Adam J. de Smith, PhD¹, Lara Wahlster, MD, PhD^2*, Soyoung Jeon, BSc^1*, Fulong Yu, PhD^2*, Susan Black^2*, Steven Gazal, PhD^1*, Nicholas Mancuso, PhD^1*, Catherine Metayer, MD, PhD^3*, Xiaomei Ma, PhD^4*, Joseph L. Wiemels, PhD^1*, Charleston W. K. Chiang, PhD^1* and Vijay G. Sankaran, MD, PhD²

¹Center for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA
²Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA
³School of Public Health, University of California Berkeley, Berkeley, CA
⁴Department of Chronic Disease Epidemiology, Yale University School of Public Health, New Haven, CT

Hari S. Raman, MD^1*, Se Eun Kim, MB^2*, Daniel J DeAngelo, MD, PhD³, Kristen E. Stevenson, MS^2*, Donna S. Neuberg, ScD², Eric S. Winer, MD³, Martha Wadleigh, MD³, Jacqueline S. Garcia, MD³, Annette S. Kim, MD, PhD⁴, Richard M. Stone, MD⁵, Vincent T Ho, MD^6* and Marlise R. Luskin, MD³

¹Department of Medicine, Brigham and Women's Hospital, Brookline, MA
²Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
³Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁴Department of Pathology, Brigham and Women's Hospital, Boston, MA
⁵Center for Leukemia, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁶Dana-Farber Cancer Institute, Boston, MA

Xian Zhang^1,2, Lefu Huang^2,3*, Gailing Zhang, MD.^2*, Yunchao Su^2*, Xiaona Hu^2*, Shulian Xia^2*, Jingjing Li^1,2* and Peihua Lu, MD^1,2

¹Beijing Lu Daopei Institute of Hematology, Beijing, China
²Hebei Yanda Lu Daopei Hospital, Langfang, China
³Tsinghua University School of Medicine, Beijing, China

Merete Eybye Dam, MD^1*, Maddalena Centanni^2*, Lena Friberg^2*, Mats Karlsson^2*, Line Stensig Lynggaard, MD, PhD^3*, Inga M. Johannsdottir, MD^4*, Hilde Skuterud Wik, MD, PhD^4*, Mats Heyman⁵, Johan Malmros, MD, PhD^6*, Helene Hallböök, MD, PhD^7*, Goda Elizabeta Vaitkeviciene, MD, PhD^8*, Laimonas Griskevicius, MD, PhD^9*, Ólafur Gísli Jónsson, MD, PhD^10*, Ulrik Malthe Overgaard, MD^11*, Kjeld Schmiegelow, MD, DMSc¹² and Birgitte Klug Albertsen, MD, PhD^3*

¹Children and Adolescent Health, Aarhus University Hospital, Aarhus N, Denmark
²Department of Pharmacy, Uppsala University, Uppsala, Sweden
³Children and Adolescent Health, Aarhus University Hospital, Aarhus, Denmark
⁴Oslo University Hospital, Oslo, Norway
⁵Karolinska University Hospital, Stockholm, Sweden
⁶Karolinska Institutet, Stockholm, SWE
⁷Department of Hematology, Uppsala University Hospital, Uppsala, Sweden
⁸Center of Pediatric Oncology and Hematology, Children's hospital, affiliation of Vilnius University Hospital Santaros Klinikos and Vilnius University, Vilnius, Lithuania
⁹Department of Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santaros Klinikos, Vilnius University, Vilnius, Lithuania
¹⁰Department of Pediatrics, Landspitali, University Hospital, Reykjavik, Iceland
¹¹Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
¹²Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

Franziska Auer¹, Adela Escuerdo^2*, Ulrike Anne Friedrich^3*, Polina Stepensky^4*, Arndt Borkhardt, MD⁵, Sarah Elitzur, MD^6*, Masatoshi Takagi⁷ and Julia Hauer, MD^1*

¹Technical University of Munich, School of Medicine, Department of Pediatrics, Munich, Germany
²Institute of Medical and Molecular Genetics (INGEMM) La Paz University Hospital, Madrid, Spain
³Pediatric Hematology and Oncology, Department of Pediatrics, University Hospital "Carl Gustav Carus", TU Dresden, Dresden, Germany
⁴Department of Bone Marrow Transplantation & Cancer Immunotherapy, Hadassah Medical Center and Faculty of Medicine, Hebrew University, Jerusalem, Israel
⁵Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University, Medical Faculty, Duesseldorf, Germany
⁶Pediatric Hematology and Oncology, Schneider Children's Medical Center and Tel Aviv University, Tel Aviv, Israel
⁷Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan

Sjoerd J.F. Hermans, MD^1*, Yvette Norden, PhD^1,2*, Jurjen Versluis, MD, PhD^1*, Anita W. Rijneveld, MD, PhD^1*, Okke De Weerdt, MD^3*, Bart J Biemond⁴, Arjan A. van de Loosdrecht, MD, PhD^5*, Lotte E. Van der Wagen, MD, PhD^6*, Mar Bellido, MD, PhD^7*, Michel Van Gelder, MD, PhD⁸, Walter J.F.M. Van der Velden, MD, PhD⁹, Dominik Selleslag, MD, PhD¹⁰, Danielle van Lammeren, MD¹¹, Vincent H.J. van der Velden, PhD^12*, Liesbeth C. de Wreede, PhD^13*, Douwe Postmus, PhD^14*, Francesco Pignatti, MD^15* and Jan J. Cornelissen, MD, PhD¹

¹Erasmus University Medical Center Cancer Institute, Rotterdam, Netherlands
²HOVON Data Center, Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands
³Department of Hematology, St Antonius Hospital, Nieuwegein, Netherlands
⁴Department of Hematology, Amsterdam UMC location University of Amsterdam, Amsterdam, Netherlands
⁵Department of Hematology, Amsterdam University Medical Centers, Vrije Universiteit University Medical Center, Amsterdam, Netherlands
⁶Department of Hematology, University Medical Center, Utrecht, Netherlands
⁷Department of Hematology, University Medical Center Groningen, Groningen, Netherlands
⁸Department of Hematology, University Hospital Maastricht, Maastricht, Netherlands
⁹Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands
¹⁰St Jan Hospital, Brugge, Belgium
¹¹Department of Hematology, Haga Teaching Hospital, The Hague, Netherlands
¹²Department of Immunology, Erasmus Medical Center, University Medical Center, Rotterdam, Netherlands
¹³Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands
¹⁴University Medical Center, University Groningen, Groningen, Netherlands
¹⁵Oncology and Hematology Office, European Medicines Agency, Amsterdam, Netherlands

Van T Huynh, MD^1,2, Sonia Morales, MD^3*, Anurag K. Agrawal, MD^4*, Christine L Phillips, MD^5,6, Keith J August, MD, MS⁷, Erin Guest, MD⁸, Beth Apsel Winger, MD, PhD⁹, Catherine Aftandilian, MD¹⁰, Janel R. Long-Boyle, PharmD, PhD^11*, Kirsten Kasper, BA^3*, Keri Zabokrtsky, MS^3* and Carol Hwang Lin, MD^3*

¹Division of Oncology and Stem Cell Transplant/Cellular Therapy, Children’s Hospital of Orange County (CHOC), Orange, CA
²UC Irvine School of Medicine, Irvine, CA
³Division of Oncology, Children's Hospital of Orange County (CHOC), Orange, CA
⁴Division of Oncology, Department of Pediatrics, UCSF Benioff Children's Hospital Oakland, Oakland, CA
⁵Division of Oncology, Department of Pediatrics, Cincinnati Children's Hospital, Cincinatti, OH
⁶Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁷Chidren's Mercy Hospital, Kansas City, MO
⁸Children's Mercy Kansas City, Kansas City, MO
⁹Division of Hematology-Oncology, UCSF Benioff Children’s Hospital, San Francisco, CA
¹⁰Division of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Lucile Packard Children's Hospital, Palo Alto, CA
¹¹Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, UCSF Benioff Children's Hospital, San Francisco, CA

Dinora Virginia Aguilar, MD¹, Pablo Gonzalez-Montalvo, MD^2*, Hugo Romo, MD^3*, Daniela Arce, MD^4*, Nataly Mercado, MD, MPH^5*, Naomi Echeandia, MS^6*, Karla Guerrero, MD^5*, Margarita Gonzalez-Zamorano, PhD^7*, Lourdes Vega, MD^1*, Sergio Garay, PhD^1*, Berenice Jarquín-Ramirez, BSc^1*, Netzi Rivera-Sanchez, MSc^1*, Julio Moreno, BSc^1*, Victor Ramos-Solis, BSc^1* and Paola Friedrich, MD, MPH^6*

¹Hospital Infantil Teletón de Oncología, Querétaro, Mexico
²Hospital General Agustín O'Horán, Mérida, YC, Mexico
³Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Guadalajara, JA, Mexico
⁴Hospital Pediátrico de Sinaloa, Culiacan, SI, Mexico
⁵Casa de la Amistad para Niños con Cáncer, I.A.P., Ciudad de México, Mexico
⁶Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN
⁷Hospital General con Especialidades Juan María de Salvatierra, La Paz, México, Hospital General con Especialidades Juan María de Salvatierra, La Paz, México, La Paz, BJ, Mexico

Jack T Seki, PharmD^1*, Reem Alsibai, MD^2*, Ruiqi Chen, MD, MSc³, Eshetu G. Atenafu, M.Sc., P.Stat^4* and Hassan Sibai, MBBS, MD^5,6*

¹university of Toronto, Toronto, ON, Canada
²Evidence-Based Practice Research Program, Mayo Clinic, Rochester, MN, USA., Rochester, MN
³University of Toronto - University Health Network-Princess Margaret Cancer Centre, TORONTO, Canada
⁴Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
⁵Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada
⁶Department of Medicine, University of Toronto, Toronto, ON, Canada

Ruth Namazzi, MD¹, Peter Wasswa, MD^2,3*, Amos S. Gaikwad, PhD^2,4*, Hellen Mugarura, Msc^5*, Micheal Cubbage, PhD^2,3*, Moreen Nanvuma, CO^6*, Betty Najjukko^5*, Fred Lutwama, PhD^5*, David G. Poplack, MD^2,4*, Michael E. Scheurer, PhD⁴ and Joseph Lubega, MBChB, MPH^4,7*

¹Makerere University College of Health Sceinces, Kampala, Uganda
²Texas Children's Hospital, Houston, TX
³Baylor College of Medicine, Houston
⁴Baylor College of Medicine, Houston, TX
⁵Joint Clinical Research Center, Kampala, Uganda
⁶Makerere University College of Health Sciences, Kampala, Uganda
⁷Texas Children's Hospital, Houston

Yannis K. Valtis, MD¹, Yael Flamand, MS^2*, Shai Shimony, MD^3*, Andrew E. Place, MD, PhD⁴, Lewis B. Silverman, MD⁵, Lynda M. Vrooman, MD⁶, Andrew M. Brunner, MD⁷, Stephen E. Sallan, MD⁸, Martha Wadleigh, MD³, Richard M. Stone, MD⁹, Daniel J DeAngelo, MD, PhD⁹ and Marlise R. Luskin, MD³

¹Memorial Sloan Kettering Cancer Center, New York, Ny
²Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
³Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁴Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA
⁵Dana-Farber Cancer Inst., Boston, MA
⁶Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA
⁷Mass General Cancer Center, Massachusetts General Hospital, Boston, MA
⁸Division of Hematology/Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, MA
⁹Center for Leukemia, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

Jessica Zalapa, MD^1*, Mario Meza^1*, Juan Rangel-Patiño, MD¹ and Roberta Demichelis, MD²

¹Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
²Hematology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, Mexico City, Mexico

Sabine Kayser, MD¹, Chiara Sartor, MD, PhD^2*, Fabio Giglio, MD^3*, Alessandro Bruno, MD^4*, Jonathan Webster, MD^5*, Mark J. Levis, MD⁶, Richard F. Schlenk, MD^7,8,9 and Cristina Papayannidis, MD, PhD¹⁰

¹German Cancer Research Center (DKFZ), Heidelberg, Germany
²Istituto di Ematologia “Seràgnoli”, Bologna, Italy
³Haematology and BMT Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy
⁴Hematology and BMT Unit. IRCCS San Raffaele Scientific Institute, Milano, Italy
⁵The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore, MD
⁶Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
⁷Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany
⁸National Center of Tumor Diseases, Heidelberg, Heidelberg, Germany
⁹National Center of Tumor Diseases, NCT-Trial Center, German Cancer Research Center, Heidelberg, Germany
¹⁰IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy, Bologna, Italy