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Joint Session: Lymphomagenesis - What Normal Immunology, Abnormal Immunology, and Genomics Can Teach Us About Lymphoma Biology and Novel Therapeutic Strategies

PhD Trainee
Sponsor: Scientific Committee on Hematopathology and Clinical Laboratory Hematology||Scientific Committee on Lymphoid Neoplasia
Program: Scientific Program
Saturday, December 9, 2023: 4:00 PM-5:35 PM
Ballroom 20AB (San Diego Convention Center)

Description:
This joint session between the subcommittees on lymphoid neoplasia and hematopathology will investigate four different areas of study that can teach us about how lymphoma develops and provide insights into new or improved therapeutic strategies.

Dr. Aswin Sekar will discuss his work on clonal hematopoiesis and precursor mutations as it relates to the development of lymphoid neoplasms, so-called L-CHP, and what it may teach us about the precursor genetic events that increase one's risk of developing lymphoma.

Dr. Laura Pascqualucci will relate aberrant germinal center expansion with the process of lymphomagenesis in discussing her work related to epigenetic alterations and key genetic mutations that play a role in germinal centers gone wrong.

Dr. Christian Munz is an infectious disease specialist with an expertise in EBV infection and EBV related lymphomagenesis and will discuss what we know about viral oncogenesis and how it can be applied to our understanding on non-viral causes of lymphoma evolution.

Dr. Mandeep Singh studies autoimmunity and has identified lymphoma driver mutations associated with the development of rheumatoid factor autoantibodies and will discuss the intersections between autoimmunity and lymphomagenesis and how the abnormal immune response in autoimmune diseases may be relevant to the development of lymphoid neoplasms and to their therapies.

Co-chairs:
Parul Bhargava, MD, University of California San Francisco and Caron A Jacobson, MD, MMSc, Dana-Farber Cancer Institute
Disclosures:
Bhargava: Gilead: Ended employment in the past 24 months, Other: Spouse ex employee; Ophirex: Consultancy. Jacobson: Kite, a Gilead company: Consultancy, Honoraria, Research Funding; Novartis: Consultancy, Honoraria, Other: Travel support; Bristol Myers Squibb/Celgene: Consultancy; Abbvie: Consultancy, Honoraria; ADC Therapeutics: Consultancy; AstraZeneca: Consultancy; Abintus Bio: Consultancy, Membership on an entity's Board of Directors or advisory committees; Caribou Bio: Consultancy; Instil Bio: Consultancy, Honoraria; ImmPACT Bio: Consultancy, Honoraria; Daiichi-Sankyo: Consultancy, Honoraria; Ipsen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Morphosys: Consultancy; Synthekine: Consultancy, Honoraria; Pfizer: Research Funding; Miltenyi Biotec: Consultancy; Sana: Consultancy, Honoraria; BMS: Consultancy, Honoraria; Celgene: Consultancy, Honoraria, Other: Travel support; Lonza: Consultancy, Honoraria, Other: Travel support; Epizyme: Consultancy, Honoraria; Bluebird Bio: Consultancy, Honoraria; Humanigen: Consultancy, Honoraria, Other: Travel support; Nkarta: Consultancy, Honoraria; Precision BioSciences: Consultancy, Honoraria, Other: Travel support; Clinical Care Options: Speakers Bureau; Axis: Speakers Bureau.
This joint session between the subcommittees on lymphoid neoplasia and hematopathology will investigate four different areas of study that can teach us about how lymphoma develops and provide insights into new or improved therapeutic strategies.

Dr. Aswin Sekar will discuss his work on clonal hematopoiesis and precursor mutations as it relates to the development of lymphoid neoplasms, so-called L-CHP, and what it may teach us about the precursor genetic events that increase one's risk of developing lymphoma.

Dr. Laura Pascqualucci will relate aberrant germinal center expansion with the process of lymphomagenesis in discussing her work related to epigenetic alterations and key genetic mutations that play a role in germinal centers gone wrong.

Dr. Christian Munz is an infectious disease specialist with an expertise in EBV infection and EBV related lymphomagenesis and will discuss what we know about viral oncogenesis and how it can be applied to our understanding on non-viral causes of lymphoma evolution.

Dr. Mandeep Singh studies autoimmunity and has identified lymphoma driver mutations associated with the development of rheumatoid factor autoantibodies and will discuss the intersections between autoimmunity and lymphomagenesis and how the abnormal immune response in autoimmune diseases may be relevant to the development of lymphoid neoplasms and to their therapies.

Aswin Sekar, MD, PhD

Dana-Farber Cancer Institute, Boston, MA

Laura Pasqualucci, MD

Institute for Cancer Genetics, COLUMBIA UNIVERSITY, New York, NY

Mandeep Singh

Garvan Institute of Medical Research, Darlinghurst/Sydney, NSW, Australia

Christian Munz, PhD

Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland

See more of: Scientific Program