Robert F. Sidonio, Jr., MD, MSc¹, Ana Boban^2*, Leonid Dubey, MD, PhD^3*, Adlette Inati, MD, FAAP⁴, Csongor Kiss, MD, PhD, DSc^5*, Toshko Lissitchkov^6*, Dzmitry Novik^7*, Elina Peteva^8*, Ali T. Taher, MD, PhD, FRCP⁹, Margarita Arkadevna Timofeeva, MD^10*, Kateryna V. Vilchevska, MD^11*, Vladimir Vdovin, MD^12*, Sylvia Werner^13*, Sigurd Knaub, M.D.¹⁴ and Claudia Khayat, MD, BS^15*

¹Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
²Department of Internal Medicine, University Hospital Centre Zagreb, Zagreb University School of Medicine, Zagreb, Croatia
³Communal Nonprofit Enterprise "Western Ukrainian Specialized Children's Medical Center" of Lviv Regional Council, Lviv, Ukraine
⁴Nini Hospital, Tripoli, Lebanon
⁵Thrombosis and Haemostasis Center, University of Debrecen Clinical Center Nagyerdei Campus, Debrecen, Hungary
⁶Department of Chemotherapy, Hemotherapy and Hereditary Blood Diseases at Clinical Hematology Clinic, Specialized Hospital for Active Treatment of Hematological Diseases, Sofia, Bulgaria
⁷Government Agency "Republican Research Center for Radiation Medicine and Human Ecology", Gomel, Belarus
⁸Pediatric Clinic of Haematology and Oncology, University Hospital St.Marina - Varna, Varna, Bulgaria
⁹Department of Internal Medicine, Division of Hematology-Oncology, American University of Beirut Medical Center, Beirut, Lebanon
¹⁰Federal State Budgetary scientific institution Kirov scientific-research institute of Hematology and Blood Transfusion of Federal Medical and Biological Agency, Kirov, AL, Russia
¹¹National Specialized Children’s Hospital Okhmatdyt, Kyiv, Ukraine
¹²Morozovskaya Children's City Clinical Hospital, Moscow, Russia
¹³Octapharma USA, Paramus, NJ
¹⁴Octapharma AG, Lachen, Switzerland
¹⁵Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon

Vincenzo La Mura, MD, PhD^1,2*, Niccolò Bitto, MD^2*, Cecilia Capelli, MD^1*, Simona Maria Siboni, MD^2*, Sara Arcudi, MD^1,2*, Alessandro Ciavarella, MD^2,3*, Roberta Gualtierotti^4,5* and Flora Peyvandi, MD^1,6

¹Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy
²Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
³Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy
⁴Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy
⁵Department of Pathophysiology and Transplantation, Università Degli Studi Di Milano, Milan, Italy
⁶Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy

Konrad Van Der Zwet^1*, Marloes de Kovel^2*, Jayashree Motwani, MD^3*, Christel Van Geet, MD PhD⁴, Beatrice Nolan, FRCPath^5*, Heidi Glosli, MD^6*, Gili Kenet, MD^7,8 and Kathelijn Fischer, MD^1*

¹Van Creveldkliniek, Center for Benign Hematology, Thrombosis and Haemostasis, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
²PedNet Haemophilia Research Foundation, Baarn, Netherlands
³Birmingham Children's Hospital, Birmingham, United Kingdom
⁴University Hospitals Leuven, Leuven, Belgium
⁵Children Health Ireland at Crumlin, Dublin, Ireland
⁶Centre for Rare Disorders, Oslo University Hospital, Oslo, Norway
⁷The National Hemophilia Center, and Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Israel
⁸Tel Aviv University, Tel Aviv, Israel

Laetitia Faye^1*, Pamela A Christopherson^2*, Sandra L Haberichter, PhD³, Kenneth D. Friedman, MD⁴, Robert R Montgomery, MD⁵ and Veronica H Flood, MD⁶

¹Medical College of Wisconsin, Milwaukee, WI
²Blood Center of WI Blood Research Institute, Milwaukee, WI
³Blood Research Institute and Diagnostic Laboratories, Versiti, Milwaukee, WI
⁴Division of Hematology and Oncology, Medical College of Wisconsin, Versiti BloodCenter of Wisconsin, Milwaukee, WI
⁵Blood Research Institute, Milwaukee, WI
⁶Pediatric Hematology, Medical College of Wisconsin, Milwaukee, WI

Magdolna Nagy^1*, Joep Schellens^2*, Anne-Marije Hulshof^1,3*, Frank van Rosmalen, PhD^2*, Rene van Oerle^1*, Thijs T.W. van Herpt, MD, PhD^2*, Teba Alnima, MD, PhD^2*, Mark Mulder, MD, PhD^2*, Dave Hellenbrand^3*, Hugo ten Cate, MD, PhD^1,4,5,6, Yvonne M.C. Henskens, Prof.^3*, Bas C.T. Van Bussel, MD, PhD^2,7* and Henri M.H. Spronk, PhD^1,4,6

¹Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands
²Department of Intensive Care Medicine, Maastricht University Medical Centre+, Maastricht, Netherlands
³Central Diagnostic Laboratory, Maastricht University Medical Centre+, Maastricht, Netherlands
⁴Thrombosis Expertise Center, Heart+Vascular Center, Maastricht University Medical Center+, Maastricht, Netherlands
⁵Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
⁶Department of Internal Medicine, Maastricht University Medical Centre+, Maastricht, Netherlands
⁷Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, Netherlands

Nicoletta C Machin, DO, MS¹, Scott Rothenberger, PhD^2*, Veronica H Flood, MD^3,4,5, Pamela A Christopherson^6,7*, Robert R Montgomery, MD^3,6,8 and Margaret V. Ragni, MD, MPH^1,9

¹University of Pittsburgh and Hemophilia Center of Western Pennsylvania, Pittsburgh, PA
²Center for Research on Health Care Data Center, University of Pittsburgh, Pittsburgh, PA
³Department of Pediatrics, Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI
⁴Pediatric Hematology, Medical College of Wisconsin, Milwaukee, WI
⁵Blood Research Institute, Versiti, Milwaukee, WI
⁶Blood Research Institute, BloodCenter of Wisconsin, part of Versiti, Milwaukee, WI
⁷Blood Center of WI Blood Research Institute, Milwaukee, WI
⁸Blood Research Institute, Milwaukee, WI
⁹Department of Medicine, University of Pittsburgh, Pittsburgh, PA

Pratik Bhagunde^1*, Qiang Lu^1*, Marek Demissie^2*, Annemieke Willemze, MD, PhD^3* and Suresh Katragadda^2*

¹Sanofi, Bridgewater, NJ
²Sanofi, Cambridge, MA
³Sanofi, Amsterdam, Netherlands

Jerzy Windyga, MD, PhD^1*, Edyta Odnoczko, PhD^2*, Ewa Stefanska-Windyga, MD, PhD^3*, Beata Baran, PhD^2*, Anna Sikorska, MD, PhD^3*, Magdalena Gorska-Kosicka, MD, PhD^4*, Janusz Zawilski, PhD^5* and Magdalena Letowska, MD, PhD^6*

¹Department of Hemostasis Disorders and Internal Medicine, Laboratory of Hemostasis and Metabolic Diseases, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
²Laboratory of Hemostasis and Metabolic Diseases, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
³Clinic of Hemostasis Disorders, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
⁴Department of Hemostasis Disorders and Internal Medicine, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
⁵INTERLAB, Poznan, POL
⁶Department of Transfusion Medicine, Institute of Hematology and Transfusion Medicine, Warsaw, Poland

Viviane Grassmann, MSc, PhD^1*, Dagmar M Hajducek, PhD^2*, Andrea N Edginton, PhD^2*, Vanessa Bouskill, MN, NP^3*, Christine Brown^4*, Manuel Carcao, MD, MSc⁵, David Lillicrap, MD, FRCPC⁴, Roxy H O’Rourke, MSc^1*, Roona Sinha, MD, MHPE⁶, Jayson Stoffman, MD, FRCPC⁷, Cindy Wakefield, RN^3*, Margaret L. Rand, PhD^8,9 and Victor Blanchette, MD, FRCP, FRCPC^5,8

¹Child Health Evaluative Sciences/ Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
²School of Pharmacy, University of Waterloo, Waterloo, ON, Canada
³Department of Nursing, The Hospital for Sick Children, Toronto, ON, Canada
⁴Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada
⁵Department of Paediatrics, University of Toronto, Toronto, ON, Canada
⁶Royal University Hospital, University of Saskatchewan, Saskatoon, SK, Canada
⁷Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada
⁸Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada
⁹Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada

Gregorio Campos-Cabrera, MD¹, Esther Mendez-Garcia, MD^2*, Virginia Campos-Cabrera, QFB EBC^3*, Salvador Campos-Cabrera, MD^4* and Jose-Luis Campos-Villagomez, MD^4*

¹Hematology and Blood Bank, Laboratorios Fatima de Michoacan, Morelia, MEX
²Radiology, Laboratorios Fatima de Michoacan, Morelia, Mexico
³Patologia Clinica, Laboratorios Fatima de Michoacan, Morelia, Mexico
⁴Hematology and Blood Bank, Laboratorios Fatima de Michoacan, Morelia, Mexico

Joanna Larson, FNP-C^1*, Katherine Addy, RN^2*, Deborah L. Brown, MD³, Nidra Rodriguez, MD^4*, Neethu M Menon, MD⁵, Miguel Escobar, MD^6,7,8* and Lakshmi Srivaths, MD⁹

¹Gulf States Hemophilia and Thrombophilia Center, McGovern Medical School and University of Texas HSC at Houston, Houston, TX
²Gulf States Hemophilia and Thrombophilia Center, McGovern Medical Center and University of Texas HSC at Houston, Houston, TX
³Division of Hematology, Department of Pediatrics, Gulf States Hemophilia and Thrombophilia Center, McGovern Medical School and University of Texas Health Science Center at Houston, Houston, TX
⁴McGovern Medical Center and University of Texas HSC at Houston, Houston, TX
⁵Department of Pediatrics, Division of Hematology, Gulf States Hemophilia and Thrombophilia Center, UT Southwestern Medical Center, Houston, TX
⁶McGovern Medical School and Gulf States Hemophilia and Thrombophilia Center, University of Texas Health Science Center, Houston Medical School, Houston, TX
⁷Gulf States Hemophilia and Thrombophilia Center, Houston, TX
⁸University of Texas Health Science Center, Houston, TX
⁹Department of Pediatrics, Division of Hematology, Gulf States Hemophilia and Thrombophilia Center, McGovern Medical School and University of Texas HSC at Houston, Houston, TX

Francisco José López-Jaime, MD^1*, Olga Benitez, MD^2,3*, Nuria Caballero^4*, Rubén Berrueco, MD^5,6*, Eva Álvarez^2*, Ihosvany Fernandez-Bello, BSPharm, PhD^1*, Miguel Blanquer Blanquer, MD, PhD⁷ and Adrián Montaño, Biotechnologist, PhD^1,8*

¹Hospital Universitario Regional de Málaga-IBIMA, Málaga, Spain
²Departamento de Hematología Experimental, Instituto de Oncología (VHIO), Hospital Universitario Vall d’Hebron, Barcelona, Spain
³Departamento de Medicina, Universidad Autónoma de Barcelona, Barcelona, Spain
⁴Universidad de Barcelona. Departamento de Hematología y Oncología Pediátrica,, Hospital Sant Joan de Déu, Barcelona, Spain
⁵Universidad de Barcelona. Departamento de Hematología y Oncología Pediátrica, Hospital Sant Joan de Déu., Barcelona, Spain
⁶Instituto de Investigación Pediátrica, Hospital Sant Joan de Déu (IRP-HSJD), Barcelona, Spain
⁷Hospital Clínico Universitario Virgen De La Arrixaca, Murcia, Murcia, Spain
⁸University of Salamanca, Salamanca, Spain

María Isabel Rivas Pollmar, MD, PhD^1,2*, Elena G Arias-Salgado, PhD^1,2*, María Teresa Alvarez Román, MD, PhD^1,2,3*, Elena Monzón Manzano, PhD^1,2*, Paula Acuña, BSc^1,2*, Mónica Martín Salces, MD, PhD^1,2*, Sara García Barcenilla^1,2*, Nora V. Butta, PhD^1,4*, Cédric Hermans, MD, MRCP, PhD⁵ and Víctor Jiménez-Yuste, MD, PhD^1,2,3*

¹IdiPAZ, Madrid, Spain
²Hospital Universitario La Paz, Madrid, Spain
³Universidad Autónoma de Madrid, Madrid, Spain
⁴Hospital Universitario La Paz, Madrid, Madrid, Spain
⁵Cliniques Saint-Luc, Université Catholique de Louvain, Brussels, Belgium

Dana Egan-Sherry, MD¹ and James D. Cooper, MD²

¹Upmc Children's Hospital of Pittsburgh, Pittsburgh, PA
²Pediatric Hematology & Oncology, UPMC - Children's Hospital of Pittsburgh, Pittsburgh, PA

Man-Chiu Poon, MD^1,2, Adrienne Lee, MD³, Federico Germini, MD^4,5*, Arun Keepanasseril, MDS^4*, Quazi Ibrahim, MSc^4*, Francis Nissen, MD, PhD^6*, Katya Moreno, MD^6*, Michelle Santos, MN, NP^7*, Emma Iserman, BA^4*, Davide Matino, MD^4,5* and Alfonso Iorio, MD^4,5

¹Department of Medicine, University of Calgary, Calgary, AB, Canada
²Department of Pediatrics and Oncology, University of Calgary, Calgary, AB, Canada
³Department of Medicine, University of British Columbia, Victoria, BC, Canada
⁴Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada
⁵Department of Medicine, McMaster University, Hamilton, ON, Canada
⁶F. Hoffmann-La Roche Ltd., Basel, Switzerland
⁷F. Hoffmann-La Roche Ltd., Mississauga, ON, Canada

Feng Xue, MD^1*, Hu Zhou^2*, Yun Chen, MD^3*, Jing Sun^4*, Xiaojing Zeng^5*, Chenghao Jin^6*, Pingchong Lei^7*, Zhenyu Li, M.D., Ph.D.^8*, Yaming Xi, MD^9*, Lirong Sun^10*, Zhongguang Cui^10*, Xielan Zhao^11*, Linhua Yang^12*, Bangshuo Zhang^13*, Aizong Shen^14*, Runhui Wu, MD, PhD^15*, Xiaolin Wang^16*, Ling Liu^17*, Yuhua Wang^18*, Lizhi Sun^19*, Yan Xia^20*, Weichuan Mo^21*, Dong Yuan^21*, Jiwei Lou^22*, Taiping Gan^21*, Chengli Hu^21*, Chen Ling^21*, Hongsheng Su^21*, Yali Wang^23*, Baolin Tang^24* and Renchi Yang, MD^25,26

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, China
²Department of Hematology, the Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, zhengzhou, China
³Jinan Central Hospital Affiliated to Shandong University, Jinan, China
⁴Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⁵The Affiliated Hospital of Guizhou Medical University, Guiyang, China
⁶Department of Hematology, Jiangxi Provincial People's Hospital, Nanchang, China
⁷Henan provincial People's Hospital, zhenzhou, China
⁸The Affiliated Hospital of Xuzhou Medical College, xuzhou, China
⁹The First Hospital of Lanzhou University, Lanzhou, China
¹⁰The Affiliated Hospital of Qingdao University, qingdao, China
¹¹Xiangya Hospital, Central South University, Changsha, China
¹²Department of Hematology, The Second Affiliated Hospital of Shanxi Medical University, Taiyuan, China
¹³Chongqing Three Gorges Central Hospital, chongqing, China
¹⁴Anhui Provincial Hospital, hefei, China
¹⁵Department of Hematology, National Center for Children's Health, Beijing Children's Hospital, Beijing, China
¹⁶Capital Medical University affiliated Beijing Children's Hospital, Beijing, China
¹⁷The Second Affiliated Hospital of Guangzhou Medical University, guangzhou, China
¹⁸Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
¹⁹Jinan central hospital, Jinan, China
²⁰JOINN Laboratories News JOINN (Suzhou),, suzhou, China
²¹Jiangsu Gensciences Inc., Nantong, Nantong, China
²²Jiangsu Gensciences Inc., Nantong,, Nantong, China
²³iangsu Gensciences Inc., Nantong, Nantong, China
²⁴Department of Hematology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
²⁵Institute of Hematology & Blood Disease, Tianjin, China
²⁶Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China

Jonathan C. Roberts, MD, Sarah E Gonzales^*, Amanda M. Kilgore^*, Dominique N. Barclay^* and Michael D Tarantino, MD

Bleeding & Clotting Disorders Institute, Peoria, IL

Susan Halimeh, Dr.,¹, Hannelore Rott, Dr^2*, Manuela Siebert^3*, Günther Kappert^4* and Dirk Reinhardt, MD^5,6

¹Coagulation research center Duisburg, Gerinnungszentrum Rhein Ruhr, Duisburg, AL, DEU
²Gerinnungszentrum rhein ruhr, Duisburg, DEU
³Gerinnungszentrum rhein ruhr, Duisurg, DEU
⁴Gerinnungszentrum Rhein-Ruhr, Duisburg, DEU
⁵Clinic of pediatrics III, University Hospital of Essen, Essen, Germany
⁶Department of Pediatrics III, University Hospital Essen, University Duisburg-Essen, Essen, Germany

Wei Liu^1*, Feng Xue, MD^1*, Rongfeng Fu, MD^1*, Bingjie Ding, MD^2*, Mengjuan Li, MD^2*, Ting Sun, MD^1*, Yunfei Chen, MD^1*, Liu Xiaofan, MD^1*, Mankai Ju, MD^1*, Xinyue Dai, MD^1*, Quanrui Wu^3*, Zan Zhou^3*, Xiaomin Wang^3*, Jiaojiao Yu^3*, Hu Zhou, MD, PhD^2*, Renchi Yang, MD¹ and Lei Zhang, MD^1*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, China
²Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital，Hemostasis and Thrombosis Diagnostic Engineering Research Center of Henan Province, Zhengzhou, China
³Staidson (Beijing) Biopharmaceuticals Co., Ltd, Beijing, China

Aikaterini Michalopoulou, MD, MSc^1*, Aimilia Mantzou, PhD^2*, Vassiliki Kappou, MSc^2*, Athina Dettoraki^1*, Anastasia Pilichou, MD, PhD^3*, Zoey Kapsimali, PhD^1*, John Anastasopoulos, MD, PhD^3*, Christina Kanaka-Gantenbein, MD, PhD, FMH (CH)^2*, Ioannis Papassotiriou, PhD² and Eleni Pergantou, MD, PhD^1*

¹Haemophilia Centre/Haemostasis and Thrombosis Unit, Aghia Sophia Children's Hospital, Athens, Greece
²First Department of Pediatrics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
³2nd Orthopaedic Department, Aghia Sophia Children's Hospital, Athens, Greece

Maria Eugenia de la Morena-Barrio, PhD¹, Belen De La Morena-Barrio, PhD^1*, Carlos Bravo-Perez, MD^1*, Antonia Miñano^1*, Jose Padilla^1*, Rosa Cifuentes-Riquelme, PhD Student^1*, Juan Jose Rojo-Carrillo^1*, Angeles Palomo Bravo^2*, Vicente Vicente, MD, PhD^1*, Maria Luisa Lozano, MD, PhD^1* and Javier Corral, PhD^1*

¹Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Arrixaca, CIBERER-U765, Murcia, Spain
²Servicio de Hematología y Hemoterapia del centro Materno-Infantil del Hospital Regional Universitario Carlos de Haya, Malaga, ESP

Gianna M. Guzzardo, MD¹, Suvoshree Ghosh, PhD^2*, Behnaz Pezeshkpoor, PhD^2*, Anna Pavlova, MD, PhD^2*, Katrin Czogalla-Nitsche, PhD^2*, Johannes Oldenburg, MD^2* and Meera B. Chitlur, MD^1,3

¹Department of Pediatrics, Division of Hematology Oncology, Children's Hospital of Michigan, Detroit, MI
²University Clinic Bonn, Institute of Experimental Haematology and Transfusion Medicine, Bonn, Germany
³Carman and Ann Adams Department of Pediatrics, Division of Hematology Oncology, Children's Hospital of Michigan/Central Michigan University, Detroit, MI

Michelle Sholzberg, MD^1,2, Grace H Tang, MSc^3*, Paula D. James, MD, FRCPC⁴, Filomena Meffe, MD, MSc^5*, Emily Rimmer^6*, Shannon Jackson, MD, FRCPC⁷, Haowei Linda Sun⁸, Sue Robinson, MD, FRCPC^9*, Georgina Floros, RN^10*, Shamshah Aratia^11*, Peter Jüni^12,13* and Bruno R. da Costa^12,13*

¹St. Michael's Hospital, University of Toronto, Toronto, ON, Canada
²Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, ON, Canada
³St Michael's Hospital, University of Toronto, Toronto, ON, Canada
⁴Department of Medicine, Queen's University, Kingston, ON, Canada
⁵Department of Obstetrics and Gynecology, St. Michael’s Hospital, University of Toronto, Toronto, ON, Canada
⁶Health Sciences Center, Winnipeg, Canada
⁷St Paul's Hospital, Vancouver, Canada
⁸Department of Medicine, University of Alberta, Edmonton, Canada
⁹Queen Elizabeth II Health Science Center, Halifax, NS, Canada
¹⁰Hospital for Sick Children, Toronto, ON, Canada
¹¹St. Michaels Hospital, University of Toronto, Toronto, Canada
¹²St Michael's Hospital, University of Toronto, Toronto, Canada
¹³Li Ka Shing Knowledge Institute, Toronto, Canada

Amy L. Dunn, MD¹, Yesim Dargaud, MD, PhD², Yasmina L. Abajas, MD³, Manuel Carcao, MD, MSc⁴, Giancarlo Castaman, MD^5*, Adam Giermasz, MD, PhD⁶, Cédric Hermans, MD, PhD^7*, Magdalena D. Lewandowska, MD⁸, Johnny Mahlangu, BSc, MBBCh, MMed, FCPath⁹, Shannon L. Meeks, MD¹⁰, Wolfgang A. Miesbach, MD, PhD^11*, Michael Recht, MD, PhD, MBA¹², Vanessa Salinas, MD^13,14*, Tammuella Chrisentery-Singleton, MD¹⁵, Hongying Wang, MS^16*, Ian S Mitchell, PhD^17* and Guy Young, MD¹⁸

¹Nationwide Children's Hospital, Department of Pediatrics at The Ohio State University College of Medicine, Columbus, OH
²Unite d'Hemostase Clinique, Centre National de Reference de l'Hemophilie, Hopital Louis Pradel Universite, Lyon, France
³University of North Carolina, Department of Pediatric Hematology/Oncology, Chapel Hill, NC
⁴The Hospital for Sick Children, Toronto, ON, Canada
⁵Center for Bleeding Disorders and Coagulation, Careggi University Hospital,, Florence, Italy
⁶Division of Hematology/Oncology, University of California Davis, Sacramento, CA
⁷Cliniques Saint-Luc, Université Catholique de Louvain, Brussels, Belgium
⁸Indiana Hemophilia & Thrombosis Center, Indianapolis, IN
⁹Haemophilia Comprehensive Care Centre, University of the Witwatersrand, NHLS and Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa
¹⁰Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA
¹¹Department of Haemostaseology and Hemophilia Center, Medical Clinic 2, Institute of Transfusion Medicine, University Hospital Frankfurt, Frankfurt, Germany
¹²American Thrombosis and Hemostasis Network, Rochester, NY
¹³Center for Inherited Blood Disorders, Orange, CA
¹⁴CHOC Children's, Orange, CA
¹⁵Louisiana Center for Advanced Medicine, Slidell, LA
¹⁶LFB-USA, Inc., Framingham, MA
¹⁷HEMA Biologics, Louisville, KY
¹⁸Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA

Poojitha Byreddy, MD^1* and M. Joseph John, MD, DM²

¹Department of Clinical Haematology, Christian Medical College, Ludhiana, Ludhiana, India
²Department of Clinical Haematology and BMT, Christian Medical College & Hospital, Ludhiana, India