Damia Romero-Moya^1*, Oskar Marin-Bejar, PhD^1*, Maximiliano Distefano^2*, Joan Pera^1*, Julio Castaño, PhD^3*, Jessica Gonzalez, PhD^4*, Lili Kotmayer^5*, Csaba Bödör, PhD^6*, Albert Català, MD, PhD^2,7*, Marcin W. Wlodarski, MD, PhD⁸, Anna Bigas, PhD^4,9* and Alessandra Giorgetti, PhD^1,10*

¹Regenerative Medicine Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Hospitalet De Llobregat, Spain
²Department of Hematology and Oncology, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Deu, Barcelona, Spain
³Immunotherapy Unit, Banc de Sang i Teixits, Barcelona, Spain
⁴Cancer Research Program, Institut Hospital del Mar d'Investigacions Mèdiques, CIBERONC, Hospital del Mar, Barcelona, Spain
⁵HCEMM-SE Momentum Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, AL, Hungary
⁶HCEMM-SE Momentum Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
⁷Instituto de Salud Carlos III, Biomedical Network Research Centre on Rare Diseases, Madrid, Spain
⁸Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
⁹Josep Carreras Research Institute (IJC), Badalona, Spain
¹⁰Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Barcelona University, Barcelona, Spain

Suying Liu^1,2*, Juliana Ehnot^2,3*, Greer Jeffery, BA^4*, Seul K Jung, BS^5,6*, Theresa N Menna, BS^3,6*, Haotian Zheng, BS^7*, Louise E. Purton, PhD⁸ and Peter Kurre, MD^6,9

¹Perelman School of Medicine, University of Pennsylvannia, Philadelphia, PA
²Comprehensive Bone Marrow Failure Center, Children’s Hospital of Philadelphia, Philadelphia, PA
³Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
⁴Comprehensive Bone Marrow Failure Center, Department of Pediatrics, Children's hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
⁵Perelman School of Medicine, University of Pennsylvania,, Philadelphia, PA
⁶Comprehensive Bone Marrow Failure Center, Children's Hospital of Philadelphia, Philadelphia, PA
⁷Department of Biostatistics, Epidemiology and informatics, University of Pennsylvania, Philadelphia, PA
⁸Stem Cell Regulation Unit, St Vincent's Institute of Medical Research, Melbourne, Australia
⁹Perelman School Medicine, University of Pennsylvania, Philadelphia, PA

Willian R. Gomes, MSc^1*, Vinicius S. Carvalho, MsC^2*, Bárbara A. Santana, PhD^3*, Edson Z. Martinez, PhD^4*, Leandra Z. Ramalho, MD, PhD^5*, Antonio Condino-Neto, MD, PhD^6* and Rodrigo T. Calado, MD, PhD⁷

¹Department of Medical Imaging, Hematology, and Clinical Oncology, Ribeirão Preto School of Medicine, University of São Paulo, RIBEIRAO PRETO, AL, Brazil
²Department of Medical Imaging, Hematology, and Clinical Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil
³Department of Medical Imaging, Hematology, and Clinical Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil
⁴Department of Social Medicine, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirao Preto, Brazil
⁵Department of Pathology and Forensic Medicine, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirao Preto, Brazil
⁶Institute of Biomedical Sciences - University of Sao Paulo, Sao Paulo, SP, BRA
⁷Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirão Preto School of Medicine, University of São Paulo, São Paulo, Brazil

Mayuresh Anant Sarangdhar^1,2*, Martina Stillinovic, PhD^1,2*, Nicola Daniele Andina, MD, PhD^1,2,3*, Aubry Tardivel^1*, Anne Angelillo-Scherrer, MD-PhD^1,2 and Ramanjaneyulu Allam, PhD^1,2*

¹Department for BioMedical Research, University of Bern, Bern, Switzerland
²Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland
³Department of Biomedicine, University Hospital Basel, Basel, Switzerland

Alejandro Ferrer, PhD¹, Rekha Mudappathi^2*, Terra L. Lasho, PhD¹, Ryan M. Carr, MD, PhD¹, Jenna A. Fernandez, PhD^1*, Christy Finke, BS^1*, Naseema Gangat, MBBS¹, Roshini S. Abraham, PhD³, Moritz Binder, MD, MPH¹, Abhishek A. Mangaonkar, MBBS¹, Junwen Wang, PhD^2* and Mrinal M. M. Patnaik, MD¹

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Mayo Clinic, Scottsdale, AZ
³Nationwide Childrens Hospital, Columbus, OH

Sunisa Kongkiatkamon, MD^1*, Chupong Ittiwut^2*, Thanawat Rattanathammethee, MD^3*, Wanna Chetruengchai^2*, Kitsada Wudhikarn^4*, Sirorat Kobbuaklee^5*, Amornchai Suksusut^6*, Pimjai Niparuck, MD^7*, Noppacharn Uaprasert, MB, BCH^8*, Suporn Chuncharunee, MD⁷, Udomsak Bunworasate, MD^6*, Kanya Suphapeetiporn^2*, Ponlapat Rojnuckarin, MD, PhD⁵ and Chantana Polprasert, MD^5*

¹Chulalongkorn University and King Chulalongkorn Memorial Hospital, Department of Medicine, Faculty of Medicine, Bangkok, Thailand
²Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Center of Excellence for Medical Genomics,Medical Genomics Cluster, Bangkok, Thailand
³Division of Hematology, Department of Internal Medicine, Chiang Mai University, Chiangmai, THA
⁴Blood and Marrow Transplantation Program, Chulalongkorn University, Bangkok, Thailand
⁵Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand
⁶Division of Hematology, Department of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand
⁷Division of Hematology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
⁸Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand

Anna Maierhofer, PhD^1*, Lucy C. Fox, MBBS², Stephan Hutter, PhD^1*, Constance Baer, PhD¹, Ella Thompson, PhD, BSc^2,3*, Tamia Nguyen^2*, Nicole Den Elzen, PhD^2*, Robin J Filshie, MBChB, PhD, FRACP, FRCPA⁴, Ing S Tiong, FRACP, FRCPA, MPhil⁵, Niroshan Nadarajah^1*, Manja Meggendorfer, PhD¹, Wolfgang Kern, MD¹, Claudia Haferlach, MD¹, Torsten Haferlach, MD¹ and Piers Blombery, MBBS^2,3,6

¹MLL Munich Leukemia Laboratory, Munich, Germany
²Peter MacCallum Cancer Centre, Melbourne, Australia
³University of Melbourne, Melbourne, Australia
⁴Department of Hematology, St. Vincent's Hospital Melbourne, Melbourne, VIC, Australia
⁵Peter MacCallum Cancer Centre and the Royal Melbourne Hospital, Melbourne, VIC, Australia
⁶Torsten Haferlach Leukaemiediagnostik Stiftung, Munich, Germany

Felicia Andresen, MD^1,2, Martina Sukova, MD^3*, Jan Stary, MD^4*, Barbara De Moerloose, MD^5*, Jutte Van Der Werff Ten Bosch, MD, PhD^6*, Michael Dworzak, MD, PhD^7,8*, Markus G Seidel, MD^9*, Sophia Polychronopoulou, MD, PhD^10*, Rita Beier, MD^11*, Christian P. Kratz, MD¹¹, Michaela Nathrath, MD, PhD^12*, Michael C. Frühwald, MD, PhD^13*, Gudrun Göhring, MD^14*, Anke K. Bergmann, MD^15*, Christina Mayerhofer, MD^16,17*, Natalia Rotari, MD^16*, Dirk Lebrecht, PhD^1*, Senthilkumar Ramamoorthy, PhD^16,18*, Ayami Yoshimi, MD, PhD^16*, Brigitte Strahm, MD^19*, Marcin W. Wlodarski, MD, PhD^20,21, Charlotte M. Niemeyer^1,22 and Miriam Erlacher, MD, PhD^1,22*

¹Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
²Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA
³Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
⁴Dept. of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
⁵Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
⁶Department of Pediatric Hematology-Oncology, University Hospital Brussel, Brussels, Belgium
⁷Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria
⁸Department of Pediatrics, St. Anna Children's Hospital and Cancer Research Institute, Medical University of Vienna, Vienna, Austria
⁹Division of Pediatric Hematology-Oncology, Medical University Graz, Department of Pediatrics and Adolescent Medicine, Graz, Austria
¹⁰Department of Pediatric Hematology-Oncology (T.A.O.), Aghia Sophia Children's Hospital, Athens, Greece
¹¹Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
¹²Department of Pediatric Hematology and Oncology, Klinikum Kassel, Kassel, Germany
¹³Pediatrics and Adolescent Medicine, Department of Pediatric Hematology and Oncology, University Medical Center Augsburg, Augsburg, Germany
¹⁴Department of Human Genetics, Medical School Hannover, Hannover, Germany
¹⁵Department of Human Genetics, Hannover Medical School (MHH), Hannover, Germany
¹⁶Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Faculty of Medicine, University of Freiburg, Freiburg, Germany
¹⁷Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA
¹⁸Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine, University of Freiburg, Freiburg, Germany
¹⁹Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
²⁰University of Freiburg, Freiburg, Germany
²¹St. Jude Children's Research Hospital, Memphis, TN
²²partner site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany