-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

636. Myelodysplastic Syndromes—Basic and Translational: Poster III

Symposia: Myelodysplastic Syndromes—Basic and Translational Program: Oral and Poster Abstracts
Type: Poster
Monday, December 12, 2022: 6:00 PM-8:00 PM
Hall D (Ernest N. Morial Convention Center)

Sofía M Toribio Castelló1*, Felix Lopez-Cadenas, MD2,3*, Claude Preudhomme, PharmD, PhD4,5,6, Angela Villaverde Ramiro1*, Laurène Fenwarth, MD, MSc7,8,9*, Eva Lumbreras1*, Teresa González10,11*, Mónica Del Rey1*, Blanca Xicoy, MD12,13,14*, Aline Renneville, MD, PhD15,16*, Joaquín Sánchez-Garcia, MD17,18,19, Rosa Coll, MD20,21*, Bohrane Slama22*, José Ángel Hernández-Rivas23,24*, Sylvain Thepot25*, Teresa Bernal, MD, PhD26,27*, Agnès Guerci-Bresler, MD, PhD28,29*, Katharina Götze30,31*, Jesús María Hernández-Rivas, MD, PhD32,33,34,35, Pierre Fenaux36,37,38,39, Consuelo Del Cañizo, MD, PhD40 and Maria Diez-Campelo, MD41,42,43*

1Unidad de Diagnóstico Molecular y Celular del Cáncer, Centro de Investigación del Cáncer-Universidad de Salamanca (IBMCC, USAL-CSIC); Genética Molecular en Oncohematología, Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain
2Hematology Departement Hospital del Mar, Barcelona, Spain
3Group of Applied Clinical Research in Hematology, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain
4ALFA Group, Paris, France
5Laboratory of Hematology, Lille University Hospital, Lille, France
6Cancer Research Institute, INSERM Unité Mixte de Recherche (UMR)-S 1172, F-59000 Lille, CHU Lille, Laboratory of Hematology, F-59000 Lille, Lille, France
7University of Lille, Lille, France
8UMR-S 1172, INSERM, Lille, France
9Laboratory of Hematology, CHU Lille, Lille, France
10Molecular Genetics in Oncohematology, Institute of Biomedical Research of Salamanca (IBSAL) - Cancer Research Center of Salamanca (USAL-CSIC), Salamanca, Spain
11Hematology Dept., Hospital Universitario de Salamanca, Spain, Salamanca, Spain
12HU German Trias i Pujol - Institut Català d' Oncologia, Barcelona, Spain
13Universitat Autònoma de Barcelona, Barcelona, Spain
14Hematology Department, Institut Català d’Oncologia-Hospital Germans Trias i Pujol, Josep Carreras Leukemia Research Institute, Universitat Autònoma de Barcelona, Badalona, Spain
15Claude Huriez University Hospital, University Lille, Lille, France
16Centre de Biologie-Pathologie, Centre Hospitalier Universitaire de Lille, Lille, France
17IMIBIC, Hematology, Hospital Universitario Reina Sofía, UCO, Córdoba, Spain
18Reina Sofia UniversityHospital, Hematology service, Córdoba, Spain
19Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain
20Hospital Josep Trueta - ICO, Girona, ESP
21Hematology Department. Institut Català d’Oncologia. Hospital Doctor Josep Trueta. Institut d'Investigació Biomèdica de Girona (IDIBGI), Universitat de Girona, Girona, Spain
22CH Avignon, Avignon, FRA
23Medicine Department, Universidad Complutense de Madrid, Madrid, Spain
24Hematology Department, Hospital Universitario Infanta Leonor, Madrid, Spain
25Department of Clinical Hematology, Angers University Hospital, ANGERS, NA, France
26Programa Español de Tratamientos en Hematologia, PETHEMA, Valencia, Spain
27Hospital Universitario Central de Asturias, Instituto Universitario (IUOPA), Instituto de investigación del Principado de Asturias (ISPA), Oviedo, Spain
28Service d'Hématologie, Centre Hospitalier Universtaire Brabois, Vandoeuvre-lès-Nancy, France
29Institut Bergonié, French Group of CML (Fi-LMC), Bordeaux, France
30German Cancer Research Center (DKFZ) Munich, German Cancer Consortium (DKTK), Munich, Germany
31Department of Internal Medicine III, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany
32Hematology Department, University Hospital of Salamanca, Salamanca, Spain
33Cancer Research Center (IBMCC) CSIC, University of Salamanca, Salamanca, Spain
34HARMONY Alliance Chair, Salamanca, Spain
35Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain
36Université de Paris, Hematology department, Saint-Louis hospital, APHP, Paris, France
37The European Myelodysplastic Syndromes Cooperative Group (EMSCO), Leipzig, Germany
38Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France
39Groupe Francophone des Myélodysplasies (GFM), Paris, France
40Departamento de Hematología, Hospital Clínico Universitario de Salamanca (CAUSA/IBSAL), Salamanca, Spain
41Hospital Universitario de Salamanca Instituto de Investigación Biomédica de Salamanca, Responsable de Síndromes Mielodisplásicos Servicio de Hematología, Salamanca, Spain
42Hematology Department, Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, Salamanca, Spain
43Grupo Español de Síndromes Mielodisplásicos (GESMD), Valencia, Spain

Saverio D'Amico, MSc1*, Elisabetta Sauta, PhD1*, Matteo Bersanelli, PhD2*, Daniele Dall'Olio, PhD3*, Claudia Sala, PhD3*, Lorenzo Dall'Olio, PhD3*, Pierandrea Morandini, MEng1*, Tobia Tommasini, MSc1*, Marilena Bicchieri, PhD2*, Matteo Zampini, PhD2*, Victor Savevski, MEng1*, Iñigo Prada-Luengo, PhD4*, Anders Krogh, PhD4*, Uwe Platzbecker, MD5, Maria Diez-Campelo, MD6*, Valeria Santini, MD7, Pierre Fenaux8, Torsten Haferlach, MD9, Castellani Gastone, PhD3* and Matteo G. Della Porta, MD10*

1Artificial Intelligence Center, Humanitas Research Hospital, Rozzano (Milan), Italy
2IRCCS Humanitas Research Hospital, Rozzano, Italy
3DIMES, University of Bologna, Bologna, Italy
4University of Copenhagen, Copenhagen, Denmark
5Medical Clinical and Policlinic 1, Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany
6Department of Hematology. Salamanca-IBSAL university hospital, Salamanca, salamanca, Spain
7MDS Unit, University of Florence, AOUC, Florence, Italy
8Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France
9MLL Munich Leukemia Laboratory, Munich, Germany
10Cancer Center, Humanitas Research Hospital and Center for Accelerating Leukemia Research (CALR), Humanitas University, Artificial Intelligence Center, Milan, Italy

Carmelo Gurnari, MD1,2, Arda Durmaz2*, Yasuo Kubota, MD, PhD2*, Mai Aly, MD, BSc, MS2,3*, Olisaemeka Ogbue4, Fauzia Ullah, MD2*, Danai Dima, MD2*, Hussein Awada2*, Naomi Kawashima, MD, PhD2*, Thomas LaFramboise, Ph.D.5*, Richard A Padgett, PhD6*, Torsten Haferlach, MD7, Jaroslaw P. Maciejewski, MD, PhD, FACP2 and Valeria Visconte, PhD2

1Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy
2Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
3Assiut University, Clinical Hematology unit, Faculty of Medicine, Assiut, Egypt
4Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Rocky River, OH
5Department of Genetics and Genome Sciences Case Western Reserve University School of Medicine, Cleveland, OH
6Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Foundation, Cleveland, OH
7MLL Munich Leukemia Laboratory, Munich, Germany

Vladimir Riabov, PhD1*, Qingyu Xu1*, Nanni Schmitt, MSc1*, Alexander Streuer, MD1*, Guo Ge2*, Johann-Christoph Jann, MD1*, Alina Wein1*, Eva Altrock, PhD1*, Felicitas Rapp, PhD1*, Verena Nowak1*, Nadine Weimer1*, Julia Obländer1*, Iris Palme1*, Melda Göl1*, Mark Wunderlich, MS3*, Ahmed Jawhar, MD4*, Ali Darwich, MD4*, Patrick Wuchter, MD5, Christel Weiss, PhD6*, Jason M Foulks7*, Daniel T. Starczynowski, PhD3, Feng-Chun Yang, MD, PhD2, Georgia Metzgeroth, MD1*, Laurenz Steiner, MD1*, Wolf-Karsten Hofmann, MD1, Daniel Nowak, MD1* and Mohamad Jawhar, MD1*

1Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
2Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, San Antonio
3Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
4Department of Orthopedic Surgery, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
5Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
6Department of Medical Statistics and Biomathematics, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
7Sumitomo Pharma Oncology, Inc, Lehi

Julie A.I. Thoms1*, Annatina Schnegg-Kaufmann, MD2,3*, Golam Sarower Bhuyan4*, Henry R. Hampton, PhD3*, Lachlin Vaughan, MBBS, BSc, FRACP, FRCPA4*, Kayleigh Rutherford5*, Purvi M. Kakadia, PhD6*, Hui Mei Lee6*, Emma Johansson, PhD7*, Tim W. Failes, PhD8*, Greg M. Arndt, PhD8*, Jason Koval, PhD9*, Sarah Davidson10*, Robert Lindeman, MD11*, Pauline Warburton, MD12*, Alba Rodriguez-Meira, PhD13*, Adam J Mead, MD PhD13, Ashwin Unnikrishnan, PhD4, Mark Hertzberg, MD14, Mark N. Polizzotto, MBBS, FRACP, FRCPA15*, Elli Papaemmanuil, PhD16, Stefan K. Bohlander, MD6, Omid Faridani, PhD3,17,18*, Christopher J. Jolly, PhD3*, Fabio Zanini, PhD4,17,18* and John E. Pimanda, MBBS, FRACP, FRCPA, PhD3,4,19

1School of Medical Sciences, University of New South Wales, Randwick, Australia
2Department of Haematology and Central Haematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
3School of Medical Sciences, University of New South Wales, Sydney, Australia
4School of Clinical Medicine, University of New South Wales, Sydney, Australia
5Memorial Sloan Kettering Cancer Center, New York, NY
6Leukaemia & Blood Cancer Research Unit, Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
7Flow Cytometry Facility, Mark Wainwright Analytical Centre, University of New South Wales, Randwick, AUS
8Children's Cancer Institute, Randwick, Australia
9Ramaciotti Centre for Genomics, University of New South Wales, Randwick, AUS
10Kirby Institute, University of New South Wales, Sydney, Australia
11Department of Haematology, Prince of Wales Hospital, Sydney, Randwick, AUS
12Wollongong Hospital, Australia, Wollongong, AUS
13Medical Research Council Weatherall Institute of Molecular Medicine and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
14Department of Clinical Haematology, Prince of Wales Hospital, Sydney, Australia
15ANU Clinical Hub for Interventional Research (CHOIR), John Curtin School of Medical Research, Canberra, Australia
16Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, NEW YORK, NY
17UNSW Cellular Genomics Futures Institute, University of New South Wales, Sydney, Australia
18Garvan-Weizmann Centre for Cellular Genomics, Sydney, Australia
19Haematology Department, Prince of Wales Hospital, Sydney, Australia

Onima Chowdhury, MD PhD1, Douglas RA Silveira, MD2*, Sophie Reed, BSc1*, Jennifer O'Sullivan, MB BCh1*, Sally-Ann Clark, PhD1*, Neil Ashley, PhD1*, Bethan Psaila, MD, PhD1, Supat Thongjuea, PhD1*, Adam J Mead, MD PhD1 and Lynn Quek, MBBCh, DPhil, MRCP (UK), FRCPath2*

1Medical Research Council Weatherall Institute of Molecular Medicine and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
2School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom

Monika M Kutyna, MSc1,2,3*, Chung Hoow Kok, PhD, BSc1,2, Yoon Lim, PhD4*, David Campbell, PhD, B.M.B.S., F.R.A.C.S., F.A.Oth.A2,5*, Sharon Paton, BSc1,2*, Chloe AL Thompson-Peach, PhD1,2*, Kelly SY Lim, MSc1,2*, Timothy Hughes, MD, MBBS, FRACP, FRCPA1,2,3, Sharad Kumar, PhD4*, Daniel Thomas, MD, PhD1,2, Stan Gronthos, PhD1,2* and Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA1,2,3

1Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia
2Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia
3Department of Haematology, Royal Adelaide Hospital, Adelaide, SA, Australia
4Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia
5Wakefield Orthopaedic Clinic, Calvary Wakefield Hospital, Adelaide, Australia

Noah Salama, MS1*, Olivia Lynch, BA, MPH2*, Emily R Quarato, MS3*, Yuko Kawano, MD, PhD4*, Benjamin Rodems, MS5*, Eric Cefaloni, MS6*, Tzu-Chieh Ho, PhD7, Kathleen E. McGrath, PhD8,9, Michael W. Becker, MD10,11, Jane L. Liesveld, MD11, Paula M Vertino, PhD12*, James Palis, MD13,14, Jeevisha Bajaj, PhD5 and Laura M. Calvi, MD10,15

1University of Rochester/Strong Memorial Hospital/Wilmot Cancer Center, Rochester, NY
2University of Rochester School of Medicine and Dentistry, Rochester, NY
3Department of Environmental Medicine and Toxicology, University of Rochester, Rochester, NY
4James P. Wilmot Cancer Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA, Rochester, NY
5Department of Biomedical Genetics, Wilmot Cancer Institute, University of Rochester, Rochester, NY
6University of Rochester, Rochester, NY
7Division of Hematology/Oncology, University of Rochester Medical Center, Rochester, NY
8Department of Pediatrics, University of Rochester, Rochester, NY
9Center for Children’s Health Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY
10Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY
11Wilmot Cancer Institute, Division of Hematology and Oncology, University of Rochester Medical Center, Rochester, NY
12Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY
13Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY
14Wilmot Cancer Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY
15Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY

Xuan Zhang, PhD, MBBS1, Baobao (Annie) Song1, Mohammad Daud Khan2*, Kyle Ferchen, BSc1, Chih-Hsing Chou, PhD3, Guangyuan Li2*, Amy E. DeZern, MD4, Gabriel Ghiaur, MD, PhD5, Stephanie Halene, MD6, Nathan Salomonis, PhD2,7* and H. Leighton Grimes, PhD1,7

1Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
2Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
3Department of Immunobiology, Cincinnati Children's Hospital Medical Center, Mason, OH
4Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
5Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore, MD
6Yale Univ. School of Medicine, New Haven, CT
7Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH

Xiaoying Zhang1*, Xingcheng Yang1*, Chunyan Wang1*, Liang Huang, MD1, Yicheng Zhang, MD, PhD1 and JIA Wei, MD, PhD1,2*

1Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2Department of Hematology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Shanxi Medical University; Shanxi Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Taiyuan, China

Blake S Moses, PhD, Chris Materna, MS*, Remya Nathan, MS*, Tandicka Nurse*, Keith Babbs, PhD*, Claire Tseng, PhD*, Ffolliott Fisher, PhD*, Jasbir Seehra, PhD* and Jenn Lachey, PhD

Keros Therapeutics, Lexington, MA

Roshani Sinha, PhD1*, Rachana Patil, MS1*, Rosa Romano, PhD2*, Esmond Lee, MSc3*, Zhenyu Yao, MD, PhD4*, Y. Lucy Liu, MD, PhD5, Matthew H. Porteus, MD, PhD6 and Alice Bertaina, MD, PhD1

1Department of Pediatrics/Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA
2Walking Fish Therapeutics, San Francisco, CA
3Stanford University, Stanford
4Stanford University Medical Center, Stanford, CA
5Department of Pediatrics/Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Stanford Medical School, Stanford, CA
6Department of Pediatrics, Stanford Medical School, Stanford, CA

Qi Zhang1*, Wei Lang2*, Lu Wang3*, Wenli Yang4*, Yingwan Luo, Ph.D5*, Shuanghong Zhu6*, Lingxu Jiang7*, Yuxia Wang8*, Chen Mei9*, Xinping Zhou9*, Yanling Ren, M.D.10*, Liya Ma, M.D.9*, Li Ye9*, Xingnong Ye, M.D.11*, Gaixiang Xu, MD12*, Jie Sun, PhD13*, Jie Jin, M.D., Ph.D.5 and Hongyan Tong, MD, PhD14*

1Department of Hematology,, The First Affiliated Hospital, Zhejiang University School of Medicine, hangzhou, China
2Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, hangzhou, China
3Department of Hematology, The first affiliated hospital, Zhejiang university school of medicine, Hangzhou, China
4The First Affiliated Hospital, Zhejiang University School of Medicine, hangzhou, China
5Department of Hematology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
6the first affiliated hospital of zhejiang university, hangzhou, China
7Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
8The First Affiliated Hospital, Zhejiang University School of Medicine,, hangzhou, China
9Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
10Department of Hematology, The First Affiliated Hospital Zhejiang University, Hangzhou, China
11the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
12Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
13Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
14Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China, Hangzhou, China

*signifies non-member of ASH