denotes an abstract that is clinically relevant.
denotes that this is a recommended PHD Trainee Session.
denotes that this is a ticketed session.Hematology Disease Topics & Pathways:
Bleeding and Clotting, Acute Myeloid Malignancies, Clinical Practice (Health Services and Quality), APL, Workforce, Diseases, thrombocytopenias, Immune Disorders, Adverse Events, Myeloid Malignancies
Description:
Hematologists make a huge impact by managing inpatient hematology emergencies. These may be life-threatening conditions or those that could become life-threatening if not managed quickly and capably. One of the challenges is the need to start treatments while diagnostic tests are in process, and often there is diagnostic uncertainty for a while. Sometimes these conditions require urgent transfer to tertiary care centers. Evidence-based interventions and consensus guidelines are not available for many inpatient hematology emergency conditions. In this session, expert opinions are presented for Acute Promyelocytic Leukemia (APL), Immune Thrombocytopenia (ITP) with life-threatening bleeding, and Hemophagocytic Lymphohistiocytosis (HLH).
Acute promyelocytic leukemia (APL) is an inpatient hematology emergency in which patients present with life-threatening risk of intracranial hemorrhage. A hitherto highly fatal disease, APL has transformed into the most curable acute myeloid leukemia in adults since the introduction of differentiating agents, all-trans retinoic acid and arsenic trioxide. Still, early mortality constitutes a significant proportion of deaths attributed to APL, with hemorrhage being the most common cause. In this presentation, Dr. Martin Tallman discusses strategies to prevent early mortality among newly diagnosed APL patients.
Immune thrombocytopenia (ITP) with life-threatening bleeding is an inpatient hematology emergency, usually presenting with extremely low platelet counts. Urgent assessment and treatment are required, including quickly excluding other causes of low platelet counts. Combination treatment usually include simultaneous corticosteroids and intravenous immune globulin (IVIG), platelet transfusions, and anti-fibrinolytic agents. In this presentation, Dr. Steven Fein describes the challenges associated with identifying and treating adult ITP patients who have life-threatening bleeding.
Hemophagocytic lymphohistiocytosis (HLH) is an inpatient hematology emergency in which patients present with life-threatening systemic inflammation. In this presentation, Dr. Adi Zoref-Lorenz will outline the approach to the recognition and rapid assessment of HLH syndromes in critically ill inpatients. The importance of the newly described "OHI index" in hematologic malignancy-associated HLH will be highlighted. She will discuss the recognition and management of pertinent HLH triggers. The talk will provide practical guidance regarding immunosuppressive therapy and the emergence of novel targeted agents for HLH.
Acute promyelocytic leukemia (APL) is an inpatient hematology emergency in which patients present with life-threatening risk of intracranial hemorrhage. A hitherto highly fatal disease, APL has transformed into the most curable acute myeloid leukemia in adults since the introduction of differentiating agents, all-trans retinoic acid and arsenic trioxide. Still, early mortality constitutes a significant proportion of deaths attributed to APL, with hemorrhage being the most common cause. In this presentation, Dr. Martin Tallman discusses strategies to prevent early mortality among newly diagnosed APL patients.
Immune thrombocytopenia (ITP) with life-threatening bleeding is an inpatient hematology emergency, usually presenting with extremely low platelet counts. Urgent assessment and treatment are required, including quickly excluding other causes of low platelet counts. Combination treatment usually include simultaneous corticosteroids and intravenous immune globulin (IVIG), platelet transfusions, and anti-fibrinolytic agents. In this presentation, Dr. Steven Fein describes the challenges associated with identifying and treating adult ITP patients who have life-threatening bleeding.
Hemophagocytic lymphohistiocytosis (HLH) is an inpatient hematology emergency in which patients present with life-threatening systemic inflammation. In this presentation, Dr. Adi Zoref-Lorenz will outline the approach to the recognition and rapid assessment of HLH syndromes in critically ill inpatients. The importance of the newly described "OHI index" in hematologic malignancy-associated HLH will be highlighted. She will discuss the recognition and management of pertinent HLH triggers. The talk will provide practical guidance regarding immunosuppressive therapy and the emergence of novel targeted agents for HLH.