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4771 A Whole Foods Plant-Based Weight Loss Intervention Improves Quality of Life, Metabolic, Microbiome and Immune Profile in MGUS/SMM As Well As Progression Trajectory in a Subset – the Nutrivention Trial

Program: Oral and Poster Abstracts
Session: 654. MGUS, Amyloidosis and Other Non-Myeloma Plasma Cell Dyscrasias: Clinical and Epidemiological: Poster III
Hematology Disease Topics & Pathways:
clinical trials, adult, Research, Clinical Research, Plasma Cell Disorders, Diversity, Equity, and Inclusion (DEI) , Diseases, immune mechanism, patient-reported outcomes, Lymphoid Malignancies, metabolism, Biological Processes, microbiome, Metabolic Disorders, Human, Study Population
Monday, December 11, 2023, 6:00 PM-8:00 PM

Urvi A Shah, MD1, Francesca Castro, MS2*, Andriy Derkach, PhD3*, Teng Fei, PhD4*, Kinga K Hosszu, PhD5*, Devin McAvoy, BS5*, Susan DeWolf, MD6, Justin Cross, PhD7*, Ana Gradissimo, PhD2*, Alexis Nwankwo8*, Aishwarya Anuraj8*, Miranda Burge2*, Blaslov Jenna8*, Elizabeth Raynor8*, Jenna Wosleger8*, Peter Adintori2*, Michael Pollak, MD9*, Jenny Paredes Sanchez, PhD2, Thomas Atkinson, PhD10*, Kylee H Maclachlan, MBChB, PhD1, Sham Mailankody, MBBS1, Neha Korde, MD1, Carlyn Tan, MD1, Malin Hultcrantz, MD, PhD1, Hani Hassoun, MD1, Jonathan U. Peled, MD, PhD11, Gunjan L. Shah2, Michael Scordo12, Oscar Boutros Lahoud13, David Chung, MD, PhD12, Heather Landau, MD13, Anita D'Souza, MD, MS14, Ola Landgren, MD15, Sergio A. Giralt, MD, FACP16, Neil M. Iyengar, MD, BS, BA17*, Saad Z Usmani, MD12,18, Alexander Lesokhin, MD1 and Marcel R.M. van den Brink19

1Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
2Memorial Sloan Kettering Cancer Center, New York, NY
3Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY
4Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
5Department of Pediatrics and Immune Discovery & Modeling Service, Memorial Sloan Kettering Cancer Center, New York, NY
6Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
7Memorial Sloan Kettering, New York, NY
8Memorial Sloan Kettering Cancer Center, New York
9McGill University, Montreal, QC, CAN
10Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York
11Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY
12Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
13Adult Bone Marrow Transplant Service, Division of Hematologic Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
14Medical College of Wisconsin, Wisconsin
15Sylvester Comprehensive Cancer Center, Myeloma Division, University of Miami, Miami, FL
16Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center, New York, NY
17Memorial Sloan-Ketter Cancer Ctr/NY Presb Hosp (Cornell), New York, NY
18Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
19Department of Medicine, Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY

Introduction

Obesity, low adiponectin, high leptin, high insulin, and diets lacking plant-based foods are risk factors for plasma cell disorders (PCDs). Patients (pts) with monoclonal gammopathy (MGUS) and smoldering myeloma (SMM) and an elevated body mass index (BMI) are twice as likely to progress to myeloma (MM). There is evidence of microbiome dysbiosis in pts with PCDs and dietary changes can induce large microbial shifts. Therefore, there is a rationale to study a whole food plant-based dietary (WFPBD) intervention to improve modifiable biomarkers and disease trajectory.

Methods

This was a pilot, single-arm trial of WFPBD (self-selected prepared frozen lunch/dinner provided by Plantable with breakfast/snack guidance and no calorie restriction) for 12-weeks (w) and health coaching for 24w (by Plantable coach and a research dietitian) in pts with MGUS/SMM and BMI ≥25 (NCT04920084). The primary endpoint was feasibility (mean BMI reduction ≥5% and mean dietary adherence [kcal % unprocessed plant food intake] ≥70%) at 12w; secondary endpoints included quality of life (QoL) (EORTC QLQ C30 survey using a linear-mixed effect model), metabolic markers (plasma insulin, adiponectin leptin (AL) ratio via ELISA), gut microbiome (inverse Simpson index α-diversity and relative abundance of butyrate producers (RABP) via stool 16S sequencing), peripheral blood immune profile (leukocyte subsets via 36 color flow cytometry), secreted biomarkers (plasma via Olink inflammation panel) and change in monoclonal (M)-spike concentrations. Rate of change of M-spike/year (y) measured by slope with 95% CI was calculated for up to 20 months (m) pre-intervention and 20m post intervention start (baseline (BL)). A p-value for difference in M-spike rates was calculated.

Results

The study enrolled 23 pts of which 20 completed the 12w intervention and 16 completed 1y. The median age was 62y with 43% male, 43% non-White, 52% MGUS, 74% obese, and 26% prediabetic/diabetic. The study met feasibility endpoints with 90% mean and 92% median adherence during 12w intervention and 77% median at 24w. There was an 8.3% mean and 6.6% median BMI reduction at 12w and 8.6% median at 24w.

There was an improvement in global health status/QoL (median increase 16.7 points, p=0.03), a reduction in dyspnea (median decrease -33.3 points, p=0.001), fatigue (median decrease -11.1 points, p=0.06), and insulin (median decrease 0.791 mU/L; p=0.01), and an increase in AL ratio (median increase 0.09; p=0.0002), α-diversity (median increase 6.18 to 8.42; p= 0.03) and RABP (median increase 0.03 to 0.08; p=0.042) at 12w.

Prelim results at 12w suggest a measurable, albeit not significant change in immune subsets such as an increase in monocytes, regulatory T cells, and a decrease in dendritic cells, trends previously associated with anti-inflammatory diets, as well as increase in butyrate. A decrease in proinflammatory cytokines IL8 (p=0.065), IL12B (p=0.068), and TNFB (p=0.082) and an increase in FGF21 (p=0.043) (promoter of insulin sensitivity) was also observed. Butyrate is known to reduces pro-inflammatory cytokines and increase anti-inflammatory proteins, including FGF21. Further immune and microbiome analysis is ongoing.

Of 16 pts followed for 1y, 2 with significant BMI reduction had significant improvement in M-spike trajectory: Case 1: Mayo Int Risk IgGκ/IgGλ MGUS achieved a 1y BMI reduction of 19%. Pre-intervention M-spike changed +0.28g/dL/y (6 M-spike values), and during intervention M-spike changed +0.03g/dL/y (11 M-spike values); p=0.008. BL M-spike 1.2g/dL and bone marrow plasma cells (BM PC) <5%; 1.5y BM PC 5-9%. Case 2: IMWG Int Risk IgGκ SMM achieved a 1y BMI reduction of 13%. Pre-intervention M-spike changed +0.11g/dL/y (8 M-spike values), and during intervention M-spike changed -0.05g/dL/y (8 M-spike values); p=0.04. BL M-spike 1.2g/dL and BM PC 20-30%; 1y BM PC 10-15%. Two pts without significant BMI reduction (-4% and -1% at 1y) had rising M-spikes. The remaining 12 pts had median 7.5% BMI reduction at 1y with stable M-spike.

Conclusions

This is the first dietary intervention trial in PCDs with insights into the mechanisms by which a WFPBD may delay progression. The intervention improves QoL, metabolic (BMI, insulin resistance), microbiome (α-diversity and butyrate producers) as well as immune (reduced inflammation) profile with potentially slowing progression trajectory in a subset. A larger trial is underway (NCT05640843).

Disclosures: Shah: M and M Labs: Research Funding; Plantable: Research Funding; Bristol Myers Squibb: Consultancy, Other: Advisory Board, Research Funding; Sabinsa: Research Funding; Janssen: Consultancy, Other: Advisory Board, Research Funding; Sanofi: Other: Advisory Board; C4 Therapeutics: Research Funding. DeWolf: Atreca: Current equity holder in publicly-traded company, Other: Spouse is an equity holder. Mailankody: Fate Therapeutics: Research Funding; Bristol Myers Squibb: Research Funding; Takeda Oncology: Research Funding; Caribou Therapeutics: Research Funding; Legend Biotech: Consultancy; Physician Education Resource: Honoraria; Janssen Oncology: Consultancy; Allogene Therapeutics: Research Funding; Optum Oncology: Consultancy; MJH Life Sciences: Honoraria; OncLive: Honoraria; Janssen Oncology: Research Funding. Korde: Janssen: Other: Advisory Board; Amgen, Janssen, Epizyme, AbbVie: Research Funding; CCO, OncLive, Intellisphere, Remedy Health: Consultancy. Tan: Janssen: Current Employment, Honoraria, Research Funding; Sanofi: Honoraria; Takeda: Research Funding. Hultcrantz: Curio Science LLC, Intellisphere, Bristol Myer Squibb, GlaxoSmithKline: Honoraria; Amgen, Daiichi Sankyo, GlaxoSmithKline: Research Funding. Hassoun: Celgene, Takeda, and Janssen Pharmaceuticals: Research Funding. Peled: CSL Behring: Consultancy; MaaT Pharma: Consultancy; Postbiotics Plus Research: Current equity holder in private company, Membership on an entity's Board of Directors or advisory committees; DaVolterra: Consultancy; Seres Therapeutics: Other: travel reimbursement, intellectual property fee, Research Funding. Shah: Beyond Spring: Research Funding; ArcellX: Other: DSMB; BMS: Research Funding; Janssen: Research Funding; Amgen: Research Funding. Scordo: Angiocrine Bioscience, Inc.: Research Funding; Amgen, Inc.: Research Funding; CancertNetwork (Intellisphere LLC): Honoraria; Omeros Corporation: Consultancy, Research Funding; Medscape, LLC: Honoraria. Lahoud: MorphoSys Inc, Kite: Consultancy. Landau: Alexion Pharmaceuticals, Takeda, Janssen, Prothena, Protego: Research Funding; Karyopharm, Pfizer, Juno, Prothena, Caelum Biosiences, Legend Biotech, Takeda, Janssen, Nexcella: Honoraria. D'Souza: Abbvie, Sanofi, Takeda, TeneoBio, Caelum, Prothena: Research Funding; Janssen, Prothena: Consultancy; Imbrium, Pfizer, Bristol Myers Squibb: Membership on an entity's Board of Directors or advisory committees. Landgren: Merck: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Membership on independent data monitoring committees; Amgen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Membership on independent data monitoring committees; Takeda: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Membership on independent data monitoring committees; Janssen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Membership on independent data monitoring committees; Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Membership on independent data monitoring committees; Adaptive: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Membership on independent data monitoring committees; Theradex: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Membership on independent data monitoring committees. Giralt: Amgen, Actinuum, Celgene/BMS, Omeros, Johnson & Johnson, Miltenyi, Takeda: Research Funding; Amgen, Actinuum, Celgene/BMS, Kite Pharma, Janssen, Jazz Pharmaceuticals, Johnson & Johnson, Novartis, Spectrum Pharma, Takeda: Membership on an entity's Board of Directors or advisory committees. Usmani: SecuraBio: Membership on an entity's Board of Directors or advisory committees; SkylineDX: Membership on an entity's Board of Directors or advisory committees, Research Funding; Takeda: Membership on an entity's Board of Directors or advisory committees, Research Funding; TeneoBio: Membership on an entity's Board of Directors or advisory committees; Pharmacyclics: Research Funding; Merck: Research Funding; Array Biopharma: Research Funding; Seattle Genetics: Membership on an entity's Board of Directors or advisory committees, Research Funding; Sanofi: Membership on an entity's Board of Directors or advisory committees, Research Funding; Oncopeptides: Membership on an entity's Board of Directors or advisory committees; Novartis: Membership on an entity's Board of Directors or advisory committees; K36 Therapeutics: Membership on an entity's Board of Directors or advisory committees; Moderna: Membership on an entity's Board of Directors or advisory committees; GSK: Membership on an entity's Board of Directors or advisory committees, Research Funding; Janssen: Membership on an entity's Board of Directors or advisory committees, Research Funding; Gilead Sciences: Membership on an entity's Board of Directors or advisory committees, Research Funding; Genentech: Membership on an entity's Board of Directors or advisory committees; EdoPharma: Membership on an entity's Board of Directors or advisory committees; Celgene: Membership on an entity's Board of Directors or advisory committees, Research Funding; Bristol Meyer Squibb: Membership on an entity's Board of Directors or advisory committees, Research Funding; Amgen: Membership on an entity's Board of Directors or advisory committees, Research Funding; Abbvie: Membership on an entity's Board of Directors or advisory committees, Research Funding. Lesokhin: Bristol Myers Squibb: Research Funding; Janssen: Honoraria, Research Funding; ArcellX: Consultancy; Pfizer: Honoraria, Research Funding; Caprion: Patents & Royalties. van den Brink: Wolters Kluwer: Patents & Royalties; Juno Therapeutics: Other: IP licensing; DKMS (a non-profit organization): Membership on an entity's Board of Directors or advisory committees; Pluto Immunotherapeutics: Consultancy, Current holder of stock options in a privately-held company, Honoraria, Membership on an entity's Board of Directors or advisory committees; Lygenesis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Ceramedix: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Notch Therapeutics: Consultancy, Current holder of stock options in a privately-held company, Honoraria, Membership on an entity's Board of Directors or advisory committees; Nektar Therapeutics: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Frazier Healthcare Partners: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Rheos Medicines: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Seres Therapeutics: Consultancy, Current holder of stock options in a privately-held company, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: IP licensing , Research Funding; Vor Biopharma: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; GlaxoSmithKline: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Da Volterra: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Thymofox: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees.

*signifies non-member of ASH