64th ASH Annual Meeting and Exposition: 311. Disorders of Platelet Number or Function: Clinical and Epidemiological: Poster III

Symposia: Disorders of Platelet Number or Function: Clinical and Epidemiological Oral and Poster Abstracts
Poster

Hall D (Ernest N. Morial Convention Center)

Risk of Immune Thrombocytopenia Relapse and Onset Related to Sars-Cov-2 Infection and Vaccination

Giuseppe Auteri, MD^1,2^*, Camilla Mazzoni, MD^1,2^*, Mattia Biondo, MD^1,2^*, Simona Paglia, PhD²^*, Marta Venturi, MD^1,2^*, Andrea Davide Romagnoli, MD^1,2^*, Daniela Bartoletti, MSc²^*, Michele Cavo, MD^1,2^*, Nicola Vianelli, MD²^* and Francesca Palandri, PhD, MD³^*

¹Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università di Bologna, Bologna, Italy
²IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
³IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy

3762

Low-Dose Rhein Sensitizes Platelet Production to Thrombopoietin Receptor Agonists (TPO-RA) in Immune Thrombocytopenia

Lu Sun¹^*, Ruting Wang¹^*, Juan Wang²^*, Yafei Yu¹^*, Haoyi Wang¹^*, Yitong Xu¹^*, Mingfang Zhu¹^*, Xin Wang, PhD³, Yu Hou¹^* and Ming Hou, MD, PhD¹^*

¹Department of Hematology, Qilu Hospital, Shandong University, Jinan, China
²Department of Haematology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, China
³Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China

3763

A Randomized, Placebo-Controlled, Phase 1 Study in Healthy Adult Volunteers of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ALPN303, a Potent Dual BAFF/APRIL Antagonist for the Treatment of Autoimmune Cytopenias

Stacey R. Dillon, PhD¹^*, Rupert Davies, PhD²^*, Jason D. Lickliter, MBBS, PhD³^*, Kristi L. Manjarrez¹^*, Alina Smith⁴^*, Mary C. Lessig⁴^*, Lori Blanchfield⁴^*, Russell J. Sanderson⁴^*, Allison Chunyk⁴^*, Tiffany Blair⁴^*, Amanda Enstrom⁴^*, Hany Zayed⁴^* and Stanford L. Peng, MD, PhD¹

¹Alpine Immune Sciences, Inc., Seattle, WA
²Alpine Immune Sciences, Seattle
³Nucleus Network, Melbourne, AUS
⁴Alpine Immune Sciences, Seattle, WA

3764

Rapamycin Inhibits Cytotoxic T Lymphocytes-Mediated Platelet Destruction in Immune Thrombocytopenia

Xiaofei Ni¹^*, Yajing Zhao²^*, Tianshu Yu¹^*, Haoyi Wang³^*, Lingjun Wang⁴^*, Pengcheng Xu²^*, Hai Zhou²^*, Yanfeng Liu⁵^*, Xinguang Liu²^*, Yu Hou²^*, Jihua Qiu, MD⁶^* and Ming Hou, MD⁷

¹Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong U, Jinan, China
²Department of Hematology, Qilu Hospital, Shandong University, Jinan, China
³Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong U, Jinan, AL, CHN
⁴Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, CHN
⁵Department of Hematology, Qilu hospital, Shandong University, Jinan, China
⁶Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China
⁷Department of Hematology, Qilu Hospital of Shandong University, Jinan, China

3765

Role of Platelet Indices and Thrombopoietin (TPO) Serum Levels in the Differential Diagnosis of Thrombocytopenia

Elisa Lucchini, MD¹^*, Ilaria Fortunati²^*, Barbara Toffoletto³^*, Lucio Torelli²^*, Francesca Sirianni³^* and Francesco Zaja, MD²^*

¹UCO Ematologia, Azienda Sanitaria Universitaria Giuliano-Isontina, Trieste, Italy
²Department of Medical, Surgery and Health Sciences, University of Trieste, Trieste, Italy
³SC Laboratorio Unico di ASUGI, Burlo, Gorizia e Monfalcone, Dipartimento di Medicina dei Servizi, ASUGI, Trieste, Italy

3766

Efficacy and Safety of Tyrosine Kinase Inhibitors in the Treatment of Relapsed/Refractory Immune Thrombocytopenia

Muhammad Ashar Ali, MBBS¹, Memoona Saeed²^*, A. Supraja, MS Orthopedics³^*, Maha Zafar⁴^*, Ashish Nepal, MBBS⁵^*, Muhammad Suleman⁶^*, Rooma Habib, MBBS⁷^*, Sana Rashid⁸^*, Sumaiya Asfund⁹^*, Muhammad Abdul Basit¹⁰^*, Hafsa Zahoor¹¹^*, Sviatoslav Kosach¹²^*, Aqsa Anwar¹³^* and Wajeeha Aiman, MD^14,15^*

¹Prime Health Care Consortium at Saint Clare's and Saint Mary's Hospital, Denville, NJ
²King Edward Medical University, Lahore, Pakistan
³NTRUHS, Vijayawada, Andhra Pradesh, India
⁴Arkansas College of Osteopathic Medicine Mercy Program, Fort Smith, AR
⁵University Hospitals Sussex NHS Foundation Trust, Brighton, United Kingdom
⁶Islamic International Medical College, Rawalpindi, Pakistan
⁷Dr Nikhil Gupta Medicine Professional Corporation NGMPC, Scarborough, ON, Canada
⁸Baqai Medical University, Karachi, Pakistan
⁹Jinnah Sindh Medical University, Karachi, Pakistan
¹⁰Services Institute of Medical Sciences, Lahore, Pakistan
¹¹BronxCare Health System, Bronx, NY
¹²United HealthCare Global, Grat Britain, Ukraine
¹³Ameer Ud Din Medical College, Lahore, Pakistan
¹⁴Nishtar Medical University, Multan, Pakistan
¹⁵Internal Medicine, Saint Michael's Medical Center, Newark, NJ

3767

Eltrombopag Plus Diacerein Versus Eltrombopag in Adult Primary Immune Thrombocytopenia: Interim Analysis of a Multicenter, Randomized, Controlled, Phase 2 Trial

Lu Sun¹^*, Ping Qin¹^*, Ruirong Xu²^*, Juandong Wang³^*, Hongyu Zhao⁴^*, Yan Wang⁵^*, Juan Wang⁶^*, Xin Wang, PhD⁷, Yu Hou¹^* and Ming Hou, MD, PhD¹^*

¹Department of Hematology, Qilu Hospital, Shandong University, Jinan, China
²Department of Hematology, Shandong Provincial Hospital of Traditional Chinese Medicine, Jinan, China
³Department of Hematology, The Second Hospital of Shandong University, Jinan, China
⁴Jinan Central Hospital of Shandong University, Jinan, CHN
⁵The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China
⁶Department of Haematology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, China
⁷Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China

3768

Use of Psychotropic Prescription Drugs and Mental Health in Adult Patients with Primary Immune Thrombocytopenia – a Danish Nationwide Cohort Study

Nikolaj Mannering, M.D.^1,2^*, Dennis Lund Hansen, MD, PhD^1,2^*, Anton Pottegård, MSc Pharm, Med.Sc.D., Ph.D.³^* and Henrik Frederiksen, M.D., Ph.D.^1,2^*

¹Clinical Institute, University of Southern Denmark, Odense, Denmark
²Department of Hematology, Odense University Hospital, Odense, Denmark
³Department of Public Health, University of Southern Denmark, Odense, Denmark

3769

Comparative Length of Therapy and Persistence Among Thrombopoietin Receptor Agonists (TPO-RA) in Immune Thrombocytopenia (ITP): United States Healthcare Claims and Specialty Pharmacy Prescription Analyses

Scott Kolodny, MD¹^*, Brian Jamieson, MD¹ and Thomas Darden²^*

¹Sobi, Inc., Waltham, MA
²Sobi, Inc., Durham, NC

3770

Efficiency and Safety of Avatrombopag in the Management of Thrombocytopenia with TPO or Tpora Ineffective：a Prospective, Single Arm, Exploratory Clinical Study

Shengjie Wang¹^*, Xinlu Zhang^1,2^*, Chen DAN¹^* and Jian Huang, MD, PhD^1,2,3

¹Department of Hematology, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, China
²Zhejiang Provincial Clinical Research Center for Hematological Disorders, Hangzhou, China
³Department of Hematology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China

3771

Gut-Bile Acid-Immune Axis Regulates T Cell Homeostasis in the Pathogenesis of Immune Thrombocytopenia

Feng-Qi Liu¹^*, Qingyuan Qu²^*, Yu-xiu Chen¹^*, Qi Chen³^*, Meng-lin Li¹^*, Xueyan Sun³^*, Hai-xia Fu¹^*, Kaiyan Liu, MD, PhD⁴ and Xiao-hui Zhang¹^*

¹Peking University People’s Hospital, Peking University Institute of Hematology, Beijing, China
²Peking University People’s Hospital, Peking University Institute of Hematology, beijing, China
³Peking University People’s Hospital, Peking University Institute of Haematology, Beijing, China
⁴Peking University People's Hospital, Peking University Institute of Haematology, Beijing, China., Beijing, China

3772

Combination of Thrombopoietin Receptor Agonist and Recombinant Human Thrombopoietin for Treating Cancer Therapy Induced Thrombopenia

Jing Yang, MS^*, Dong Yan, MD^*, Yunfei Gao^*, Peihua Zhang^*, Chan Zhang^*, Yurong Cheng^*, Xuyang Zhang^*, Cong Fan^*, Kai Wang^*, Siyu Zhu^*, Baogen Zhang^*, Fengyuan Liu^*, Yingying Tong^* and Lei Wu^*

Beijing Luhe Hospital, Capital Medical University, Beijing, China

3773

Cognitive Impairment Among Patients with Chronic Immune Thrombocytopenia

David J. Kuter, MD, DPhil¹, Umer Khan, MS²^*, Paul Maruff, PhD³^*, Chris Edgar, PhD³^*, Jason Cromer, PhD³^*, Gabe Stellman³^*, Lydia King, PhD⁴^*, Kathie Markowski³^* and Ahmed Daak, MD, PhD⁵^*

¹Hematology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA
²Biostatistics, Sanofi US Services Inc., Bridgewater, NJ
³Cogstate, New Haven, CT
⁴Catalyst Clinical Research, LLC, Clinton, CT
⁵Sanofi, Cambridge, MA

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