Description:
Allogeneic hematopoietic cell transplantation (HCT) is a curative intervention for both malignant and non-malignant hematological disorders. Despite its potential, HCT is accompanied by considerable challenges in patient care, particularly related to treatment-associated morbidity and mortality. In considering the transplant candidate, transplant teams rely on a comprehensive assessment of HCT candidates across three key dimensions encompassing patient, disease, and transplantation-related factors. This detailed evaluation allows clinicians to balance the benefits and risks of HCT and to personalize the parameters of HCT to the individual patient. This educational session centers on the tools and evidence for evaluating the physiological resilience of HCT candidates. We will delve into the available evidence and literature surrounding the assessment of geriatric, frailty, and comorbidity factors that have vital roles in the overall evaluation process. Moreover, the session will emphasize the practical implementation of these evaluations in clinical decision-making processes and how they can guide both patient discussions and decision-making for transplantation recipients. Overall, our aim is to equip clinicians with a comprehensive understanding of candidate evaluation while indicating areas needing further research. We hope to enhance patient outcomes in HCT and foster advancements in the field.