Correlative studies are essential to improve our understanding of the bioactivity and/or potential resistance mechanisms of candidate therapeutics in clinical trials. We know that the design of clinical trials through a translational research lens requires true bench to bedside thought. Some trials do this better than others. Here the speakers will rationally discuss the role of laboratory correlates in clinical trials and how they are viewed by those with clinical and laboratory expertise. They will also emphasize the impact to the patient in terms of burden of added testing and where burden could outweigh benefit. The titles are intentionally provocation with some satire as obviously both sides "Care" we just need to emphasize each point of view of why to care.