Qin Yang^1*, Alice Brogi, PhD^2*, Elizabeth A. Griffiths, MD³, Matilde Y Follo, PhD^4*, Carlo Finelli, MD^5*, Jerald P. Radich, MD⁶, Michael J Rauh, MD PhD⁷, Mikkael A. Sekeres, MD⁸, Rafael Bejar, MD, PhD⁹, Valeria Santini, MD¹⁰ and Maria Ken E. Figueroa, MD¹¹

¹University of Miami, Sylvester Cancer Center, Miami, FL
²Department of Experimental and Clinical Medicine, Genetics and Cytogenetics, AOU Careggi - University of Florence, Florence, Italy
³Roswell Park Comprehensive Cancer Center, Buffalo, NY
⁴Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
⁵Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, "S. Orsola-Malpighi" Hospital, Bologna, (bo), Italy
⁶Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA
⁷Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada
⁸University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL
⁹Division of Hematology and Oncology, University of California San Diego Moores Cancer Center, La Jolla, CA
¹⁰MDS Unit, University of Florence, AOUC, Florence, Italy
¹¹Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL

Guillermo Montalban-Bravo, MD¹, Courtney D. DiNardo, MD, MSCE¹, Nicholas Short, MD², Tapan M. Kadia, MD¹, Farhad Ravandi, MD¹, Kelly S. Chien, MD¹, Joby Joseph^1*, Jane Waukau, BSN, RN^1*, Sherry A. Pierce, BSN, BA^1*, Hagop Kantarjian, MD³ and Guillermo Garcia-Manero, MD⁴

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
³Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX

Kelly S. Chien, MD¹, Kunhwa Kim, MD¹, Ziyi Li, PhD^2*, Rashmi Kanagal-Shamanna, MD³, Faustine Ong, MD^4*, Guillermo Montalban-Bravo, MD¹, Tapan M. Kadia, MD¹, Elias Jabbour, MD¹, Naveen Pemmaraju, MD¹, Danielle Hammond, MD¹, Nicholas Short, MD⁵, Farhad Ravandi, MD¹, Yesid Alvarado, MD¹, Sherry A. Pierce, BSN, BA^1*, Xiao Qin Dong^1*, Hui Yang, MD, PhD¹, Yue Wei, PhD¹, Irene Ganan-Gomez, PhD¹, Simona Colla, PhD^1*, Hagop Kantarjian, MD⁶ and Guillermo Garcia-Manero, MD⁷

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, The University of Texas MD Anderson Cancer Center, HOUSTON, CA
⁵Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX

Chen Mei^1*, Yaping Xie, MD^2*, Yanping Shao^3*, Jie Jin, PhD^4,5,6,7,8 and Hongyan Tong, MD, PhD^4,7,9,10,11*

¹Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
²Hangzhou First People's Hospital,Hangzhou, P. R. China, Hangzhou, Zhejiang, CHN
³Taizhou Hospital of Zhejiang Province, TAIZHOU, CHN
⁴Zhejiang University Cancer Center, Hangzhou, China
⁵Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁶Department of Hematology, The First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China
⁷Zhejiang Provincial Key Laboratory of Hematopoietic Malignancy, Zhejiang University, Hangzhou, China
⁸Zhejiang Provincial Clinical Research Center for Hematological Disorders, Hangzhou, China
⁹Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China, Hangzhou, China
¹⁰Department of Hematology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
¹¹Zhejiang Provincial Clinical Research Center for Hematological Disorders, Hangzhou, China, Hangzhou, China

Marco Gabriele Gabriele Raddi, MD^1*, Sara Bencini^2*, Benedetta Peruzzi^2*, Roberto Caporale^2*, Angela Consagra, MD^3*, Enrico Attardi, MD^3*, Luca Rigodanza, MD^4*, Cristina Amato, RN^3*, Alessandro Sanna, MD^5*, Alice Brogi, PhD^6*, Elena Tofacchi^1*, Margherita Cassari^1*, Sven de Pourcq^1*, Giorgio Mattiuz, PhD^1*, Francesco Annunziato, PhD^2,7* and Valeria Santini, MD^8,9

¹Department of Experimental and Clinical Medicine, MDS Unit, Hematology, AOU Careggi - University of Florence, Firenze, Italy
²Flow Cytometry and Immunotherapy Diagnostic Center, AOU Careggi, Florence, Italy
³Department of Experimental and Clinical Medicine, MDS Unit, Hematology, AOU Careggi - University of Florence, Florence, Italy
⁴MDS Unit, Hematology, AOU Careggi - University of Florence, Firenze, Italy
⁵Department of Hematology, AOU Careggi - University of Florence, Florence, Italy
⁶Department of Experimental and Clinical Medicine, Genetics and Cytogenetics, AOU Careggi - University of Florence, Florence, Italy
⁷Department of Experimental and Clinical Medicine and DENOTHE Center, University of Florence, Florence, Italy
⁸DMSC, MDS Unit, AOU Careggi, University of Florence, Firenze, Italy
⁹MDS Unit, Hematology, AOU Careggi, University of Florence, Florence, Italy

Amer M. Zeidan, MD¹, Karen Mosher^2*, Sonia Souza, PhD^2*, Beloo Mirakhur, MD, PhD^2*, Harold N. Keer, MD, PhD² and Jason A. Taylor, MD, PhD²

¹Yale University, New Haven, CT
²Astex Pharmaceuticals, Inc., Pleasanton, CA

Akio Mori, MD, PhD¹, Masahiro Onozawa, M.D., Ph.D.², Mirei Kobayashi, M.D.^1*, Shihori Tsukamoto, M.D.^1*, Hajime Senjo, M.D.^1,2, Takashi Ishio, M.D., Ph.D.^1*, Emi Yokoyama, M.D., Ph.D.^1*, Koh Izumiyama^1*, Makoto Saito, M.D., Ph.D.^1*, Haruna Muraki^3,4*, Masanobu Morioka, M.D., Ph.D.^1*, Takanori Teshima, M.D., Ph.D.² and Takeshi Kondo, M.D., Ph.D.¹

¹Blood Disorders Center, Aiiku Hospital, Sapporo, Japan
²Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan
³Division of Laboratory, Aiiku Hospital, Sapporo, Japan
⁴Sapporo Clinical Laboratory Inc., Sapporo, Japan

Grant Hogg, MSc^1*, Qian Zeng^2*, Heidi M Hoffman^2*, Eric A. Severson, MD, PhD, MMSc³, Li Cai^4*, Wenjie Chen, PhD^2*, Sabrina Gardner^4*, Kimberly A Holden^1*, Lax Iyer^5*, Angela Leo Kenyon^2*, Deborah Boles^4*, Scott Parker^4*, Stanley Letovsky^2*, Henry Dong^6*, Narasimhan Nagan^2*, Shakti Ramkissoon^4*, Marcia Eisenberg, PhD^7*, Anjen Chenn, MD, PhD^4* and Taylor J Jensen, PhD, BS^4*

¹Labcorp, San Diego, CA
²Labcorp, Westborough, MA
³Labcorp Oncology, Durham, NC
⁴Labcorp, Durham, NC
⁵Labcorp, Westborough, NC
⁶Labcorp, New York, NY
⁷Labcorp, Burlington, NC

Maria Sirenko^1,2*, Elsa Bernard, PhD^2,3*, David B. Beck, MD, PhD^4*, Maria Creignou, MD^5*, Dylan Domenico^2*, Andrea Farina, PhD^6*, Juan E Arango^2*, Olivier Kosmider, MD, PhD^7*, Robert P. Hasserjian, MD⁸, Martin Jadersten, MD, PhD^9*, Ulrich Germing^10*, Guillermo Sanz, MD, PhD¹¹, Arjan A. van de Loosdrecht, MD, PhD^12*, Matilde Y Follo, PhD^13*, Felicitas R. Thol, MD¹⁴, Lurdes Zamora, PhD^15*, Ronald Feitosa Pinheiro, MD, PhD^16*, Andrea Pellagatti, PhD^17*, Harold K. Elias, MD^18,19, Detlef Haase, MD, PhD^20*, Christina Ganster, PhD²¹, Lionel Ades²², Magnus Tobiasson, MD, PhD^5*, Laura Palomo, PhD^23*, Matteo G. Della Porta, MD^24*, Kety Huberman^6*, Pierre Fenaux²⁵, Monika Belickova, PhD^26*, Michael R. Savona, MD²⁷, Virginia M. Klimek, MD²⁸, Fabio Pires de Souza Santos, MD, PhD²⁹, Jacqueline Boultwood, PhD¹⁷, Ioannis Kotsianidis, MD, PhD³⁰, Valeria Santini, MD³¹, Francesc Solé, PhD³², Uwe Platzbecker, MD³³, Michael Heuser, MD¹⁴, Peter Valent, MD³⁴, Carlo Finelli, MD^35*, Maria Teresa Voso, MD³⁶, Lee-Yung Shih, MD³⁷, Seishi Ogawa, MD, PhD^38,39, Michaela Fontenay, MD, PhD^7,40, Joop H. Jansen, PhD⁴¹, Jose Cervera, MD, PhD^42*, Benjamin L. Ebert, MD, PhD^43,44, Rafael Bejar, MD, PhD⁴⁵, Peter L Greenberg, MD⁴⁶, Norbert Gattermann, MD⁴⁷, Luca Malcovati, MD^48,49, Mario Cazzola, MD⁵⁰, Eva Hellström-Lindberg, MD, PhD⁵¹ and Elli Papaemmanuil, PhD^52,53

¹Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, Bedminster, NJ
²Computational Oncology Service, Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
³Center for Molecular Oncology, Center for Heme Malignancies and Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA, New York, NY
⁴Center for Human Genetics and Genomics, New York University Grossman School of Medicine, New York, NY
⁵Center for Hematology and Regenerative Medicine (HERM), Department of Medicine (MedH), Karolinska Institutet, Huddinge, Sweden
⁶Integrated Genomics Operation, Memorial Sloan Kettering Cancer Center, New York, NY
⁷Assistance Publique-Hôpitaux de Paris.Centre-Université Paris Cité, Hôpital Cochin, Laboratory of Hematology, Paris, France
⁸Department of Pathology, Massachusetts General Hospital, Boston, MA
⁹Center for Hematology and Regenerative Medicine (HERM), Department of Medicine (MedH), Karolinska Institutet, Huddinge, Stockholm, Sweden
¹⁰Department of Hematology, Oncology and Clinical Immunology, Universitatsklinik Dusseldorf, Dusseldorf, Germany
¹¹Hematology Deparment, Health Research Institute La Fe, Valencia, Spain
¹²Amsterdam University Medical Centers, Cancer Center Amsterdam, Amsterdam, Netherlands
¹³Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
¹⁴Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
¹⁵Institut de Recerca contra la Leucèmia Josep Carreras, Badalona, Spain
¹⁶; Department of Clinical Medicine; Center for Research and Drug Development (NPDM), Federal University of Ceará, Fortaleza, Brazil
¹⁷Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
¹⁸Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁹National Institutes of Health, Bethesda, MD
²⁰Clinics of Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen, Germany
²¹INDIGHO Laboratories, Clinics of Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen, Germany
²²Department of Hematology, Hopital Saint Louis, Paris, France
²³Department of Hematology, University Hospital Vall d’Hebron, Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
²⁴Cancer Center IRCCS Humanitas Research Hospital, Milan, Italy, Italy
²⁵Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France
²⁶Department of Genomics, Institute of Hematology and Blood Transfusion, Prague, Czech Republic
²⁷Vanderbilt University School of Medicine, Nashville, TN
²⁸Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
²⁹Oncology-Hematology Center, Hospital Israelita Albert Einstein, Sao Paulo, SP, AC, Brazil
³⁰Department of Hematology, University hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece, Alexandroupolis, Greece
³¹DMSC, MDS Unit, AOU Careggi, University of Florence, Firenze, Italy
³²MDS Group. Institut de Recerca Contra la Leucèmia Josep Carreras (IJC), ICO-Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain
³³Medical Clinic and Policlinic of Hematology, Cell Therapy and Hemostaseology, University Hospital Leipzig,, Leipzig, Germany
³⁴Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
³⁵Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, "S. Orsola-Malpighi" Hospital, Bologna, (bo), Italy
³⁶MDS Cooperative Group GROM-L, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
³⁷Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan
³⁸Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan
³⁹Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto, Japan
⁴⁰Université Paris Cité, CNRS, INSERM U1016, Institut Cochin, Paris, France
⁴¹Laboratory of Hematology, Dept LABGK, Radboud University Medical Centre, Nijmegen, The Netherlands., Nijmegen, Netherlands
⁴²Department of Hematology and Genetics Unit, Hospital Universitario La Fe, Valencia, Va, Spain
⁴³Dana-Farber Cancer Institute, Boston, MA
⁴⁴Howard Hughes Medical Institute, Boston, MA
⁴⁵Division of Hematology and Oncology, University of California San Diego Moores Cancer Center, La Jolla, CA
⁴⁶Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA
⁴⁷Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine University, Düsseldorf, Germany
⁴⁸Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Pavia, Italy
⁴⁹Department of Molecular Medicine & Hematology Oncology, University of Pavia & IRCCS Policlinico S. Matteo Foundation, Pavia, Italy
⁵⁰University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
⁵¹Center for Hematology and Regenerative Medicine, Department of Medicine (MedH), Karolinska Institutet, Huddinge, Sweden
⁵²Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, NEW YORK, NY
⁵³Computational Oncology Service, Department of Epidemiology & Biostatistics, Center for Computational Oncology, Memorial Sloan Kettering Cancer Center, New York, NY

Felicitas Schulz^1*, Kathrin Nachtkamp, MD^1*, Howard S. Oster, MD PhD^2,3, Moshe Mittelman, MD^4,5, Norbert Gattermann, MD⁶, Carmen Barthuber, Dr. med.^7*, Sarah Schweier^7* and Ulrich Germing^1*

¹Department of Hematology, Oncology and Clinical Immunology, Universitätsklinik Düsseldorf, Düsseldorf, Germany
²Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
³Department of Internal Medicine A, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel, Israel
⁴Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
⁵Department of Hematology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel
⁶Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine University, Düsseldorf, Germany
⁷Universitätsklinik Düsseldorf, Düsseldorf, Germany

Jiale Ma^1,2*, Yanhui Wei^1*, Xuee Wang^1*, Peixuan Wang^1*, Chunhua Song, MD，PhD^3,4 and Zheng Ge, MD, PhD¹

¹Department of Hematology, Zhongda Hospital, School of Medicine, Institute of Hematology, Southeast University, Nanjing, China
²Department of Hematology,Xuzhou Central Hospital, Xuzhou, China
³Hershey Medical Center, Pennsylvania State University Medical College, Hershey
⁴Division of Hematology, The Ohio State University Wexner Medical Center, the James Cancer Hospital, Columbus

Alex Bataller, MD, PhD^1*, Rashmi Kanagal-Shamanna, MD², Kelly S. Chien, MD¹, Guillermo Montalban-Bravo, MD¹, Tapan M. Kadia, MD³, Farhad Ravandi, MD¹, Courtney D. DiNardo, MD, MSCE¹, Naval Daver, MD¹, Nicholas Short, MD⁴, Gautam Borthakur, MD¹, Elias Jabbour, MD¹, Danielle Hammond, MD¹, Lucia Masarova, MD¹, Irene Ganan-Gomez, PhD¹, Vera Adema, PhD^1*, Hagop Kantarjian, MD⁵, Guillermo Garcia-Manero, MD⁶ and Koji Sasaki, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX
³Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX

Gaixiang Xu, MD^1*, Shuanghong Zhu^2*, Xinping Zhou^3*, Kongfei Li^4*, Lingxu Jiang^5*, Hongyan Tong, MD, PhD^6* and Jie Jin, PhD⁷

¹Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
²the first affiliated hospital of zhejiang university, hangzhou, China
³Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
⁴Yinzhou People’s Hospital Affiliated to Medical College of Ningbo University, ningbo, China
⁵Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁶Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China, Hangzhou, China
⁷Department of Hematology, The First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China

Mithun V. Shah, MD, PhD¹, Christopher N Hahn, PhD², Elizabeth Ngoc Hoa Tran, PhD^3,4*, Kirsty M Sharplin, MBBS⁵, Rakchha Chhetri, MBBS MHID Grad Cert. Biostat.^3,5*, Anmol Baranwal, MBBS^1*, Monika M Kutyna, MSc^3,5,6*, Paul Wang, PhD^2,7*, Dariusz Ladon^8*, Aref Al-Kali, MD¹, Hassan B. Alkhateeb, MD^1*, David M Ross, MBBS, PhD, FRACP, FRCPA^3,5,6*, David T Yeung, MBBS, PhD, BSc, FRACP, FRCPA^5,6,9, Naranie Shanmuganathan, MBBS, FRACP, FRCPA^3,5, Mark R. Litzow, MD¹, Abhishek A. Mangaonkar, MBBS¹, William J. Hogan, MB, BCh¹, Naseema Gangat, M.B.B.S^1*, Mrinal M. M. Patnaik, MD, MBBS¹, Begna Kebede, MD^1*, Sharad Kumar, PhD^2*, Deepak Singhal, MBBS, MD, FRCPA, FRACP^5,6*, Anna Brown, PhD², Hamish S Scott, PhD², Daniel Thomas, MD, PhD^3,6, Chung Hoow Kok, PhD, BSc^3,6, Ayalew Tefferi, MD¹ and Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA^3,5,6

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, Australia
³Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia
⁴The University of Adelaide, Adelaide, Australia
⁵Department of Haematology, Royal Adelaide Hospital, Adelaide, SA, Australia
⁶Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia
⁷ACRF Cancer Genomic Facility, Adelaide, Australia
⁸Genetic and Molecular Pathology, SA Pathology, Adelaide, Australia
⁹Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia

Cedric De almeida Braga, PhD in training^1*, Maxence Bauvais^2*, Maxence Dominici^3*, Alice Garnier, MD^4*, Pierre Peterlin, MD^5*, Camille Debord, PharmD^6*, Soraya Wuillème, PharmD, PhD^6*, Olivier Theisen, MD^6*, Catherine Godon^7*, Simon Bouzy, PharmD^6*, Yannick Le Bris, PhD, PharmD^8*, Marie C Bene, PharmD, DPhil^6*, Patrice Chevallier, MD⁹, Nicolas Normand, PhD^1* and Marion Eveillard, PharmD, PhD^10*

¹LS2N, Polytech, Nantes University, Nantes, France
²Hematology laboratory, Nantes University Hospital, Nantes, France
³Polytech, Nantes University, Nantes, France
⁴Hematology Department, Nantes University Hospital, Nantes, France
⁵Clinical Hematology, HOPITAL HOTEL DIEU ET HME, NANTES CEDEX 1, France
⁶Hematology Biology, Nantes University Hospital, Nantes, France
⁷Hematology Biology, Nantes University Hospital, NANTES, FRA
⁸Department of Biological Hematology, CHU Nantes, Nantes, France
⁹Department of Clinical Hematology, Nantes University Hospital, Nantes, France
¹⁰Hematology biology department, Nantes University Hospital, Nantes, France

Inga Mandac Smoljanovic, MD^1*, Adele Taylor^2*, Pierre Fenaux³, Agnès Guerci-Bresler, MD, PhD^4*, Raphael Itzykson, MD, PhD⁵, Argiris Symeonidis, MD, PhD⁶, Ioannis Kotsianidis, MD, PhD⁷, Moshe Mittelman, MD⁸, Guillermo Sanz, MD, PhD^9,10, Dominic J. Culligan^11*, Jaroslav Cermak, MD, PhD¹², Reinhard Stauder, a.o. Univ. Prof., MD, M.Sc.^13,14, Eva Hellström-Lindberg, MD, PhD¹⁵, Luca Malcovati, MD¹⁶, Saskia MC Langemeijer, MD, PhD^17*, Ulrich Germing^18*, Krzysztof Madry, MD, PhD^19*, Howard S. Oster, MD PhD²⁰, Alexandra Smith, PhD^21*, Corine van Marrewijk, PhD^22*, Theo M de Witte, MD²³ and David Bowen, MD²⁴

¹Hematology Department, Clinical Hospital Merkur, Zagreb, Croatia
²Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, United Kingdom
³Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France
⁴Service d'Hématologie, Centre Hospitalier Universtaire Brabois, Vandoeuvre-lès-Nancy, France
⁵Hematology Department, Saint-Louis Hospital AP-HP Paris France, Paris, France
⁶Hematology Division, Dept. of Internal Medicine, University of Patras Medical School, Patras, Greece
⁷Department of Hematology, Democritus University of Thrace Medical School, University Hospital of Alexandroupolis, Alexandroupolis, Greece
⁸Department of Hematology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel
⁹Hematology Deparment, Health Research Institute La Fe, Valencia, Spain
¹⁰Hospital Universitari i Politècnic La Fe, Valencia and CIBERONC, IS Carlos III, Madarid, Spain
¹¹Aberdeen Royal Infirmary, Aberdeen, United Kingdom
¹²Institute of Hematology and Blood Transfusion, Praha, Czech Republic
¹³Dep. of Internal Medicine V (Hematology and Oncology), Medical University Innsbruck, Innsbruck, Austria
¹⁴Department of Internal Medicine V (Hematology and Oncology), Innsbruck Medical University, Innsbruck, Austria
¹⁵HERM, Dept. of Medicine, Huddinge, Karolinska Institute, and PO Hematology, Karolinska University Hospital, Stockholm, Sweden
¹⁶Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Pavia, Italy
¹⁷Department of Hematology, Radboud university medical center, Nijmegen, Netherlands
¹⁸Department of Hematology, Oncology and Clinical Immunology, Universitatsklinik Dusseldorf, Dusseldorf, Germany
¹⁹Department of Hematology, Oncology and Internal Diseases, Medical University of Warsaw, Warszawa, Poland
²⁰Department of Internal Medicine A, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel, Israel
²¹Epidemiology and Cancer Statistics Group, Department of Heath Sciences, University of York, York, United Kingdom
²²Dep. of Hematology, Radboud university medical center, Nijmegen, The Netherlands, Nijmegen, Netherlands
²³Dep. of Tumor Immunology - Nijmegen Center for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, Netherlands
²⁴Department of Haematology, Leeds Teaching Hospitals, Leeds, United Kingdom

Rami S. Komrokji, MD¹, Najla Al Ali, MS¹, Virginia Olivia Volpe, MD¹, Onyee Chan, MD^2*, Andrew Kuykendall, MD³, Kendra Sweet, MD¹, Jeffrey E. Lancet, MD¹, Eric Padron, MD¹ and David A. Sallman, MD¹

¹Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
²Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, TAMPA, FL
³Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL

Sylvain Thepot^1*, Adja Ciss^2*, Iden al Sabty^3*, Jérôme Paillassa, MD^4*, Aline Schmidt^5*, Aurelien Giltat, MD^6*, Corentin Orvain^6*, Franck Genevieve, PharmD^7*, Marianne Schwarz^8*, Anne Bouvier, MD PhD^9*, Guillaume Mabilleau, MD/PhD^10*, Norbert Ifrah, MD PhD⁶, Beatrice Bouvard, Md/PhD^3* and Mathilde Hunault, MD; PhD^11*

¹Department of Clinical Hematology, Angers University Hospital, ANGERS, NA, France
²rheumatology, CHU d'Angers, angers, France
³rheumatology, CHU angers, angers, France
⁴CHU Angers, Hematology, Angers, France
⁵Service d’Hématologie, CHU Angers, Angers, France
⁶Clinical Hematology, Angers University Hospital, Angers, France
⁷Laboratoire d'Hématologie, Centre Hospitalier Universitaire d'Angers, Angers, France
⁸hematology, CHU angers, angers, France
⁹Angers University Hospital, Angers, France
¹⁰Cell and Tissue Pathology Department, Angers University Hospital, angers, France
¹¹Clinical Hematology, CHU d'Angers, Angers, France

Uwe Platzbecker, MD¹, Valeria Santini, MD, PhD^2*, Rami S. Komrokji³, Amer M. Zeidan, MD⁴, Guillermo Garcia-Manero, MD⁵, Rena Buckstein⁶, Esther Natalie Oliva, MD⁷, Dimana Miteva^8*, Veronika Pozharskaya^9*, Xianwei Ha^9*, Jose Alberto Nadal, PhD, MSc^8* and Pierre Fenaux¹⁰

¹Department for Hematology, Cell Therapy and Hemostaseology, University of Leipzig Medical Center, Leipzig, Germany
²University of Florence, Florence, Italy
³Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁴Yale School of Medicine and Yale Cancer Center, Yale University, New Haven, CT
⁵University of Texas, MD Anderson Cancer Center, Houston, TX
⁶Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
⁷Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Reggio Calabria, Italy
⁸Celgene International Sàrl, a Bristol-Myers Squibb Company, Boudry, Switzerland
⁹Bristol Myers Squibb, Princeton, NJ
¹⁰Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France

Jan Philipp Bewersdorf, MD¹, Alyssa Grimshaw, MSLIS^2*, Uwe Platzbecker, MD³, Pierre Fenaux⁴, Mikkael A. Sekeres, MD⁵, Amer M. Zeidan, MD⁶ and Maximilian F. Stahl, MD⁷

¹Department of Medicine; Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
²Harvey Cushing/John Hay Whitney Medical Library, Yale University, New Haven, CT
³Medical Clinical and Policlinic 1, Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany
⁴Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France
⁵University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL
⁶Department of Internal Medicine, Yale School of Medicine and Yale Cancer Center, New Haven, CT
⁷Department of Medical Oncology, Dana-Farber Institute, Boston, MA

Luis E. E. Aguirre, MD¹, Najla Al Ali, MS², Somedeb Ball, MD¹, Avani M Singh, MD¹, Akriti G Jain, MD³, Onyee Chan, MD^1*, Zaker I. Schwabkey, MD¹, Sara M Tinsley-Vance, PhD, ANP¹, Andrew Kuykendall, MD¹, Kendra Sweet, MD¹, Jeffrey E. Lancet, MD¹, Eric Padron, MD¹, David A. Sallman, MD² and Rami S. Komrokji, MD¹

¹Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
²Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
³Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, WESLEY CHAPEL, FL

Guillermo Montalban-Bravo, MD¹, Gautham Borthakur^1*, Kelly S. Chien, MD¹, Danielle Hammond, MD¹, Rajani K Medury, BSN, RN^1*, Jane Waukau, BSN, RN^1*, Sherry A. Pierce, BSN, BA^1*, Hagop Kantarjian, MD² and Guillermo Garcia-Manero, MD³

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX

Mikkael A. Sekeres, MD¹, Guillermo Garcia-Manero, MD², David L. Grinblatt³, Rami S. Komrokji⁴, Michael R. Savona, MD⁵, Harry P. Erba, MD, PhD⁶, Gail J. Roboz, MD⁷, Irene S. DeGutis^8*, Pavel Kiselev^8*, Edward Yu, ScD^8*, Adeola Y. Makinde^8*, Ali McBride⁸ and Bart L. Scott, MD⁹

¹University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL
²The University of Texas MD Anderson Cancer Center, Houston, TX
³NorthShore University HealthSystem, Evanston, IL
⁴Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL
⁵Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN
⁶Duke University, Durham, NC
⁷Weill Cornell Medicine and New York-Presbyterian Hospital, New York, NY
⁸Bristol Myers Squibb, Princeton, NJ
⁹Fred Hutchinson Cancer Research Center, Seattle, WA

Yannick LE Bris, PhD, PharmD^1*, Simon Bouzy, PharmD^1*, Audrey Ménard^1*, Pascal Turlure, MD^2*, Patrice Chevallier, MD³, Marie-Pierre Gourin, MD^4*, Pierre-Yves Dumas, M.D., Ph.D.^5*, Sylvain Thepot^6*, Anna Berceanu, MD^7*, Sophie Park, MD, PhD⁸, Marie-Anne Hospital^9*, Thomas Cluzeau, MD, PhD^10*, Jose-Miguel Torregrosa Diaz, MD^11*, Louis Devron, MD^12*, Rosa Sapena^13*, Fatiha Chermat^13*, Sophie Dimicoli Salazar, MD^5*, Marie C Béné, PharmSciD, PhD^14*, Pierre Fenaux¹³ and Pierre Peterlin, MD^3*

¹Hematology Biology, Nantes University Hospital, Nantes, France
²Department of Clinical Hematology, Limoges University Hospital, Limoges, France
³Clinical Hematology, Nantes University Hospital, Nantes, France
⁴Clinical Hematology, Limoges University Hospital, Limoges, France
⁵Clinical Hematology, Bordeaux University Hospital Haut-Lévèque, Bordeaux, Haut-Lévèque, France
⁶Clinical Hematology, Angers University Hospital, Angers, France
⁷Clinical Hematology, Besançon University Hospital, Besançon, France
⁸Grenoble University Hospital, Grenoble, France
⁹Clinical Hematology, Aix-Marseille University, INSERM U1068, CNRS, Institut Paoli-Calmettes, Marseille, France, Marseille, France
¹⁰Clinical Hematology, Nice University Hospital, Nice, France
¹¹Department of Clinical Hematology, Poitiers University Hospital, Poitiers, France
¹²Clinical Hematology, Saint-Louis University Hospital, Paris, France
¹³Groupe Francophone des Myélodysplasies (GFM), Paris, France
¹⁴Hematology Biology, Nantes University Hopital, Nantes, France

Anthony Hunter, MD¹, Hannah Newman, BS^2*, Eric Solary, MD PhD³, Klaus Geissler, MD, PhD^4*, Laura Palomo, PhD^5*, Lurdes Zamora, PhD^6*, Francesc Solé, PhD⁷, Valeria Santini, MD⁸, Timothy A. Graubert, MD⁹, Swapna Thota, MD¹⁰, Elizabeth A. Griffiths, MD¹¹, Lisa Pleyer, Assoc. Prof., MD, MBI, EMBA^12,13,14*, Felicitas R. Thol, MD¹⁵, Rafael Bejar, MD, PhD¹⁶, Luis E. E. Aguirre, MD¹⁷, David A. Sallman, MD¹⁸, Andrew Kuykendall, MD¹⁹, Rami S. Komrokji¹⁹, Tracy I. George, MD^20,21 and Eric Padron, MD²

¹Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA
²Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL
³Université Paris-Saclay, INSERM U1287, Gustave Roussy Cancer Campus, Villejuif, France
⁴Sigmund Freud University, Vienna, Austria
⁵Department of Hematology, University Hospital Vall d’Hebron, Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
⁶Hematology Department. Institut Català d’Oncologia, Hospital Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras. Universitat Autònoma de Barcelona, Badalona. Barcelona, Spain
⁷MDS Group. Institut de Recerca Contra la Leucèmia Josep Carreras (IJC), ICO-Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain
⁸MDS Unit, Hematology, AOU Careggi, University of Florence, Florence, Italy
⁹Massachusetts General Hospital Cancer Center, Boston, MA
¹⁰St. Jude Research Hospital, The University of Tennessee Health Science Center, Memphis, TN
¹¹Roswell Park Comprehensive Cancer Center, Buffalo, NY
¹²Austrian Group of Medical Tumor Therapy (AGMT) Study Group, Vienna, Austria
¹³3rd Medical Dept. with Hematology, Medical Oncology, Hemostaseology, Rheumatology and Infectiology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria
¹⁴Salzburg Cancer Research Institute (SCRI) Center for Clinical Cancer and Immunology Trials (CCCIT), Salzburg, Austria and Cancer Cluster Salzburg (CCS), Salzburg, Austria
¹⁵Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
¹⁶Division of Hematology and Oncology, University of California San Diego Moores Cancer Center, La Jolla, CA
¹⁷Division of Hematology and Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
¹⁸Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
¹⁹Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
²⁰ARUP Laboratories, Salt Lake City, UT
²¹Department of Pathology, Spencer Fox Eccles School of Medicine at the University of Utah, Huntsman Cancer Institute, Salt Lake City, UT

Saverio D'Amico, MSc^1*, Lorenzo Dall'Olio, PhD^2*, Cesare Rollo, PhD^3*, Patricia Alonso, PhD^4*, Iñigo Prada-Luengo, PhD^5*, Daniele Dall'Olio, PhD^2*, Claudia Sala, PhD^2*, Matteo Bersanelli, PhD^6*, Elisabetta Sauta, PhD^1*, Marilena Bicchieri, PhD^6*, Pierandrea Morandini, MEng^1*, Tobia Tommasini, MSc^1*, Victor Savevski, MEng^1*, Lin-Pierre Zhao, MD^7*, Uwe Platzbecker, MD⁸, Maria Diez-Campelo, MD^9*, Valeria Santini, MD¹⁰, Pierre Fenaux¹¹, Torsten Haferlach, MD¹², Anders Krogh, PhD^5*, Santiago Zazo, PhD^4*, Piero Fariselli, PhD^3*, Tiziana Sanavia, PhD^3*, Matteo G. Della Porta, MD^13* and Castellani Gastone, PhD^2*

¹Artificial Intelligence Center, Humanitas Research Hospital, Rozzano (Milan), Italy
²DIMES, University of Bologna, Bologna, Italy
³University of Turin, Torino, Italy
⁴Department of Signals, Systems and Radiocommunications, Polytechnic University of Madrid, Madrid, Spain
⁵University of Copenhagen, Copenhagen, Denmark
⁶IRCCS Humanitas Research Hospital, Rozzano, Italy
⁷Department of Hematology and Bone Marrow Transplantation, Hôpital Saint-Louis, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France
⁸Medical Clinical and Policlinic 1, Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany
⁹Department of Hematology. Salamanca-IBSAL university hospital, Salamanca, salamanca, Spain
¹⁰MDS Unit, University of Florence, AOUC, Florence, Italy
¹¹Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France
¹²MLL Munich Leukemia Laboratory, Munich, Germany
¹³Cancer Center, Humanitas Research Hospital and Center for Accelerating Leukemia Research (CALR), Humanitas University, Artificial Intelligence Center, Milan, Italy

Laurenz Steiner, MD^*, Navkirandeep Kaur^*, Alexander Streuer, MD^*, Johann-Christoph Jann, MD^*, Alice Fabarius, PhD^*, Georgia Metzgeroth, MD^*, Wolf-Karsten Hofmann, MD, Daniel Nowak, MD^* and Mohamad Jawhar, MD^*

Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

Benjamin Kroger, BS^1*, Yi Huang, Ph.D.^1*, Prapti Patel, MD^2*, Aimaz Afrough, MD³, Gurbakhash Kaur, MD^4*, Larry D. Anderson Jr., MD, PhD⁵, Farrukh T. Awan, M.D.⁶, Praveen Ramakrishnan, M.D.^4*, Kunal Verma, B.S.^4*, Russell Vittrup, B.S.^4*, Robert H. Collins, M.D.⁴, Madhuri Vusirikala, M.D.^4*, Yazan F. Madanat, MD⁴, Roni Tamari, M.D.⁷ and Stephen S. Chung, MD¹

¹Division of Hematology and Oncology, Department of Internal Medicine, Children's Research Institute, University of Texas Southwestern, Dallas, TX
²Servier Pharmaceuticals, Boston
³Division of Hematology/Oncology, Department of Internal Medicine, University of Texas Southwestern, dallas, TX
⁴Division of Hematology/Oncology, Department of Internal Medicine, University of Texas Southwestern, Dallas, TX
⁵Division of Hematology/Oncology, Department of Internal Medicine, University of Texas Southwestern, Dallas
⁶Division of Hematologic Malignancies and Cellular Therapy, Dept of Internal Medicine, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX
⁷Department of Internal Medicine, Memorial Sloan Kettering Cancer Center, New York, NY