Hematology Disease Topics & Pathways:
Research, Clinical Practice (Health Services and Quality), Diseases, Therapies, Adverse Events
This CME activity is provided by Penn State College of Medicine and developed with our educational partner, PVI, PeerView Institute for Medical Education.
This activity is supported by an independent educational grant from AstraZeneca LP.
Hundreds of thousands of patients with hematologic malignancies in the United States must take medications that leave them immunocompromised. Though vaccinated, these patients have hundred-fold higher rates of serious breakthrough COVID-19 infections compared with healthy individuals because of inadequate responses to vaccination. Tixagevimab/cilgavimab lost its emergency use authorization as prevention for immunocompromised patients because of its lack of efficacy against newer variants. However, next-generation prevention agents are in development, including a new monoclonal antibody, AZD3152. Meanwhile prevention of COVID-19 for immunocompromised people is shifting to a more individualized approach, increasing the complexity of clinical decision-making.
PeerView's expert faculty will discuss strategies to engage patients with elevated risk of serious COVID-19 infection in the development of customized prevention plans. In addition, they will explore approaches to overcoming real-time barriers to access and use of available options for prevention of serious COVID-19 illness.