihai Li, MD, PhD¹³, Kieran D Sahasrabudhe, MD¹⁴, Lynne V. Abruzzo, MD, PhD⁸, Daniel Pollyea¹⁵, Christine M. McMahon¹⁶, Arwa Shana'Ah^8*, John C. Byrd, MD⁸, Aristotelis Tsirigos, PhD^1,2, Elaine R Mardis, PhD^8*, Alice Mims, MD^17,18, Iannis Aifantis, PhD^2,18 and Ann-Kathrin Eisfeld, MD*^7,14,18

¹Division of Precision Medicine, Department of Medicine, NYU Grossman School of Medicine, New York, NY
²Department of Pathology, NYU Grossman School of Medicine, New York, NY
³equal contribution, *
⁴Hematopathology, MD Anderson Cancer Center, Houston, TX
⁵The Ohio State Comprehensive Cancer Center, Columbus, OH
⁶Nationwide Children's Hospital and Ohio State University College of Medine, Columbus, OH
⁷Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University, Columbus, OH
⁸The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁹The Steve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute at Nationwide Children’s Hospital, Columbus, OH
¹⁰Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH
¹¹Department of Hematopathology, The University of Texas, MD Anderson Cancer Center, Houston, TX
¹²The Steve and Cindy Rasmussen Institute For Genomic Medicine, Abigail Wexner Res, Columbus, OH
¹³Pelotonia Institute for Immunology-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH
¹⁴Division of Hematology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
¹⁵University of Colorado, Aurora, CO
¹⁶University of Colorado School of Medicine, Aurora, CO
¹⁷Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH
¹⁸equal contribution, #

Dominic Fowler-Shorten, BSc^1*, Rebecca S Maynard, MSc^1*, Katherine Hampton, MSc, BSc^1*, Martha Ehikioya^1*, Edyta E Wojtowicz, PhD^2*, Kristian Bowles, MBBS, PhD^1,3, Stuart Rushworth, PhD¹ and Charlotte Hellmich, PhD, BSc, MBBChir^1,3

¹Norwich Medical School, University of East Anglia, Norwich, United Kingdom
²Earlham Institute, Norwich, United Kingdom
³Norfolk and Norwich University Hospital, Norwich, United Kingdom

Isabel Weinhaeuser, PhD^1*, Diego Pereira-Martins, PhD^1*, Dominique Sternadt, MSc^1*, Emmanuel F Griessinger, Ph.D.^1*, Douglas RA Silveira, MD, PhD^2*, Juan L Coelho-Silva, Ph.D.^3*, Antonio Bruno Alves-Silva, MSc^4*, Ayşegül Erdem, Ph.D.^5*, Bruno Koza Lino Duarte, MD^6*, Lynn Quek, MD, PhD^7*, Fabiola Traina, MD, PhD⁸, Sara Teresinha Olalla Saad, MD⁹, Jacobien R Hilberink, MD, BSc^1*, Emanuele Ammatuna, MD, PhD^1*, Eduardo Magalhães Rego, MD, PhD^10,11, Gerwin A. Huls, Prof.¹², Antonio R Lucena-Araujo, Prof.^3* and Jan Jacob Schuringa, PhD¹³

¹Department of Experimental Hematology, University Medical Centre Groningen, Groningen, Netherlands
²School of Cancer and Pharmaceutical Sciences, King's College London, London, ENG, United Kingdom
³Department of Genetics, Federal University of Pernambuco, Recife, Brazil
⁴Department of Medical Images, Haematology, and Clinical Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil
⁵Cellular Metabolism and Microenvironment Laboratory, de Duve Institute, UCLouvain, Brussels, Belgium
⁶Centro de Hematologia e Hemoterapia, Universidade Estadual de Campinas, Caminas, Brazil
⁷Myeloid Leukaemia Genomics and Biology Group, School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
⁸Department of Medical Images, Hematology, and Oncology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil
⁹Hematology and Transfusion Medicine Center - University of Campinas/Hemocentro-UNICAMP, Campinas, São Paulo, Brazil
¹⁰Hematology Service, LIM-31 and State of Sao Paulo Cancer Institute, University of São Paulo, Faculdade de Medicina, São Paulo, São Paulo, Brazil
¹¹Instituto do Cancer do Estado de Sao Paulo, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, BRA
¹²Department of Hematology, University Medical Center Groningen, Groningen, Netherlands
¹³Department of Experimental Hematology, University Medical Center - Groningen, Groningen, Netherlands

Guo Qiu^1*, Xi Xu^2*, Huiwen Xue^2*, Tian Zhang^3*, Li Xuan^4* and Qifa Liu, MD¹

¹Nanfang Hospital, Southern Medical University, Guangzhou, China
²Nanfang Hospital, Southern Medical University, Guangzhou, CHN
³Nanfang Hospital, Southern Medical University, Guang Zhou, China
⁴Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China