-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

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301.O2.6 301. Vasculature, Endothelium, Thrombosis and Platelets: Basic and Translational: Targeting platelet reactivity in thrombosis

Symposia: Vasculature, Endothelium, Thrombosis and Platelets: Basic and Translational Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Fundamental Science, Bleeding and Clotting, Anticoagulant Drugs, Translational Research, Non-Biological therapies, thromboembolism, drug development, Diseases, Immune Disorders, immune mechanism, thrombotic disorders, Therapies, Pharmacology, Biological Processes, molecular biology, Technology and Procedures, omics technologies
Monday, December 11, 2023: 10:30 AM-12:00 PM
Room 30 (San Diego Convention Center)
Harvey G. Roweth, PhD, BSc, Brigham and Women's Hospital and Anthony Washington, PhD, Oakland University
No relevant conflicts of interest to declare.
The purpose of this Oral Session 301_2 is to present new mechanisms/targets of platelet hyperreactivity in cardiovascular and immune thrombosis. The theme of this session includes novel insights into the role of lung platelets in immunothrombosis, a novel platelet protein, Sec61b, involved in calcium flux in diabetes, and the role of anti-PF4, ELISA negative, platelet activating antibodies in thrombosis with monoclonal gammopathy. Two new antithrombotic platelet targets are presented (kinase Ask1 and cytoskeletal protein ARP2), as well as a novel class of antithrombotics (galloylated polyphenols).
10:30 AM

Cristobal Rivera, MSc1, Michele Silvestro, MD1*, Muhammad Yogi Pratama, PhD, MD2*, Steven Medvedovsky3* and Bhama Ramkhelawon, PhD1*

1Department of Surgery, NYU School of Medicine, New York, NY
2NYU School of Medicine, New York, NY
3SUNY Downstate Health Sciences University, New York, NY

10:45 AM

Yvonne X Kong1,2,3*, Rajan Rehan4*, Cesar L Moreno2,5,6*, Huiwen Zhao3*, David James2,7*, Michelle Cielesh2,6*, Grant Morahan8*, Sian Cartland9*, Mary Kavurma9*, Greg Neely2,5,6*, Matthew T. Rondina, MD10, James Weaver4*, Mark Larance2,6* and Freda H Passam, MD, PhD1,2,3

1Institute of Haematology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
2Charles Perkins Centre, University of Sydney, Camperdown, NSW, Australia
3Central Clinical School, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia
4Department of Cardiology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
5Dr. John and Anne Chong Lab for Functional Genomics, Centenary Institute, Sydney, NSW, Australia
6School of Medical Sciences, University of Sydney, Camperdown, NSW, Australia
7School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW, Australia
8University of Western Australia Centre for Medical Research, University of Western Australia, Perth, Western Australia, Australia
9Heart Research Institute, Sydney, NSW, Australia
10Molecular Medicine Program, Department of Internal Medicine, and Division of Hematology and Hematologic Malignancies, University of Utah, Salt Lake City, UT

11:00 AM

Meghna U Naik, MS1, Noor Shaik2*, Timothy Stalker, PhD3* and Ulhas P. Naik, PhD1

1Cardeza Center for Hemostasis, Thrombosis, and Vascular Biology, Cardeza Foundation for Hematology Research, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA
2Thomas Jefferson University, Philadelphia, PA
3JAH, Room 394B, Thomas Jefferson University, Philadelphia

11:15 AM

Adam Kanack, PhD1, Nelson Leung, MD2, Noah Splinter, MS1*, Emily Mauch, BS1*, Morayma Reyes Gil, MD3*, Leben Tefera, MD4*, Sakshi Jasra, MD5, Andrew Goodwin, MD6*, Hadiyah Audil, MD7, Aneel Ashrani, MBBS, MSc8, Nathaniel L. Robinson, MD9*, Ana I. Casanegra, MD10*, Curtis Jones, BS11*, Shannon Pechauer, BS12*, Erin Yttre, BS13*, Mindy Kohlhagen, BS1*, Rachel Leger, BS1*, David L Murray, MD, PhD1*, Dong Chen, MD, PhD14, Rajiv K. Pruthi, M.B.B.S.15 and Anand Pabmanabhan, MBBS, PhD1

1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
2Department of Medicine, Mayo Clinic, Rochester, Rochester, MN
3Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH
4Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH
5Department of Hematology/Oncology, University of Vermont Larner College of Medicine, Burlington, VT
6University of Vermont Medical Center, Burlington, VT
7Mayo Clinic, Rochester, MN
8Mayo Clinic College of Medicine, Rochester, MN
9Department of Surgery, Mayo Clinic, Rochester, MN
10Gonda Vascular Center, Mayo Clinic, Rochester, MN
11Retham Technologies, Wauwatosa, WI
12Versiti Blood Research Institute, Wauwatosa, WI
13Versiti Blood Research Institute, Milwaukee, WI
14Division of Hematopathology, Mayo Clinic, Rochester, MN
15Department of Internal Medicine, Mayo Clinic, Rochester, MN

11:30 AM

Caitlin Schneider, B.S.1*, Marisa A Brake, PhD2, Amy Siebert-Mckenzie, PhD3*, Adrianna Jurek, BS1*, Audrey C Cleuren, PhD4,5, Linzi Hobbs, MD1, Alexander Johnston1*, Michael Powers, MS1*, Azaj Ahmed6*, Melissa Jensen6*, Javier Menendez, MS1*, Sanjana Dayal, PhD7, Anthony Washington, PhD1 and Randal Joseph Westrick, PhD1

1Oakland University, Rochester, MI
2Harvard University, Boston
3Versiti Blood Research Institute, Milwaukee, WI
4Oklahoma Medical Research Foundation, Oklahoma City, OK
5Life Sciences Institute, University of Michigan, Ann Arbor
6University of Iowa, Iowa City, IA
7University of Iowa Department of Internal Medicine, Iowa City

11:45 AM

Moua Yang, PhD1, Quinn Kennedy1*, Anika Patel1, Da-Yuan Chen, PhD2,3*, Christina Scartelli1*, Soravis Osataphan, MD4*, Roelof Bekendam, MD, PhD1, Huanzhang Xie5*, Lin Lin, PhD5*, Alec A Schmaier, MD, PhD1, Mohsan Saeed, PhD, DVM2,3* and Robert Flaumenhaft, MD, PhD1

1Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA
2Department of Biochemistry, Boston University School of Medicine, Boston, MA
3National Emerging Infectious Diseases Laboratories, Boston, MA
4Division of Medical Oncology and Hematology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
5College of Materials and Chemical Engineering, Minjiang University, Fuzhou, China

*signifies non-member of ASH