denotes an abstract that is clinically relevant.
denotes that this is a recommended PHD Trainee Session.
denotes that this is a ticketed session.Hematology Disease Topics & Pathways:
Diversity, Equity, and Inclusion (DEI) , pediatric, Therapies, pregnant, metabolism, Biological Processes, Study Population, Human
Description:
A revolution is defined as a great and sudden change. Our speakers will discuss how in iron deficiency we need to change how we use laboratory tests to diagnose iron deficiency to insure we are correctly diagnosing ALL with iron deficiency and not just the select few with severe iron depletion. For therapy we need to recognized oral iron either fails or is not appropriate for many patients and that intravenous iron is safe and effective
Dr. Deloughery will discuss what ferritin is and why it is used as a measure of body iron stores. Then he will demonstrate the high incidence of iron deficiency in women - up to 50% of healthy women with absent iron stores on bone marrow exam. Finally, he will advocate that ferritin cuts off need to be much higher to properly diagnose iron deficiency in all affected women and the implications of such a change.
In this section on The Iron Revolution, Dr Auerbach will be highlighting the administration of the four available iron products permitting complete replacement dosing in a single setting. He will discuss methods of administration, safety, and indications. Most importantly he will dispel notions of danger created by antiquated folklore and show a video of a minor infusion reaction, how to manage it, and how the inappropriate intervention for the minor reaction can lead to a hemodynamically significant serious adverse event ostensibly and inappropriately ascribed to the IV iron.
Dr Powers will discuss that iron deficiency anemia occurs most commonly in young children due to low iron diet and adolescent girls due to menstrual blood loss. However, children with gastrointestinal conditions such as intestinal failure, inflammatory bowel disease, celiac disease, and/or other chronic conditions including chronic kidney disease and heart failure, also commonly have iron deficiency. In children who have an incomplete response to oral iron, intravenous iron therapy is increasingly being utilized with benefits such as rapid repletion of iron stores, in addition to resolution of anemia, less gastrointestinal side effects, and relief for patients and families struggling with long-term iron supplementation. Four intravenous iron formulations have approved indications in pediatrics and many are increasingly utilized off-label in children as well. Here we discuss the indications and appropriate timing of intravenous iron therapy in children with a wide range of underlying etiologies.
Dr. Deloughery will discuss what ferritin is and why it is used as a measure of body iron stores. Then he will demonstrate the high incidence of iron deficiency in women - up to 50% of healthy women with absent iron stores on bone marrow exam. Finally, he will advocate that ferritin cuts off need to be much higher to properly diagnose iron deficiency in all affected women and the implications of such a change.
In this section on The Iron Revolution, Dr Auerbach will be highlighting the administration of the four available iron products permitting complete replacement dosing in a single setting. He will discuss methods of administration, safety, and indications. Most importantly he will dispel notions of danger created by antiquated folklore and show a video of a minor infusion reaction, how to manage it, and how the inappropriate intervention for the minor reaction can lead to a hemodynamically significant serious adverse event ostensibly and inappropriately ascribed to the IV iron.
Dr Powers will discuss that iron deficiency anemia occurs most commonly in young children due to low iron diet and adolescent girls due to menstrual blood loss. However, children with gastrointestinal conditions such as intestinal failure, inflammatory bowel disease, celiac disease, and/or other chronic conditions including chronic kidney disease and heart failure, also commonly have iron deficiency. In children who have an incomplete response to oral iron, intravenous iron therapy is increasingly being utilized with benefits such as rapid repletion of iron stores, in addition to resolution of anemia, less gastrointestinal side effects, and relief for patients and families struggling with long-term iron supplementation. Four intravenous iron formulations have approved indications in pediatrics and many are increasingly utilized off-label in children as well. Here we discuss the indications and appropriate timing of intravenous iron therapy in children with a wide range of underlying etiologies.