Mihir Gupta^1*, Joseph Bradley, B.S.^2*, Elie Massaad^2*, Amanda Gordon, B.S., CNP^2*, Michelle Pisapia, NP^2*, Sooae Jones^3*, Ying Sun, CNP^2*, Brian Nahed^3*, Pamela Jones^2*, Fred Barker^3*, William Curry^3*, Priscilla Brastianos^3*, Tracy Batchelor, MD⁴, Jorg Dietrich, MD PhD^5*, Maria Martinez-Lage^3*, Deborah A. Forst, MD^3*, Kensuke Tateishi, MD^6*, Jochen Lennerz, MD, PhD^2*, Daniel Cahill, MD, PhD^2*, Bob Carter, MD, PhD^3* and Ganesh M. Shankar, MD, PhD^3*

¹Massachusetts General Hospital, San Diego, CA
²Massachusetts General Hospital, Boston
³Massachusetts General Hospital, Boston, MA
⁴Department of Neurology, Brigham and Women's Hospital, Boston, MA
⁵Division of Neuro-Oncology, Massachusetts General Hospital Cancer Center, Boston, MA
⁶Yokohama City University, Yokohama, JPN

Brody Foy, DPhil^1*, Jonathan Stefely, MD, PhD^2*, Pavan K. Bendapudi, MD^3,4, Robert P. Hasserjian, MD⁵, Hanny Al-Samkari, MD⁶, Abner Louissaint Jr., MD, PhD⁷, Megan J Fitzpatrick, MD^8*, Bailey Hutchison^7*, Christopher Mow^9*, Julia Collins^7*, Hasmukh P. Patel^7*, Chhaya Patel^7*, Nikita Patel^5*, Samantha Ho^7*, Richard M Kaufman, MD¹⁰, Walter Dzik, MD¹¹, John M. Higgins, MD^12* and Robert S Makar, MD, PhD³

¹Center for Systems Biology, Harvard Medical School & Massachusetts General Hospital, Boston, MA
²Harvard Medical School & Massachusetts General Hospital, Boston, MA
³Blood Transfusion Service, Massachusetts General Hospital, Boston, MA
⁴Division of Hematology and Blood Transfusion Service, Massachusetts General Hospital, Cambridge, MA
⁵Department of Pathology, Massachusetts General Hospital, Boston, MA
⁶Division of Hematology/Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
⁷Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
⁸Pathology, Massachusetts General Hospital, Boston, MA
⁹Mass General Brigham Enterprise Research, Boston, MA
¹⁰Department of Pathology, Brigham and Women's Hospital, Boston, MA
¹¹Massachusetts General Hospital, Boston, MA
¹²Center for Systems Biology, Massachusetts General Hospital, Boston, MA

Daniel D Vagie, PhD^*, Derek M Walkama, PhD^*, Laurel M Mayhew, PhD^*, Todd E Oakland, PhD^* and Bruce W Church, PhD^*

GNS Healthcare, Inc., Somerville, MA

Abigail l. Rich, BS¹, Philip Lin, B.S.^2*, Eric Gamazon, Ph.D.^2* and Sandra Zinkel, M.D., Ph.D.³

¹Molecular Pathology, Vanderbilt University, Nashville, TN
²Medicine/Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN
³Medicine/Division of Hematology-Oncology, VUMC, Nashville, TN

Alexandra Rezazadeh, MD¹, Mehdi Hamadani, MD², Nirav N. Shah, MD³ and Timothy S. Fenske, MD¹

¹Medical College of Wisconsin, Milwaukee, WI
²The BMT & Cellular Therapy Program, Medical College of Wisconsin, Milwaukee, WI
³Medical College of Wisconsin, Brookfield, WI

Alicia Palomino Mosquera, MD¹, Hitomi Hosoya, MD, PhD², Michael C. Jin^2*, Mohammad Shahrokh Esfahani, PhD^2*, Joseph Schroers-Martin, MD², Brian Sworder, MD, PhD², Chih Long Liu, PhD^2*, Elizabeth Spiteri^3*, Yasodha Natkunam, MD, PhD⁴, James L Zehnder, MD³, Henning Stehr, PhD^3*, David M. Kurtz, MD, PhD² and Ash A. Alizadeh, MD, PhD⁵

¹Divisions of Oncology and Hematology, Department of Medicine, Stanford University School of Medicine, Emerald Hills, CA
²Divisions of Oncology and Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA
³Department of Pathology, Stanford University School of Medicine, Stanford, CA
⁴Stanford University School of Medicine, Stanford, CA
⁵Divisions of Oncology and Hematology, Department of Medicine, Stanford University School of Medicine, San Mateo, CA

Iva Lelios, PhD^1*, Enrique Gómez, PhD^1*, Iryna Dekhtiarenko, PhD^2*, Priscila Camillo Teixeira, PhD^1* and Ann-Marie E Bröske^3*

¹Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland
²Roche Pharma Research and Early Development, Roche Innovation Center Zurich, Zurich, Switzerland
³Roche Pharma Research and Early Development, Roche Innovation Center Munich, Penzberg, Germany

Danny E. Miller, MD, PhD^1,2,3,4*, Miranda Galey, MS^2*, Shelley N Fletcher^5*, Kerry Lannert, MT(ASCP)^6*, Marsha M Wheeler, PhD^7*, Renuka Kandhaya-Pillai^8*, Junko Oshima^8*, Barbara A. Konkle, MD^9,10, Evan E Eichler, PhD^2,3,11* and Jill M. Johnsen, MD^10,12,13

¹Department of Pediatrics, Seattle Children's Hospital, Seattle, WA
²Department of Genome Sciences, University of Washington, Seattle, WA
³Brotman Baty Institute for Precision Medicine, Seattle, WA
⁴Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA
⁵Bloodworks Research Institute, Seattle, WA
⁶Division of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, WA
⁷Department of Genome Sciences, University of Washington, Washington, MD
⁸Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA
⁹Washington Institute for Coagulation, Washington Center for Bleeding Disorders, Seattle, WA
¹⁰Department of Medicine, University of Washington, Seattle, WA
¹¹Howard Hughes Medical Institute, Seattle, WA
¹²Bloodworks NW, Seattle, WA
¹³Washington Center for Bleeding Disorders, Seattle, WA

Besmira Alija^1*, Varun S Sudunagunta, BA^1,2, Laura E Mittleman^1*, John Pantazi^1*, Stephanie Braunstein^1*, Jane J Xu, PhD^1*, Tom O'Hare, PhD^3*, Angela Garding, PhD^3* and Aaron D Viny, MD, MS^1,4,5

¹Division of Hematology and Oncology, Department of Medicine, Columbia University, New York, NY
²Vagelos College of Physicians & Surgeons, Columbia University, NEW YORK, NY
³Covaris, Woburn, MA
⁴Columbia Stem Cell Initiative, Columbia University, New York, NY
⁵Vagelos College of Physicians & Surgeons, Columbia University, New York, NY

Gian Maria Zaccaria, PhD^1*, Francesco Berloco, MSc^2*, Felice Clemente, MSc^3*, Anita Susanna Pappagallo, MSc^1*, Maria Carmela Vegliante, PhD^1*, Grazia Gargano, MSc^1*, Paolo Mondelli, MSc^1*, Giacomo Volpe, PhD^1*, Antonella Bucci, MSc^1*, Tetiana Skrypets, MD, PhD^1*, Carla Minoia, PhD^1*, Angela Maria Quinto, MD^1*, Giacomo Loseto, MD^3*, Bernardo Rossini, MD^1*, Fabio Pavone, PhD^1*, Anna Scattone, MD^4*, Giuseppe Carella, MBA^5*, Vito Angiulli, PhD^5*, Chiara Pagani, MD^6*, Alice Di Rocco, MD^7*, Francesca Maria Quaglia^8*, Valentina Tabanelli, PhD^9*, Angelo Fama, MD^10*, Benedetta Puccini, MD^11*, Riccardo Moia, MD^12*, Simone Ferrero, MD^13,14, Luigi Alfredo Grieco, PhD^2*, Simona Colucci, PhD^2*, Attilio Guarini, MD^1* and Sabino Ciavarella, PhD^1*

¹Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy
²Department of Electrical and Information Engineering, Polytechnic of Bari, Bari, Italy
³Hematology Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy
⁴Pathology Department, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy
⁵Technology Transfer Office, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy
⁶Department of Hematology, ASST Spedali Civili, Brescia, Italy
⁷Unit of Hematology, Azienda Ospedaliero-Universitaria Policlinico Umberto I, Roma, Italy
⁸Department of Medicine, Section of Hematology, University of Verona, Verona, Italy
⁹Division of Diagnostic Haematopathology, IEO Istituto Europeo di Oncologia IRCCS, Milano, Italy
¹⁰Hematology, AUSL/IRCCS di Reggio Emilia, Reggio Emilia, Italy
¹¹Careggi University Hospital, Firenze, Italy
¹²Division of Hematology, Azienda Ospedaliero-Universitaria Maggiore della Carità di Novara, Novara, Italy
¹³Division of Hematology , AOU Città della Salute e della Scienza di Torino, Torino, Italy
¹⁴Department of Molecular Biotechnologies and Health Sciences, Division of Hematology, University of Torino, Torino, Italy

Hironori Arai^1,2*, SungGi Chi, MD, PhD^2*, Yoshikazu Utsu, MD, PhD^1*, Shinichi Masuda^1*, Nobuyuki Aotsuka, MD, PhD^1*, Tomoaki Ueda^3*, Kentaro Fukushima, MD^4*, Daisuke Ikeda, MD^5*, Naoko Hosono, MD⁶, Takahiro Yamauchi⁶, Goichi Yoshimoto, MD, PhD^7*, Hiroto Horiguchi, MD, PhD⁸, Satoshi Iyama, M.D, Ph.D.^8*, Junya Kanda, MD, PhD⁹, Seiichiro Katagiri, MD, PhD^10*, Akihiko Gotoh, MD, PhD¹⁰, Daisuke Koyama^11*, Takayuki Ikezoe, MD, PhD¹¹, Takeshi Kondo¹², Yukinori Nakamura, MD^13*, Fumiya Ogasawara^14*, Suguru Fukuhara, MD^15*, Koji Izutsu^16*, Nobuhiko Yamauchi, MD^2*, Junichiro Yuda, MD, PhD^2* and Yosuke Minami, MD, PhD¹⁷

¹Department of Hematology and Oncology, Japanese Red Cross Narita Hospital, Narita, Japan
²Department of Hematology, National Cancer Center Hospital East, Kashiwa, Japan
³Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan
⁴Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita-city,Osaka, Japan
⁵Division of Hematology/Oncology, Kameda Medical Center, Kamogawashi, Japan
⁶Department of Hematology and Oncology, University of Fukui Hospital, Fukui, Japan
⁷Department of Hematology, Saga Prefectural Medical Center Koseikan, Saga, JPN
⁸Department of Hematology, Sapporo Medical University School of Medicine, Sapporo, Japan
⁹Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
¹⁰Department of Hematology, Tokyo Medical University, Tokyo, Japan
¹¹Department of Hematology, Fukushima Medical University School of Medicine, Fukushima, Japan
¹²Aiiku Hospital, Sapporo, Japan
¹³Third Department of Internal Medicine, Yamaguchi University School of Medicine, Yamaguchi, Japan
¹⁴Department of Hematology, Kochi University Hospital, Nankoku, Japan
¹⁵Department of Hematology, National Cancer Center Hospital, Tokyo, Japan
¹⁶National Cancer Center Hospital, Tokyo, Japan
¹⁷National Cancer Center Hospital East, Kashiwa, Japan

Christian Pohlkamp, MD^1*, Niroshan Nadarajah^1*, Piyush Srivastava, MBA^2*, Sven Maschek^1*, Rudolf Drescher, PhD^3*, Siegfried Hänselmann, PhD^3*, Thomas Lörch, PhD^3*, Claudia Haferlach, MD¹, Wolfgang Kern, MD¹ and Torsten Haferlach, MD¹

¹MLL Munich Leukemia Laboratory, Munich, Germany
²Amazon Web Services, Seattle
³MetaSystems, Altlussheim, Germany

Valentin Jacquier^1*, Antoine Guillemin^1*, Sara Ovejero-Merino, PhD^1*, Guilhem Requirand^2*, Ouissem Karmous-Gadacha^3*, Laure Dutrieux^1*, Andrea Romero^1*, Alizée Steer, PhD^1,4*, Amelie Machura^4*, Hugues De Boussac, PhD^4*, Jerome Moreaux, PhD^1,2,5,6 and Charles Herbaux⁷

¹Institute of Human Genetics, UMR 9002 CNRS-UM, Montpellier, France
²Laboratory for Monitoring Innovative Therapies, Department of Biological Hematology, CHU Montpellier, Montpellier, France
³CHU Montpellier, Montpellier, France
⁴Diag2Tec, Montpellier, France
⁵UFR Médecine, Université Montpellier, Montpellier, France
⁶Institut Universitaire de France, Paris, France
⁷Hematology Department, Montpellier University Hospital, Montpellier, France, Montpellier, France

Bingliang Zhou^*, Qingqing Yang^*, Chengxing Zhou^*, Jinhu Zou^*, Xuefeng Gao^*, Yuanyuan Huang^*, Qiongxi Lin^*, Min Long, PhD^* and Hong Cao, MD, PhD^*

Department of Microbiology, School of Public Health (Guangdong Provincial Key Laboratory of Tropical Disease Research), Southern Medical University, Guangzhou, China

Imogen R Caldwell, FRACP, FRCPA¹, Michael Ingbritsen^1*, Yan Zhuang Yap^1*, Mark R Dowling, MBBS, PhD^2,3, Ing S Tiong, FRACP, FRCPA, MPhil¹, David A Westerman, MBBS, FRCPA, FRACP^1,3 and Piers Blombery, MBBS^2,3,4

¹Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
²Department of Clinical Haematology, Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
³Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia
⁴Peter MacCallum Cancer Centre, Peter Maccallum Cancer Centre, East Melbourne, VIC, Australia

Martin Hutchings, MD, PhD^1*, Annika Loft^1*, Wendy Osborne^2*, George Petrides^2*, Fritz Offner, MD, PhD³, Ciel De Vriendt^3*, Giuseppe Gritti, MD, PhD^4*, Roberto Boni^4*, William Townsend^5*, Irfan Kayani^5*, Ian Wilson^6*, Yanjie Wang^7*, Maria Jadhav^8*, Cristina Santini^9*, Claire Kelly^10*, Martin Kornacker⁹, Jean J.L. Tessier^9*, Ann-Marie E Bröske^11*, Angelika Lahr^11*, Axel Boehnke^9* and Christoph M. Griessinger^9*

¹Rigshospitalet, Copenhagen, Denmark
²The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom
³Universitair Ziekenhuis Gent, Ghent, Belgium
⁴Ospedale Papa Giovanni XXIII, Bergamo, Italy
⁵University College London Hospital Cancer Research UK and UCL Cancer Trials Centre, London, United Kingdom
⁶ImaginAb Inc, Inglewood, CA
⁷Roche Pharma Research and Early Development, Roche Innovation Center Shanghai, Shanghai, China
⁸Roche Pharma Research and Early Development, Roche Innovation Center Zurich, Zurich, Switzerland
⁹Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland
¹⁰Roche Pharma Research and Early Development, Roche Products Limited, Welwyn Garden City, United Kingdom
¹¹Roche Pharma Research and Early Development, Roche Innovation Center Munich, Penzberg, Germany

David Bermejo-Peláez, PhD^1*, Sandra Rueda Charro, MD^2*, Adriana Mousa^2*, Elisa Alamo^2*, Maria Garcia Roa^3*, Roberto Trelles-Martínez^3*, Marta Hidalgo Soto^4*, Alejandro Bobes-Fernández^5*, Roberto Garcia-Vicente^6,7*, María Luz Morales^6,7*, Alba Rodríguez García^6,8*, Alejandra Ortiz-Ruiz^6,7*, Alberto Blanco-Sánchez, MD^9*, Lin Lin^2,10*, Elena Dacal^2*, Rosa Ayala^6,11*, Miguel Luengo-Oroz^2*, María Linares^6,9,12* and Joaquin Martinez Lopez^6,7,9*

¹Spotlab, Madrid, AL, Spain
²Spotlab, Madrid, Spain
³Department of Hematology, Hospital Universitario Fundación Alcorcón, Alcorcón, Spain
⁴Vall Hebron Institute of Oncology (VHIO), Barcelona, Spain
⁵Department of Hematology, Hospital Clínico San Carlos, Madrid, Spain
⁶Department of Translational Hematology, Research Institute Hospital 12 de Octubre (imas12), Madrid, Spain
⁷Hematological Malignancies Clinical Research Unit H120-CNIO, CIBERONC, Madrid, Spain
⁸Hematological Malignancies Clinical Research Unit H12O-CNIO, Madrid, Spain
⁹Department of Hematology, Hospital Universitario 12 de Octubre, Madrid, Spain
¹⁰Biomedical Image Technologies Laboratory, ETSI Telecomunicación, Universidad Politécnica de Madrid, Madrid, Spain
¹¹Haematological Malignancies Clinical Research Unit, Hospital 12 de Octubre Universidad Complutense, CNIO, CIBERONC, Madrid, Spain
¹²Department of Biochemistry and Molecular Biology, Pharmacy School, Universidad Complutense de Madrid, Madrid, Spain

Ghayas C. Issa, MD¹, Aram Bidikian^1*, Hannah Roberts^2*, Wenjun Li^2*, Cailin Weller^2*, Rafita Alam^2*, Paola Gonzalez^2*, Blair Maupin^2*, Kaitlyn Nguyen^2*, Edaena Guzman^2*, Evelynn Nguyen^2*, Laura Casas Lumbreras^2*, Deepak Thirunavukarasu^2*, Alessandro Pinto, PhD^2* and David Yu Zhang, PhD^2*

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²NuProbe, Houston, TX