Claire N. Harrison, DM¹, Marina Kremyanskaya, MD, PhD², Prithviraj Bose, MD³, Vikas Gupta, MD, FRCP, FRCPath⁴, Raajit K Rampal, MD, PhD⁵, Jonathan Lambert, BmedSci, PhD, FRCP, FRCPath^6*, Moshe Talpaz, MD⁷, Alessandro Vannucchi, MD⁸, Andrew Kuykendall, MD⁹, Jean-Jacques Kiladjian, MD¹⁰, Srdan Verstovsek, MD, PhD¹¹, Ruben Mesa, MD, FACP¹², Gozde Colak, PhD^13*, Sandra Klein, PhD^13*, Soumik Dutta, PhD^14* and John Mascarenhas, MD¹⁵

¹Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
²Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
³The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Division of Medical Oncology and Hematology, University Health Network, Toronto, ON, Canada
⁵Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY
⁶University College London Hospitals NHS Foundation Trust, London, United Kingdom
⁷University of Michigan Comprehensive Cancer Center, Ann Arbor, MI
⁸University of Florence, Azienda Ospedaliero Universitaria Careggi, CRIMM, Florence, Italy
⁹Department of Malignant Hematology, H. Lee Mofitt Cancer Center, Tampa, FL
¹⁰Hopital Saint-Louis, Paris, France
¹¹Leukemia Department, The University of Texas MD Anderson Cancer Center, Houston, TX
¹²Mays Cancer Center at UT Health San Antonio MD Anderson Cancer Center, San Antonio, TX
¹³Constellation Pharmaceuticals, Inc., a MorphoSys Company, Boston, MA
¹⁴MorphoSys AG, Planegg, Germany
¹⁵Department of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY

Jean-Jacques Kiladjian, MD¹, Christoph Klade, PhD^2*, Pencho Georgiev, MD^3*, Dorota Krochmalczyk, MD^4*, Liana Gercheva-Kyuchukova, MD^5*, Miklos Egyed, MD, PhD^6*, Petr Dulicek, MD^7*, Arpad Illes, MD^8*, Halyna Pylypenko, MD^9*, Lylia Sivcheva, MD^10*, Jiří Mayer, MD¹¹, Vera Yablokova, MD^12*, Kurt Krejcy, MD^2*, Victoria Empson, MSc^13*, Hans Carl Hasselbalch, MD¹⁴, Robert Kralovics, PhD¹⁵ and Heinz Gisslinger, MD^16*

¹Centre d'Investigations Cliniques (INSERM CIC 1427), AP-HP, Hôpital Saint-Louis, Université Paris Cité, Paris, France
²AOP Orphan Pharmaceuticals GmbH, Vienna, Austria
³Medical University of Plovdiv, Plovdiv, Bulgaria
⁴Teaching Unit of the Hematology Department, University Hospital in Krakow, Kracow, Poland
⁵Clinical Hematology Clinic, Multiprofile Hospital for Active Treatment "Sveta Marina", Varna, Bulgaria
⁶Department of Internal Medicine II, Kaposi Mor County Teaching Hospital, Kaposvar, Hungary
⁷Department of Clinical Hematology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
⁸Department of Hematology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
⁹Regional Treatment and Diagnostics Haematology Centre, Cherkassy Regional Council, Cherkassy, Ukraine
¹⁰First Department of Internal Medicine, Multiprofile Hospital for Active Treatment - HristoBotev, Vratsa, Bulgaria
¹¹Clinic of Internal Medicine-Haematology and Oncology, University Hospital Brno, Brno, Czech Republic
¹²Department of Hematology, Yaroslavl Regional Clinical Hospital, Yaroslavl, Russian Federation
¹³AOP Orphan Pharmaceuticals GmbH, Vienna, Vienna, Austria
¹⁴Department of Hematology, Zealand University Hospital, Roskilde, Denmark
¹⁵Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria
¹⁶Department of Internal Medicine I, Division of Hematology and Blood Coagulation, Medical University Vienna, Vienna, Austria

Rosa Ayala^1*, Nieves Lopez^1*, Adi Shacham Abulafia, MD^2*, Maan Alwan^3*, Costas K. Yannakou, MBBS^4*, Indu Raman^4*, Vincent Ribrag, MD⁵, Chun Yew Fong, MBBS, PhD, FRACP, FRCPA⁶, Yulia Volchek^7*, Massimiliano Bonifacio, MD^8*, Alessandra Tucci, MD^9*, Jean-Jacques Kiladjian, MD¹⁰, Henry Chang^11*, Sharmila Das^12*, Bin Wu^13*, Palanikumar Ravindran^14*, Vivian Shan^12*, Guan Wang^14*, Oriana Esposito^15*, Yu Liu^13*, Zariana Nikolova^15*, Christopher Tehlirian^13*, Shodeinde Coker^14* and David Lavie, MD^16*

¹Hematology and Hemotherapy Department, Hospital Universitario 12 de Octubre, CNIO, Complutense University, CIBERONC, Madrid, Spain
²Institute of Hematology, Davidoff Cancer Centre, Beilinson Hospital, Rabin Medical Centre, Petah-Tiqva, Israel
³Perth Blood Institute, West Perth, Western Australia, Australia
⁴Epworth HealthCare, Melbourne, VIC, Australia
⁵Département d'Innovation Thérapeutique et d'Essais Précoces (DITEP), Gustave Roussy Institute of Cancer, Villejuif, France
⁶Department of Haematology, Austin Hospital, Heidelberg, VIC, Australia
⁷Department of Hematology, Assaf Harofeh Medical Center, Zeriffin, Israel
⁸Department of Medicine, Section of Hematology, University of Verona and Azienda Ospedaliera Universitaria Integrata, Verona, Italy
⁹Hematology, ASST Spedali Civili di Brescia, Brescia, Italy
¹⁰Centre d'Investigations Cliniques (CIC 1427), Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Louis, INSERM, Université Paris 7, Paris, France
¹¹Bristol Myers Squibb, San Francisco, CA
¹²Bristol Myers Squibb, Princeton, NJ
¹³Bristol Myers Squibb, Cambridge, MA
¹⁴Bristol Myers Squibb, Lawrenceville, NJ
¹⁵Centre for Innovation and Translational Research Europe, A Bristol Myers Squibb Company, Seville, Spain
¹⁶Hadassah Medical Center, Jerusalem, Israel

Yannick LE Bris, PhD, PharmD^1,2*, Jean Galtier^3*, Dina Naguib, MD^4*, Mathieu Wemeau, MD^5,6*, Jean Claude Chomel, MD^7*, Laurence Legros, MD, PhD^8*, Yan Beauverd, MD^9*, Lise Willems, MD^10*, Guillaume Denis, MD^11*, Françoise Boyer perrard^12*, Damien Luque-Paz, PharmD, PhD^13*, Kamel Laribi, MD^14*, Mélanie Mercier, MD^15*, Pascale Cony-Makhoul, MD^16*, Olivier Herault, MD¹⁷, Lydia Roy, MD^18*, Pierre Sujobert, MD, PhD^19*, Lenaig Le Clech, MD^20*, Sylvie Tondeur, PharmD PhD^21*, Gaelle Laboure, MD^22*, Jerome Rey, MD^23*, Guillou Sophie, MD^24*, Cedric Pastoret, MD, PhD^25*, Pascaline Etancelin, MD^26*, Suzanne Tavitian, MD^27*, Charles Bescond, MD^28*, Francois Girodon, MD, PhD ²⁹, Shanti Amé, MD^30*, Viviane Dubruille, MD^31*, Eric Lippert, MD, PhD^32*, Chloe James, MD, PhD^33*, Barbara Burroni, MD^34*, Marc Fouassier, MD^35*, Marie C Béné, PharmSciD, PhD^36* and Jean Christophe Ianotto, MD, PhD^37*

¹Hematology Biology, CHU Nantes, Nantes, France
²CRCINA, INSERM, CNRS, Angers University and Nantes University, Nantes, France
³CHU Bordeaux, Service d'hématologie clinique et thérapie cellulaire, PESSAC, FRA
⁴Laboratoire d'hématologie, CHU de Caen Normandie, Caen, Ca, France
⁵Hématologie Clinique, Centre Hospitalier de Roubaix, Roubaix, France
⁶CHRU Lille, Paris, FRA
⁷CHU De Poitiers, Poitiers, FRA
⁸Hematology department, Hôpital Paul Brousse, Villejuif, France
⁹Geneva University Hospitals, Geneva, Switzerland
¹⁰Department of Hematology, APHP, Hôpital Cochin, Paris, France
¹¹Department of Internal Medicine and Hematology, Rochefort Hospital, Rochefort, France
¹²Service des maladies du sang, Centre Hospitalier Universitaire d’Angers, Angers, France
¹³Hematology biology, CHU Angers, Angers, France
¹⁴Hématologie clinique, CH Le Mans, Le Mans, France
¹⁵Clinical Hematology, Centre Hospitalier Bretagne Atlantique, Vannes, France
¹⁶Service d'Hématologie, Centre Hospitalier Annecy-Genevois, Pringy, France
¹⁷Service d'Hématologie Biologique, Centre Hospitalier Universitaire, Tours, France
¹⁸Hematology department, Hopital Henri Mondor, Creteil, France
¹⁹Laboratory of Hematology, Centre Hospitalier Lyon Sud, Pierre Bénite, France
²⁰Hematology clinic, Centre Hospitalier de Quimper, Quimper, France
²¹Laboratoire de Génétique des hémopathies, CHU Grenoble Alpes, Grenoble, France
²²Centre Hospitalier de Libourne, Libourne, France
²³Onco-Hematology Department, Paoli-Calmette Cancer Institute, Marseille, France
²⁴Hematology biology, CHU Reims, Reims, France
²⁵INSERM U1236 /Hematology Laboratory, University Hospital of Rennes, RENNES, FRA
²⁶Centre Henri Becquerel, Rouen, FRA
²⁷Service d'Hématologie, CHU de Toulouse - Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France
²⁸CHU De Nantes, Nantes, FRA
²⁹Laboratorie D'Hematologie CHU Dijon, Dijon, France
³⁰Hematology department, Hopital Civil , CHU Strasbourg, Strasbourg, France
³¹Hematology Department, Nantes University Hospital, Nantes, France
³²France Intergroupe des Néoplasies Myéloprolifratives, FIM collaborative group, Paris, France
³³UMR Inserm U1034, 33600, FRA
³⁴Pathology Department, Hopital Cochin, Paris, France
³⁵CHRU Hotel Dieu, Nantes cedex, FRA
³⁶Biology Department, Nantes University Hospital, Nantes, France
³⁷Department of Hematology, CHU de Brest, Brest, FRA

Srdan Verstovsek, MD, PhD¹, Ruben Mesa, MD, FACP², Vikas Gupta, MD, FRCP, FRCPath³, David Lavie, MD^4*, Viviane Dubruille, MD^5*, Nathalie Cambier, MD^6*, Uwe Platzbecker, MD⁷, Marek Hus, MD, PhD^8*, Blanca Xicoy, MD^9*, Stephen T Oh, MD, PhD¹⁰, Jean-Jacques Kiladjian, MD¹¹, Alessandro M Vannucchi, MD¹², Aaron T. Gerds, MD, MS¹³, Miklos Egyed, MD, PhD^14*, Jiri Mayer, Prof, MD^15*, Tomasz Sacha, MD, PhD^16*, Jun Kawashima, MD^17*, Marc Morris^17*, Mei Huang, MS^17* and Claire N. Harrison, DM¹⁸

¹Leukemia Department, The University of Texas MD Anderson Cancer Center, Houston, TX
²UT Health San Antonio Cancer Center, San Antonio, TX
³Division of Medical Oncology and Hematology, University Health Network, Toronto, ON, Canada
⁴Hadassah-Hebrew University Medical Centre, Jerusalem, Israel
⁵Hematology Department, Nantes University Hospital, Nantes, France
⁶Hospital Saint Vincent de Paul—GHICL Lille, Lillie, France
⁷Department for Hematology, Cell Therapy and Hemostaseology, University of Leipzig Medical Center, Leipzig, Germany
⁸Medical University of Lublin, Lublin, Poland
⁹Universitat Autònoma de Barcelona, Barcelona, Spain
¹⁰Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO
¹¹Université de Paris, AP-HP, Hôpital Saint-Louis, Centre d’Investigations Cliniques, Paris, France
¹²University of Florence, Firenze, Italy
¹³Department of Hematology and Medical Oncology,, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
¹⁴Somogy County Mór Kaposi General Hospital, Kaposvár, Hungary
¹⁵Masaryk University and University Hospital Brno, Brno, Czech Republic
¹⁶Jagiellonian University Hospital, Kraków, Poland
¹⁷Sierra Oncology Inc., San Mateo, CA
¹⁸Guy's and St Thomas' NHS Foundation Trust, London, ENG, United Kingdom

Andreas K. Oevlisen, MD^1*, Daniel Kristensen, MD^1*, Lasse Hjort Jakobsen, MSc, PhD^1,2*, Marianne Tang Severinsen, MD, PhD^1,3*, Tarec Christoffer Christoffer El-Galaly, MD, DSc^1,3 and Anne Stidsholt Roug, MD, PhD^1,3,4*

¹Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark
²Department of Mathematical Science, Aalborg University, Aalborg, Denmark
³Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
⁴Department of Hematology, Aarhus University Hospital, Aarhus, Denmark

Naseema Gangat, MBBS¹, Rimal Ilyas, MBBS^2*, Kristen McCullough, PharmD³, Kebede H. Begna, MD⁴, Aref Al-Kali, MD¹, Mrinal M. M. Patnaik, MD, MBBS¹, Mark R. Litzow, MD¹, William J. Hogan, MB, BCh¹, Abhishek A. Mangaonkar, MBBS¹, Hassan B. Alkhateeb, MD^1*, Mithun V. Shah, MD, PhD¹, Michelle A Elliott, MD¹, James M. Foran, MD⁵, Talha Badar, MD⁶, Jeanne M. Palmer, MD⁷, Curtis A. Hanson, MD⁸, Animesh Pardanani, MBBS, PhD ¹ and Ayalew Tefferi, MD¹

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Mayo Clinic, Rochester, MN
³Division of Pharmacology, Mayo Clinic, Rochester, MN
⁴Divison of Hematology, Mayo Clinic, Rochester, MN
⁵Division of Hematology/Oncology and Blood and Marrow Transplanation and Cellular Therapy, Mayo Clinic, Jacksonville, FL
⁶Division of Hematology and Oncology, Mayo Clinic Florida, Jacksonville, FL
⁷Division of Hematology/Oncology, Mayo Clinic, Phoenix, AZ
⁸Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

Ruben Mesa, MD, FACP^1,2, Claire N. Harrison, DM³, Jeanne M. Palmer, MD⁴, Vikas Gupta, MD, FRCP, FRCPath⁵, Donal P. McLornan, MD, PhD^6*, Mary Frances McMullin, MD, FRCPath, FRCP⁷, Jean-Jacques Kiladjian, MD⁸, Lynda Foltz, MD, FRCPC⁹, Uwe Platzbecker, MD¹⁰, Maria Laura Fox, MD^11*, Adam J Mead, MD PhD¹², David M Ross, MBBS, PhD, FRACP, FRCPA^13*, Stephen T Oh, MD, PhD¹⁴, Andrew Charles Perkins, MBBS, PhD¹⁵, Michael F. Leahy, FRACP, FRCPath, FRCP¹⁶, Jun Kawashima, MD^17*, Sunhee Ro, PhD^17*, Rafe Donahue, PhD^17*, Samineh Deheshi, PhD^18* and Srdan Verstovsek, MD, PhD¹⁹

¹UT Health San Antonio MD Anderson Cancer Center, San Antonio, TX
²UT Health San Antonio Cancer Center, San Antonio, TX
³Guy's and St Thomas' NHS Foundation Trust, London, ENG, United Kingdom
⁴Mayo Clinic, Phoenix, AZ
⁵Division of Medical Oncology and Hematology, University Health Network, Toronto, ON, Canada
⁶Haematology Department, Guy's and St Thomas' NHS Trust, London, United Kingdom
⁷Centre for Medical Education, Queen's University, Belfast, United Kingdom
⁸Clinical Investigations Center, Saint-Louis hospital, Université de Paris, Paris, France
⁹University of British Columbia, Vancouver, BC, Canada
¹⁰University Hospital Leipzig, Leipzig, Germany
¹¹University Hospital Vall d’Hebron, Barcelona, Spain
¹²Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
¹³Royal Adelaide Hospital and SA Pathology, Adelaide, Australia
¹⁴Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO
¹⁵Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia
¹⁶PathWest Laboratory Medicine WA, Perth, Australia
¹⁷Sierra Oncology Inc., San Mateo, CA
¹⁸Sierra Oncology Inc., Vancouver, BC, Canada
¹⁹MD Anderson Cancer Center, University of Texas, Houston, TX

Jessie J. F. Medeiros, BSc^1,2, Andy G.X. Zeng, BSc^1,2, Michelle Chan-Seng-Yue^3*, Tristan Woo^1*, Jessica L McLeod^4*, Andrea Arruda, MSc^5*, Hubert Tsui, MD, PhD, FRCPC^6,7,8,9, Burhan Goraya^1*, Jaime O. Claudio, PhD^1,10*, Jenny M. Ho, MD^11,12, James A. Kennedy, MD, PhD^13,14, Dawn Maze, MD, FRCPC, MSc¹⁵, Hassan Sibai, MBBS, MD^16*, Mark D. Minden, MD, PhD¹⁷, Jean C.Y. Wang, MD^1,17,18, John E. Dick, PhD^1,2 and Vikas Gupta, MD, FRCP, FRCPath¹

¹Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
²Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
³Princess Margaret Cancer Centre, University Health Network (UHN), Toronto, ON, Canada
⁴Phillip Orsino Cell Processing Laboratory, Princess Margaret Cancer Centre, Toronto, ON, Canada
⁵University Health Network, Toronto, ON, Canada
⁶Division of Hematological Pathology, Precision Diagnostics and Therapeutics Program, University of Toronto, Toronto, ON, Canada
⁷Sunnybrook Research Institute, Toronto, Canada
⁸Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
⁹Department of Immunology, University of Toronto, Toronto, Canada
¹⁰Division of Medical Oncology and Hematology, University of Toronto, Toronto, Canada
¹¹Division of Hematology, London Health Sciences Centre, London, ON, Canada
¹²Department of Medicine, University of Western Ontario, London, ON, Canada
¹³Division of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
¹⁴Sunnybrook Health Sciences Centre, Toronto, ON, Canada
¹⁵Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
¹⁶Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada
¹⁷Division of Medical Oncology and Hematology, University Health Network, Toronto, ON, Canada
¹⁸Department of Medicine, University of Toronto, Toronto, Canada

Lucia Masarova, MD¹, Prithviraj Bose, MD², Naveen Pemmaraju, MD¹, Mary Ann Richie^1*, Gautam Borthakur, MD¹, Zeev E. Estrov, MD¹, Hagop Kantarjian, MD³, Keyur P. Patel, MBBS, PhD⁴ and Srdan Verstovsek, MD, PhD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX

Cristina Papayannidis, MD, PhD¹, Francesco Mannelli, MD^2*, Lara Crosera, MD^3*, Roberta Parente, MD^4*, Alessandra Romano, MD, PhD⁵, Michela Rondoni, MD^6*, Chiara Elena, MD^7*, Marianna Criscuolo, MD^8*, Nicola Di Renzo, MD^9*, Fiorina Giona, M.D.¹⁰, Fabrizio Pane, MD¹¹, Daniela Cilloni, MD^12*, Elena Maria Elli, MD^13*, Maurizio Miglino, MD, PhD^14*, Patrizio Mazza, MD^15*, Alessandra Malato, MD^16*, Lara Pochintesta, MD^17*, Roberta Bini, MSc^18*, Diletta Valsecchi, MSc^18* and Federica Irene Grifoni, MD^19*

¹IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy, Bologna, Italy
²SOD Ematologia, CRIMM (Center Research and Innovation of Myeloproliferative Neoplasms), Azienda Ospedaliera Universitaria Careggi, Firenze, Italy
³Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
⁴"Scuola Medica Salernitana", Università di Salerno, Salerno, Italy
⁵Università degli Studi di Catania, Catania, Italy
⁶Hematology Unit, Azienda USL della Romagna, Ravenna, Italy
⁷Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
⁸Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
⁹UOC Ematologia e Trapianto di Cellule Staminali, PO Vito Fazzi, Lecce, Italy
¹⁰Department of Translational and Precision Medicine - Sapienza University of Rome, AOU Policlinico Umberto I, Rome, Italy
¹¹Division of Hematology and Bone Marrow Transplantation, Department of Medicine and Surgery University of Naples Federico II, Napoli, Italy
¹²Azienda Ospedaliero-Universitaria San Luigi Gonzaga, Orbassano, Italy
¹³San Gerardo Hospital, ASST Monza, Monza, Italy
¹⁴Ospedale San Martino, Genova, Italy
¹⁵Ospedale San Giuseppe Moscati, Statte, Italy
¹⁶Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy
¹⁷Division of Hematology, "G.da Saliceto" Hospital, Piacenza, Italy
¹⁸Novartis Farma SpA, Origgio, Italy
¹⁹Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Hematology Unit, Milan, Italy

Massimo Breccia, MD^1*, Paola Guglielmelli, MD, PhD², Francesco Mendicino^3*, Alessandra Malato, MD^4*, Giuseppe A. Palumbo^5*, Carmine Selleri⁶, Daniela Cilloni, MD^7*, Patrizio Mazza, MD^8*, Sergio Siragusa, MD⁹, Elisabetta Abruzzese, MD¹⁰, Maurizio Martelli^11*, Giulia Benevolo, MD^12*, Erminia Rinaldi^13*, Monica Crugnola, MD^14*, Serena Rupoli, MD^15*, Vincenzo Pavone^16*, Massimiliano Bonifacio, MD^17*, Fabrizio Pane, MD¹⁸, Giuseppe Carli^19*, Maria Langella^20*, Marta Bruno Ventre^21*, Elena Maria Elli, MD^22*, Stefana Impera, MD^23*, Anna Marina Liberati²⁴, Nicola Di Renzo, MD^25*, Bruno Martino^26*, Paolo Sportoletti, MD^27*, Mario Tiribelli, MD^28*, Gianni Binotto, MD^29*, Mario Annunziata^30*, Mauro Di Ianni^31*, Giorgio La Nasa^32*, Antonietta Pia Falcone^33*, Rossana Leanza^34*, Antonio Volpe^35*, Filippo Gherlinzoni^36*, Valerio De Stefano, MD^37*, Daniele Vallisa³⁸, Sabrina Leonetti Crescenzi, MD^39*, Francesco Cavazzini, MD^40*, Alessandra Ricco, MD^41*, Carmela Barberio^42*, Alessandra Misto^42*, Francesco Passamonti, MD^43* and Francesca Palandri, PhD, MD^44*

¹Division of Hematology, Department of Translational and Precision Medicine, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy
²CRIMM, Center for Research and Innovation of Myeloproliferative Neoplasms, AOU Careggi, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
³U.O.C. di Ematologia, Azienda Ospedaliera "Annunziata", Cosenza, Italy
⁴UOC di Oncoematologia Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy
⁵Dipartimento di Scienze Mediche Chirurgiche e Tecnologie Avanzate "G.F. Ingrassia", Unità Operativa di Ematologia con TMO AOU "Policlinico - San Marco", Università degli Studi di Catania, Catania, Italy
⁶UOC di Ematologia e Trapianti di Cellule Staminali Emopoietiche, Dipartimento di Medicina, Università di Salerno, AOU San Giovanni di Dio e Ruggi D'Aragona, Salerno, Italy
⁷Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
⁸Dept. of Hematology-Oncology, Ospedale Moscati, Taranto, Italy
⁹UOC di Ematologia, Azienda Ospedaliero-Universitaria Policlinico “P. Giaccone”, Palermo, Italy
¹⁰Hematology, S. Eugenio Hospital, Tor Vergata University, ASL Roma2, Rome, Italy
¹¹Hematology, Department of Translational and Precision Medicine, Azienda Ospedaliera Policlinico Umberto I, Sapienza University of Rome, Rome, Italy
¹²Ematologia U, A.O.U. Città della Salute e della Scienza, Turin, Italy
¹³Hematology, A. Perrino Hospital, Brindisi, Italy
¹⁴Hematology and BMT Center, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
¹⁵Clinic of Hematology, Ospedali Riuniti di Ancona, Ancona, Italy
¹⁶Department of Haematology and Bone Marrow Transplantation, “Card. G. Panico” Hospital, Tricase, Italy, Tricase, Italy
¹⁷Department of Medicine, Section of Hematology, University of Verona and Azienda Ospedaliera Universitaria Integrata, Verona, Italy
¹⁸Division of Hematology and Bone Marrow Transplantation, Department of Medicine and Surgery University of Naples Federico II, Napoli, Italy
¹⁹U.O.C. Ematologia Ospedale san Bortolo, Vicenza, Italy
²⁰U.O. Oncoematologia, Presidio Ospedaliero Andrea Tortora - ASL Salerno, Salerno, Italy
²¹Divisione di Oncologia, ASST Fatebenefratelli Sacco, Milano, Italy
²²Divisione di Ematologia adulti e Unità trapianto di midollo ASST Monza Azienda Ospedaliera San Gerardo, Monza, Italy
²³UOC Ematologia, Dipartimento Oncologico- ARNAS Garibaldi, Catania, Italy
²⁴Oncoematologia , AO S Maria di Terni - Università degli Studi di Perugia, Perugia, Italy
²⁵U.O. Ematologia, Presidio Ospedaliero Vito Fazzi ASL, Lecce, Italy
²⁶Hematology Unit, Department of Hemato-Oncology and Radiotherapy,Grande Ospedale Metropolitano "Bianchi-Melacrino-Morelli", Reggio Calabria, Italy
²⁷Section of Hematology, Department of Medicine and Surgery, Center for Hemato-Oncological Research (CREO), University of Perugia, Perugia, Italy
²⁸Clinica Ematologica, Az.Osped.-Universit.Santa Maria della Misericordia di Udine, Udine, Italy
²⁹Hematology and Clinical Immunology Unit, Department of Medicine, Padua University Hospital, Padova, Italy
³⁰Divisione di Ematologia, Azienda Ospedaliera di Rilievo Nazionale A. Cardarelli, Napoli, Italy
³¹Department of Medicine and Aging Sciences, University of Chieti-Pescara, Pescara, Italy
³²S.C Ematologia e CTMO, A O Brotzu Osp Onc Armando Businco Centro Rif Onc Reg, Cagliari, Italy
³³Unità di Ematologia, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
³⁴U.O.C. Ematologia, Az.Ospe.Universitaria Policlinico G. Martino Univ di Messina, Messina, Italy
³⁵Ematologia, Az Ospedaliera SG Moscati, Avellino, Italy
³⁶Unità Operativa Complessa di Ematologia, Pres.Ospedaliero S.Maria di Ca' Foncello, Treviso, Italy
³⁷Sezione di Ematologia, Università Cattolica, Fondazione Policlinico A. Gemelli IRCCS, Roma, Italy
³⁸Ematologia e Centro Trapianti, Dipartimento di Oncologia-Ematologia, Presidio U.Ospedaliero di Piacenza AUSL Piacenza, Piacenza, Italy
³⁹S.C. Ematologia, Azienda Ospedaliera S Giovanni Addolorata, Roma, Italy
⁴⁰Ematologia, Az Osp Univ Ferrara Arcispedale S Anna Univ. degli Studi Ferrara, Ferrara, Italy
⁴¹UOC Ematologia, Az. Osp. Univ Policlinico, Bari, Bari, Italy
⁴²Novartis Farma S.p.A., Origgio, Italy
⁴³Università degli Studi dell'Insubria, Ospedale di Circolo - ASST Sette Laghi, Varese, Italy
⁴⁴IRCCS Azienda Ospedaliero-Universitaria S. Orsola-Malpighi, Bologna, Istituto di Ematologia "Seràgnoli, Bologna, Italy

Roberto Latagliata, MD^1*, Alessandro Andriani^2*, Massimo Breccia, MD^3*, Ida Carmosino, MD^4*, Federico Vozella, MD^5*, Atelda Romano, MD^6*, Annalisa Biagi, MD^7*, Luca Maurillo, MD^8*, Malgorzata Monika Trawinska, MD^9*, Katia Paciaroni, MD^10*, Michelina Santopietro, MD^11*, Sabrina Leonetti Crescenzi, MD^12*, Ada D'Addosio, MD^13*, Caterina Tatarelli, MD, PhD^14*, Elisabetta Abruzzese, MD¹⁵, Ambra Di Veroli, MD^1*, Elena Rossi, MD, PhD^16*, Valerio De Stefano, MD^16* and Marco Montanaro, MD^17*

¹Hematology, Belcolle Hospital, Viterbo, Italy
²Latial Group for the Study of Myeloproliferative Neoplasms, Rome, Italy
³Division of Hematology, Department of Translational and Precision Medicine, Azienda Policlinico Umberto I, Sapienza University, Rome, Italy
⁴Hematology, Department of Translational and Precision Medicine, Azienda Ospedaliera Policlinico Umberto I, Sapienza University of Rome, Rome, Italy
⁵Hematology and Stem cell transplantation, Campus Biomedico University, Rome, Italy
⁶Hematology, Istituto Nazionale Tumori Regina Elena - IFO, Rome, Italy
⁷Hematology, Santa Maria Goretti Hospital – Polo Pontino “Sapienza” University, Latina, Italy
⁸Department of Onco-Hematology, Policlinico Tor Vergata, Rome, Rome, Italy
⁹Hematology S. Eugenio Hospital, ASL RM2, Rome, Italy
¹⁰UOSD Hematology, ASL RM1, Rome, Italy
¹¹U.O. di Ematologia e Trapianti di cellule Staminali. A.O.S. S. Camillo-Forlanini, Rome, Italy
¹²S.C. Ematologia, Azienda Ospedaliera S Giovanni Addolorata, Roma, Italy
¹³Hematology, Villa San Pietro Hospital, Rome, Italy
¹⁴Hematology, Sant'Andrea Hospital - University Sapienza of Rome, Roma, ITA
¹⁵Department of Hematology S. Eugenio Hospital, Rome, Italy
¹⁶Section of Hematology, Department of Radiological and Hematological Sciences, Catholic University, Fondazione Policlinico A Gemelli, IRCCS, Rome, Italy
¹⁷Hematology, Belcolle Hospital, Viterbo, ITA

Chen Zhang, MD¹, Douglas Tremblay, MD², John Magnotti, PhD^1,3*, Lukas Ronner, MD MSCR⁴, Nikolai A. Podoltsev, MD, PhD⁵, Jason Gotlib, MD, MS⁶, Mark L. Heaney, MD⁷, Andrew Kuykendall, MD⁸, Casey L. O'Connell, MD⁹, Angela G Fleischman, MD, PhD¹⁰, Ruben Mesa, MD, FACP¹¹, Abdulraheem Yacoub, MD¹², John Mascarenhas, MD¹³ and Jamile M. Shammo, MD¹⁴

¹Rush University Graduate College, Chicago, IL
²Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
³Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA
⁴Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
⁵Yale School of Medicine, New Haven, CT
⁶Stanford Cancer Center, Stanford, CA
⁷Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY
⁸Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁹Jane Anne Nohl Division of Hematology, Keck School of Medicine of the University of Southern California, Los Angeles, CA
¹⁰University of California, Irvine, Irvine, CA
¹¹Mays Cancer Institute, UT Health San Antonio MD Anderson, San Antonio, TX
¹²The University of Kansas Cancer Center, Leawood, KS
¹³Department of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
¹⁴Division of Hematology/Oncology, Rush University Medical Center, Chicago, IL

Justin Watts, MD^1*, Anthony M. Hunter, MD^2*, Alessandra Iurlo, MD, PhD^3*, Blanca Xicoy, MD^4*, Francesca Palandri, PhD, MD^5*, Brandi Reeves, MD⁶, Alessandro M. Vannucchi, MD^7*, Xuejun Chen, PhD^8*, Francis Seguy, MSc^9*, Feng Zhou, PhD^8*, Fred Zheng, MD^8* and Pankit Vachhani, MD^10*

¹Sylvester Cancer Center, University of Miami, Miami, FL
²Emory University School of Medicine, Atlanta, GA
³Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
⁴HU German Trias i Pujol - Institut Català d' Oncologia, Barcelona, Spain
⁵IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy
⁶University of North Carolina School of Medicine, Chapel Hill, NC
⁷AOU Careggi, University of Florence, Florence, Italy
⁸Incyte Corporation, Wilmington, DE
⁹Incyte Biosciences International Sàrl, Morges, Switzerland
¹⁰O'Neal Comprehensive Cancer Center at UAB, Birmingham, AL

Andreas Schmidt, MD^1*, Christiane Bernhardt, MD^2*, Anette Fries, MD^3*, Kathleen Jentsch-Ulrich, MD^4*, Andreas Josting^5*, Stephan Kreher, MD^6*, Marcel Reiser^7*, H. Tilman Steinmetz, MD^8*, Hans Tesch, MD^9*, Bernhard Kaufmann, PhD^10*, Uta Rager, MPH^11*, Carl C. Crodel, MD^12*, Francesca Palandri, PhD, MD^13* and Florian H. Heidel, MD¹⁴

¹Internal Medicine C, University Medicine Greifswald, Greifswald, Germany
²Gemeinschaftspraxis Hämatologie udn Onkologie Dortmund, Dortmund, Germany
³Onkologische Schwerpunktpraxis Bamberg, Bamberg, Germany
⁴Gemeinschaftspraxis Hämatologie und Onkologie Magdeburg, Magdeburg, Germany
⁵Praxis OnkoBer internistische Facharztpraxis, Berlin, Germany
⁶Hämatologisch-Onkologische Schwerpunktpraxis Bad Liebenwerda, Bad Liebenwerda, Germany
⁷PIOH Center, Cologne, Germany
⁸MV-Center for Hematology and Oncology, Cologne, Germany
⁹Onkologie Bethanien Frankfurt, Frankfurt a.M., Germany
¹⁰Novartis Pharma GmbH, Nuernberg, DEU
¹¹Novartis Pharma GmbH, Nürnberg, Germany
¹²Abteilung Hämatologie/Onkologie, Universitätsklinikum Jena, Jena, Germany
¹³IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy
¹⁴Innere Medicin C, Universitätsmedizin Greifswald, Greifswald, Germany

Audrey Desilets, MD^1,2*, Michael Harnois^3*, Lambert Busque, MD^2,3,4 and Natasha Szuber, MD, MSc^2,3,4

¹Department of Medicine, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada
²University of Montreal, Montreal, QC, Canada
³Groupe Québécois de Recherche en LMC-NMP/Chronic Myeloid Leukemia and Myeloproliferative Neoplasms Quebec Research Group (GQR LMC-NMP), Montreal, QC, Canada
⁴Department of Hematology, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada

Claire N. Harrison, DM¹, Shuh Ying Tan, MBBS^2*, David M Ross, MBBS, PhD, FRACP, FRCPA^3*, George Kannourakis, MB.BS, B(Med)Sci, PhD, FRACP⁴, Allie McGinty^5*, Wei Feng, PhD^5*, Ying Jiang, PhD^5*, Christine Graham, PhD^6*, Chris Rovaldi, MSc^5*, Simon Cooper, MBBS^5* and Jen L. Salstrom, MD, PhD⁵

¹Guy's and St Thomas' NHS Foundation Trust, London, ENG, United Kingdom
²St Vincent’s Hospital Melbourne, Fitzroy, VIC, Australia
³Department of Haematology, Flinders Medical Centre and University, Adelaide, SA, Australia
⁴Fiona Elsey Cancer Research Institute and Federation University Australia, Ballarat, Australia
⁵Keros Therapeutics, Lexington, MA
⁶Keros Therapeutics, Haverhill, MA

Rimal Ilyas, MBBS^1*, Kristen McCullough, PharmD², Talha Badar, MD³, Mrinal M. M. Patnaik, MD, MBBS⁴, Hassan B. Alkhateeb, MD^4*, Abhishek A. Mangaonkar, MBBS⁴, Animesh Pardanani, MBBS, PhD ⁴, Ayalew Tefferi, MD⁴ and Naseema Gangat, MBBS⁴

¹Mayo Clinic, Rochester, MN
²Division of Pharmacology, Mayo Clinic, Rochester, MN
³Division of Hematology and Oncology, Mayo Clinic Florida, Jacksonville, FL
⁴Division of Hematology, Mayo Clinic, Rochester, MN

Oni Chowdhury¹, Sophie Reed, BSc^1*, Alison Telford, PhD^2*, Adriana Roca-Fernandez, BSc MA^2*, Samiya Mahmood^3*, Soubera Rymell^2*, Michael Smith^3*, Antonella Sultana^3*, Nicole Eichert, PhD^2*, Michele Pansini, MD^2*, Helena Thomaides-Brears, PhD^2*, Bethan Psaila, MD, PhD¹ and Adam J Mead, MD PhD¹

¹Medical Research Council Weatherall Institute of Molecular Medicine and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
²Perspectum Ltd, Oxford, United Kingdom
³Cancer and Haematology Centre, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom

Ming-Chung Kuo, M.D.^1*, Chien-Chin Lin, MD, PhD^2*, Hsuan-Yu Lin, M.D.^3*, Jyh-Pyng Gau, MD^4*, Ming-Chung Wang, MD^5*, Ming-Chih Chang, M.D.^6*, Tsung-Chih Chen^7*, Shih-Peng Yeh, MD^8*, Yeu-Chin Chen Sr., MD⁹, Cih-En Huang, MD^10*, I-Ju Chiang, MA^11*, Chu-Han Chung^12*, Yee-Ming Lee, PhD¹³, Fan-Chen Ku, M.D.^13* and Cheng-Shyong Chang, MD^14*

¹Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan
²Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan
³Changhua Christian Hospital, Changhua, Taiwan
⁴Taipei Veterans General Hospital, Taipei, Taiwan
⁵Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
⁶Mackay Memorial Hospital, Taipei, Taiwan
⁷Taichung Veterans General Hospital, Taichung, TWN
⁸Medical University Hospital, Taichung, Taiwan
⁹Division of Hematology/Oncology, Department of Internal Medicine, Tri-Service General Hospital (TSGH), Taipei, Taipei (City), Taiwan
¹⁰Division of Hematology and Oncology, Department of Medicine, Chang Gung Memorial Hospital at Chiayi, Chiayi, Taiwan
¹¹Novartis (Taiwan) Co. Ltd, Taipei, TWN
¹²Novartis (Taiwan) Co. Ltd, Taipei, Taiwan
¹³Novartis (Taiwan) Co. Ltd., Taipei, Taiwan
¹⁴Changhua Christian Hospital, Changhua City, Taiwan

Fabrizio Cavalca^1,2*, Francesca Palandri, PhD, MD^3,4*, Novella Pugliese, MD^5*, Alessia Ripamonti, MD^1,6*, Ambra Di Veroli, MD^7*, Mattia Biondo, MD^8,9*, Carlo Gambacorti-Passerini, MD^10,11, Roberto Latagliata, MD^12* and Elena Maria Elli, MD^13*

¹Università degli Studi di Milano-Bicocca, Milano, Italy
²Hematology Division and Bone Marrow Transplant Unit, San Gerardo Hospital, ASST Monza, Monza, Italy
³IRCCS Azienda Ospedaliero-Universitaria S. Orsola-Malpighi, Bologna, Istituto di Ematologia "Seràgnoli, Bologna, Italy
⁴Department of Hematology/Oncology, Seràgnoli Institute of Hematology, Bologna University School of Medicine, Bologna, Italy
⁵Hematology - Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy
⁶Hematology Division and Bone Marrow Unit, San Gerardo Hospital, ASST Monza, Monza, Italy., Monza, Italy
⁷Hematology, Belcolle Hospital, Viterbo, Italy
⁸IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
⁹Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università di Bologna, Bologna, Italy
¹⁰Dept of Medicine and Surgery, University of Milano Bicocca, Monza, MB, Italy
¹¹University of Milano-Bicocca, Milan, Italy
¹²Haematology Division, Ospedale Belcolle, Viterbo, Italy, Viterbo, ITA
¹³Hematology Division, Ospedale San Gerardo - ASST Monza, Monza, Italy

Raphael Costa Bandeira de Melo, MD^1*, Tania Rubia Rocha^2*, Alexandre Eiji Kayano^1*, Guilherme Souza Villar Cassimiro Fonseca^2*, Vanderson Rocha, Prof, MD, PhD^1,2*, Wellington F Silva Jr., MD PhD¹ and Fernanda S Seguro, MD^1,2*

¹Instituto do Cancer do Estado de Sao Paulo da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
²Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil

Giuseppe Gaetano Loscocco, MD^1*, Raffaella Santi, MD^2*, Carmela Mannarelli, PhD^1*, Francesco Mannelli, MD^1*, Francesca Gesullo, BSci^1*, Giacomo Coltro, MD^1*, Paola Guglielmelli, MD, PhD¹, Umberto Gianelli, MD^3* and Alessandro Maria Vannucchi, MD⁴

¹CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, University of Florence, AOU Careggi, Florence, Italy
²Hemopathology Unit, AOU Careggi, University of Florence, Florence, Italy
³Pathology Unit, ASST Santi Paolo e Carlo, University of Milan, Milan, Italy
⁴University of Florence, Firenze, Italy

Kristen M. Pettit¹, Harinder Gill, MD, MBBS, FRCP, FRCPath², Abdulraheem Yacoub, MD³, Terrence Bradley, MD⁴, Aaron T. Gerds, MD, MS⁵, Maciej Tatarczuch, BMBS⁶, Jake Shortt, FRACP, FRCPA, PhD⁷, Natasha Joan Curtin, MD, FRACP, FRCPA^8*, James M. Rossetti, DO⁹, Kate Burbury, MBBS, FRACP, FRCPA, DPhil^10*, Adam J Mead, MD PhD¹¹, Joachim R Göthert, MD¹², Steffen Koschmieder¹³, Matt Reyer, PhD^14*, Benjamin Siranosian, PhD^14*, Georges Natsoulis, Ph.D.^14*, William S Stevenson, MBBS, PhD, FRACP, FRCPA¹⁵, Joanne Ewing, MD, PhD^16*, Joseph M. Chacko, MD, MBBS, BSc, FRCP, FRCPath¹⁷, Elisa Rumi^18*, Anna B. Halpern, MD¹⁹, Francesca Palandri, PhD, MD^20*, Nicola Vianelli, MD^21*, Francesco Passamonti, MD^22*, Ruben Mesa, MD, FACP²³, Monia Marchetti^24*, Claire N. Harrison, DM²⁵, Alessandro M. Vannucchi²⁶, Justin Watts, MD²⁷, David M Ross, MBBS, PhD, FRACP, FRCPA^28*, Moshe Talpaz, MD²⁹ and Hugh Young Rienhoff Jr., MD¹⁴

¹Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI
²Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong
³The University of Kansas Cancer Center, Leawood, KS
⁴University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL
⁵Department of Hematology and Medical Oncology,, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
⁶Monash Health, Melbourne, Australia
⁷School of Clinical Sciences at Monash Health, Peter MacCallum Cancer Centre, Clayton, VIC, Australia
⁸Monash Health, Monash University, Melbourne, Australia
⁹UPMC Hillman Cancer Center, Pittsburgh, PA
¹⁰Peter MacCallum Cancer Centre, Melbourne, Australia
¹¹Medical Research Council Weatherall Institute of Molecular Medicine and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
¹²Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
¹³Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, University Hospital of Aachen, Aachen, Germany
¹⁴Imago BioSciences, San Carlos, CA
¹⁵Department of Haematology, Royal North Shore Hospital, Sydney, NSW, Australia
¹⁶University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
¹⁷The Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust, Bournemouth, United Kingdom
¹⁸Department of Molecular Medicine, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
¹⁹Department of Medicine, University of Washington, Seattle, WA
²⁰IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy
²¹Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology L. e A. Seragnoli, Hematology, Bologna, Italy
²²Hematology, Università Degli Studi Dell'Insubria, Varese, VA, Italy
²³Mays Cancer Center at UT Health San Antonio, San Antonio, TX
²⁴Hematology Unit & TMO Center, AO SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
²⁵Guy's and St Thomas' NHS Foundation Trust, London, ENG, United Kingdom
²⁶CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, University of Florence, Firenze, Italy
²⁷Sylvester Comprehensive Cancer Center, University of Miami, Coral Gables, FL
²⁸Department of Haematology, Flinders Medical Centre and University, Adelaide, SA, Australia
²⁹University of Michigan Comprehensive Cancer Center, Ann Arbor, MI

Alexandros Rampotas, MRCP, PGDip^1*, Luke Carter-Brzezinski, MBChB^2*, Tim C.P Somervaille, PhD FRCP FRCPath², James Forryan^1*, Bethan Psaila, MD, PhD³, Adam J Mead, MD PhD³, Mamta Garg, MD, FRCP, FRCPath^4*, Heather Laing^4*, Louise Wallis^5*, Nauman M Butt, MBChB, MRCP(UK), FRCPath, MD^6*, Conal McConville^7*, Ali Sahra^8*, Andrew McGregor^9*, Hannah Cowan^10*, Andrew J. Innes, PhD, FRCPath, MRCP^11*, Joanne Ewing^12*, Matthew Carter^13*, Peter Dyer^14*, Chun Huat Teh^15*, Sebastian Francis, MBChB, FRCPath, MD^16*, Frances Wadelin, MB ChB, PhD, FRCPath^17*, Claire N. Harrison, DM¹⁰, Anna L Godfrey, BMBCh, PhD^13*, Elizabeth Kulakov^18*, Donal P. McLornan, MD, PhD^1,19* and Jonathan Lambert, BmedSci, PhD, FRCP, FRCPath^1*

¹Haematology Department, University College London Hospitals NHS Foundation Trust, London, United Kingdom
²Haematology Department, The Christie Hospital NHS Foundation Trust, Manchester, United Kingdom
³Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
⁴Haematology Department, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom
⁵Haematology Department, University Hospitals Dorset NHS Foundation Trust, Bournemouth, United Kingdom
⁶The Clatterbridge Cancer Centre, Bebington, United Kingdom
⁷Haematology Department, Belfast Health & Social Care Trust, Belfast, United Kingdom
⁸Haematology Department, King's College Hospital NHS Foundation Trust, London, United Kingdom
⁹Haematology Department, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, United Kingdom
¹⁰Haematology Department, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
¹¹Haematology Department, Imperial College Healthcare NHS Trust, London, United Kingdom
¹²Haematology Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
¹³Haematology Department, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom
¹⁴Haematology Department, University hospitals of North Midlands, Stoke, United Kingdom
¹⁵Haematology Department, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
¹⁶Haematology Department, Sheffield Teaching Hospitals NHS trust, Sheffield, United Kingdom
¹⁷Haematology Department, Nottingham University Hospital, Nottingham, United Kingdom
¹⁸Dermatology Department, University College London Hospitals, London, United Kingdom
¹⁹Haematology Department, Guy's and St Thomas' NHS Trust, London, United Kingdom

James T. England, MD¹, Eshetu G. Atenafu, M.Sc., P.Stat^2*, James A. Kennedy, MD, PhD³, Burhan Goraya^1*, Verna Cheung, RN BScN MN^1*, Taylor Nye, RN MN^1*, Karine Gauthier, MD¹, Marta B. Davidson, MD, PhD⁴, Aniket Bankar, MBBS, MD, DM⁴, Hassan Sibai, MBBS, MD^1*, Dawn Maze, MD, FRCPC, MSc⁴, Auro Viswabandya⁵ and Vikas Gupta, MD, FRCP, FRCPath¹

¹Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
²Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
³Sunnybrook Health Sciences Centre, Toronto, ON, Canada
⁴Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁵Hans Messner Allogeneic Transplant Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada

Francesca Palandri, PhD, MD^1*, Elena Maria Elli, MD^2*, Alessandra Iurlo, MD, PhD^3*, Giuseppe Auteri, MD^4,5*, Malgorzata Monika Trawinska, MD^6*, Massimiliano Bonifacio, MD^7*, Francesco Mendicino^8*, Roberto Latagliata, MD^9*, Camilla Mazzoni, MD^4,5*, Mattia Biondo, MD^4,5*, Valentina Sangiorgio, MD^2*, Daniele Cattaneo, MD^3*, Edoardo Tamellini, MD^7*, Elisabetta Abruzzese, MD¹⁰, Mauro Krampera, MD, PhD^7*, Stefana Impera, MD^11*, Bruno Garibaldi, MD^12*, Simona Paglia, PhD^5*, Daniela Bartoletti, MSc^5*, Nicola Vianelli, MD^5*, Michele Cavo, MD^4,5*, Florian H. Heidel, MD¹³, Massimo Breccia^14*, Giovanni Caocci, MD¹⁵ and Giuseppe A. Palumbo^12*

¹IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy
²Hematology Division, Ospedale San Gerardo - ASST Monza, Monza, Italy
³Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
⁴Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università di Bologna, Bologna, Italy
⁵IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
⁶Hematology, S. Eugenio Hospital, Tor Vergata University, ASL Roma2, Rome, Italy
⁷Department of Medicine, Section of Hematology, University of Verona, Verona, Italy
⁸Hematology Unit, Department of Hemato-Oncology, Ospedale Annunziata, Cosenza, Italy
⁹Haematology Division, Ospedale Belcolle, Viterbo, Italy, Viterbo, ITA
¹⁰Hematology, S. Eugenio Hospital, Tor Vergata University, ASL Roma2, Roma, I, Italy
¹¹Division of Hematology, ARNAS Garibaldi-Nesina, Catania, Italy
¹²Dipartimento di Scienze Mediche Chirurgiche e Tecnologie Avanzate "G.F. Ingrassia", Unità Operativa di Ematologia con TMO AOU "Policlinico - San Marco", Università degli Studi di Catania, Catania, Italy
¹³Innere Medicin C, Universitätsmedizin Greifswald, Greifswald, Germany
¹⁴A.O.U. Policlinico Umberto I, Università degli Studi di Roma "La Sapienza", Rome, Italy
¹⁵Hematology Unit, Businco Hospital, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy

Orly Leiva, MD¹, Emaad Siddiqui, MD^2*, Gabriela S. Hobbs, MD³ and Sripal Bangalore, MD^1*

¹Division of Cardiovascular Medicine, Department of Medicine, New York University Grossman School of Medicine, New York City, NY
²New York University Grossman School of Medicine, New York City, NY
³Cancer Center, Massachusetts General Hospital, Boston, MA

Yuhui Zhang^1*, Yingdi Han^1*, Guangshuai Teng^1*, Chenxiao Du^1*, Shan Gao^2*, Weiping Yuan, PhD, MD³, Lei Zhang, MD, PhD^4* and Jie Bai, MD¹

¹Department of Hematology, The Second Hospital of Tianjin Medical University, Tianjin, China
²Second Hospital of Tianjin Medical University, tianjin, China
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem,Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, China

Aldo A. Acosta Medina, MD¹, Saurabh Zanwar², Gordon Ruan, MD^2*, Jithma P. Abeykoon, MD², Karen Rech, MD^3*, Aishwarya Ravindran, MBBS⁴, N. Nora Nora Bennani, MD², Caroline J Davidge-Pitts, MBBCh^5*, Matthew Koster, MD^6*, Jay Ryu, MD^7*, Mithun V. Shah, MD, PhD², W. Oliver Tobin, MB BCh^8*, Robert Vassallo, MD^7*, Jason R. Young, MD^9*, Gaurav Goyal, MD^10,11 and Ronald Go, MD²

¹Department of Internal Medicine, Mayo Clinic, Rochester, MN
²Division of Hematology, Mayo Clinic, Rochester, MN
³Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁴Division of Laboratory Medicine, University of Alabama at Birmingham, Birmingham, AL
⁵Division of Endocrinology and Metabolism, Mayo Clinic, Rochester, MN
⁶Division of Rheumatology, Mayo Clinic, Rochester, MN
⁷Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN
⁸Department of Neurology, Mayo Clinic, Rochester, MN
⁹Department of Radiology, Mayo Clinic, Jacksonville, FL
¹⁰Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL
¹¹Research Collaborator (limited-tenure), Division of Hematology, Mayo Clinic, Birmingham, AL

Maymona Abdelmagid^1*, Aref Al-Kali, MD², Kebede H. Begna, MD³, William J. Hogan, MB, BCh², Mark R. Litzow, MD², Abhishek A. Mangaonkar, MBBS², Mrinal M. M. Patnaik, MD, MBBS², Michelle A Elliott, MD², Hassan B. Alkhateeb, MD^2*, Min Shi, MD, PhD⁴, Matthew Howard, MD^5*, Kaaren K. Reichard, MD^4*, Rhett P. Ketterling, MD^4*, Animesh Pardanani, MBBS, PhD ², Naseema Gangat, MBBS² and Ayalew Tefferi, MD²

¹Mayo Clinic, Rochester, MN
²Division of Hematology, Mayo Clinic, Rochester, MN
³Divison of Hematology, Mayo Clinic, Rochester, MN
⁴Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁵Mayo Clinic, Rochester

Barbara Mora, MD^1,2*, Giacomo Pellegrini, MSc^1*, Matteo Franchi, PhD^3,4*, Margherita Maffioli, MD^1*, Marco Brociner, MD^1*, Paola Guglielmelli, MD, PhD⁵, Maria Teresa Voso, MD⁶, Tiziana Ottone, PhD^6*, Marta Ubezio, MD^7*, Giulia Maggioni, MD^7*, Michele Merli, MD^1*, Alessandro M. Vannucchi⁵, Matteo G. Della Porta, MD^7,8*, Giovanni Corrao, PhD^3,4* and Francesco Passamonti, MD^1,2*

¹Hematology, Ospedale di Circolo e Fondazione Macchi, ASST Sette Laghi, Varese, Italy
²Department of Medicine and Surgery, University of Insubria, Varese, Italy
³National Center for Healthcare Research and Pharmacoepidemiology, University of Milano-Bicocca, Milan, Italy
⁴Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy
⁵CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, University of Florence, AOU Careggi, Florence, Italy
⁶Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
⁷Cancer Center, IRCCS Humanitas Research Hospital & Humanitas University, Rozzano, Italy
⁸Department of Biomedical Sciences, Humanitas University, Milan, Italy