Nicholas Short, MD¹, Elias Jabbour, MD², Farhad Ravandi, MD², Musa Yilmaz, MD³, Tapan M. Kadia, MD³, Philip A. Thompson, MBBS², Xuelin Huang, PhD^4*, Marina Konopleva, MD, PhD¹, Alessandra Ferrajoli¹, Nitin Jain, MD³, Koji Sasaki, MD², Walid Macaron, MD, MSc^2*, Yesid Alvarado, MD², Gautam Borthakur, MD², Courtney D. DiNardo, MD, MSCE², Maro Ohanian, DO^2*, Steven M. Kornblau, MD², Min Zhao^2*, Monica Kwari, BSN², Jennifer Thankachan^2*, Christopher Loiselle, BS^2*, Ricardo Delumpa, BSN^2*, Rebecca Garris^2* and Hagop Kantarjian, MD⁵

¹Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁴Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Luke Maese, DO¹, Mignon L. Loh, MD², Mi Rim Choi³, Tong Lin^3*, Etsuko Aoki^3*, Shirali Agarwal^3*, Xiaotian Wu^4*, Robert Iannone^4*, Jeffrey A. Silverman^4*, Lewis B. Silverman, MD⁵, Elizabeth A. Raetz, MD⁶ and Rachel E. Rau, MD⁷

¹Primary Children's Hospital, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
²Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of California Benioff Children’s Hospital, Seattle, WA
³Jazz Pharmaceuticals, Palo Alto, CA
⁴Jazz Pharmaceuticals, Philadelphia, PA
⁵Dana-Farber Cancer Inst., Boston, MA
⁶Division of Pediatric Hematology and Oncology, Stephen D. Hassenfeld Children's Center for Cancer and Blood Disorders, NYU Langone Health, New York, NY
⁷Texas Children’s Cancer and Hematology Center, Baylor College of Medicine, Houston, TX

Matthew Greenwood, FRACP^1,2, Shane Gangatharan, FRACP FRCPA^3*, Michael Philip Osborn, MB, BS FRACP FRCPA^4*, Ashley P Ng, FRACP FRCPA^5*, Shaun Fleming, FRACP FRCPA^6*, Pasquale Fedele, FRACP FRCPA^7*, Toby Trahair, MD FRACP^8*, John Casey, FRACP, FRCPA, MBBS^9*, Sally Mapp, FRACP FRCPA^10*, Carol Cheung, FRACP FRCPA^11*, Tasman Armytage, FRACP FRCPA^12*, Michelle Henderson, PhD^13*, Rosemary Sutton, BSc MSc PhD^14*, Philip McCloud, PhD^15*, Stephen R Larsen, MBBS PhD FRACP FRCPA¹⁶, Peter Presgrave, FRACP FRCPA^17*, John Kwan, MBBS, FRACP, FRCPA^18*, Samuel Bennett, FRACP FRCPA^19*, Chun Yew Fong, MBBS, PhD, FRACP, FRCPA²⁰ and Luciano Dalla Pozza, FRACP^21*

¹University of Sydney, Sydney, Australia
²Department of Haematology, Royal North Shore Hospital, Sydney, NSW, Australia
³Fiona Stanley Hospital, Perth, Australia
⁴Dept of Haematology & Oncology, Women's & Children's Hospital, Adelaide, Australia
⁵Department of Clinical Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, Australia
⁶The Alfred Hospital and Monash University, Melbourne, VIC, Australia
⁷Monash Hospital, Melbourne, Australia
⁸Sydney Children’s Hospital, Randwick, Australia
⁹The Townsville Hospital, Townsville, Australia
¹⁰Princess Alexandra Hospital, Brisbane, Australia
¹¹Prince of Wales Hospital, Sydney, Australia
¹²Gosford Hospital, Gosford, NSW, Australia
¹³Children's Cancer Institute Australia, University of NSW, Randwick, Australia
¹⁴Children's Cancer Institute, University of NSW, Randwick, NSW, Australia
¹⁵McCloud Consulting Group, Sydney, Australia
¹⁶Institute of Haematology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
¹⁷Wollongong Hospital, Wollongong, Australia
¹⁸Blood Transplant and Cellular Therapies Program, Westmead Hospital, Sydney, NSW, Australia
¹⁹The Canberra Hospital, Canberra, Australia
²⁰Department of Haematology, Austin Hospital, Heidelberg, VIC, Australia
²¹Children's Hospital at Westmead, Sydney, Australia

Walid Macaron, MD, MSc^1*, Hagop Kantarjian, MD², Nicholas Short, MD³, Nitin Jain, MD⁴, Xuelin Huang, PhD^5*, Guillermo Montalban-Bravo, MD¹, Tapan M. Kadia, MD⁴, Naval Daver, MD¹, Kelly S. Chien, MD¹, Yesid Alvarado, MD¹, Guillermo Garcia-Manero, MD⁶, Ghayas C. Issa, MD¹, Fadi Haddad, MD^1*, Monica Kwari, BSN¹, Ricardo Delumpa, BSN^1*, Ejiroghene Mayor, BSN, RN^1*, Wuliamatu Deen, BSN, RN^1*, Jennifer Thankachan^1*, Christopher Loiselle, BS^1*, Juan Rivera^1*, Anna Milton^1*, Lourdes Waller^1*, Glenda Banks^1*, Rebecca Garris^1*, Marina Konopleva, MD, PhD³, Farhad Ravandi, MD¹ and Elias Jabbour, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁵Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX

Edoardo Pennesi^1,2*, Erica Brivio, MD^1,3*, Anneke C. J. Ammerlaan^1,3*, Yilin Jiang, MSc^3*, Vincent H.J. van der Velden, PhD^4*, Berna Beverloo, PhD^5*, Barbara Sleight, MD^6*, Susana Rives^7*, Cristina Díaz de Heredia Rubio, MD, PhD^8*, Francisco J. Bautista Sirvent^3*, Alba Rubio-San-Simón^9*, Fanny Rialland, MD^10*, Carmelo Rizzari, MD^11*, Bella Bielorai, MD^12*, Arnaud Petit, MD, PhD^13*, Bénédicte Bruno, MD^14*, Ingrid Øra^15*, Anna Nilsson^15*, Gernot Engstler, MD^16*, Claudia Rossig^17*, Benoit Brethon, MD^18*, Franco Locatelli, MD¹⁹ and Christian M. Zwaan, Prof, MD, PhD^1,3*

¹Department of Pediatric Oncology, Erasmus MC-Sophia Children’s Hospital, Rotterdam, Netherlands
²Princess Máxima Center for Pediatric Oncology, Rotterdam, Netherlands
³Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
⁴Department of Immunology, Erasmus Medical Center, University Medical Center, Rotterdam, Netherlands
⁵Department of Clinical Genetics, Erasmus MC, Rotterdam, Netherlands
⁶Pfizer Inc, Groton, CT
⁷Department of Pediatric Hematology and Oncology, Hospital Sant Joan de Déu de Barcelona, Barcelona, Spain
⁸Division of Pediatric Hematology and Oncology, Hospital Universitari Vall d’Hebron, Barcelona, Spain
⁹Department of Pediatric Oncology and Hematology, Hospital Niño Jesús, Madrid, Spain
¹⁰Service Onco-Hématologie Pédiatrique, Hôpital Mère-Enfant, Nantes University Hospital, Nantes, France
¹¹Pediatric Hematology-Oncology Unit, University of Milano-Bicocca, MBBM Foundation, San Gerardo Hospital, Monza, Italy
¹²Division of Pediatric Hematology and Oncology, Sheba Medical Center, Ramat-Gan, Israel
¹³Department of pediatric Hematology and Oncology, Hôpital Armand Trousseau, APHP, Sorbonne Université, Paris, France
¹⁴Pediatric Hematology, Hôpital Jeanne de Flandre, CHRU de Lille, Lille, France
¹⁵Pediatric Oncology and Hematology, Karolinska University Hospital, Stockholm, Sweden
¹⁶St Anna Children's Hospital, Medical University of Vienna, Vienna, Austria
¹⁷Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany
¹⁸Department of Pediatric Hematology and Immunology, Robert-Debré Hospital, AP-HP, University of Paris, Paris, France
¹⁹IRCCS Ospedale Pediatrico Bambino Gesú, Catholic University of the Sacred Heart, Rome, Italy

Francesco Malfona, MD^1*, Ilaria Tanasi, MD^2*, Cristina Papayannidis, MD, PhD³, Vincenzo Federico, MD^4*, Matteo Piccini^5*, Valentina Mancini, MD^6*, Elisa Roncoroni^7*, Elisabetta Todisco, MD, PhD^8*, Fabio Giglio, MD^9*, Massimo Gentile, MD^10*, Valentina Gianfelici, MD^11*, Antonino Mulè, MD^12*, Francesco Saraceni^13*, Calogero Vetro, MD^14*, Francesco Zallio^15*, Maria Ilaria Del Principe, MD^16*, Eleonora De Bellis, MD^17*, Robin Foà, MD, PhD, Full Professor^1*, Massimiliano Bonifacio, MD^2* and Sabina Chiaretti, MD, PhD¹

¹Hematology, Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy
²Department of Medicine, Section of Hematology, University of Verona, Verona, Italy
³IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy, Bologna, Italy
⁴Hematology and Transplant Unit, Vito Fazzi Hospital, Lecce, ITA
⁵SOD Ematologia, SOD Ematologia, Università Di Firenze, AOU Careggi, Firenze, Italy, Firenze, Italy
⁶ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy
⁷Department of Hematology Oncology, Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
⁸IEO, European Institute of Oncology IRCCS, Milan, Milan, Italy
⁹Haematology and BMT Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy
¹⁰Hematology Unit AO Cosenza, Cosenza, Italy
¹¹Department Hematology-Oncology- Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro,Italy, Catanzaro, Italy
¹²Division of Hematology and Bone Marrow Transplantation, Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy
¹³Hematology and Stem Cell Transplant, Ancona University Hospital, Ancona, Italy
¹⁴Hematology and BMT Unit, Azienda Ospedaliero Universitaria Policlinico "G.Rodolico-San Marco", Catania, Italy
¹⁵Hematology Department, SS Antonio & Biagio and C. Arrigo Hospital, Alessandria, ITA
¹⁶Ematologia, Dipartimento di Biomedicina e Prevenzione, Università degli studi di Roma Tor Vergata, Roma, Italy
¹⁷Hematology,, Azienda sanitaria universitaria Giuliano-Isontina, trieste, ITA

Weiyang Liu, MD^*, Yuanfang Liu, MD, PhD^*, Yongmei Zhu, PhD^*, Xiangqin Weng, Master^*, Cheng Wang, Master^*, Wanyan Ouyang, MD, PhD^*, Jie Xu, MD, PhD, Jian-Qing Mi, MD, PhD^* and Jin Wang, MD, PhD^*

Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Richard B Lock, PhD¹, Kathryn Evans, BBiomedSci^1*, Joanna Randall, MSc^1*, Stephen W Erickson, PhD^2*, Eric J Earley, PhD^2*, Steven Neuhauser, PhD^3*, Tim Stearns^3*, Vivek Philip, PhD^3*, Beverly A Teicher, PhD^4*, Krystal Watkins, MS^5*, Callum M Sloss, PhD⁵, Patrick A Zweidler-McKay, MD, PhD⁶ and Malcolm A Smith, MD, PhD^4*

¹Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Randwick, NSW, Australia
²RTI International, Research Triangle Park, NC
³The Jackson Laboratory, Bar Harbor, ME
⁴National Cancer Institute, Bethesda, MD
⁵ImmunoGen, Inc., Waltham, MA
⁶ImmunoGen, Inc., Lincoln, MA

Karamjeet S. Sandhu, MD¹, Alan Macias^2*, Marissa Del Real, PhD^2*, Asuscena L. Beltran^1*, Young Sun Kim, MD^3*, Jianying Zhang, PhD^4*, Joycelynne Palmer, PhD^5*, Marjorie Robbins, PhD^6*, Reyna Loomis, BSN^1*, Mojtaba Akhtari, MD^7*, Ahmed Aribi, MD^1*, Shukaib Arslan, MD^1*, Amandeep Salhotra, MD¹, Matthew Mei, MD¹, Hoda Pourhassan, MD^1*, Paul B. Koller, MD¹, Idoroenyi Amanam, MD¹, Vaibhav Agrawal, MD¹, Peter T. Curtin, MD¹, Ricardo Spielberger, MD^1*, Vinod A. Pullarkat, MD^1*, Ibrahim Aldoss, MD¹, F. Mark Stewart, MD^1*, Eileen P. Smith, MD¹, Stephen J Forman, MD¹, Anthony S. Stein, MD^1*, Guido Marcucci, MD¹ and Elizabeth L. Budde, MD, PhD⁸

¹Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA
²T-Cell Therapeutics Research Laboratory, BRI, City of Hope National Medical Center, Duarte, CA
³Department of Pathology, City of Hope National Medical Center, Duarte, CA
⁴Department of Computational and Quantitative Medicine-BRI, City of Hope National Medical Center, Duarte, CA
⁵Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope, Duarte, CA
⁶Department of Clinical and Translational Project Development, City of Hope National Medical Center, Duarte, CA
⁷Loma Linda University Cancer Center, Loma Linda, CA
⁸Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA

Angus Hodder, MBBS^1*, Avijeet K Mishra^1*, Susan Baird, MD^2*, Ismail Bisho^3*, Denise Bonney^4*, Katherine Clesham, MD PhD^5*, Michelle Cummins^6*, Emmy Dickens^7*, Brenda Gibson^8*, Lindsay George, PhD, FRCPath^9*, Danielle Ingham^10*, Galina Jigoulina^11*, Donna Lancaster^12*, Katherine Lindsay^13*, Majid Madni^14*, Andrea Malone^15*, Bethany Mitchell^16*, John Moppett, PhD FRCPath^17*, Jayashree Motwani, MD^18*, Anthony V. Moorman¹⁹, Katharine Patrick^20*, Lamia Samrin^21*, Sanjay Tewari, FRCPath, MBBS^22*, Indu Rakesh Thakur, FRCPath, MD, MBBS^23*, David O'Connor, MBBS, PhD, FRCPath (Haem)^24*, Ajay Vora, MD¹ and Sujith Samarasinghe, PhD, FRCPath^25*

¹Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom
²Department of Haematology, Royal Hospital for Sick Children, Edinburgh, United Kingdom
³Haematology, Oxford University Hospital NHS Trust, Oxford, United Kingdom
⁴Royal Manchester Children's Hospital, Manchester, GBR
⁵Department of Haematology, University College London Hospitals NHS Trust, London, United Kingdom
⁶Department of Haematology, Bristol Children's Hospital, Bristol, GBR
⁷Cambridge University Hospitals NHS Foundation Trust, Cambridge, GBR
⁸The Royal Hospital for Children, Glasgow, United Kingdom
⁹Birmingham Children's Hospital, Birmingham, GBR
¹⁰Haematology, Leeds Children's Hospital, Leeds, GBR
¹¹Haematology, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
¹²The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom
¹³Haematology, Alder Hey Children's Hospital Trust, LIverpool, United Kingdom
¹⁴Nottingham University Hospitals, Nottingham, GBR
¹⁵Our Lady's Children Hospital, Crumlin, IRL
¹⁶Haematology, Royal Belfast Hospital for Sick Children, Belfast, United Kingdom
¹⁷Department of Haematology, Bristol Children's Hospital, Bristol, United Kingdom
¹⁸Birmingham Children's Hospital, Birmingham, United Kingdom
¹⁹Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle, United Kingdom
²⁰Sheffield Childrens NHS Foundation Trust, Sheffield, United Kingdom
²¹Great Ormond Street Hospital, London, United Kingdom
²²Haematology, The Royal Marsden, London, United Kingdom
²³Children's Hospital For Wales, Cardiff, GBR
²⁴Cancer Institute, University College London, London, United Kingdom
²⁵Department of Paediatric Haematology, Great Ormond Street Hospital for Children, London, United Kingdom

Shai Shimony, MD^1,2*, Yiwen Liu^3*, Yannis K. Valtis, MD⁴, Jonathan D. Paolino, MD⁵, Andrew E. Place, MD, PhD⁶, Andrew M. Brunner, MD⁷, Lachelle D. Weeks, MD, PhD⁸, Lewis B. Silverman, MD⁵, Lynda M. Vrooman, MD⁶, Donna S. Neuberg, ScD³, Richard M. Stone, MD⁹, Daniel J. DeAngelo, MD, PhD² and Marlise R. Luskin, MD²

¹Rabin Medical Center and Faculty of Medicine, Tel Aviv University, Petah Tikva, ISR
²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
³Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
⁴Brigham and Women's Hospital, Boston, MA
⁵Division of Hematology/Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA
⁶Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA
⁷Division of Hematology/Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
⁸Center for Prevention of Progression, Dana-Farber Cancer Institute, Boston, MA
⁹Center for Leukemia, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA