Garima Pandey^*, Nathan Horvat^*, Narmin E. Amin^*, Guolin Zhang^*, Lucia Mazzacurati^*, Afua A. Akuffo^*, Christelle Colin-Leitzinger^*, Eric B. Haura^*, Pearlie K. Epling-Burnette^* and Gary W. Reuther, PhD

Moffitt Cancer Center, Tampa, FL

Frederike Kramer, PhD¹, Anna E Marneth, PhD¹, Olga Pozdnyakova, MD, PhD^2*, Jessica Hem^1*, Malvina Papanastasiou, PhD^3*, Andrew Reiter^3*, Steven A Carr, PhD^4* and Ann Mullally, MD^1,5,6

¹Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
²Department of Pathology, Brigham and Women's Hospital, Boston, MA
³Broad Institute of MIT and Harvard, Cambridge, MA
⁴Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA
⁵Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁶Broad Institute, Cambridge, MA

Gu Wenjing, MD^1*, Jingyuan Tong^1*, Rongfeng Fu, MD^2*, Lihong Shi^1* and Lei Zhang, MD^3*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²CAMS Key Laboratory of Gene Therapy for Blood Diseases, Tianjin Key Laboratory of Gene Therapy for Blood Diseases, Tianjin, China
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, China

Marc Usart^1*, Cédric B. Stoll^2*, Riikka Karjalainen^2*, Hui Hao-Shen^2* and Radek C. Skoda²

¹Department of Biomedicine, Experimental Hematology, University Hospital Basel and University of Basel, Basel, Basel-Stadt, Switzerland
²Department of Biomedicine, Experimental Hematology, University Hospital Basel and University of Basel, Basel, Switzerland

Meenu Kesarwani^1*, Mohammad Azhar, PhD^2*, Zachary Kincaid, BS^3* and Mohammad Azam, PhD⁴

¹Cincinnati Childrens Hospital Medical Center, Mason, OH
²Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Cincinnati Childrens Hospital Medical Center, Cincinnati, OH
⁴CBDI, Cincinnati Children's Hospital, Cincinnati, OH

Rebecca Austin^1,2,3*, Madeline Kowalski, MS^3,4,5*, Xiaoli Wang, PhD^6*, Bettina Nadorp, PhD^7,8,9*, Audrey Lasry, PhD^1,2*, Zhengxi Sun, M.Phil^1,2*, Julia Rojo-Tomillo^1,2*, Andrew Davis, MS^6*, Dimitrios Papaioannou, MD^1,2*, Rahul Satija, PhD^4,5,10*, Ioannis Aifantis, PhD^1,2* and Ronald Hoffman, MD⁶

¹Department of Pathology, NYU Grossman School of Medicine, New York, NY
²Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY
³Equal contribution, #
⁴Institute for Systemics Genetics, NYU Grossman School of Medicine, New York, NY
⁵New York Genome Center, New York, NY
⁶Division of Hematology/Medical Oncology, Tisch Cancer Institute, Ichan School of Medicine at Mount Sinai, New York, NY
⁷Applied Bioinformatics Laboratories, NYU Grossman School of Medicine, New York, NY
⁸Department of Pathology, New York University School of Medicine, New York, NY
⁹Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY
¹⁰Center for Genomics and Systems Biology, New York University, New York

Niccolò Bartalucci, PhD, BSc^1*, Laura Calabresi, PhD^1*, Manjola Balliu, PhD^1*, Danilo Tarantino, PhD^1*, Simone Romagnoli, PhD^1*, Alessio Enderti^1*, Francesca Arciprete^2*, Maria Zingariello, PhD^2*, Christian A Di Buduo, PhD^3*, Alessandra Balduini^4*, Anna Rita Migliaccio, PhD⁵, Paola Guglielmelli, MD, PhD⁶ and Alessandro M Vannucchi, MD¹

¹CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, University of Florence, AOU Careggi, Florence, Italy
²Unit of Microscopic and Ultrastructural Anatomy, Dept of Medicine, University Campus Bio-Medico Roma, Rome, Italy
³Department of Molecular Medicine, University of Pavia, Pavia, Italy
⁴University of Pavia, Pavia, Italy
⁵Medicine and Surgery, University Campus Bio-Medico, Rome, Italy
⁶CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, University of Florence, AOU Careggi, Florence, Italy

Ho-Jae Han, PhD^1*, Hyeok-Jae Jang^1*, Youngseok Yoo^2*, Taehyung Simon Kim^2*, Jong-Won Kim, MD, PhD^3* and Dennis Dong Hwan Kim, MD, PhD⁴

¹Samsung Medical Center, Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Korea, Republic of (South)
²Princess Margaret Cancer Centre, Toronto, ON, Canada
³Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KOR
⁴Department of Medical Oncology & Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada

Guadalupe Rojas Sanchez, Ph D^1*, Orlando Esparza, MD², Brandon McMahon, MD³, Giovanny Hernandez, BS^4*, Dennis Le, BS^1*, Travis Nemkov, PhD^5*, Angelo D'Alessandro, PhD⁶, Andrew Thorburn, Ph D^7*, José A. López, MD⁸ and Pavel Davizon-Castillo, MD^1*

¹University of Colorado - Pediatric Hematology/Oncology/BMT, Aurora, CO
²Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantation, University of Colorado Anschutz Medical Campus, Denver, CO
³Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora, CO
⁴Department of Pediatrics Hematology/Oncology and Bone Marrow Transplantation, University of Colorado Anschutz Medical Campus, Aurora, CO
⁵University of Colorado Anschutz Medical Campus, University, Aurora, CO
⁶Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO
⁷University of Colorado Anschutz Medical Center, Department of Pharmacology, Aurora, CO
⁸Bloodworks Northwest Research Institute, Seattle, WA

John Mascarenhas, MD¹, Aaron T. Gerds, MD, MS², Jean-Jacques Kiladjian, MD³, Konstanze Döhner, MD⁴, Sarah Buckley, MD^5*, Jennifer A. Smith, PhD^5*, Adam R Craig, MD, PhD⁵, Simran Bedi Singh^6*, Srdan Verstovsek, MD, PhD⁷ and Claire N. Harrison, DM⁸

¹Department of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
²Department of Hematology and Medical Oncology,, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
³Hopital Saint-Louis, Paris, France
⁴Ulm University Hospital, Ulm, Germany
⁵CTI BioPharma, Seattle, WA
⁶CTI Biopharma, Seattle, WA
⁷Leukemia Department, The University of Texas MD Anderson Cancer Center, Houston, TX
⁸Guy's and St Thomas' NHS Foundation Trust, London, ENG, United Kingdom

Raveen Stephen Stallon Illangeswaran, MSc^1*, Bharathi M Rajamani, M.Phil^1*, Esther Sathya Bama Benjamin, M.Tech^1*, Saswati Das, Msc^1*, Daniel Zechariah Paul Jebanesan, M.Tech^1*, Vikram Mathews, MD, DM¹, Shaji Ramachandran Velayudhan, PhD^1,2* and Poonkuzhali Balasubramanian, MSc, PhD¹

¹Department of Haematology, Christian Medical College, Vellore, India
²Centre for Stem Cell Research, Christian Medical College, Vellore, India

C. Matthias Wilk, MD^1*, Brooks Scull, MS^2*, Ryan Fleischmann, MS^2*, Tsz-Kwong Man, PhD^3*, Kenneth L. McClain, MD, PhD⁴, Miriam Merad, MD, PhD^5*, Florent Ginhoux, PhD^6* and Carl E. Allen, MD, PhD⁷

¹Precision Immunology Institute and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
²Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX
³Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, TX
⁴Texas Childrens Cancer and Hematology Centers, Houston, TX
⁵Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY
⁶Singapore Immunology Network ( SIgN), Agency for Science, Technology and Research ( A *STAR), Singapore, Singapore
⁷Division of Pediatric Hematology and Oncology, Baylor College of Medicine, Houston, TX

Ernesto J Cuenca^1,2*, Pedro J Guijarro-Carrillo, BSc^3*, María J López-Poveda, MD^4*, Paula Durán-Espin, BSc^3*, Eva Soler, MD^3*, María Luz Morales^3*, Maria Luisa Lozano, MD, PhD^1,3*, Alberto Alvarez-Larran, MD, PhD^5*, Nuria Garcia-Barbera, BSc^3*, Rocio Gonzalez-Conejero, PhD^3*, Constantino Martínez, PhD^3*, Raul Teruel Montoya, PhD^1,3* and Francisca Ferrer Marin, MD, PhD^1,3,6

¹CIBERER U-765, Murcia, Spain
²Centro Regional De HemodonacióN, Murcia, Spain
³Servicio de Hematología y Oncología Médica. H.U. Morales Meseguer. Centro Regional de Hemodonación. Universidad de Murcia. IMIB-Arrixaca, Murcia, Spain
⁴Servicio de Anatomía Patológica. H.U. Morales Meseguer, Murcia, Spain
⁵Hematology Department, Hospital Clínic, Barcelona, Spain
⁶UCAM, Murcia, Spain

Lara Tavernari^1*, Sebastiano Rontauroli^1*, Monica Maccaferri^2*, Barbara Mora^3*, Elia Venturelli^1*, Elisa Bianchi^1*, Sandra Parenti^1*, Elena Genovese^1*, Paola Guglielmelli, MD, PhD⁴, Chiara Carretta^1*, Margherita Mirabile^1*, Stefano Sartini^1*, Corrado Colasante^5*, Leonardo Potenza^5*, Francesco Passamonti, MD^3*, Enrico Tagliafico^5,6*, Mario Luppi^5*, Alessandro M. Vannucchi⁴ and Rossella Manfredini^1*

¹Centre for Regenerative Medicine "S. Ferrari", University of Modena and Reggio Emilia, Modena, Italy
²Department of Laboratory Medicine and Pathology, Diagnostic Hematology and Clinical Genomics, AUSL/AOU Policlinico, Modena, Italy
³Division of Hematology, Ospedale ASST Sette Laghi, University of Insubria, Varese, Italy
⁴Department of Experimental and Clinical Medicine, and Center Research and Innovation of Myeloproliferative Neoplasms (CRIMM), University of Florence, Careggi University Hospital, Florence, Italy
⁵Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, AOU Policlinico, Modena, Italy
⁶Center for Genome Research, University of Modena and Reggio Emilia, Modena, Italy

Yenny Moreno Vanegas, MD, BSc¹, Ahmad Nanaa, MD^2,3, Aref Al-Kali, MD⁴, Rong He, MD⁵, Hassan B. Alkhateeb, MD^4*, Mrinal M. M. Patnaik, MD⁴, Naseema Gangat, MBBS⁴, Mithun V. Shah, MD, PhD⁴, Mark R. Litzow, MD⁴, Ayalew Tefferi, MD⁴ and Talha Badar, MD⁶

¹Division of Hematology/Oncology and Blood and Marrow Transplanation and Cellular Therapy, Mayo Clinic, Jacksonville, FL
²Division of Hematology, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL
³Mayo Clinic/Rochester/Hematology, Mayo Clinic, ROCHESTER
⁴Division of Hematology, Mayo Clinic, Rochester, MN
⁵Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁶Division of Hematology and Oncology, Mayo Clinic Florida, Jacksonville, FL

Vibe Skov, PhD^1*, Mads Thomassen, PhD^2*, Lasse Kjær, PhD^1*, Morten Kranker Larsen, MSc^1*, Christina Ellervik, PhD^3,4,5,6*, Trine Alma Knudsen^1*, Torben A. Kruse^2* and Hans Carl Hasselbalch, MD¹

¹Department of Hematology, Zealand University Hospital, Roskilde, Denmark
²Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
³Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
⁴Department of Production, Research, and Innovation, Region Zealand, Sorø, MA, Denmark
⁵Department of Laboratory Medicine, Boston Children's Hospital, Boston, MA
⁶Department of Pathology, Harvard Medical School, Boston, MA

Ariel Monet Leyte-Vidal, B.S.^1* and Neil P. Shah, MD, PhD²

¹University of Miami, Miami, FL
²Department of Medicine/Hematology-Oncology, UCSF School of Medicine, San Francisco, CA