Jessica Nunes¹, Ann Ventura^2*, Kevan Zapolnik, BS^3*, Xiaokui Mo, PhD, MAS^4*, Liwen Zhang^2*, John C. Byrd, MD⁵, Christoph Rader, Ph.D.^6* and Natarajan Muthusamy, DVM, PhD³

¹MCDB Program, Ohio State University, Columbus, OH
²The Ohio State University, Columbus, OH
³Comprehensive Cancer Center, The Ohio State University, Columbus, OH
⁴Department of Biomedical informatics, college of medicine, The Ohio State University, Columbus, OH, USA, columbus, OH
⁵University of Cincinnati College of Medicine, Cincinnati, OH
⁶Scripps Research, Jupiter, FL

Susan Klaeger^1,2*, Eugen Tausch, MD³, Binyamin A. Knisbacher, PhD^1*, Annie Apffel, BA^1*, Karl R Clauser, BS^1*, Corinne Williams^1*, Clary Clish^1*, Laura Z. Rassenti, PhD⁴, Thomas J. Kipps, MD, PhD⁴, Kirsten Fischer, MD^5*, Michael Hallek, MD⁵, Michael A Gillette^6*, Donna S. Neuberg, ScD⁷, Gad Getz, PhD^1,8,9*, DR Mani, PhD^6*, Stephan Stilgenbauer, MD³, Catherine J. Wu, MD^1,10,11,12 and Steven A Carr, PhD^6*

¹Broad Institute of MIT and Harvard, Cambridge, MA
²Genentech Inc., South San Francisco, CA
³Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
⁴Moores Cancer Center, University of California, San Diego, La Jolla, CA
⁵Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, German CLL Study Group, University Hospital Cologne, Cologne, Germany
⁶Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA
⁷Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
⁸Department of Medicine, Harvard Medical School, Boston, MA
⁹Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, MA
¹⁰Department of Medicine, Brigham and Women's Hospital, Boston, MA
¹¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
¹²Harvard Medical School, Boston, MA

Lisa Brandmeier, MSc^1,2*, Veronika Ecker^1,2*, Martina Stumpf^1,2*, Piero Giansanti^2,3,4*, Aida Varela Moreira^5*, Lisa Pfeuffer^1,2*, Marcel Fens^5*, Junyan Lu^6*, Bernhard Küster, PhD^3,7,8*, Thomas Engleitner^2,9*, Simon Heidegger^10*, Ingo Ringshausen¹¹, Thorsten Zenz¹², Clemens-Martin Wendtner¹³, Markus Müschen, MD¹⁴, Jürgen Ruland^1,2,7,8* and Maike Buchner^1,2*

¹Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technical University of Munich, Munich, Germany
²TranslaTUM - Central Institute for Translational Cancer Research, Technical University of Munich, Munich, Germany
³Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany
⁴Bavarian Center for Biomolecular Mass Spectrometry at the University hospital rechts der Isar (BayBioMS@MRI), Technical University of Munich, Munich, Germany
⁵Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands
⁶European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
⁷German Cancer Consortium (DKTK), Munich Partner Site, Munich, Germany
⁸German Cancer Research Center (DKFZ), Heidelberg, Germany
⁹Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Munich, Germany
¹⁰Department of Medicine III, School of Medicine, Technical University of Munich, Munich, Germany
¹¹Wellcome Trust/MRC Cambridge Stem Cell Institute and Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, United Kingdom
¹²Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, BW, Switzerland
¹³Munich Clinic Schwabing, Academic Teaching Hospital, Ludwig-Maximilian University, Munich, Germany
¹⁴Center of Molecular and Cellular Oncology and Department of Immunobiology, Yale University, New Haven, CT

Prajish Iyer, PhD^1*, Bo Zhang, MD, PhD², Tingting Liu^3*, Meiling Jin^1*, Kevyn Hart^4*, Joo Y. Song, MD^5,6, Wing C Chan, MD^5,6*, Tanya Siddiqi, MD⁷, Alexey V Danilov, MD^6,7, Steve T Rosen, MD^6,7 and Lili Wang, MD-PhD^1,6

¹Department of Systems Biology, Beckman Research Institute, City of Hope, Monrovia, CA
²Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
³City of Hope, Duarte, CA
⁴Department of Human Genetics Human Genetics, University of California, Los Angeles, Los Angeles, CA
⁵Department of Pathology, City of Hope National Medical Center, Duarte, CA
⁶Toni Stephenson Lymphoma Center, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA
⁷Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA

Erika Tissino, PhD^1*, Nicola Calonaci^2*, Federico Pozzo, PhD^1*, Gabriela Forestieri^3*, Lodovico Terzi Di Bergamo^3*, Filippo Vit^1*, Annalisa Gaglio^1*, Riccardo Bergamin^2*, Salvatore Milite^4*, Stefano Cozzini^5*, Maria Ilaria Del Principe, MD^6*, Roberta Laureana, MD^6*, Annalisa Chiarenza^7*, Jacopo Olivieri^8*, Francesco Zaja^9*, Cristoforo Fabbris^10*, Valentina Lupato^10*, Riccardo Bomben, PhD^1*, Davide Rossi, MD, PhD³, Valter Gattei, MD¹, Antonella Zucchetto, PhD^1* and Giulio Caravagna^2*

¹Clinical and Experimental Onco-Hematology Unit, Centro Di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
²Cancer Data Science Laboratory, University of Trieste, Trieste, Italy
³Institute of Oncology Research, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
⁴Fondazione Human Technopole, Milano, Italy
⁵Area Science Park, Trieste, Italy
⁶Ematologia, Dipartimento di Biomedicina e Prevenzione, Università degli studi di Roma Tor Vergata, Roma, Italy
⁷Divisione di Ematologia, Ospedale Ferrarotto, A.O.U. Policlinico-OVE, Università di Catania, Catania, Italy
⁸Azienda Sanitaria Universitaria Integrata Santa Maria della Misericordia, Udine, Italy
⁹Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy
¹⁰SOC Otorinolaringoiatria, Azienda Sanitaria Friuli Occidentale, Pordenone, Italy

Clare Sun, MD¹, Melih Acar^2*, David Jenkins^3*, Barrett Nuttall^3*, Rafael White^2*, Veerendra Munugalavadla² and Adrian Wiestner, MD, PhD¹

¹Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
²AstraZeneca, South San Francisco, CA
³AstraZeneca, Waltham, MA

Judith Mateos-Jaimez^1*, Maurizio Mangolini, PhD^2*, Anna Vidal, PhD^1*, Dolors Colomer, PhD^1,3,4,5*, Elías Campo, PhD MD^1,3,4,5, Ingo Ringshausen², José I. Martín-Subero, PhD^1,3,5,6* and Alba Maiques-Diaz, PhD^1*

¹Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
²Wellcome Trust/MRC Cambridge Stem Cell Institute and Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, United Kingdom
³Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain
⁴Hematopathology Section, Pathology Department, Hospital Clinic, Barcelona, Spain
⁵Universitat de Barcelona, Barcelona, Spain
⁶Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

Paul Hengeveld^1,2, Pieter M. Kolijn, MSc^1*, Jeroen A.A. Demmers, PhD^3*, Wouter Doff, BSc.^3*, Julie M.N. Dubois, MD, PhD^4*, Melissa Rijken^5*, Jorn Assmann, PhD^1*, Lina Van Der Straten, MD^1,2*, Henk-Jan Boiten, MD, PhD, MSc^1*, Kirsten J. Gussinklo^5*, Peter J.M. Valk, PhD⁵, Peter E. Westerweel, MD, PhD^2*, Arnon P. Kater, MD, PhD⁶, Anton W. Langerak, PhD^1* and Mark-David Levin²

¹Department of Immunology, Erasmus MC, Rotterdam, Netherlands
²Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands
³Proteomics Center, Erasmus MC, Rotterdam, Netherlands
⁴Department of Hematology, Amsterdam University Medical Centers, Amsterdam, Netherlands
⁵Department of Hematology, Erasmus MC, Rotterdam, Netherlands
⁶Academic Medical Center, Amsterdam Zuidoost, NH, Netherlands

Kiyomi Mashima, MD, PhD^1,2,3, Benjamin L. Lampson, MD, PhD^2,3,4, Aditi Gupta, PhD^5*, Nicholas Moore, M.D.^2,3,5*, Anna Petrackova^6*, Samantha J. Shupe, BS^4,7*, Stacey M. Fernandes, BS^8,9*, Amaro Taylor-Weiner, PhD^3*, Riaz Gillani, M.D.^2,3,10,11*, Hoyin Chu, BS^3,12*, Seunghun Han, BS^5,13*, Sabrina Camp^5,13*, Eric Kofman, BS^3,5*, Gad Getz, PhD^3,14*, Catherine J. Wu, MD^3,7,15, Eliezer Van Allen, MD^3,12*, Saud H AlDubayan, MD^3,7,12* and Jennifer R. Brown, MD, PhD^7,9,16

¹Division of Medical Oncology, CLL Center, Dana-Farber Cancer Institute, Boston, MA
²Department of Medicine, Harvard Medical School, Boston, MA
³Broad Institute of MIT and Harvard, Cambridge, MA
⁴Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁵Dana-Farber Cancer Institute, Boston, MA
⁶Department of Immunology, Palacky University Olomouc, Olomouc, Czech Republic
⁷Harvard Medical School, Boston, MA
⁸Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
⁹Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA
¹⁰Boston Children's Hospital, Boston, MA
¹¹Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
¹²Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
¹³Broad Institute, Cambridge
¹⁴Center for Cancer Research, Massachusetts General Hospital, Boston, MA
¹⁵Department of Medical Oncology, Dana-Farber Cancer Institute, Inc, Boston, MA
¹⁶Department of Medical Oncology, Dana-Farber Cancer Institute, Newton, MA

Alicia Vaca, PhD^1*, Mariela Sivina, PhD^1*, Ekaterina Kim, PhD, MS^2*, Alessandra Ferrajoli², William G. Wierda, MD, PhD³ and Jan A. Burger, MD, PhD²

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
³The University of Texas M.D. Anderson Cancer Center, Houston, TX

Jyotsana Singh, PhD^1*, Daisy Diaz Rohena^1*, Chaomei Liu^1*, Bailey Slawin^1*, Janani Ravikrishnan, PhD², Nitin Jain, MD³, William G. Wierda, MD, PhD⁴, Kai Zhang, MD^5*, Michael Niesman, PhD^5*, Jennifer A. Woyach, MD² and Deepa Sampath, PhD¹

¹Department of Hematopoietic Biology & Malignancy, The University of Texas, MD Anderson Cancer Center, Houston, TX
²Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH
³Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁴The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁵MingSight Pharmaceuticals, Inc., San Diego, CA

Gonzalo Blanco^1,2*, Florencia Palacios^3*, Kamala Vanarsa^4*, Poojitha Dugyala^4*, Pui Yan Chiu^5*, Steven L Allen, MD^1,6,7, Yasmine Kieso, MSCR^1*, Anna Puiggros, PhD^8*, Jacqueline C. Barrientos, MD, MS^9,10,11, Xavier Calvo, MD, PhD^12*, Jonathan E. Kolitz, MD^1,13,14, Eva Gimeno^15*, Joanna M. Rhodes, MD, MSCE^1,7,16, Ana Ferrer, MD, PhD^12*, Kanti R Rai, MD^1,14,17, Barbara Sherry, PhD^18,19, Blanca Espinet, PhD^12*, Chandra Mohan^4* and Nicholas Chiorazzi, MD^1,9,14

¹Karches Center for Oncology Research, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY
²Hospital del Mar Medical Research Institute (IMIM), Hospital del Mar, Barcelona, Spain
³Institut Pasteur Montevideo, Montevideo, URY
⁴Biomedical Engineering & Medicine, University of Houston, Houston, TX
⁵Center for Immunology & Inflammation, The Feinstein Institute for Medical Research, Manhasset, NY
⁶Department of Medicine, Division of Hematology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY
⁷Department of Medicine, North Shore University Hospital and Long Island Jewish Medical Center, Northwell Health, Manhasset, NY
⁸Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain
⁹North Shore University Hospital, Northwell Health, Manhasset, NY
¹⁰Karches Center for Chronic Lymphocytic Leukemia Research, The Feinstein Institute for Medical Research, Northwell Health, Manhasset
¹¹Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY
¹²Group of Translational Research on Hematological Neoplasms, Hospital del Mar-IMIM, Barcelona, Spain
¹³Monter Cancer Center, North Shore University Hospital and Long Island Jewish Medical Center, Northwell Health, New Hyde Park, NY
¹⁴Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY
¹⁵Dr. Aiguader, 88, IMIM, Hospital del Mar Medical Research Institute, Barcelona, Spain
¹⁶Donald Zucker School of Medicine, Hempstead, NY
¹⁷Department of Medicine, Northwell Health, Manhasset, NY
¹⁸Departments of Medicine and of Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY
¹⁹Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, Northwell Health System, Manhasset, NY

Natalia Timofeeva, MD^1*, Varsha Gandhi, PhD², Marina Konopleva, MD, PhD^3,4 and Mary Ayres^5*

¹University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Experimental Therapeutics, Univ. of Texas M.D. Anderson Cancer Center, Houston, TX
³MD Anderson Cancer Center, Houston, TX
⁴Albert Einstein College of Medicine, Bronx, NY
⁵U.T. M.D. Anderson Cancer Center, Houston, TX