-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

4220 Protective Role of Oxaliplatin Among Platinum-Based Therapies in the Development of Therapy-Related Myeloid Neoplasms

Program: Oral and Poster Abstracts
Session: 613. Acute Myeloid Leukemias: Clinical and Epidemiological: Poster III
Hematology Disease Topics & Pathways:
Research, Acute Myeloid Malignancies, AML, epidemiology, Clinical Research, Diseases, Biological Processes, Myeloid Malignancies, Study Population, Human, pathogenesis
Monday, December 11, 2023, 6:00 PM-8:00 PM

Jeremy S Connors, MD1, Linda Zhang, BA2*, Koji Sasaki, MD3, Courtney D. DiNardo, MD, MSc4, Nicholas J. Short, MD4, Naval Daver, MD4, Gautam Borthakur, MD4, Tapan M. Kadia, MD4, Hagop Kantarjian, MD5, Elias Jabbour6, Margaret A Goodell, PhD7*, Guillermo Garcia-Manero, MD8 and Koichi Takahashi, MD, PhD4

1Pediatric Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Hospital, Houston, TX
2Baylor College of Medicine, Houston, TX
3Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
4Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
5The University of Texas MD Anderson Cancer Center, Houston, TX
6University of Texas M.D. Anderson Cancer Ctr., Houston, TX
7Center For Cell and Gene Therapy, Houston, TX
8University of Texas MD Anderson Cancer Center, Houston, TX


As a DNA-damaging agent, platinum-based chemotherapy serves as a cornerstone in cancer treatment. However, its widespread use has been associated with increased incidence of therapy-related myeloid neoplasms (t-MNs). Among the three most commonly used platinum chemotherapies - cisplatin, carboplatin, and oxaliplain - oxaliplatin presents a distinctive clinical usage and toxicity profile. Predominantly utilized in treating gastrointestinal tract (GI) cancers, oxaliplatin manifests a distinct toxicity pattern when compared to its counterparts. This variance is supported by a previous study that postulated oxaliplatin-induced cytotoxicity primarily results from ribosomal stress as opposed to a DNA-damage response (Bruno et al. Nature Medicine 2017). Further, epidemiological and anecdotal data suggest a lower incidence of t-MNs associated with oxaliplatin. In this study, we aimed to investigate and compare the clinical manifestations, molecular phenotypes, and patient outcomes associated with t-MNs following exposure to various platinum-based therapies.


All patients clinically diagnosed with t-MNs between 2008 and 2022, based upon a presentation with a myeloid neoplasm (AML or MDS) with any previous cancer associated with exposure to platinum-based chemotherapy, at a single center were analyzed. Descriptive statistics were used to compare the clinical and molecular profiles between the groups of patients receiving different types of platinum.


153 patients were found to have been diagnosed with t-MNs during the study time period following platinum exposure. 45 (29.4%) had been exposed to only cisplatin, 72 (47.1%) to carboplatin alone, 9 (5.9%) to oxaliplatin alone, 25 (16.3%) to both cisplatin and carboplatin, and 1 each (0.7%) to carboplatin or cisplatin in combination with oxaliplatin. The most frequent primary cancers included non-Hodgkin lymphoma (19.6%), followed by ovarian (14.4%), breast (11.8%), and lung (7.8%). Median time from platinum exposure to t-MN diagnosis was 2.7, 3.5, and 3.6 years for patients having previously received only cisplatin, carboplatin, or oxaliplatin respectively (P value not significant between oxaliplatin vs. cisplatin or vs. carboplatin). In regard to MDS/AML diagnosis ratio, there was no significant difference between cisplatin-only, carboplatin-only, and oxaliplatin-only t-MNs. Cytogenetics data and gene mutation data were available in 139 patients. Del 5q/-5 and/or Del7q/-7 were numerically rare in oxaliplatin-only t-MNs compared to cis-only (22.2% vs. 43.9%, P = 0.285) or carbo-only t-MNs (22.2% vs. 48.4%, P = 0.171). Also, complex karyotype was only found in 1 patient (11%) in oxaliplatin-only t-MNs, whereas 51% and 58% of cisplatin-only and carboplatin-only t-MNs were found to have complex karyotype. Despite the low frequency of complex karyotype in oxaliplatin-only t-MNs, TP53 mutations were prevalent and found in 56%, 60%, and 60% of cisplatin-only, carboplatin-only, and oxaliplatin-only t-MNs, respectively (no statistical difference among the groups). Median overall survival (OS) was not significantly different among the three groups.


In the patients with t-MNs post-platinum exposure, oxaliplatin-induced t-MNs represented only 6% of the entire cohort, with a significantly lower incidence of t-MN-associated chromosomal abnormalities (del5q/-5, del7q/-7, and complex karyotype). This discrepancy cannot be solely attributed to the less frequent use of oxaliplatin in comparison to other platinum agents. The findings underscore the protective role of oxaliplatin in the development of t-MNs, warranting further investigation in both clinical practice and biological mechanism.

Disclosures: DiNardo: AbbVie/Genentech: Honoraria; Takeda: Honoraria; Servier: Honoraria; Novartis: Honoraria; ImmuniOnc: Honoraria; Notable Labs: Honoraria; Fogham: Honoraria; BMS: Honoraria; Astellas: Honoraria; Schrödinger: Consultancy. Short: Astellas: Research Funding; Stemline therapeutics: Research Funding; Takeda: Consultancy, Research Funding; AstraZeneca: Consultancy; Novartis: Consultancy; Pfizer: Consultancy; Amgen: Honoraria. Daver: Shattuck Labs: Consultancy; Amgen: Consultancy, Research Funding; Kite, a Gilead company: Consultancy, Research Funding; AbbVie: Consultancy, Research Funding; Astellas: Consultancy, Research Funding; AROG: Consultancy; Glycomimetics: Research Funding; Novimmune: Research Funding; FATE: Research Funding; Gilead: Consultancy, Research Funding; Novartis: Consultancy; Agios: Consultancy; Trovagene: Research Funding; ImmunoGen: Consultancy, Research Funding; Jazz: Consultancy; Servier: Consultancy, Research Funding; Genentech: Consultancy, Research Funding; Trillium: Consultancy, Research Funding; Hanmi: Research Funding; Syndax: Consultancy; Celgene: Consultancy; Pfizer: Consultancy, Research Funding; Daiichi Sankyo: Consultancy, Research Funding; Bristol-Myers Squibb: Consultancy, Research Funding; Kronos Bio: Research Funding. Borthakur: Astex Pharmaceuticals, Ryvu, PTC Therapeutics: Research Funding; Pacylex, Novartis, Cytomx, Bio Ascend:: Membership on an entity's Board of Directors or advisory committees; Catamaran Bio, Abbvie, PPD Development, Protagonist Therapeutics, Janssen: Consultancy. Kadia: Cyclacel: Research Funding; Cure: Speakers Bureau; Cellenkos Inc.: Research Funding; Sanofi-Aventis: Consultancy; Genentech: Consultancy, Research Funding; AbbVie, Amgen, Inc, Ascentage Pharma Group, Astellas Pharma Global Development, Astex, AstraZeneca, BMS, Celgene, Cellenkos Inc, Cyclacel, Delta-Fly Pharma, Inc, Genentech, Inc., Genfleet, Glycomimetics, Iterion, Janssen Research and Development: Research Funding; Agios: Consultancy; Amgen, Inc.: Research Funding; Pulmotect, Inc.: Consultancy, Research Funding; Ascentage Pharma Group: Research Funding; Jazz Pharmaceuticals, Pfizer, Pulmotect, Inc, Regeneron Pharmaceuticals, SELLAS Life Sciences Group: Research Funding; GenFleet Therapeutics: Research Funding; Delta-Fly Pharma, Inc.: Research Funding; Regeneron Pharmaceuticals: Research Funding; Celgene: Research Funding; Astellas Pharma Global Development: Research Funding; Pinotb-Bio: Consultancy; Servier: Consultancy; AstraZeneca: Research Funding; BMS: Consultancy, Research Funding; Biologix, Cure, Hikma Pharmaceuticals: Speakers Bureau; Daiichi Sankyo, Genentech, Inc., Genzyme, Jazz Pharmaceuticals, Liberum, Novartis, Pfizer, PinotBio, Inc, Pulmotect, Inc, Sanofi-Aventis, Servier: Consultancy; Genzyme: Honoraria; Iterion: Research Funding; Glycomimetics: Research Funding; Hikma Pharmaceuticals: Speakers Bureau; Janssen Research and Development: Research Funding; Liberum: Consultancy; Novartis: Consultancy; Pfizer: Consultancy, Research Funding; SELLAS Life Sciences Group: Research Funding; Astex: Honoraria. Kantarjian: Abbvie: Consultancy, Honoraria; Amgen: Honoraria; Ascentage Pharma Group: Honoraria; Astellas Pharma: Honoraria; AstraZeneca/MedImmune: Honoraria; Daiichih-Sankyo (Inst): Honoraria, Research Funding; Immunogen (Inst): Honoraria, Research Funding; Ipsen: Honoraria; Jazz Pharmaceuticals (Inst): Honoraria, Research Funding; KAHR Medical: Honoraria; Novartis: Honoraria; Pfizer: Honoraria; Precision Biosciences: Honoraria; Shenzhen Target Rx: Honoraria; Taiho Pharmaceutical: Honoraria; Abbvie (Inst): Research Funding; Amgen (Inst): Research Funding; Ascentage Pharma (Inst): Research Funding; Bristol-Myers Squibb (Inst): Research Funding; Novartis (Inst): Research Funding. Jabbour: Takeda: Consultancy, Honoraria, Research Funding; Genentech: Consultancy, Honoraria, Research Funding; Novartis: Consultancy, Research Funding; Hikma Pharmaceuticals: Consultancy, Honoraria, Research Funding; Pfizer: Consultancy, Honoraria, Research Funding; Ascentage Pharma Group: Consultancy, Honoraria, Research Funding; Adaptive Biotech: Consultancy, Honoraria, Research Funding; Amgen: Consultancy, Honoraria, Research Funding; Astex: Honoraria, Research Funding; Bristol-Myers Squibb: Consultancy, Honoraria, Research Funding; Abbvie: Consultancy, Honoraria, Research Funding. Garcia-Manero: Bristol Myers Squibb: Other: Medical writing support, Research Funding; AbbVie: Research Funding; Genentech: Research Funding.

*signifies non-member of ASH