Kyra J. Fuchs, MSc^1*, M. Willy Honders, ing.^2*, Marian van de Meent, Ing^1*, Indu Khatri, PhD^3*, Eva A.S. Koster, MD^1*, Cornelis A.M. van Bergen, PhD^1*, Erik B. van den Akker, PhD^3*, Constantijn J.M. Halkes, MD, PhD¹, J.H. Frederik Falkenburg^1* and Marieke Griffioen^1*

¹Department of Hematology, Leiden University Medical Center, Leiden, Netherlands
²Department of Hematology, Leiden University Medical Center (LUMC), Leiden, Netherlands
³Center for Computational Biology, Leiden University Medical Center, Leiden, Netherlands

Livius Penter, MD^1,2,3,4, Yang Liu, PhD^5*, Lin Yang, MS^5*, Len Taing, MS^5*, Aashna Jhaveri, MS^5*, Jackson Southard, BS^6*, Manishkumar Patel, MSc^7*, Jacquelyn Wolff, BS^8*, Nicole Cullen, BS^8*, Kathleen Pfaff, PhD^8*, Nicoletta Cieri, MD, PhD^3,4,9*, Giacomo Oliveira, PhD^9*, Seunghee Kim-Schulze, PhD^7*, Srinika Ranasinghe, PhD^8*, Rebecca Leonard, BA^9*, Taylor Robertson, BS^9*, Helen Chen, MD^10*, Magdalena Thurin, PhD^10*, Shuqiang Li, PhD^6,9*, Scott J. Rodig, MD, PhD¹¹, Carrie Cibulskis, BSc^4*, Stacey Gabriel, PhD^4*, Jerome Ritz, MD, PhD⁹, Howard Streicher, MD^10*, Donna S. Neuberg, ScD⁵, Stephen Hodi, MD^9*, Sacha Gnjatic, PhD^7*, Kenneth J Livak, PhD^6,9*, Jennifer Altreuter, MD^5*, Franziska Michor, Ph.D.^5*, Robert J Soiffer, MD¹², Jacqueline S. Garcia, MD⁹ and Catherine J. Wu, MD⁹

¹Department of Hematology, Oncology, and Tumorimmunology, Campus Virchow Klinikum, Berlin, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
²Department of Medical Oncology, Dana-Farber Cancer Institute, Brookline, MA
³Harvard Medical School, Boston, MA
⁴Broad Institute of MIT and Harvard, Cambridge, MA
⁵Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
⁶Translational Immunogenomics Lab, Dana-Farber Cancer Institute, Boston, MA
⁷Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY
⁸Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA
⁹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
¹⁰Division of Cancer Treatment and Diagnosis, National Cancer Institute, Cancer Therapy Evaluation Program, Bethesda, MD
¹¹Department of Pathology, Brigham and Women's Hospital, Boston, MA
¹²Division of Stem Cell Transplant and Cellular Therapies, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

Shrijan Khanal, MSc^1*, Lotus Neidemire-Colley^1*, Kara M Braunreiter, PhD^1*, Katiri Snyder^1*, Yandi Gao^1*, Sonu Kalyan^2*, Meisam Naeimi Kararoudi, PhD, DVM³, Molly Erin Duszynski^4*, Mengna Chi, PhD⁴, Punam Malik, MD⁴, Hannah Choe, MD¹, Ramiro Garzon, MD¹ and Parvathi Ranganathan, PhD¹

¹Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
²Department of Pathology, New York University Langone Health, Long Island
³CRISPR/Gene Editing Core, Department of Pediatrics, Abigail Wexner Research Institute at Nationwide Children’s Hospital, The Ohio State University, College of Medicine, Columbus
⁴Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati

Yui Kambara^1*, Hideaki Fujiwara, MD, PhD², Akira Yamamoto, MD, PhD^2*, Mari Kunihiro^1*, Tadashi Oyama^1*, Takumi Kondo, MD, PhD^2*, Noboru Asada, MD, PhD², Daisuke Ennishi, MD, PhD², Hisakazu Nishimori, MD, PhD^2*, Nobuharu Fujii, MD, PhD^3*, Keiko Fujii, MD, PhD^4*, Ken-ichi Matsuoka, MD, PhD² and Yoshinobu Maeda, MD, PhD^1,2

¹Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
²Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan
³Department of Blood Transfusion, Okayama University Hospital, Okayama, Japan
⁴Department of Clinical Laboratory, Okayama University Hospital, Okayama, Japan

Shuhong Zhang, PhD^1*, Xingkui Xue, MD, PhD^2*, Maggie Granatir, BS^3*, George E. Sandusky, DVM, PhD.^3*, Sheng Liu, PhD^4*, Jun Wan, PhD^5*, Xiaoling Xuei, PhD^6*, Yunlong Liu, PhD^6*, Anthony L. Sinn, BS, LAT^7*, Karen E. Pollok, PhD⁷ and Sherif S Farag, MD, PhD¹

¹Division of Hematology and Oncology, Department of Medicine, Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN
²Current Adress: People's Hospital of New District Longhua Shenzhen, Guangdong, China. Division of Hematology and Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN
³Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN
⁴Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN
⁵Department of Medical and Molecular Genetics, Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN
⁶Department of Medical and Molecular Genetics, Center for Medical Genomics, Indiana University School of Medicine, Indianapolis, IN
⁷Preclinical Modeling & Therapeutics Core, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN

Lorenzo Iovino, MD, PhD¹, Kirsten Cooper^1*, Paul DeRoos^1*, Cindy Evandy^2*, David Granadier, BS^3*, Sinéad Kinsella, MSc, PhD¹, Dante Denny Acenas, BS^3* and Jarrod A Dudakov, PhD¹

¹Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
²Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
³Fred Hutchinson Cancer Research Center, Seattle, WA

Danny W. Bruce, PhD^1*, Oleg Kolupaev, PhD^2*, Sonia J. Laurie, PhD², Hemamalini Bommiasamy, PhD^3* and Jonathan S. Serody, MD²

¹Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC
²Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
³Department of Genetics, University of North Carolina, Chapel Hill, NC

Sanam Shahid, MD¹, Nicholas Ceglia^2*, Jean-Benoit Le Luduec^3*, Andrew McPherson^2*, Barbara Spitzer, MD¹, Viktoria Bojilova^2*, M. Kazim Panjwani^3*, Mikhail Roshal, MD⁴, Sohrab Shah^2*, Omar Abdel-Wahab, MD⁵, Benjamin Greenbaum^2* and Katharine C. Hsu, MD, PhD⁵

¹Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
³Memorial Sloan Kettering Cancer Center, New York, NY
⁴Department of Pathology and Laboratory Medicine, Hematopathology Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

Jenny Yeung, PhD^1,2*, Aiyin Liao, PhD^1*, Matthew Shaw, PhD^1*, Soraia Caetano-Silva, PhD^1*, Winston Vetharoy^1*, Ian Kirby, PhD^3*, Francesca Zammarchi, PhD^3*, Karin Havenith, PhD^3*, Patrick H van Berkel, PhD^3*, Claire Booth, MBBS, PhD, MSc^1,4*, H Bobby Gaspar, MBBS, PhD, BS^1*, Adrian J. Thrasher, MBBS, PhD, FMedSci^1*, Kerry Chester, PhD^2* and Persis J Amrolia, MD PhD^1,4*

¹UCL Great Ormond Street Institute of Child Health, London, United Kingdom
²UCL Cancer Institute, London, United Kingdom
³ADC Therapeutics (UK) Ltd, London, United Kingdom
⁴Great Ormond Street Hospital, London, United Kingdom

S. Haihua Chu, PhD^*, Elizabeth Budak^*, Nandini Mondal, PhD^*, Kathy Zhang, PhD^*, Alexander Harmon^*, Jeffrey Wong^*, Dieter Lam^*, Corrina Lucini^*, Brent Coisman^*, Kangjian Qiao, PhD^*, Tao Bai, PhD^*, Jeremy Decker^*, Bob Gantzer, M.S.^*, Kindo Lee^*, Maya Sen, PhD^*, Tanggis Bohnuud, PhD^*, Luis Barrera, PhD^*, Brian Cafferty, PhD^*, Seung-Joo Lee, PhD^*, Paul Kopesky, PhD^*, Nicole M. Gaudelli, Ph.D.^*, Charlotte F McDonagh, PhD^*, Giuseppe Ciaramella, Ph.D.^* and Adam J. Hartigan, PhD^*

Beam Therapeutics, Cambridge, MA

Melinda Ann Biernacki, MD¹, Olivia Waltner^2*, Sami B Kanaan, PhD^3*, Rula Green Gladden, MD¹, Shruti Bhise^4*, Todd M. Cooper, DO^5,6, Monica Thakar, MD², Soheil Meshinchi, M.D., Ph.D.⁷, Marie Bleakley, MBBS MMSc PhD¹, Xueyan Chen, MD, PhD^8* and Scott N Furlan, MD^1*

¹Fred Hutchinson Cancer Center, Seattle, WA
²Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
³Fred Hutchinson Cancer Research Center, Seattle, WA
⁴Fred Hutchinson Cancer Center, Seattle
⁵Seattle Children’s Hospital, Cancer and Blood Disorders Center, Seattle, WA
⁶Seattle Children's Cancer and Blood Disorders Center, University of Washington, Seattle, WA
⁷Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA
⁸Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA

Juliana Xavier-Ferrucio, PhD^*, Gabriella Angelini, MS^*, Sushma Krishnamurthy, MS^*, Nipul Patel^*, Michael Pettiglio^*, Timothy Collingsworth, MS^*, Amanda Halfond, MS^*, Julia Etchin, PhD^*, Yonina Keschner, BS^*, Guy Mundelboim, BA^*, Huan Qiu, PhD^*, Ruijia Wang, PhD^*, Gary Ge, PhD^*, John Lydeard, PhD, Michelle I Lin, PhD and Tirtha Chakraborty, PhD^*

Vor Biopharma, Cambridge, MA

Shuhua Wang, MD^1*, Tenzin Passang^1*, Yiwen Li^2*, Hanwen Zhang, MD, PhD¹, Pankoj Kumar Das^1*, Kevin Chen, BS^1*, Christopher R. Funk, MD¹ and Edmund K. Waller, MD, PhD³

¹Winship Cancer Institute Department of Hematology and Medical Oncology, Emory University, Atlanta, GA
²School of Medicine, Emory University, Atlanta, GA
³Winship Cancer Institute, Emory University, Atlanta, GA

John S Riley, MD, MS¹, Apeksha Dave^2*, Osheiza Y. Abdulmalik, DVM^3* and William H Peranteau, MD^1*

¹Center for Fetal Research, Children's Hospital of Philadelphia, Philadelphia, PA
²Center for Fetal Research, The Children's Hospital of Philadelphia, Philadelphia, PA
³Division of Hematology, The Children’s Hospital of Philadelphia, Philadelphia, PA

Sascha Göttert^1*, Julius Clemens Fischer^2*, Gabriel Eisenkolb^3*, Erik Thiele Orberg, MD, PhD^4*, Sebastian Jarosch^5*, Ernst Holler, MD, PhD⁶, Dirk Busch^7*, Simon Heidegger^8* and Hendrik Poeck, MD⁹

¹University Hospital Regensburg, Regensburg, Germany
²Department of Radiation Oncology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
³Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Gynecology and Obstetrics, Munich, Germany
⁴Department of Hematology and Oncology, University Hospital Rechts der Isar of the Technical University of Munich, Munich, Germany
⁵Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany
⁶Department of Internal Medicine III, Univeristy Hospital Regensburg, Regensburg, Germany
⁷Medical Microbiology, Immunology and Hygiene, Munich, DEU
⁸Department of Medicine III, School of Medicine, Technical University of Munich, Munich, Germany
⁹Department of Internal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, Bavaria, Germany

Qingxiao Song, MD, PhD¹, Moqian Zheng^1*, Qinjian Li^1*, Xiwei Wu, PhD^2*, Hanjun Qin, PhD^2*, Tae Hyuk Kang^3*, Yaqun Hong^1*, Bixin Wang, MD^4*, Maciej Kujawski^1*, Jack Shively, PhD^1*, Ryotaro Nakamura, MD⁵, Paul J Martin, MD⁶ and Defu Zeng, MD, PhD^7,8

¹Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, CA
²Integrative Genomics Core, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
³The Beckman Research Institute of City of Hope, Duarte, CA
⁴Authur D. Riggs Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, CA
⁵Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA
⁶Clinical Research Division, Fred Hutchinson Cancer Research Center, SEATTLE, WA
⁷Author D. Riggs Diabetes and Metabolism Research Institute, The Beckman Research institute of City of Hope, Duarte, CA
⁸City of Hope National Medical Center, Department of Hematology and Hematopoietic Cell Transplantation, Duarte

Kirk Bertelsen, PhD^*, Leanne Lanieri, MS^*, Rahul Palchaudhuri, PhD^* and Lisa Olson, PhD^*

Magenta Therapeutics, Cambridge, MA

Katiri Snyder^*, Lotus Neidemire-Colley, BS^*, Yandi Gao^* and Parvathi Ranganathan, PhD

Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH

Oleg Kolupaev, PhD^1*, Danny W. Bruce, PhD^1*, Sonia J. Laurie, PhD¹, Hemamalini Bommiasamy, PhD^2* and Jonathan S. Serody, MD¹

¹Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
²Department of Genetics, University of North Carolina, Chapel Hill, NC