65th ASH Annual Meeting & Exposition: 101. Red Cells and Erythropoiesis, Excluding Iron: Red Cells: Emerging Gene Regulatory Mechanisms in Erythroid Differentiation

Symposia: Red Cells and Erythropoiesis, Excluding Iron Oral and Poster Abstracts
Oral

Room 25 (San Diego Convention Center)

Moderators:

Marlies P. Rossmann, MD, PhD, University of Rochester School of Medicine and Dentistry and Andrew C. Perkins, MBBS, PhD, Monash University

Disclosures:

No relevant conflicts of interest to declare.

This symposium will discuss gene transcription during development and differentiation of red blood cells. The purpose of this session is to present unpublished data on mechanisms that regulate erythropoiesis.

9:30 AM

Bromodomain Protein BRD4 Is a Transcriptional Repressor of Terminal Erythropoiesis By Interacting with EHMT1/2

Meng Zhang^1,2,3^*, Yijin Chen, PhD^2,3,4^*, Qian Luo, PhD^2,3,4^*, Pengxu Qian, PhD^2,3,5^* and He Huang, MD^2,3,5^*

¹Bone Marrow Transplantation Center, First Affiliated Hospital Zhejiang University, HANGZHOU, China
²Institute of Hematology, Zhejiang University, Hangzhou, China
³Liangzhu Laboratory, Zhejiang University, Hangzhou, China
⁴Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁵Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China

9:45 AM

TIF1γ Counteracts Ferroptosis to Drive Erythroid Progenitor Differentiation

Marlies P. Rossmann, MD, PhD^1,2,3, Song Yang⁴^*, Brian J. Abraham, PhD⁵^*, Ying Wang, PhD⁶^*, Richard A. Young, PhD⁷^*, Siegfried Hekimi, PhD⁶^* and Leonard I. Zon, MD^8,9

¹Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY
²Department of Stem Cell and Regenerative Biology, Harvard University, Rochester, NY
³Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA
⁴Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA
⁵Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN
⁶Department of Biology, McGill University, Montreal, QC, Canada
⁷Whitehead Institute for Biomedical Research, Cambridge, MA
⁸Harvard Stem Cell Institute, Cambridge, MA
⁹Harvard University, Cambridge, MA

10:00 AM

Identification of a Novel Gene Regulatory Element in Human Erythroid Progenitor Cells

Vincent P Schulz, PhD¹^*, Kimberly Lezon-Geyda, PhD¹^*, Peiying Shan, MD²^*, Julien Papoin, MS³^*, Mohandas Narla, DSc^4,5, Laurie A. Steiner, MD⁶, Lionel Blanc, PhD³, James Palis, MD⁷ and Patrick G Gallagher, MD^8,9

¹Department of Pediatrics, Yale University School of Medicine, New Haven, CT
²Dept of Pediatrics, Yale University School of Medicine, New Haven, CT
³Feinstein Institutes for Medical Research, Northwell, Manhasset, NY
⁴Research Laboratory of Red Cell Physiology, New York Blood Center, New York
⁵LFKRI, New York Blood Center Enterprises, New York, NY
⁶Department of Pediatrics, University of Rochester, Rochester, NY
⁷University of Rochester Medical Center, Rochester, NY
⁸Yale University School of Medicine, New Haven, CT
⁹Dept of Pediatrics, Ohio State University, Nationwide Childrens Hospital, Columbus, OH

10:15 AM

A Mediator Switch Tunes Transcription Pausing to Drive Erythropoiesis

Hsiang-Ying Lee, PhD¹, Shicong Zhu¹^*, Xiaoting Zhang¹^*, Man Li¹^*, Xinying Zhao¹^*, Na Li¹^*, Si Xie¹^*, Qiuyu Yue¹^*, Yunfeng Li¹^*, Dong Li, PhD¹^*, Fan Wu, PhD¹^*, Zile Zhang¹^*, Ziqi Feng¹^*, Yuelin Deng¹^*, Qi Hu¹^*, Xingyun Yao²^* and Xiaofei Gao, PhD²^*

¹School of Life Sciences, Peking University, Beijing, China
²School of Life Sciences, Westlake University, Hangzhou, China

10:30 AM

The Integrator Complex Is Essential for Erythropoiesis

Xiurui Lv, MBBS, MS¹, Michael Getman¹^*, Nabil Rahman¹^*, Kristin Murphy²^*, Eric J Wagner³^* and Laurie A. Steiner, MD¹

¹Department of Pediatrics, University of Rochester, Rochester, NY
²University of Rochester, Rochester, NY
³Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY

10:45 AM

Whole-Genome CRISPR-Cas9 Screen Identifies ZBTB7A As a Potential Therapeutic Target for Cda-II

Lei Yu¹^*, Greggory Myers, B.S.¹, Beth McGee²^*, Xiaofang Liu³^*, Gallagher Patrick³^*, Richard King³^*, Ann Friedman, B.S.⁴^*, Ginette Balbin-Cuesta, MD, PhD^5,6, Zesen Lin, BS⁷, Claire Drysdale, BSc^1,6, Claire Kerpet³^*, Singh Sharon³^*, James Engel, Ph.D.¹ and Rami Khoriaty, M.D.^1,4,8,9

¹Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI
²Howard Hughes Medical Institute, Ann Arbor, MI
³University of Michigan, Ann Arbor, MI
⁴Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI
⁵Cellular and Molecular Biology Program, University of Michigan Medical School, Northville, MI
⁶Medical Scientist Training Program, University of Michigan Medical School, Ann Arbor, MI
⁷Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI
⁸Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI
⁹University of Michigan Rogel Cancer Center, Ann Arbor, MI

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^*signifies non-member of ASH

101.O2.6 101. Red Cells and Erythropoiesis, Excluding Iron: Red Cells: Emerging Gene Regulatory Mechanisms in Erythroid Differentiation