Cathelijne Fokkema, MD^1*, Madelon M.E. de Jong, MD^1*, Sabrin Tahri, MD^1*, Davine Hofste Op Bruinink, MD^1*, Zoltan Kellermayer, MD, PhD^1*, Chelsea den Hollander, BSc^1*, Michael Vermeulen, BSc^1*, Natalie Papazian, BSc^1*, Mark van Duin, PhD^1*, Remco Hoogenboezem, MSc^1*, Michiel J.W. Wevers, MSc^1*, Vincent H.J. van der Velden, PhD^2*, Mathijs A. Sanders, PhD, MSc^1*, Annemiek Broijl, MD, PhD^3*, Pieter Sonneveld, MD¹ and Tom Cupedo, PhD^1*

¹Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands
²Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands
³Erasmus MC Cancer Institute, Rotterdam, Netherlands

Mohammad Issam Abu Zaid, MBBS¹, Parvathi Sudha, MS^2*, Travis S Johnson, PhD³, Vivek S. Chopra, PhD^4*, Cedric E. Dos Santos, PhD⁵, Michael Nixon, MSN, MPH^4*, Attaya Suvannasankha, MD^6*, Sherif S Farag, MD, PhD⁷, Kelvin P. Lee, MD⁸, Rafat Abonour, MD² and Brian A. Walker, PhD²

¹Melvin and Bren Simon Comprehensive Cancer Center, Indiana Cancer Pavilion, Indianapolis, IN
²Melvin and Bren Simon Comprehensive Cancer Center, Division of Hematology Oncology, Indiana University, Indianapolis, IN
³Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN
⁴Genentech, Inc., South San Francisco, CA
⁵Genentech, Inc., San Francisco, CA
⁶Indiana University Simon Cancer Center, Indiana University and Roudebush VAMC, Indianapolis, IN
⁷Division of Hematology and Oncology, Department of Medicine, Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN
⁸Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN

Zainul Hasanali, MD, PhD¹, Alfred L. Garfall^2,3,4,5,6*, Martin P. Carroll, MD⁷, Anthony Secreto^1*, Nicolas Skuli, PhD^8*, Carly Roman^1,9*, Leonard Shultz, PhD^10*, Neil Sheppard, D.Phil^11*, Edward A. Stadtmauer, MD^2,12 and David Allman, PhD^13*

¹University of Pennsylvania, Philadelphia, PA
²Abramson Cancer Center, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA
³Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA
⁴Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
⁵Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
⁶Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA
⁷Division of Hematology/Oncology, Department of Medicine, The Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA
⁸University of Pennsylvania, Phiadelphia, PA
⁹Emory University, Atlanta, GA
¹⁰The Jackson Laboratory, Bar Harbor, ME
¹¹University of Pennsyvlania, Philadelphia, PA
¹²Division of Hematology and Oncology, Abramson Cancer Center University of Pennsylvania, Philadelphia, PA
¹³Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA

Sigrún Thorsteinsdóttir, MD, PhD^1,2, Jon Þórir Oskarsson, MSc^3*, Sæmundur Rögnvaldsson, MD^4,5*, Gauti Gíslason^1*, Thor Aspelund, PhD^1*, Gudrún Ásta Sigurdardóttir^1*, Ásdis Rósa Thórdardottir^1*, Brynjar Vidarsson, MD⁵, Páll Torfi Onundarson, MD⁵, Bjarni Agnar Agnarsson, MD^5*, Margrét Sigurdardóttir, MD^5*, Ingunn Thorsteinsdóttir, MD, PhD^5*, Ísleifur Ólafsson, MD, PhD^5*, Elias Eythorsson, MD, PhD^5*, Ásbjorn Jónsson, MD^6*, Malin Hultcrantz, MD, PhD⁷, Ola Landgren, MD⁸, Stephen Harding, PhD⁹, Brian G.M. Durie, MD¹⁰, Thorvardur Jon Love, MD, PhD^1* and Sigurdur Y Kristinsson, MD, PhD^1,5

¹Faculty of Medicine, University of Iceland, Reykjavik, Iceland
²Department of Hematology, Rigshospitalet, Copenhagen, Copenhagen, Denmark
³Faculty of Medicine, University of Iceland, Reykjavik, Reykjavik, Iceland
⁴Faculty of Medicine, University of Iceland, Reykjavík, Iceland
⁵Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland
⁶Akureyri Hospital, Akureyri, Iceland
⁷Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁸Myeloma Division, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
⁹The Binding Site Inc., Birmingham, United Kingdom
¹⁰Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Outpatient Cancer Center, Los Angeles, CA

Johannes M. Waldschmidt, MD^1,2, Sankalp Arora, MD^3*, Tushara Vijaykumar^1*, Noori Sotudeh, PhD^4*, Praveen Anand, PhD^1*, Hannah Stuart^1*, Julia Frede, PhD, MPhil¹, Tim Campbell^5*, Shari M. Kaiser, PhD^5*, Manisha Lamba, PhD^5*, Nikhil C Munshi, MD, PhD⁶, Kenneth C. Anderson, MD¹, Andrew J. Yee, MD, PhD⁷, Birgit Knoechel, MD, PhD⁴, Jens G. Lohr, MD, PhD¹ and Noopur Raje, MD⁷

¹Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Boston, MA
²Department of Hematology, Oncology and Stem Cell Transplantation, University of Freiburg Medical Center, Freiburg, Baden Wurttemberg, Germany
³University of Alabama at Birmingham, Birmingham, AL
⁴Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
⁵Bristol Myers Squibb, Princeton, NJ
⁶Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Boston, MA
⁷Massachusetts General Hospital, Boston, MA

Ankit K. Dutta, PhD^1,2,3*, Jean-Baptiste Alberge, PhD^1,2,4*, Elizabeth D. Lightbody, PhD^1,2,3, Cody J. Boehner, BS^1,2*, Romanos Sklavenitis-Pistofidis, MD^1,2,3, Amanda Cao^2*, Tarek H. Mouhieddine, MD^1,2,3, Anna Cowan, BA^2*, Nang Kham Su, MSc^1,2*, Andrew Dunford^3*, Erica Horowitz, BA^2*, Hadley Barr, BA^1,2*, Jenna B. Beckwith, MPH^2*, Laura Hevenor, BS^2*, Jacqueline Perry, MPH^1,2*, Ornkleaw Zepp^5*, Thai Bui^5*, Steven Gross, MA^5*, Omar Nadeem, MD^1,2, Chip Stewart, PhD^3*, Daniel Auclair, PhD^6,7, Gad Getz, PhD^3,8* and Irene Ghobrial, MD^1,2,3

¹Department of Medicine, Harvard Medical School, Boston, MA
²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
³Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA
⁴Broad Institute of MIT and Harvard, Cambridge, MA
⁵Menarini Silicon Biosystems, Huntingdon Valley, PA
⁶Multiple Myeloma Research Foundation, Norwalk, CT
⁷Hematology R&D, AstraZeneca, Waltham, MA
⁸Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, MA

Debora Soncini, PhD^1*, Pamela Becherini^2*, Elisa Gelli, PhD^3*, Claudia Martinuzzi^2*, Fabio Guolo, MD^1*, Antonino Neri, MD⁴, Antonia Cagnetta, MD^1*, Roberto Massimo Lemoli, MD¹ and Michele Cea^1*

¹Clinic of Hematology, Department of Internal Medicine (DiMI), IRCCS Ospedale Policlinico San Martino, Genova, Italy
²University of Genoa, Genoa, ITA
³DIMI, University of Genoa, Genova, Italy
⁴BMT Center - Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, MI, Italy

Jing Fu, PhD¹, Shirong Li, PhD², Huihui Ma, MD, PhD^3*, Jun Yang, MS^4*, Lewis M Brown, PhD^5*, Gabriel M. Pagnotti, PhD^6*, Stephen J. Weiss, MD, PhD^7*, Markus Y. Mapara, MD, PhD³ and Suzanne Lentzsch, MD, PhD⁴

¹Department of Medicine, Division of Hematology/Oncology, Columbia University Medical Center, New York, NY
²Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NJ
³Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY
⁴Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY
⁵Quantitative Proteomics Center, Columbia University, New York, NY
⁶Department of Endocrine, Neoplasia and Hormonal Disorders, University of Texas - MD Anderson Cancer Center, Houston, TX
⁷Department of Internal Medicine, University of Michigan, Life Sciences Institute, Ann Arbor, MI

Sridurga Mithraprabhu, PhD, MSc^1,2*, John Reynolds, PhD^3,4*, Rose Turner^5*, Hang Quach⁶, Noemi Horvath, MB ChB FRACP FRCPA⁷, Ian H Kerridge, BA, BMed(Hons), MPhil(Cantab), FRACP, FRCPA^8*, Flora Yuen, BBiomedSc^3*, Tiffany Khong, BSc, PhD⁹, Brian G.M. Durie, MD¹⁰ and Andrew Spencer¹¹

¹Alfred Health - Monash University, Melbourne, Australia
²Myeloma Research Group, Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia
³The Alfred Hospital and Monash University, Melbourne, VIC, Australia
⁴Department of Haematology, The Alfred Hospital and Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia
⁵Alfred Hospital, Melbourne, Australia
⁶Clinical Haematology Service, St. Vincent’s Hospital, Melbourne, VIC, Australia
⁷Department of Haematology, Royal Adelaide Hospital, Adelaide, Australia
⁸Royal North Shore Hospital, Sydney, NSW, Australia
⁹Australian Center for Blood Diseases, Myeloma Research Group, Alfred Hospital, Monash University, Melbourne, VIC, Australia
¹⁰Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Outpatient Cancer Center, Los Angeles, CA
¹¹Clinical Hematology, Alfred Health, Melbourne, Australia

Evan Flietner, BS¹, Mei Yu, PhD^2*, Adhithi Rajagopalan, PhD³, Yun Zhou, MS^3*, Yubin Feng, PhD^3*, Anthony Veltri, PhD^2*, Terra L. Lasho, PhD⁴, Zhi Wen, PhD^5*, Yuqian Sun^3*, Robert Burns, PhD^2*, Mrinal M. M. Patnaik, MD⁴, Natalie Callander, MD⁶, Fotis Asimakopoulos, PhD, MBBChir,⁷, Demin Wang, PhD² and Jing Zhang, PhD³

¹School of Medicine and Public Health, Cellular and Molecular Pathology Program, University of Wisconsin-Madison, Madison, WI
²Blood Research Institute, Versiti, Milwaukee, WI
³McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI
⁴Division of Hematology, Mayo Clinic, Rochester, MN
⁵Center for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, WI
⁶Division of Hematology/Oncology, Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI
⁷Department of Medicine, Division of Blood and Marrow Transplant, University of California San Diego & Moores Cancer Center, La Jolla, CA

Yanni Zhang, PhD^1*, Zhen Sheng, PhD^1*, Jie Xia^1*, Chunyan Ye, PhD^1*, Yan Liu, M.S.^1*, Zhengyi Wang, PhD^1*, John Hayslip, MD, MSCR² and Andrew Zhu^1*

¹I-Mab Biopharma, Shanghai, China
²I-Mab Biopharma, Gaithersburg, MD

Takahiro Kamiya, MD^1,2*, Motohiko Oshima, PhD^1*, Shuhei Koide, PhD^1*, Yaeko Nakajima-Takagi, PhD^1*, Kazumasa Aoyama, PhD^1*, Naoki Itokawa, MD, PhD^1*, Masayuki Yamashita, MD, PhD^1*, Noriko Doki, MD, PhD^3*, Keisuke Kataoka, MD, PhD^2,4 and Atsushi Iwama, MD, PhD¹

¹Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
²Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
³Hematology Division, Komagome Hospital, Tokyo, Japan
⁴Division of Molecular Oncology, National Cancer Center Research Institute, Tokyo, Japan

Yoon Seok Choi, MD, PhD^1,2, Yuri Lee, MS^1,2*, Jun Soung Park, MD^1*, Minsuk Kwon, MD, PhD^1*, Seong Hyun Jeong, MD^1*, Jeong Seok Lee, MD, PhD^3*, Eui-Cheol Shin, MD, PhD^3* and Joon Seong Park^1*

¹Department of Hematology-Oncology, Ajou University School of Medicine, Suwon, Korea, Republic of (South)
²Department of Biomedical Science, Ajou University Graduate School, Suwon, Korea, Republic of (South)
³Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea, Republic of (South)

Anna Maria Corsale^1*, Mojtaba Shekarkar Azgomi, PhD^1*, Federica Plano^1*, Marta Di Simone^1*, Cristina Perez^2*, Carmela Picone^3*, Emilia Gigliotta^1*, Candida Vullo^1*, Giulia Camarda^1*, Cristina Rotolo^1*, Maria Speciale^1*, Marco Santoro, MD, PhD^1*, Nadia Caccamo^3*, Francesco Dieli^3*, Bruno Paiva^2*, Serena Meraviglia^3*, Sergio Siragusa, MD¹ and Cirino Botta, MD, PhD¹

¹Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (ProMISE), University of Palermo, Palermo, Italy
²Centro de Investigacion Medica Aplicada, Instituto de Investigacion Sanitaria de Navarra Hematology Unit, Clinica Universitad de Navarra, Centro de Investigacion Biomedica en Red, Cancer Hematology Unit, Pamplona, Spain
³Department of Biomedicine, Neurosciences and Advanced Diagnosis, University of Palermo, Palermo, Italy

Scott R. Goldsmith, MD^1,2, Reyka G. Jayasinghe, PhD^3*, Jonathan Adam Scolnick, PhD^4*, Jaren Sia^5*, Mark A Fiala, PhD^6*, Michael J Slade, MD, MS⁷, Tianjiao Wang⁸, Li Ding, PhD^9* and Ravi Vij, MD¹⁰

¹Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO
²Division of Myeloma, Department of Hematology and HCT, City of Hope Comprehensive Cancer Center, Duarte, CA
³Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO
⁴Singleron Biothechnologies, Singapore, AL, Singapore
⁵Singleron Biotechnologies, Singapore, Singapore
⁶Department of Medicine, Division of Hematology & Oncology, Washington University School of Medicine, St. Louis, MO
⁷Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO
⁸Medicine, Washington University School of Medicine, Saint Louis, MO
⁹Department of Medicine, Washington University School of Medicine, Saint Louis, MO
¹⁰Division of Oncology, Washington University School of Medicine, Saint Louis, MO

Young Eun Lee, MS^1,2*, Ju Heon Park, MD^1*, Ha Jin Lim, MD^1*, Hye Ran Kim, PhD^3*, Jong Hee Shin, MD, PhD^1* and Myung-Geun Shin, MD, PhD^1,2,4

¹Department of Laboratory Medicine, Chonnam National University Medical School and Chonnam National University Hwasun Hospital, Hwasun, Korea, Republic of (South)
²BioMedical Sciences Graduate Program (BMSGP), Chonnam National Univerisity and Chonnam National University Hwasun Hospital, Hwasun, Korea, Republic of (South)
³College of Korean Medicine, Dongshin University, Naju, Korea, Republic of (South)
⁴KBlueBio Inc., Hwasun, Korea, Republic of (South)

Kentaro Mizuhara^1*, Yuji Shimura, MD, PhD^1*, Taku Tsukamoto, MD, PhD^1*, Akinori Kanai, PhD^2,3*, Saeko Kuwahara-Ota, MD, PhD^1,4*, Junko Yamaguchi, MD, PhD^1,5*, Ayako Muramatsu, MD^1*, Haruya Okamoto, MD^1*, Yoko Katsuragawa-Taminishi, MD^1*, Yuka Kawaji-Kanayama, MD^1*, Reiko Isa, MD^1*, Shinsuke Mizutani, MD, PhD^1*, Toshiya Inaba^2* and Junya Kuroda, MD, PhD¹

¹Division of Hematology and Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan
²Department of Molecular Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
³Laboratory of Systems Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, the University of Tokyo, Chiba, Japan
⁴Department of Hematology, Japan Community Health Care Organization, Kyoto Kuramaguchi Medical Center, Kyoto, Japan
⁵Department of Hematology, Japanese Red Cross Kyoto Daini Hospital, Kyoto, Japan

Mateo Mejia Saldarriaga, MD¹, Aubrie Sowa^1,2*, David S Jayabalan, MSc^3*, Cara A. Rosenbaum, MD^1*, Roger Pearse, MD, PhD¹, Jorge Monge, MD⁴, Ruben Niesvizky, MD¹ and Mark Bustoros, MD¹

¹Division of Hematology & Medical Oncology, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY
²University College Dublin Medical School, Dublin, Ireland
³Department of Pathology & Laboratory Medicine, Weill Cornell Medical College, New York, NY
⁴Hematology & Medical Oncology, Weill Cornell Medical College/New York Presbyterian Hospital, New York, NY

Guangfeng Wang, PhD^1*, Eric Liang, PhD^2*, Ping Min, MS^1*, Yangfeng Ge, BS^1*, Bingxing Wu, BS^3*, Huidan Yu, BS^3*, Dajun Yang^2,4* and Yifan Zhai²

¹Ascentage Pharma Co., Ltd., Shanghai, China
²Ascentage Pharma Group Inc., Rockville, MD
³Ascentage Pharma (Suzhou) Co., Ltd., Suzhou, China
⁴Department of Experimental Research, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China

Yao Yao^1,2*, Jessica Fong Ng^3*, Woojun D Park^4*, Mehmet K. Samur, PhD⁵, Eugenio Morelli, MD⁶, Nicholas P Kwiatkowski, PhD^7,8*, Jessica Encinas Mayoral^9*, Zuzana Chyra^10*, Yan Xu, MD^11*, Behnam Nabet, PhD^5*, Marta Chesi, PhD¹², Nathaniel Gray^13*, Richard A. Young, PhD^14*, Kenneth C. Anderson, MD⁵, Charles Y Lin, PhD^15*, Nikhil C Munshi, MD, PhD⁶ and Mariateresa Fulciniti, PhD⁵

¹Dana Farber Cancer Institute, Boston, MA
²Blood Disease Institute, Key Laboratory of Bone Marrow Stem Cell, Xuzhou Medical University, Xuzhou, China
³Dana farber cancer institute, Boston, MA
⁴Baylor college of medicine, Huston, TX
⁵Dana-Farber Cancer Institute, Boston, MA
⁶Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Boston, MA
⁷Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
⁸Broad Institute of MIT and Harvard, Cambridge, MA
⁹Hospital Doce de Octubre, Madrid, Spain
¹⁰Department of Hematooncology, University Hospital of Ostrava; Masaryk University, Ostrava, Czech Republic
¹¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
¹²Mayo Clinic, Scottsdale, AZ
¹³Department of Chemical and Systems Biology, Chem-H and Stanford Cancer Institute, Stanford Medicine, Stanford, CA
¹⁴Whitehead Institute For Biomedical Research/ MIT, Cambridge, MA
¹⁵Dan L. Duncan Cancer Center, Department of Molecular and Human Genetics, Baylor College of Medicine, HOUSTON, TX

Melissa R Junttila, PhD^1*, Arghya Ray, PhD², Robert Warne^1*, Xi R Chen^1*, Ting Du^2*, Fang Lui^1*, Subhash Katewa, PhD^1*, Brian Blank, PhD^1*, Jared Moore, PhD^1*, Chudi Ndubaku, PhD^1*, Christophe Colas, PhD^1*, Pratik S Multani, MD^1*, Omar Nadeem, MD^2*, Dharminder Chauhan, PhD^2*, Kenneth C. Anderson, MD³ and Lori Friedman, PhD^1*

¹ORIC Pharmaceuticals, South San Francisco, CA
²Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
³The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

Mara John^1*, Moutaz Helal^2*, Lars Grundheber^2*, Greta Mattavelli^2*, Nazia Afrin^2*, Xiang Zhou^3*, Benedict Engel^2*, Werner Schmitz^4*, Emilia Stanojkovska^5*, Cornelia Vogt, MSc^6*, Silvia Nerreter^6*, Eva Teufel, MSc^6*, Julia Mersi, MD^6*, Hermann Einsele, MD⁷, K. Martin Kortuem^8*, Angela Riedel^9* and Leo Rasche, MD^6*

¹Mildred Scheel Early Career Center (MSNZ), University Hospital Wuerzburg, Wuerzburg, DEU
²Mildred Scheel Early Career Center (MSNZ), University Hospital Würzburg, Würzburg, Germany
³Department of Internal Medicine II, University Hospital Wuerzburg, WüRzburg, Germany
⁴Biozentrum, University Würzburg, Würzburg, Germany
⁵Mildred Scheel Early Career Center (MSNZ), University Hospital Würzburg, Würzburg, DEU
⁶Department of Internal Medicine II, University Hospital Wuerzburg, Wuerzburg, Germany
⁷Universitaetsklinikum Wuerzburg, Med. Klinik und Poliklinik II, Wuerzburg, Germany
⁸Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany
⁹University Hospital Wuerzburg, Wuerzburg, DEU

James P Roy^1,2*, Georgina S.F. Anderson^1,2*, Ieuan Walker, MBBS, MSc, BSc, MRCP^1,3* and Michael A Chapman, PhD, MRCP, FRCPath^1,2,3

¹MRC Toxicology Unit, University of Cambridge, Cambridge, United Kingdom
²Department of Haematology, University of Cambridge, Cambridge, United Kingdom
³Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom

Chengcheng Liao, PhD, MD^1*, Srikanth Talluri, PhD^1*, Shidai Mu, MD, PHD^1*, Subodh Kumar, PhD^1*, Lakshmi B. Potluri, MD^1*, Jialan Shi, MD, PhD¹, Leutz Buon^1*, Masood A. Shammas, PhD^1* and Nikhil C Munshi, MD, PhD^2,3

¹Dana-Farber Cancer Institute, Boston, MA
²Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Boston, MA
³VA Boston Healthcare System, Boston

Remi Tilmont, MD^*, Ranjan Maity, PhD^*, Noemie Leblay, PhD^*, Holly Lee, MD, Elie Barakat, MSc^*, Paola Neri, MD, PhD and Nizar J. Bahlis, MD

Arnie Charbonneau Cancer Research Institute, University of Calgary, Calgary, AB, Canada

Gabriel Alvares Borges, PhD, MSc, DDS^1*, Angelo Jose Guilatco, BS^1,2*, Christine M. Hachfeld^1*, Ming Ruan^3*, Sonya Royzenblat^4*, Ming Xu, PhD, BS^5*, Claire M. Edwards, PhD^6*, Marta Diaz-delCastillo, PhD^7*, Thomas L. Andersen, PhD^7*, Taxiarchis Kourelis, MD¹, Tamar Tchkonia, PhD^3*, James L. Kirkland, MD/PhD^3*, Matthew T. Drake, MD, PhD^1,3,8 and Megan Weivoda, PhD¹

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Cancer Biology Graduate Program, University of Michigan, Ann Arbor, MI
³Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN
⁴Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI
⁵Center on Aging and the Department of Genetics and Genome Sciences, University of Connecticut, Farmington, CT
⁶Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
⁷Department of Forensic Medicine, Aarhus University Hospital, Aarhus, Denmark
⁸Division of Endocrinology, Mayo Clinic, Rochester, MN

Hailin Chen, MD^1*, Tengteng Yu, MD^2*, Liang Lin, PhD^1*, Lijie Xing, MD^3*, Shih-Feng Cho, MD, PhD^4*, Kenneth Wen^1*, Kimberly Aardalen^5*, Mike Daley^6*, Haihui Lu, PhD⁷, Adwait Oka^7*, Joni Lam^6*, Nikhil C Munshi, MD, PhD⁸, Kenneth C. Anderson, MD⁹ and Yu-Tzu Tai, PhD¹⁰

¹Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, LeBow Institute for Myeloma Therapeutics, Dana-Farber Cancer Institute, Boston, MA
²the Jerome Lipper Multiple Myeloma Center, LeBow Institute for Myeloma Therapeutics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
³Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China
⁴Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
⁵Novartis Institutes For Biomedical Research, Cambridge, MA
⁶Novartis Institutes for Biomedical Research, Cambridge
⁷Novartis Institutes for Biomedical Research, Cambridge, MA
⁸Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
⁹LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
¹⁰Harvard Medical School, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Boston, MA

Nathan Becker, MS^1*, Enze Liu, PhD^1*, Parvathi Sudha, MS^1*, Aneta Mikulasova^2*, Travis S Johnson, PhD³, Attaya Suvannasankha, MD¹, Mohammad Issam Abu Zaid, MBBS¹, Rafat Abonour, MD¹ and Brian A. Walker, PhD¹

¹Melvin and Bren Simon Comprehensive Cancer Center, Division of Hematology Oncology, Indiana University, Indianapolis, IN
²Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
³Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN

Li Du, PhD^1,2*, Wei Liu, PhD^3,4*, Enrico Caserta, PhD^5,6*, Flavia Pichiorri, PhD^5,7 and Steve T Rosen, MD^8,9

¹Toni Stephenson Lymphoma Center, Beckman Research Institute City of Hope, Duarte, CA
²Judy and Bernard Briskin Center for Multiple Myeloma Research, Beckman Research Institute City of Hope, Duarte, CA
³Xiangya Hospital Central South University, Changsha, China
⁴Beckman Research Institute City of Hope, Duarte, CA
⁵Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA
⁶Department of Hematologic Malignancies Translational Science, Beckman Research Institute, City of Hope, Duarte, CA
⁷Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope, Duarte, CA
⁸City of Hope National Medical Center, Duarte, CA
⁹City of Hope Comprehensive Cancer Center, Duarte, CA

Ko Abe^1*, Sho Ikeda, MD^1*, Miho Nara, MD^1*, Akihiro Kitadate, MD, PhD², Hiroyuki Tagawa, MD, PhD¹ and Naoto Takahashi, MD, PhD¹

¹Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan
²Department of Hematology, Nephrology, and Rheumatology, Akita University, Akita, Japan

Lixin Gong^1*, Hao Sun, PhD^2*, Junqiang Lv^3*, Lugui Qiu⁴ and Mu Hao, PhD^1*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical Colleg, Tianjin,China, China
³Tianjin Medical UniversityKey Laboratory of Immune Microenvironment and Diseases (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Moritz Binder, MD, MPH¹, Amelia Mazzone, PhD^2*, Jenna A. Fernandez, PhD^1*, Wazim Mohammed Ismail, PhD^2*, S. Vincent Rajkumar, MD^1*, Alexandre Gaspar Maia, PhD^2* and Shaji K Kumar, MD¹

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

Sara ovejero-Merino, PhD^1*, Julie Devin, PharmD^2*, Tatiana Cañeque^3*, Laura Alibert^4*, Guilhem Requirand^5*, Nicolas Robert^5*, Alizée Steer, PhD^6,7*, Amelie Machura^7*, Christophe Hirtz^8*, Angélique Bruyer^6,7*, Laure Vincent, MD^9*, Guillaume Cartron, MD, PhD^10*, Charles Herbaux^11,12,13,14, Raphael Rodriguez^3*, Caroline Bret, PhD, PharmD^6,15,16* and Jerome Moreaux, PhD^5,6,17,18

¹Institute of Human Genetics, Montpellier, FRA
²CHU Montpellier, Laboratory for Monitoring Innovative Therapies, Department of Biological Hematology, Montpellier, France
³Institut Curie, Paris, France
⁴Institute of human genetics, Montpellier, France
⁵Laboratory for Monitoring Innovative Therapies, Department of Biological Hematology, CHU Montpellier, Montpellier, France
⁶Institute of Human Genetics, UMR 9002 CNRS-UM, Montpellier, France
⁷Diag2Tec, Montpellier, France
⁸CHU Montpellier, Laboratory of Biochemistry – Clinical Proteomic, Montpellier, France
⁹Department of Hematology, Montpellier University Hospital, Montpellier, France
¹⁰Département d'Hématologie clinique, CHU de Montpellier, Montpellier, France
¹¹Hematology Department, Montpellier University Hospital, Montpellier, France, Montpellier, France
¹²University of Montpellier, Paris, France
¹³University of Montpellier, Montpellier, France
¹⁴CHU de Montpellier, Montpellier, France
¹⁵Department of Biological Hematology, CHU Montpellier, Montpellier, France
¹⁶University of Montpellier, UFR Medecine, Montpellier, France
¹⁷UFR Médecine, Université Montpellier, Montpellier, France
¹⁸Institut Universitaire de France, Paris, France

Sabrin Tahri, MD^1,2*, Madelon M.E. de Jong, MD^3*, Cathelijne Fokkema, MD^3*, Natalie Papazian, BSc^3*, Zoltan Kellermayer, MD, PhD^4*, Michael Vermeulen, BSc^3*, Mark van Duin, PhD^3*, Pieter van de Woestijne, MD PhD^5*, Kazem Nasserinejad, PhD^6*, Elona Saraci^7*, Mattia D'Agostino, MD^7*, Francesca Gay, MD, PhD⁷, Vincent H.J. van der Velden, PhD^8*, Niels WCJ Van De Donk, MD⁹, Annemiek Broijl, MD, PhD^10*, Pieter Sonneveld, MD¹¹, Sonja Zweegman, MD, PhD¹² and Tom Cupedo, PhD^3*

¹Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, MA, Netherlands
²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston
³Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands
⁴Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, NLD
⁵Department of Thoracic Surgery, Erasmus MC, Rotterdam, Netherlands
⁶Erasmus University Medical Center Cancer Institute, Rotterdam, Netherlands
⁷Myeloma Unit, Division of Hematology, University of Torino, Torino, Italy
⁸Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
⁹Department of Hematology, Cancer Center Amsterdam, Amsterdam, Netherlands
¹⁰Erasmus MC Cancer Institute, Rotterdam, Netherlands
¹¹Erasmus MC Cancer Institute, Department of Hematology, Rotterdam, Netherlands
¹²Department of Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands

Alexandre Tang, PhD^1*, Laurent Gauthier, PhD^2*, Jochen Beninga^3*, Benjamin Rossi^2*, Nicolas Gourdin^2*, Audrey Blanchard-Alvarez^2*, Céline Amara^4*, Jacqueline Courta^5*, Alexandra Basset^6*, Dorothee Bourges^1*, Alexandre Desjonqueres, MD, MSc^1*, Emmanuelle Menoret, PhD^7*, Catherine Pellat-Deceunynck, PhD⁷, Philippe Moreau, MD^7*, Yannis Morel, PhD^2*, Marielle Chiron^1*, Angela Virone-Oddos, PhD^1* and Eric Vivier, PhD^2*

¹Oncology Research, Sanofi, Vitry-sur-Seine, France
²Innate Pharma, Marseille, France
³Large Molecule Research, Sanofi, Frankfurt am Main, Germany
⁴Drug Metabolism and Pharmacokinetics, Sanofi, Chilly Mazarin, France
⁵TMED Biomarkers and Clinical Bioanalysis, Sanofi, Chilly Mazarin, France
⁶Preclinical Safety, Sanofi, Chilly Mazarin, France
⁷CRCINA, INSERM, CNRS, Angers University and Nantes University, Nantes, France

Alexandra M. Poos, PhD^1,2*, Nina Prokoph, PhD^1,2*, Moritz J. Przybilla, MSc^3,4,5*, Jan-Philipp Mallm, PhD^6*, Simon Steiger^7*, Isabelle Lander, MSc^7*, Lukas John, MD^1,2*, Stephan M Tirier, PhD^7*, Katharina Bauer^6*, Anja Baumann^1,2*, Umair Munawar, PhD^8*, Leo Rasche, MD^8,9*, Martin Kortuem^8*, Nicola Giesen, MD^1,2*, Stefanie Huhn, PhD^2*, Carsten Mueller-Tidow, MD^2,10, Hartmut Goldschmidt, MD^2,10, Oliver Stegle, PhD^3,5*, Marc S Raab, MD^1,2*, Karsten Rippe, PhD^7* and Niels Weinhold, PhD^1,2*

¹Clinical Cooperation Unit (CCU) Molecular Hematology/Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany
²Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany
³Division of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany
⁴Wellcome Sanger Institute, Cambridge, United Kingdom
⁵Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
⁶Single Cell Open Lab, German Cancer Research Center (DKFZ) and BioQuant, Heidelberg, Germany
⁷Division of Chromatin Networks, German Cancer Research Center (DKFZ) and BioQuant, Heidelberg, Germany
⁸Department of Internal Medicine II, University Hospital Wuerzburg, Wuerzburg, Germany
⁹Mildred Scheel Early Career Center (MSNZ), University Hospital of Wuerzburg, Wuerzburg, Germany
¹⁰National Center for Tumor Diseases (NCT), Heidelberg, Germany

Sivasubramanian Baskar, PhD^1*, Haiyong Peng, Ph.D.^2*, Christoph Rader, Ph.D.^2* and Adrian Wiestner, MD³

¹Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
²Department of Immunology and Microbiology, UF Scripps Biomedical Research, University of Florida, Jupiter, FL
³Hematology Branch, National Heart, Lung, and Blood Institute, NIH, NHLBI, Bethesda, MD

Anish K Simhal, PhD¹, Kylee H Maclachlan, MBBCh, PhD², Rena Elkin, PhD^1*, Jiening Zhu^3*, Saad Usmani, MD², Jonathan J Keats, PhD⁴, Larry Norton, MD^5*, Joseph O. Deasy, PhD^1*, Jung Hun Oh, PhD^1* and Allen Tannenbaum, PhD^6*

¹Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY
²Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
³Department of Applied Mathematics & Statistics, Stony Brook University, Stony Brook, NY
⁴Translational Genomics Research Institute, Phoenix, AZ
⁵Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY
⁶Departments of Computer Science and Applied Mathematics & Statistics, Stony Brook University, Stony Brook, NY