Theresa Eifert, MSc^1*, Tina M. M Schnoeder, PhD^1*, Chen-Jen Hsu, MSc^1*, Alicia L Becker^1*, Qirui Zhang, PhD^1*, Juliane Mohr, PhD^2*, Stephanie Frey^3*, Sebastian Scholl, MD^4*, Lars Bullinger, MD⁵, Steven W Lane, MD, PhD⁶ and Florian H. Heidel, MD^1,7

¹Klinik und Poliklinik für Innere Medizin C, Universitätsklinikum Greifswald, Greifswald, Germany
²Institute of Molecular and Clinical Immunology, Otto-von-Guericke-University Medical Center, Magdeburg, Germany
³Department of Hematology and Oncology, Otto-von-Guericke-University Medical Center, Magdeburg, Germany
⁴Department of Internal Medicine II, Hematology and Oncology, University Hospital Jena, Jena, Germany
⁵Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine Berlin, Berlin, Germany
⁶Cancer Program, Queensland Institute of Medical Research, Brisbane, Australia
⁷Fritz-Lipmann Institute, Leibniz Institute on Aging, Jena, Germany

Sumiko Takao, MD, PhD^1*, Victor Morell, BS^1*, Fiona C. Brown, PhD^2*, Richard Koche, PhD^3* and Alex Kentsis, MD, PhD^4,5,6

¹Molecular Pharmacology Program, Sloan Kettering Institute and Tow Center for Developmental Oncology, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY
²Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
³Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Tow Center for Developmental Oncology, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Departments of Pharmacology and Physiology & Biophysics, Weill Cornell Medical College, Cornell University, New York, NY

Gabriela Krivdova, PhD^1*, Brian Yee, MS^2*, Stefan Aigner, PhD^2*, Martino Gabra^3*, Alexander Shishkin^4*, Long Nguyen^5*, Jessica L McLeod^6*, Leah Carley^7*, Leonardo Salmena^8*, Lorien Shakib^1*, Mark D. Minden^1,9*, Eric L Van Nostrand, PhD^10*, Gene W. Yeo, PhD^2*, Eric R. Lechman, PhD¹ and John E. Dick, PhD^11,12

¹Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
²Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA
³Pharmacology, University of Toronto, Tornto, Canada
⁴Eclipse Bioinnovations, San Diego, CA
⁵Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom
⁶Phillip Orsino Cell Processing Laboratory, Princess Margaret Cancer Centre, Toronto, ON, Canada
⁷Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
⁸Pharmacology, University of Toronto, Toronto, Canada
⁹Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
¹⁰University of California, San Diego, La Jolla, CA
¹¹Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
¹²University Health Network, Toronto, ON, Canada

Anna LW Huskey, PhD¹, Pandurang Kolekar, Ph.D^2*, Tamara Westover, BS³, Jing Ma, PhD^3*, Michael P Walsh, PhD^3*, Masayuki Umeda, MD^3*, Guangchun Song^3*, Yanling Liu, PhD^2*, Quang Tran, PhD², Xiaotu Ma, PhD^4* and Jeffery M. Klco, MD, PhD³

¹Department of Pathology, St. Jude Children's Research Hospital, Cordova, TN
²Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN
³Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁴St. Jude Children's Research Hospital, Memphis, TN

Angela Mo, PhD^1*, Hayle Kincross, BSc^1,2*, Xuan Wang, MSc^1*, Linda Ya-Ting Chang, PhD^1*, Gerben Duns, PhD^1*, Harwood Kwan^1*, Tammy Lau^1*, Rod Docking, MSc, PhD¹, Se-Wing Grace Cheng^1*, Shujun Huang, PhD^1*, Nadia Gharaee, MSc^1*, Elijah Willie, MSc^1*, Jihong Jiang, PhD^1*, Jeremy Parker, PhD^1*, Josh Bridgers^1*, Gregg Morin, PhD^1,2* and Aly Karsan, MD^2,3

¹Canada's Michael Smith Genome Sciences Centre, Vancouver, BC, Canada
²University of British Columbia, Vancouver, BC, Canada
³BC Cancer Research Centre, Canada's Michael Smith Genome Sciences Centre, Vancouver, BC, Canada

Jane J Xu, PhD^1*, Besmira Alija^1*, Stephanie Braunstein^1*, John Pantazi^1*, Varun S Sudunagunta, BA², Robert L. Bowman, PhD³ and Aaron D Viny, MD, MS⁴

¹Division of Hematology and Oncology, Department of Medicine, Columbia University, New York, NY
²Vagelos College of Physicians & Surgeons, Columbia University, NEW YORK, NY
³Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Columbia Stem Cell Initiative, Columbia University, New York, NY

Lianjun Zhang, PhD^1*, Le Xuan Truong Nguyen, PhD^1*, Wei-Kai Hua, PhD^1*, Yinghui Zhu, PhD^1*, Ying-Chieh Chen, PhD^1*, Xin He, MD^2*, Man Li, PhD^1*, Yu-Hsuan Fu, M.S.^1*, Haojie Dong, PhD^1*, Bin Zhang, PhD¹, Ling Li, PhD³, Jeremy Stark^4*, Guido Marcucci, MD⁵ and Ya-Huei Kuo, PhD¹

¹Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
²Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope National Medical Center, Monrovia, CA
³Department of Hematology/HCT, City of Hope National Medical Center, Duarte, CA
⁴Department of Cancer Genetics and Epigenetics, Beckman Research Institute - City Of Hope, Duarte, CA
⁵Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA

Liana Valin, BS^1*, Joice Kanefsky, BSc², Esteban Martinez, BSc^2*, Jacklyn Huhn, BS^3*, Orsola Di Martino, PhD⁴, Stephen M. Sykes, PhD⁵ and Judith Sokei, BS, MS^6*

¹Department of Pediatrics, Washington University in Saint Louis, Saint Louis, MO
²Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA
³Lewis Katz School of Medicine, Temple University Health System, Philadelphia, PA
⁴Department of Medicine, Division of Oncology, Washington University, Saint Louis, MO
⁵Department of Pediatrics, Washington University, Saint Louis, MO
⁶Division of Biology and Biomedical Sciences, Washington University of Saint Louis, Saint Louis, MO

Marlise L Guerrero Schimpf, PhD, Courtney C. Sparger, BS, Hsuan-Ting Huang, PhD, Dean Wade, BA^* and Maria Ken E. Figueroa, MD

Department of Human Genetics, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL

Douglas RA RA Silveira, MD, PhD^1*, Prodromos Chatzikyriakou, PhD^2*, Maria del Pilar Casares Alaez^2*, Sarah Mackie^2*, Roan Hulks^2*, Olena Yavorska, PhD^3*, Paulina Siejka-Zielinska^4*, Marlen Metzner, MSc^5*, Alastair Smith^6*, Batchimeg Usukhbayar^5*, Virginie Penard-Lacronique, PhD^7*, Chunxiao Song^4*, Anita K. Gandhi, PhD⁸, Maroof Hasan, MD^8*, Paresh Vyas, DPhil, FRCP, FRCPath, MRCP, MRCPath⁵, Thomas A. Milne⁶, Skirmantas Kriaucionis, PhD^9* and Lynn Quek, MBBCh, DPhil, MRCP (UK), FRCPath^2,10*

¹School of Cancer and Pharmaceutical Sciences, King's College London, London, ENG, United Kingdom
²School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
³Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
⁴University of Oxford, Oxford, United Kingdom
⁵MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
⁶MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
⁷INSERM U1170, Universit, Villejuif, France
⁸Translational Medicine Hematology, Bristol Myers Squibb, Summit, NJ
⁹Ludwig Institute for Cancer Research, University of Oxford, Oxford, United Kingdom
¹⁰Department of Haematological Medicine, King's College Hospital NHS Foundation Trust, London, United Kingdom

Olivia Arnold^1,2*, Luke Christiansen, Ph.D.^1,2*, Jesus Izaguirre-Carbonell, Ph.D.^2*, Theresa Bluemn, PhD^3*, Mark Wunderlich, MS^4* and Nan Zhu, PhD^1,2

¹Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI
²Blood Research Institute, Versiti, Milwaukee, WI
³Versiti Blood Research Institute, Milwaukee
⁴Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Deirdra Venney, BSc^1*, Graeme M Greenfield, BA, BMBCh, MRCP, FRCPath^2*, Lauren V Cairns, PhD, BSc^1*, Paul Strain, MSc, BSc^3*, Áine E McGill^2*, Jonathan J Morgan, BSc, MRes, PhD^2*, Róisín M McAvera, PhD^2*, Fatemeh Mirzadeh, PhD^2*, Yaser Atlasi, PhD^2*, Adone Mohd-Sarip, PhD^2* and Ken I Mills, BSc, PhD, FRCPath²

¹Queen's University Belfast, Belfast, NI, United Kingdom
²Queen's University Belfast, Belfast, United Kingdom
³Queen's University Belfast, Omagh, NI, United Kingdom

Junhua Lyu, PhD^1*, Yuxuan Liu, PhD^1*, Yuannyu Zhang, PhD^1*, Feng Cai, PhD^1*, Giovanni A. Botten^1*, Hui Cao^1*, Pranita Kaphle^1*, Ralph J Deberardinis, MD, PhD^1,2* and Jian Xu, PhD¹

¹Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX
²Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX

Marlon Arnone^1*, Elsa Görsch^2*, Simone Pöschel^2*, Anna Stanger^2*, Saskia Rudat^2* and Claudia Lengerke, MD³

¹Internal Medicin 2, Tuebingen, BW, Germany
²Internal Medicin 2, Tübingen, Germany
³Department of Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, Tuebingen, Germany

Yasuo Kubota, MD, PhD^1*, Laila Terkawi^2*, Carmelo Gurnari, MD², Juraj Bodo, PhD^3*, Naomi Kawashima, MD, PhD^2*, Mai Aly, MD, BSc, MS^2*, Arda Durmaz^2*, Minako Mori, MD, PhD^2*, BEN Ponvilawan, MD^2*, Tariq Kewan, MD^2*, Waled Bahaj, MD², Valeria Visconte, PhD², Heesun J. Rogers, MD³, Torsten Haferlach, MD⁴ and Jaroslaw P. Maciejewski, MD, PhD, FACP⁵

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Beachwood, OH
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
³Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH
⁴MLL Munich Leukemia Laboratory, Munich, Germany
⁵Translational Hematology and Oncology Research, Cleveland Clinic Foundation/ Taussig Cancer Institute, Cleveland, OH

Andrew J. Monteith, PhD^1,2*, Haley E. Ramsey, PhD, MSc^2,3, Dalton Greenwood^4*, Maria P. Arrate, MSc^2*, Londa Fuller, LVMT^2*, Agnieszka E. Gorska, MSc^2*, Alexander J. Silver, BA⁵, Donovan J. Brown, BS^2*, Sarah D. Olmstead^2*, Jackson Watke^2*, Matthew J. Stubbs, MBBS, MRCP, FRCPath⁶, Jeffrey C. Rathmell^7,8* and Michael R. Savona, MD^2,9,10,11

¹Cancer Biology Program, Vanderbilt University Medical Center, Nashville, TN
²Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
³Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN
⁴Vanderbilt Center for Immunobiology, Departments of Pathology, Microbiology, and Immunology, Cancer Biology, Vanderbilt University Medical Center, Nashville, TN
⁵Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN
⁶Incyte Corporation, Wilmington, DE
⁷Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville
⁸Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN
⁹Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN
¹⁰Vanderbilt University School of Medicine, Nashville, TN
¹¹Cancer Biology Program, Vanderbilt University, Nashville, TN

Judith S. Hecker^1*, Jennifer Rivière^1*, Mark van der Garde^1*, Michèle C. Buck^1*, Rupert Öllinger^2*, Florian Bassermann^1,3*, Bernd Giebel^4*, Robert A.J. Oostendorp¹, Roland Rad^2* and Katharina S. Goetze¹

¹Department of Medicine III, Klinikum rechts der Isar, Technical University Munich (TUM), Munich, Germany
²Institute of Molecular Oncology and Functional Genomics, Technical University Munich (TUM), Munich, Germany
³Center for Translational Cancer Research (TranslaTUM), TUM School of Medicine, Technical University of Munich (TUM), Munich, Germany
⁴Institute for Transfusion Medicine, University Hospital Essen, Essen, Germany

Masami Ohzu, MD^1*, Kazutoshi Ebisawa, MD, PhD^2*, Ken Morita, MD, PhD^2*, Yosuke Masamoto, MD, PhD³ and Mineo Kurokawa, MD, PhD⁴

¹Department of Hematology & Oncology, The University of Tokyo, Bunkyo-ku, TKY, Japan
²The University of Tokyo, Bunkyo-ku, Japan
³Department of Hematology and Oncology, The University of Tokyo Hosiptal, Tokyo, Japan
⁴Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Shuanghong Zhu^1*, Chen Mei^2*, Yuxia Wang^3*, Jie Jin, PhD⁴, Jie Sun, PhD^5* and Hongyan Tong, MD, PhD^6*

¹the first affiliated hospital of zhejiang university, hangzhou, China
²Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
³The First Affiliated Hospital, Zhejiang University School of Medicine,, hangzhou, China
⁴Department of Hematology, The First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China
⁵Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁶Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

Jiajia Pan^1*, Jie Jin, M.D., Ph.D.^2,3, Yungui Wang, Ph.D.^4*, Shujuan Huang^5*, Wenwen Wei^6*, Shihui Mao^7*, Qing Ling^8*, Chenying Li^1* and Jinghan Wang, MD, PhD^4*

¹First Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, China
²The First Affiliated Hospital, Zhejiang University of Medicine, Hangzhou, China
³Zhejiang Provincial Key Laboratory of Hematopoietic Malignancy, Zhejiang University, Hangzhou, Zhejiang, PR China, Hangzhou, China
⁴Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁵Department of Hematology, the First Affiliated Hospital of University of Science and Technology of China, Hefei, China
⁶Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China., Hangzhou, China
⁷First Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, Arizona, CHN
⁸the fisrt affliated hospital，Zhejiang university，school of medicine, Hangzhou, China

Matthew R.M. Jotte^1*, Henna S. Nam^2*, Bonnie Hu^2*, Tanner C. Martinez^1*, Saira Khan, MS^3,4*, Ningfei An, PhD^3,4*, Angela Stoddart, PhD⁴ and Megan E. McNerney, MD, PhD^3,4,5

¹Interdisciplinary Scientist Training Program, University of Chicago, Chicago, IL
²University of Chicago, Chicago, IL
³Department of Pediatrics, section of Hematology/Oncology, University of Chicago, Chicago, IL
⁴Department of Pathology, University of Chicago, Chicago, IL
⁵University of Chicago Medicine Comprehensive Cancer Center, University of Chicago, Chicago, IL

Alissa Oakes, BS^1*, Anna D Chorzalska, PhD^2*, Dennis M Bonal, MSc, BSc^3*, John L Reagan, MD⁴ and Patrycja M Dubielecka, PhD⁵

¹Signal Transduction Lab, Division of Hematology-Oncology, Rhode Island Hospital and Warren Alpert Medical School at Brown University, Providence, RI
²Signal Transduction Lab, Division of Hematology-Oncology,, Rhode Island Hospital and Warren Alpert Medical School at Brown University, Providence, RI
³Signal Transduction Lab, Division of Hematology-Oncology, Rhode Island Hospital and Warren Alpert Medical School at Brown University, Douglas, MA
⁴Division of Hematology/Oncology, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI
⁵Division of Hematology-Oncology, Warren Alpert Medical School of Brown University/Rhode Island Hospital, Providence, RI

Geethu Emily Thomas, PhD, MSc, BSc¹, Kazem Nouri, PhD^2*, Rose Hurren, BSc^1*, Yongran Yan, MSc^3*, Neil MacLean^1*, Yulia Jitkova, PhD^1*, Li Ma^2*, Xiaoming Wang^4*, Chaitra Sarathy, PhD^1*, Andrea Arruda, MSc^5*, Mark D. Minden, MD, PhD⁶, Vito Spadevecchio, B.A^7* and Aaron D. Schimmer, MD, PhD⁶

¹Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
²Princess Margaret Cancer Research, Toronto, ON, Canada
³Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada
⁴Princess Margaret Cancer Research, University Health Network, Toronto, ON, Canada
⁵University Health Network, Toronto, ON, Canada
⁶Division of Medical Oncology and Hematology, University Health Network, Toronto, ON, Canada
⁷Interlinked Therapeutics LLC, Portland, OR

Eline J.M. Bertrums^1,2,3*, Sjors Middelkamp^1,2*, Inge M. van der Werf^1,2*, Freek Manders, MSc^1,2*, Arianne M. Brandsma, PhD^2*, Niels M. Groenen^1,2*, Mark Verheul^1,2*, Markus J. van Roosmalen^1,2*, C. Michel Zwaan, Prof. MD, PhD^2,3*, Marry M. van den Heuvel-Eibrink, MD^2,4, Bianca F. Goemans, MD, PhD² and Ruben Van Boxtel, PhD^1,2*

¹Oncode Institute, Utrecht, Netherlands
²Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
³Department of Pediatric Oncology, Erasmus Medical Center - Sophia Children's Hospital, Rotterdam, Netherlands
⁴Utrecht University, Utrecht, Netherlands

Yang Li^1*, Ziheng Xu, BS^1*, Ryan B Day, MD, PhD², Yiling Mi^1*, Petra Erdmann-Gilmore^1*, R. Reid Townsend, MD, PhD^1* and Timothy J. Ley, MD²

¹Washington University in St. Louis School of Medicine, Saint Louis, MO
²Department of Medicine, Division of Oncology, Section of Stem Cell Biology, Washington University in St. Louis School of Medicine, Saint Louis, MO

Mark Hartmann, PhD^1,2*, Ling Hai, PhD^3*, Joschka Hey, PhD^4*, Maximilian Schönung^1,2,5*, Valentin Maurer, B.Sc.^1,2*, Jovana Rajak^6*, Sina Staeble, PhD^1,2, Jens Langstein, PhD^1,2*, Katharina Bauer^7*, Mariam Hakobyan, M.Sc.^1*, Laura Jardine, PhD^8*, Sheila Bohler, PhD^6*, Dominik Vonficht, MSc^5,9,10*, Abdul-Habib Maag^11*, Dirk Lebrecht, PhD^12*, Kathrin M. Bernt, MD¹³, Roland Roelz, MD^14*, Tobias Boch, MD^15*, Eleonora Khabirova, PhD^16*, Pavlo Lutsik, PhD^4*, Oliver Stegle, PhD^17,18,19*, Simon Haas, PhD^10,20,21,22*, Muzlifah Haniffa, PhD^23*, Sam Behjati, PhD^24*, Jan-Philipp Mallm, PhD^7*, Christian Buske, MD¹¹, Stefan Fröhling, MD^2,25,26, Christoph Plass, PhD^4*, Charlotte M. Niemeyer^6,26, Christian Flotho, MD^6,26*, Marc Jan Bonder, PhD^17,18,19*, Miriam Erlacher, MD, PhD^12,26*, Matthias Schlesner, PhD^27* and Daniel B. Lipka, MD^1,28

¹Division of Translational Medical Oncology, Section Translational Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany
²National Center for Tumor Diseases (NCT), Heidelberg, Germany
³Department of Neurology and Neurooncology, University Hospital Heidelberg, Heidelberg, Germany
⁴Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany
⁵Faculty of Biosciences, Heidelberg University, Heidelberg, Germany
⁶Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University of Freiburg, Faculty of Medicine, Medical Center, Freiburg, Germany
⁷Single Cell Open Lab, German Cancer Research Center (DKFZ) and BioQuant, Heidelberg, Germany
⁸Biosciences Institute, Newcastle University, Newcastle Upon Tyne, GBR
⁹Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany
¹⁰Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany
¹¹Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany
¹²Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
¹³Pediatric Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
¹⁴Department of Neurosurgery, University of Freiburg, Faculty of Medicine, Medical Center, Freiburg, Germany
¹⁵Department of Hematology and Oncology, Heidelberg University, University Hospital Mannheim, Mannheim, Germany
¹⁶Wellcome Sanger Institute, Hinxton, United Kingdom
¹⁷Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
¹⁸Division of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany
¹⁹European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, European Molecular Biology Laboratory (EMBL), Hinxton, United Kingdom
²⁰Berlin Institute of Health (BIH), Charité – Universitätsmedizin Berlin, Berlin, Germany
²¹Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center in the Helmholtz Association, Berlin, Germany
²²Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany
²³Biosciences Institute, Newcastle University, Newcastle upon Tyne, ENG, United Kingdom
²⁴Wellcome Sanger Institute, Hinxton, ENG, United Kingdom
²⁵Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany
²⁶German Cancer Consortium (DKTK), Heidelberg, Germany
²⁷Faculty of Applied Computer Sciences, Biomedical Informatics, Data Mining and Data Analytics, Augsburg University, Augsburg, Germany
²⁸National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany

Hannah Lawson^1*, James Holt-Martyn^2*, Vilma Dembitz^1*, Jozef Durko^1*, Yuka Kabayama^3*, Lydia Wang^1*, Louie Van De Lagemaat^1*, Louis Dubusse^1*, Laura Alunno^1*, Amelie Guitart^4*, Jürg Schwaller, MD⁵, Paolo Gallipoli, MD¹, Dónal O'Carroll^3*, Christopher Schofield^2* and Kamil Kranc^1*

¹Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
²University of Oxford, Oxford, United Kingdom
³University of Edinburgh, Edinburgh, United Kingdom
⁴Université De Bordeaux, Bordeaux, FRA
⁵University Children's Hospital Basel, Department of Biomedicine, University of Basel, Basel, Switzerland

Juan M. Barajas, PhD, Sherif Abdelhamed, PhD, Tamara Westover, BS^*, Masayuki Umeda, MD^*, Ryan Hiltenbrand, MS^*, Bright Arthur, MS^*, Reethu Krishnan^*, Michael P Walsh, PhD^*, Jing Ma, PhD^* and Jeffery M. Klco, MD, PhD

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN

Xinyue Zhou^1*, Steven Moreira, PhD^2*, Hong Wang, PhD^3*, Pengcheng Zhang^1*, Yang Zhou, PhD^4*, Ravi Bhatia, MD¹, Chunliang Li, PhD⁵, Kristin Hope, PhD² and Rui Lu, PhD⁶

¹Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham
²Department of Medical Biophysics, University of Toronto, Toronto, Canada
³St. Jude Children's Research Hospital, Memphis
⁴Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham
⁵St. Jude Children's Research Hospital, Memphis, TN
⁶Division of Hematology and Oncology, Department of Medicine, University of Alabama At Birmingham, Birmingham, AL

Gabriel Levy, MD^1,2,3*, Nicolas Papadopoulos^2,3,4*, Christian Pecquet, PhD^1,2,3*, Jean-Philippe Defour, BPharm, PhD^1,2,3*, Emilie Leroy, PhD^1,2,3*, Nabih Maslah, PharmD, PhD^5,6*, Bruno Cassinat, PharmD, PhD^5,6, Steven Smith, PhD^7* and Stefan N Constantinescu, MD^1,2,3,8

¹de Duve Institute, Université catholique de Louvain, Brussels, Belgium
²Ludwig Institute for Cancer Research, Brussels, Belgium
³WELBIO (Wallon Excellence in Life Sciences and Biotechnology), Brussels, Belgium
⁴de Duve Institute, Université Catholique de Louvain, Brussels, Belgium
⁵INSERM UMR 1131, Institut de Recherche Saint-Louis, Paris, France
⁶AP-HP, Hopital Saint-Louis, Laboratoire de Biologie Cellulaire, Paris, France
⁷Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY
⁸Nuffield Department of Medicine, Ludwig Institute for Cancer Research, Oxford University, Oxford, United Kingdom

Chenwei Yang^*, Li Gao, MD^*, Jing Ling, MD^*, Hu Liu^*, Qi Ji^*, Minyuan Liu^*, Yongping Zhang^*, Shaoyan Hu, MD, PhD and Yuanyuan Tian^*

Department of Pediatric Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, China

Anita Ng^1*, Yuhong Ma, PhD², Yuri Pekarsky, PhD^3*, Francesca Lovat, PhD^4*, Frank Di Caro^5*, Esha Sharma^6*, Lita Crichton^5*, Britta Will, PhD⁷, Carlo M. Croce, MD⁴ and Nicholas Chiorazzi, MD¹

¹Karches Center for Oncology Research, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY
²Albert Einstein College of Medicine, Bronx, NY
³OSU, Columbus, OH
⁴Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH
⁵Karches Center for Oncology Research, The Feinstein Institute of Medical Research, Manhasset, NY
⁶The Feinstein Institute for Medical Research, Manhasset, NY
⁷Division of Hematologic Malignancies, Department of Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY

Nicolas Niklaus, PhD^1*, Magali Humbert, PhD², Bruce E. Torbett, PhD³ and Mario P. Tschan, PhD⁴

¹Institute of Pathology, University Bern, Bern, Bern, Switzerland
²HemostOD SA, Lausanne, Switzerland
³Department of Pediatrics, School of Medicine, University of Washington, Seattle, Seattle, WA
⁴University of Bern, Bern, Switzerland