Three experts will engage in a case-based discussion of clinical data, real-world experience, and optimal management strategies for the treatment of higher-risk MF. Patient cases will be introduced and revisited throughout the program to illustrate how experts interpret and apply the latest clinical data to various case scenarios. Discussion will center around the importance of ongoing prognostic risk stratification and symptom assessment; considerations in treatment selection and sequencing, including optimizing dosage, assessing treatment resistance or intolerance, and determining when and how to switch therapies; prevention and mitigation of adverse events; and the role of allogeneic transplant and clinical trials. Learners will be prompted to share their thoughts throughout the program in audience polls and the faculty will conclude with an interactive Q&A session.