Sofía M Toribio Castelló^1*, Felix Lopez-Cadenas, MD^2,3*, Claude Preudhomme, PharmD, PhD^4,5,6, Angela Villaverde Ramiro^1*, Laurène Fenwarth, MD, MSc^7,8,9*, Eva Lumbreras^1*, Teresa González^10,11*, Mónica Del Rey^1*, Blanca Xicoy, MD^12,13,14*, Aline Renneville, MD, PhD^15,16*, Joaquín Sánchez-Garcia, MD^17,18,19, Rosa Coll, MD^20,21*, Bohrane Slama^22*, José Ángel Hernández-Rivas^23,24*, Sylvain Thepot^25*, Teresa Bernal, MD, PhD^26,27*, Agnès Guerci-Bresler, MD, PhD^28,29*, Katharina Götze^30,31*, Jesús María Hernández-Rivas, MD, PhD^32,33,34,35, Pierre Fenaux^36,37,38,39, Consuelo Del Cañizo, MD, PhD⁴⁰ and Maria Diez-Campelo, MD^41,42,43*

¹Unidad de Diagnóstico Molecular y Celular del Cáncer, Centro de Investigación del Cáncer-Universidad de Salamanca (IBMCC, USAL-CSIC); Genética Molecular en Oncohematología, Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain
²Hematology Departement Hospital del Mar, Barcelona, Spain
³Group of Applied Clinical Research in Hematology, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain
⁴ALFA Group, Paris, France
⁵Laboratory of Hematology, Lille University Hospital, Lille, France
⁶Cancer Research Institute, INSERM Unité Mixte de Recherche (UMR)-S 1172, F-59000 Lille, CHU Lille, Laboratory of Hematology, F-59000 Lille, Lille, France
⁷University of Lille, Lille, France
⁸UMR-S 1172, INSERM, Lille, France
⁹Laboratory of Hematology, CHU Lille, Lille, France
¹⁰Molecular Genetics in Oncohematology, Institute of Biomedical Research of Salamanca (IBSAL) - Cancer Research Center of Salamanca (USAL-CSIC), Salamanca, Spain
¹¹Hematology Dept., Hospital Universitario de Salamanca, Spain, Salamanca, Spain
¹²HU German Trias i Pujol - Institut Català d' Oncologia, Barcelona, Spain
¹³Universitat Autònoma de Barcelona, Barcelona, Spain
¹⁴Hematology Department, Institut Català d’Oncologia-Hospital Germans Trias i Pujol, Josep Carreras Leukemia Research Institute, Universitat Autònoma de Barcelona, Badalona, Spain
¹⁵Claude Huriez University Hospital, University Lille, Lille, France
¹⁶Centre de Biologie-Pathologie, Centre Hospitalier Universitaire de Lille, Lille, France
¹⁷IMIBIC, Hematology, Hospital Universitario Reina Sofía, UCO, Córdoba, Spain
¹⁸Reina Sofia UniversityHospital, Hematology service, Córdoba, Spain
¹⁹Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain
²⁰Hospital Josep Trueta - ICO, Girona, ESP
²¹Hematology Department. Institut Català d’Oncologia. Hospital Doctor Josep Trueta. Institut d'Investigació Biomèdica de Girona (IDIBGI), Universitat de Girona, Girona, Spain
²²CH Avignon, Avignon, FRA
²³Medicine Department, Universidad Complutense de Madrid, Madrid, Spain
²⁴Hematology Department, Hospital Universitario Infanta Leonor, Madrid, Spain
²⁵Department of Clinical Hematology, Angers University Hospital, ANGERS, NA, France
²⁶Programa Español de Tratamientos en Hematologia, PETHEMA, Valencia, Spain
²⁷Hospital Universitario Central de Asturias, Instituto Universitario (IUOPA), Instituto de investigación del Principado de Asturias (ISPA), Oviedo, Spain
²⁸Service d'Hématologie, Centre Hospitalier Universtaire Brabois, Vandoeuvre-lès-Nancy, France
²⁹Institut Bergonié, French Group of CML (Fi-LMC), Bordeaux, France
³⁰German Cancer Research Center (DKFZ) Munich, German Cancer Consortium (DKTK), Munich, Germany
³¹Department of Internal Medicine III, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany
³²Hematology Department, University Hospital of Salamanca, Salamanca, Spain
³³Cancer Research Center (IBMCC) CSIC, University of Salamanca, Salamanca, Spain
³⁴HARMONY Alliance Chair, Salamanca, Spain
³⁵Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain
³⁶Université de Paris, Hematology department, Saint-Louis hospital, APHP, Paris, France
³⁷The European Myelodysplastic Syndromes Cooperative Group (EMSCO), Leipzig, Germany
³⁸Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France
³⁹Groupe Francophone des Myélodysplasies (GFM), Paris, France
⁴⁰Departamento de Hematología, Hospital Clínico Universitario de Salamanca (CAUSA/IBSAL), Salamanca, Spain
⁴¹Hospital Universitario de Salamanca Instituto de Investigación Biomédica de Salamanca, Responsable de Síndromes Mielodisplásicos Servicio de Hematología, Salamanca, Spain
⁴²Hematology Department, Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, Salamanca, Spain
⁴³Grupo Español de Síndromes Mielodisplásicos (GESMD), Valencia, Spain

Saverio D'Amico, MSc^1*, Elisabetta Sauta, PhD^1*, Matteo Bersanelli, PhD^2*, Daniele Dall'Olio, PhD^3*, Claudia Sala, PhD^3*, Lorenzo Dall'Olio, PhD^3*, Pierandrea Morandini, MEng^1*, Tobia Tommasini, MSc^1*, Marilena Bicchieri, PhD^2*, Matteo Zampini, PhD^2*, Victor Savevski, MEng^1*, Iñigo Prada-Luengo, PhD^4*, Anders Krogh, PhD^4*, Uwe Platzbecker, MD⁵, Maria Diez-Campelo, MD^6*, Valeria Santini, MD⁷, Pierre Fenaux⁸, Torsten Haferlach, MD⁹, Castellani Gastone, PhD^3* and Matteo G. Della Porta, MD^10*

¹Artificial Intelligence Center, Humanitas Research Hospital, Rozzano (Milan), Italy
²IRCCS Humanitas Research Hospital, Rozzano, Italy
³DIMES, University of Bologna, Bologna, Italy
⁴University of Copenhagen, Copenhagen, Denmark
⁵Medical Clinical and Policlinic 1, Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany
⁶Department of Hematology. Salamanca-IBSAL university hospital, Salamanca, salamanca, Spain
⁷MDS Unit, University of Florence, AOUC, Florence, Italy
⁸Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France
⁹MLL Munich Leukemia Laboratory, Munich, Germany
¹⁰Cancer Center, Humanitas Research Hospital and Center for Accelerating Leukemia Research (CALR), Humanitas University, Artificial Intelligence Center, Milan, Italy

Carmelo Gurnari, MD^1,2, Arda Durmaz^2*, Yasuo Kubota, MD, PhD^2*, Mai Aly, MD, BSc, MS^2,3*, Olisaemeka Ogbue⁴, Fauzia Ullah, MD^2*, Danai Dima, MD^2*, Hussein Awada^2*, Naomi Kawashima, MD, PhD^2*, Thomas LaFramboise, Ph.D.^5*, Richard A Padgett, PhD^6*, Torsten Haferlach, MD⁷, Jaroslaw P. Maciejewski, MD, PhD, FACP² and Valeria Visconte, PhD²

¹Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
³Assiut University, Clinical Hematology unit, Faculty of Medicine, Assiut, Egypt
⁴Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Rocky River, OH
⁵Department of Genetics and Genome Sciences Case Western Reserve University School of Medicine, Cleveland, OH
⁶Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Foundation, Cleveland, OH
⁷MLL Munich Leukemia Laboratory, Munich, Germany

Vladimir Riabov, PhD^1*, Qingyu Xu^1*, Nanni Schmitt, MSc^1*, Alexander Streuer, MD^1*, Guo Ge^2*, Johann-Christoph Jann, MD^1*, Alina Wein^1*, Eva Altrock, PhD^1*, Felicitas Rapp, PhD^1*, Verena Nowak^1*, Nadine Weimer^1*, Julia Obländer^1*, Iris Palme^1*, Melda Göl^1*, Mark Wunderlich, MS^3*, Ahmed Jawhar, MD^4*, Ali Darwich, MD^4*, Patrick Wuchter, MD⁵, Christel Weiss, PhD^6*, Jason M Foulks^7*, Daniel T. Starczynowski, PhD³, Feng-Chun Yang, MD, PhD², Georgia Metzgeroth, MD^1*, Laurenz Steiner, MD^1*, Wolf-Karsten Hofmann, MD¹, Daniel Nowak, MD^1* and Mohamad Jawhar, MD^1*

¹Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
²Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, San Antonio
³Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁴Department of Orthopedic Surgery, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
⁵Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
⁶Department of Medical Statistics and Biomathematics, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
⁷Sumitomo Pharma Oncology, Inc, Lehi

Julie A.I. Thoms^1*, Annatina Schnegg-Kaufmann, MD^2,3*, Golam Sarower Bhuyan^4*, Henry R. Hampton, PhD^3*, Lachlin Vaughan, MBBS, BSc, FRACP, FRCPA^4*, Kayleigh Rutherford^5*, Purvi M. Kakadia, PhD^6*, Hui Mei Lee^6*, Emma Johansson, PhD^7*, Tim W. Failes, PhD^8*, Greg M. Arndt, PhD^8*, Jason Koval, PhD^9*, Sarah Davidson^10*, Robert Lindeman, MD^11*, Pauline Warburton, MD^12*, Alba Rodriguez-Meira, PhD^13*, Adam J Mead, MD PhD¹³, Ashwin Unnikrishnan, PhD⁴, Mark Hertzberg, MD¹⁴, Mark N. Polizzotto, MBBS, FRACP, FRCPA^15*, Elli Papaemmanuil, PhD¹⁶, Stefan K. Bohlander, MD⁶, Omid Faridani, PhD^3,17,18*, Christopher J. Jolly, PhD^3*, Fabio Zanini, PhD^4,17,18* and John E. Pimanda, MBBS, FRACP, FRCPA, PhD^3,4,19

¹School of Medical Sciences, University of New South Wales, Randwick, Australia
²Department of Haematology and Central Haematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
³School of Medical Sciences, University of New South Wales, Sydney, Australia
⁴School of Clinical Medicine, University of New South Wales, Sydney, Australia
⁵Memorial Sloan Kettering Cancer Center, New York, NY
⁶Leukaemia & Blood Cancer Research Unit, Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
⁷Flow Cytometry Facility, Mark Wainwright Analytical Centre, University of New South Wales, Randwick, AUS
⁸Children's Cancer Institute, Randwick, Australia
⁹Ramaciotti Centre for Genomics, University of New South Wales, Randwick, AUS
¹⁰Kirby Institute, University of New South Wales, Sydney, Australia
¹¹Department of Haematology, Prince of Wales Hospital, Sydney, Randwick, AUS
¹²Wollongong Hospital, Australia, Wollongong, AUS
¹³Medical Research Council Weatherall Institute of Molecular Medicine and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
¹⁴Department of Clinical Haematology, Prince of Wales Hospital, Sydney, Australia
¹⁵ANU Clinical Hub for Interventional Research (CHOIR), John Curtin School of Medical Research, Canberra, Australia
¹⁶Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, NEW YORK, NY
¹⁷UNSW Cellular Genomics Futures Institute, University of New South Wales, Sydney, Australia
¹⁸Garvan-Weizmann Centre for Cellular Genomics, Sydney, Australia
¹⁹Haematology Department, Prince of Wales Hospital, Sydney, Australia

Onima Chowdhury, MD PhD¹, Douglas RA Silveira, MD^2*, Sophie Reed, BSc^1*, Jennifer O'Sullivan, MB BCh^1*, Sally-Ann Clark, PhD^1*, Neil Ashley, PhD^1*, Bethan Psaila, MD, PhD¹, Supat Thongjuea, PhD^1*, Adam J Mead, MD PhD¹ and Lynn Quek, MBBCh, DPhil, MRCP (UK), FRCPath^2*

¹Medical Research Council Weatherall Institute of Molecular Medicine and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
²School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom

Monika M Kutyna, MSc^1,2,3*, Chung Hoow Kok, PhD, BSc^1,2, Yoon Lim, PhD^4*, David Campbell, PhD, B.M.B.S., F.R.A.C.S., F.A.Oth.A^2,5*, Sharon Paton, BSc^1,2*, Chloe AL Thompson-Peach, PhD^1,2*, Kelly SY Lim, MSc^1,2*, Timothy Hughes, MD, MBBS, FRACP, FRCPA^1,2,3, Sharad Kumar, PhD^4*, Daniel Thomas, MD, PhD^1,2, Stan Gronthos, PhD^1,2* and Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA^1,2,3

¹Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia
²Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia
³Department of Haematology, Royal Adelaide Hospital, Adelaide, SA, Australia
⁴Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia
⁵Wakefield Orthopaedic Clinic, Calvary Wakefield Hospital, Adelaide, Australia

Noah Salama, MS^1*, Olivia Lynch, BA, MPH^2*, Emily R Quarato, MS^3*, Yuko Kawano, MD, PhD^4*, Benjamin Rodems, MS^5*, Eric Cefaloni, MS^6*, Tzu-Chieh Ho, PhD⁷, Kathleen E. McGrath, PhD^8,9, Michael W. Becker, MD^10,11, Jane L. Liesveld, MD¹¹, Paula M Vertino, PhD^12*, James Palis, MD^13,14, Jeevisha Bajaj, PhD⁵ and Laura M. Calvi, MD^10,15

¹University of Rochester/Strong Memorial Hospital/Wilmot Cancer Center, Rochester, NY
²University of Rochester School of Medicine and Dentistry, Rochester, NY
³Department of Environmental Medicine and Toxicology, University of Rochester, Rochester, NY
⁴James P. Wilmot Cancer Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA, Rochester, NY
⁵Department of Biomedical Genetics, Wilmot Cancer Institute, University of Rochester, Rochester, NY
⁶University of Rochester, Rochester, NY
⁷Division of Hematology/Oncology, University of Rochester Medical Center, Rochester, NY
⁸Department of Pediatrics, University of Rochester, Rochester, NY
⁹Center for Children’s Health Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY
¹⁰Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY
¹¹Wilmot Cancer Institute, Division of Hematology and Oncology, University of Rochester Medical Center, Rochester, NY
¹²Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY
¹³Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY
¹⁴Wilmot Cancer Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY
¹⁵Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY

Xuan Zhang, PhD, MBBS¹, Baobao (Annie) Song¹, Mohammad Daud Khan^2*, Kyle Ferchen, BSc¹, Chih-Hsing Chou, PhD³, Guangyuan Li^2*, Amy E. DeZern, MD⁴, Gabriel Ghiaur, MD, PhD⁵, Stephanie Halene, MD⁶, Nathan Salomonis, PhD^2,7* and H. Leighton Grimes, PhD^1,7

¹Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Department of Immunobiology, Cincinnati Children's Hospital Medical Center, Mason, OH
⁴Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
⁵Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore, MD
⁶Yale Univ. School of Medicine, New Haven, CT
⁷Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH

Xiaoying Zhang^1*, Xingcheng Yang^1*, Chunyan Wang^1*, Liang Huang, MD¹, Yicheng Zhang, MD, PhD¹ and JIA Wei, MD, PhD^1,2*

¹Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
²Department of Hematology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Shanxi Medical University; Shanxi Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Taiyuan, China

Blake S Moses, PhD, Chris Materna, MS^*, Remya Nathan, MS^*, Tandicka Nurse^*, Keith Babbs, PhD^*, Claire Tseng, PhD^*, Ffolliott Fisher, PhD^*, Jasbir Seehra, PhD^* and Jenn Lachey, PhD

Keros Therapeutics, Lexington, MA

Roshani Sinha, PhD^1*, Rachana Patil, MS^1*, Rosa Romano, PhD^2*, Esmond Lee, MSc^3*, Zhenyu Yao, MD, PhD^4*, Y. Lucy Liu, MD, PhD⁵, Matthew H. Porteus, MD, PhD⁶ and Alice Bertaina, MD, PhD¹

¹Department of Pediatrics/Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA
²Walking Fish Therapeutics, San Francisco, CA
³Stanford University, Stanford
⁴Stanford University Medical Center, Stanford, CA
⁵Department of Pediatrics/Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Stanford Medical School, Stanford, CA
⁶Department of Pediatrics, Stanford Medical School, Stanford, CA

Qi Zhang^1*, Wei Lang^2*, Lu Wang^3*, Wenli Yang^4*, Yingwan Luo, Ph.D^5*, Shuanghong Zhu^6*, Lingxu Jiang^7*, Yuxia Wang^8*, Chen Mei^9*, Xinping Zhou^9*, Yanling Ren, M.D.^10*, Liya Ma, M.D.^9*, Li Ye^9*, Xingnong Ye, M.D.^11*, Gaixiang Xu, MD^12*, Jie Sun, PhD^13*, Jie Jin, M.D., Ph.D.⁵ and Hongyan Tong, MD, PhD^14*

¹Department of Hematology,, The First Affiliated Hospital, Zhejiang University School of Medicine, hangzhou, China
²Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, hangzhou, China
³Department of Hematology, The first affiliated hospital, Zhejiang university school of medicine, Hangzhou, China
⁴The First Affiliated Hospital, Zhejiang University School of Medicine, hangzhou, China
⁵Department of Hematology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
⁶the first affiliated hospital of zhejiang university, hangzhou, China
⁷Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁸The First Affiliated Hospital, Zhejiang University School of Medicine,, hangzhou, China
⁹Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
¹⁰Department of Hematology, The First Affiliated Hospital Zhejiang University, Hangzhou, China
¹¹the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
¹²Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
¹³Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
¹⁴Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China, Hangzhou, China