Lai N. Chan, PhD¹, Christian Hurtz, PhD², Mark E. Robinson, PhD^1*, Etienne Leveille, MD¹, Huimin Geng, PhD³, Rebecca Caeser, PhD^4*, Liang Xu, PhD^5*, Kohei Kume, PhD^6*, Gang Xiao, PhD^5* and Markus Müschen, MD¹

¹Center of Molecular and Cellular Oncology and Department of Immunobiology, Yale University, New Haven, CT
²Lewis Katz School of Medicine, Temple University, Philadelphia, PA
³Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA
⁴Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁵College of Life Sciences, Zhejiang University, Hangzhou, China
⁶Center of Molecular and Cellular Oncology and Department of Immunobiology, Yale University, Duarte, CA

Jan Zuna¹, Lenka Hovorkova^1*, Justina Krotka^1*, Amelie Koehrmann^2*, Michela Bardini^3*, Lucie Winkowska^1*, Eva Fronkova^1*, Julia Alten^2*, Rolf Koehler^4*, Cornelia Eckert, PhD^5*, Lisa Brizzolara^3*, Jan Stuchly^1*, Martin Zimmermann, PhD^6*, Paola De Lorenzo^7*, Maria Grazia Valsecchi, PhD^7*, Valentino Conter, MD^8*, Jan Stary, MD^9*, Martin Schrappe, MD¹⁰, Andrea Biondi, MD⁸, Jan Trka¹, Marketa Zaliova¹¹, Giovanni Cazzaniga, PhD^3,12* and Gunnar Cario^2*

¹CLIP, Dept. of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
²Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany, Kiel, Germany
³Tettamanti Research Center, Pediatrics, University of Milano-Bicocca / Fondazione Tettamanti, Monza, Italy
⁴Department of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany
⁵Charité-Universitätsmedizin Berlin, Berlin, Germany
⁶Department of Pediatric Hematology and Oncology, Medical School Hannover, Hannover, Germany
⁷EsPhALL Trial Data Center, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy
⁸Pediatric Hemato-Oncolgy, Fondazione MBBM/ASST-Monza, University of Milano-Bicocca, Monza, Italy
⁹Dept. of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
¹⁰University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany
¹¹CLIP - Childhood Leukemia Investigation Prague, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
¹²Medical Genetics, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy

Hayden L Bell, PhD^1*, Mankaran Singh, MSc^2*, Helen J Blair, PhD^2*, Olaf Heidenreich, PhD^3*, Frederik W. van Delft, MD, PhD^2*, Anthony V. Moorman⁴, John Lunec, PhD MRCR(Hon) FRCPath^5* and Julie Irving, PhD²

¹Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle-upon-Tyne, United Kingdom
²Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle upon Tyne, ENG, United Kingdom
³Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands
⁴Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle, United Kingdom
⁵Paul O'Gorman Building, Newcastle University, Newcastle upon Tyne, ENG, United Kingdom

Margot S.F. Roeten^1,2*, Johan van Meerloo^1,2*, Zinia Kwidama^1,2*, Gaye Jenkins^3*, Suzanne N. van Dijk^1,2*, David T. Teachey, MD⁴, Meenakshi Devidas, PhD, MBA⁵, Mignon L. Loh, MD⁶, Gertjan J.L. Kaspers, Prof. MD, PhD^7,8, Sonja Zweegman, MD, PhD^1,9, Gerrit Jansen, PhD^2,10*, Jacqueline Cloos, Prof^1,2* and Terzah M. Horton, MD, PhD³

¹Department of Hematology, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, Netherlands
²Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands
³Department of Pediatrics Baylor College of Medicine, Texas Children's Hospital, Houston, TX
⁴Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Rutledge, PA
⁵Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN
⁶Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of California Benioff Children’s Hospital, Seattle, WA
⁷Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
⁸Pediatric Oncology, Emma Children’s Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, Netherlands
⁹Cancer Biology and Immunology, Cancer Center Amsterdam, Amsterdam, Netherlands
¹⁰Amsterdam Rheumatology and Immunology Center, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, Netherlands

Zeljko Antic^1*, Alena van Bömmel, PhD^2*, Konstantin Riege, PhD^2*, Jana Lentes, MSc^1*, Charlotte Schröder, BSc^1*, Julia Alten^3*, Lara Fuhrmann, MD^1*, Martin Zimmermann, PhD^4*, Cornelia Eckert, PhD^5*, Gunnar Cario, MD, PhD^3*, Martin Schrappe, MD³, Brigitte Schlegelberger, MD¹, Steve Hoffmann, MD, PhD^6* and Anke K. Bergmann, MD^1*

¹Department of Human Genetics, Hannover Medical School (MHH), Hannover, Germany
²Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany
³Department of Pediatrics, Berlin-Frankfurt-Münster ALL Study Group Germany (BFM-G), University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany
⁴Department of Pediatric Hematology and Oncology, Hannover Medical School (MHH), Hannover, Germany
⁵Department of Pediatric Oncology and Hematology, Charité University Medical Center, Berlin, Germany
⁶Leibniz Institute on Ageing-Fritz Lipmann Institute (FLI), Jena, Germany

Yuta Katai^1*, Tatsuya Kamitori^2*, Hiroo Ueno^3*, Ryo Akazawa^2*, Kiyotaka Isobe^2*, Itaru Kato^2*, Toshihiko Imamura⁴, Katsuyoshi Koh^5*, Satoshi Saida^2* and Junko Takita^2*

¹Faculty of Medicine, Kyoto University, Kyoto-Shi, Japan
²Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
³Department of Pediatrics, Kyoto Katsura Hospital, Kyoto, Japan
⁴Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
⁵Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan

Louise Ahlgren, PhD^1*, Mattias Pilheden, PhD^1*, Helena Sturesson, PhD^1*, Varsha Singh, PhD^1*, Qirui Zhang, PhD^1*, Anders Castor, MD, PhD^2*, Cornelis Jan Pronk, MD, PhD^2*, Gisela Barbany, MD, PhD^3*, Katja Pokrovskaja Tamm, PhD^4*, Linda Fogelstrand, MD PhD⁵, Michael P Walsh, PhD^6*, Guangchun Song^6*, Jinghui Zhang, PhD^7*, Jing Ma, PhD^6* and Anna Hagstroem-Andersson, PhD^1,8

¹Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden
²Childhood Cancer Center, Skane University Hospital, Lund, SWE
³Department of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, Sweden
⁴Department of Oncology and Pathology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
⁵Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden
⁶Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁷Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN
⁸Center for Translational Genomics, Lund University, Lund, Sweden

Katarzyna Szoltysek, PhD^1,2*, Rachel L. Cameron^2,3*, Anja Krippner-Heidenreich, PhD^2*, Milad Rasouli^2*, Jayne Y. Hehir-Kwa, PhD^2*, Elizabeth K. Schweighart^2*, Minoo Ashtiani^2*, Janine Stutterheim, MD, PhD², Josef Vormoor, Prof, MD, PhD^2,3,4 and Olaf Heidenreich, PhD^2,3*

¹Maria Sklodowska-Curie Institute - Oncology Center, Gliwice Branch, Gliwice, Poland
²Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands
³Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom
⁴University Medical Center Utrecht, Utrecht, Netherlands

Caroline R. M. Wiggers, PhD^1,2, Eugene Y. Cho^1*, Justin Hegel^1*, Julia Frede, PhD, MPhil^2,3, Hannah Stuart^3*, Klothilda K. Lim^3*, Yana Pikman, MD^4,5, Marian H. Harris, MD, PhD^6*, Andrew E. Place, MD, PhD^1,7,8, Lewis B. Silverman, MD^7,9, Jens G. Lohr, MD, PhD^2,3,10 and Birgit Knoechel, MD, PhD^1,2,10,11

¹Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
²Harvard Medical School, Boston, MA
³Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Boston, MA
⁴Dana Farber Cancer Institute, Boston, MA
⁵Boston Children’s Hospital, Boston, MA
⁶Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA
⁷Department of Hematology/Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, MA
⁸Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA
⁹Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
¹⁰Broad Institute of MIT and Harvard, Cambridge, MA
¹¹Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA

Joshua Anil, BSc¹, Andrew Lytle, MD, PhD^2*, Ahab Alnemri, BA^1*, Brian Lockhart^3* and Vinodh Pillai, MD^3,4

¹University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
²Centre for Lymphoid Cancer, Department of Pathology, BC Cancer, Vancouver, BC, Canada
³Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA
⁴Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA

Noam E. Kopmar, MD^1,2, Xiaoyu Qu, Ph.D.^2*, Yajuan J. Liu, PhD^3*, Ted A. Gooley, Ph.D.^2*, Lucas Zarling, MD^1*, Mary-Elizabeth M. Percival, MD^1,2, Cristina Ghiuzeli, MD^1,2, Min Fang, MD, PhD^2,3 and Ryan D. Cassaday, MD^1,4

¹Department of Medicine, University of Washington, Seattle, WA
²Fred Hutchinson Cancer Center, Seattle, WA
³Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA
⁴UW/FHCRC, Seattle, WA

Qian Wang^1*, Haiping Dai^1*, Wenzhi CAI, MD^1*, Qinrong Wang^1*, Zhu Mingqing^1*, Lingzhi Yan, MD, PhD^1*, Yan Yu^1*, Hongjie Shen, MD, PhD^1*, Yang Xu, MD, PhD^2*, Ying Wang^1*, Miao Miao, MD^1*, Shengli Xue^1*, Yue Han^1*, Xiaowen Tang, MD, PhD^1*, Huiying Qiu^1*, Aining Sun^1*, Jinyan Huang^3,4*, Depei Wu¹ and Suning Chen, MD, PhD^1*

¹Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, NHC Key Laboratory of Thrombosis and Hemostasis, The First Affiliated Hospital of Soochow University, Suzhou, China
²National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Institute of Blood and Marrow Transplantation of Soochow University, Suzhou, China
³Biomedical big data center, Zhejiang Provincial Key Laboratory of Pancreatic Disease, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁴Zhejiang University Cancer Center, Zhejiang University, Hangzhou, China

Peter M. Gordon, MD, PhD¹, Jason Ostergaard, BA^2*, Leslie M. Jonart, MS^1*, M Frank Erasmus, PhD^3*, Bridget S. Wilson, PhD⁴ and Stuart S. Winter, MD⁵

¹Division of Pediatric Hematology and Oncology, University of Minnesota, Minneapolis, MN
²Pediatric Hematology/Oncology, University of Minnesota, Minneapolis, MN
³Specifica, Inc., Santa Fe, NM
⁴Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM
⁵Research Institute and Cancer and Blood Disorders Program, Children's Minnesota, Eagan, MN

Danielle Brandes^1,2*, Triantafyllia Brozou, MD^2*, Karin Nebral, PhD^3,4*, Anke K. Bergmann, MD^5*, Oskar A. Haas, MD^3,4,6, Stefan Köhrer, MD^3,4*, Martin Stanulla, MD, MSc^7*, Ute Fischer, PhD^2,8*, Arndt Borkhardt, MD^2,8 and Rabea Wagener, PhD^2,8*

¹Duesseldorf School of Oncology (DSO), Medical Faculty, Heinrich-Heine University, Duesseldorf, Germany
²Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University and University Hospital Duesseldorf, Duesseldorf, Germany
³St. Anna Children´s Cancer Research Institute (CCRI), Vienna, Austria
⁴Labdia Labordiagnostik GmbH, Clinical Genetics, Vienna, Austria
⁵Institute of Human Genetics, Hannover Medical School (MHH), Hanover, Germany
⁶St. Anna Children's Hospital, Department of Pediatric Hematology/Oncology, Pediatric Clinic, Medical University, Vienna, Austria
⁷Pediatric Hematology and Oncology, Hannover Medical School (MHH), Hanover, Germany
⁸German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Düsseldorf, Germany

Cai Zihong^*, Bingqing Tang^*, Xiuli Xu^*, Zicong Huang^*, Qifa Liu and Hongsheng Zhou^*

Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China

Hiroyuki Kimura, M.D.^1*, Masahiro Onozawa, M.D., Ph.D.¹, Shota Yoshida, MD^1*, Naoki Miyashita, M.D.^1*, Shogo Takahashi, M.D.^1*, Shota Yokoyama^2*, Toshihiro Matsukawa, M.D., Ph.D.^2*, Shinsuke Hirabayashi, M.D.^3,4*, Shinichi Fujisawa^5*, Shuichi Ota, M.D., Ph.D.⁶, Daisuke Hidaka, M.D., Ph.D.^6*, Akio Mori, MD, PhD⁷, Takeshi Kondo⁸, Yasutaka Kakinoki, M.D., Ph.D.^9*, Yutaka Tsutsumi, M.D., Ph.D.^10*, Satoshi Yamamoto, M.D., Ph.D.^11*, Takuto Miyagishima, M.D., Ph.D.^12*, Takahiro Nagashima, M.D., Ph.D.^13*, Makoto Ibata, M.D., Ph.D.^14*, Hajime Kobayashi, M.D, Ph.D.^15*, Yoshihito Haseyama, M.D, Ph.D.^16*, Katsuya Fujimoto, M.D., Ph.D.^17*, Toshimichi Ishihara, M.D., Ph.D.^18*, Hajime Sakai, M.D, Ph.D.¹⁹ and Takanori Teshima, M.D., Ph.D.^1,20

¹Department of Hematology, Hokkaido University Faculty of Medicine, Graduate school of Medicine, Sapporo, Japan
²Department of Hematology, Hokkaido University Hospital, Sapporo, Japan, Sapporo, Japan
³Hokkaido University Hospital, Sapporo, Japan
⁴Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan
⁵Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan
⁶Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
⁷Blood Disorders Center, Aiiku Hospital, Sapporo, Japan
⁸Aiiku Hospital, Sapporo, Japan
⁹Department of Hematology, Asahikawa City Hospital, Asahikawa, HOK, Japan
¹⁰Department of Hematology, Hakodate Municipal Hospital, Hakodate, Japan
¹¹Department of Hematology, Sapporo City General Hospital, Sapporo, Japan
¹²Department of Hematology, Kushiro Rosai Hospital, Kushiro, Japan
¹³Department of Internal Medicine, Kitami Red Cross Hospital, Kitami, Japan
¹⁴Department of Hematology, Sapporo-Kosei General Hospital, Sapporo, Japan
¹⁵Department of Hematology, Obihiro Kosei Hospital, Obhiro, Japan
¹⁶Department of Hematology, Tonan Hospital, Sapporo, Japan
¹⁷Department of Hematology, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan
¹⁸Department of Hematology, Kin-ikyo Chuo Hospital, Sapporo, Japan
¹⁹Department of Hematology, Teine Keijinkai Hospital, Sapporo, Japan
²⁰Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan

Noemi Di Marzo, PhD Student^1*, Francesca Pischiutta, PhD^2*, Rosaria Pascente^2*, Nicolò Panini^3*, Erica Dander, PhD^4*, Alessandra Fallati, PhD Student^5*, Elisa Zanier, MD^2*, Giovanna D'Amico, BSc, PhD, MSc^5* and Andrea Biondi, MD^{5,6,7,8,9,10,11,12}

¹Centro Ricerca Tettamanti, Pediatric Department, University of Milano-Bicocca, Fondazione MBBM, Monza, Italy
²Dipartimento Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
³IRCCS Istituto Di Ricerche Farmacologiche Mario Negri, Milano, Italy
⁴Centro Ricerca Tettamanti, Pediatric Department, University of Milano-Bicocca, Fondazione MBBM, Monza, Idaho, Italy
⁵Tettamanti Research Center, Department of Pediatrics, University of Milano - Bicocca/Fondazione MBBM, Monza, Italy
⁶Laboratorio di Terapia Cellulare e Genica Stefano Verri, ASST-Monza, Ospedale San Gerardo, Monza, Italy
⁷Centro Ricerca Tettamanti, Pediatric Department, University of Milano-Bicocca, Fondazione MBBM, Monza, MI, Italy
⁸University of North Carolina, Chapel Hill, NC
⁹Centro Ricerca Tettamanti, Clinica Pediatrica, Università Milano Bicocca, Osp. San Gerardo/Fondazione MBBM, Monza, Italy
¹⁰AIEOP - Associazione Italiana Ematologia Oncologia Pediatrica, Monza, Italy
¹¹Clinica Pediatrica Università Milano - Bicocca/Fondazione MBBM, Monza, Italy
¹²Pediatric Bone Marrow Transplant Unit, Fondazione MBBM -Milano Bicocca University, Monza, Italy