Type: Oral
Session: 905. Outcomes Research – Lymphoid Malignancies: Practice Changing Patient-Reported Outcome Measurements and Real World Evidence Studies in Patients With Lymphoma
Hematology Disease Topics & Pathways:
Hodgkin lymphoma, adult, Clinical Practice (Health Services and Quality), Lymphomas, non-Hodgkin lymphoma, B Cell lymphoma, Plasma Cell Disorders, T Cell lymphoma, Diseases, indolent lymphoma, aggressive lymphoma, Lymphoid Malignancies, Study Population, Human
Methods: This was a population-based cohort study based on electronic health records from 92 hospitals in the United States. Patients aged over 18 years with T2DM who were initiated treatment with SGLT-2i or DPP-4i between 2015 and 2023 were retrieved. Patients with type 1 diabetes or pre-existing malignancy were excluded. Cohorts were grouped into SGLT-2i or DPP-4i and were 1:1 propensity score matched for age, sex, ethnicity, comorbidities, and medication history. The primary outcome was newly diagnosed lymphoma and myeloma, including, Hodgkin lymphoma, B-cell lymphoma, T-cell/natural killer (NK)-cell lymphoma and plasma cell neoplasm. Hazard ratios (HRs) and 95% confidence intervals (95% Cis) were calculated using the Cox proportional hazard regression model. Kaplan-Meier analysis and log-rank tests were used to compare the outcomes across the cohorts.
Results: There were a total of 1,877,388 adults with T2DM and were started on SGLT-2i or DPP-4i. The final study population after 1:1 propensity score matching included 1,399,898 patients, with 46.4% of which being females. The remaining baseline characteristics were balanced between the two group, including chronic kidney disease, heart failure and advance age. There were 5,197 incident cases of lymphomas and 1,691 incident cases of plasma cell neoplasm. SGLT-2i was associated with a significantly lower risk of developing various hematological malignancy including Hodgkin lymphoma (aHR 0.696; 95% CI 0.567-0.855), follicular lymphoma (aHR 0.798; 95% CI 0.667-0.954), non-follicular lymphoma (aHR 0.800; 95% CI 0.709-0.902), and malignant plasma cell neoplasm (aHR 0.693; 95% CI 0.624-0.768),
Conclusion: The use of SGLT-2i was associated with a reduced risk of developing various lymphoma and myeloma, including Hodgkin lymphoma, non-Hodgkin lymphoma, and malignant plasma cell neoplasm, when compared to DPP-4i use. Further investigations are warranted to elucidate the mechanism and pathophysiology behind these findings.
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Disclosures: No relevant conflicts of interest to declare.
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