Caroline E. Kuczynski, BS¹, Iuri V. Perisse, Ph.D.^2*, Misha Regouski^2*, Elmira Alipour, B.S.^3*, Cecily LaPradd^4*, Ying Liu, Ph.D.^2*, Michael W. Beaty, M.D.^4*, Daniel B. Kim-Shapiro, Ph.D.^3*, Anthony Atala, M.D.^1*, Irina Polejaeva, Ph.D.^2*, Christopher D. Porada, Ph.D.^1* and M. Graca Almeida-Porada, MD⁵

¹Fetal Research and Therapy Program, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC
²Utah State University, Logan, UT
³Department of Physics, Wake Forest University, Winston-Salem, NC
⁴Wake Forest School of Medicine, Winston-Salem, NC
⁵Fetal Research and Therapy Program, Wake Forest Institute For Regenerative Medicine, Winston-Salem, NC

Satheesh Chonat, MD¹, Jayre A Jones, BS^2*, Seema R Patel, PhD^3*, Patricia E Zerra, MD^4,5, Lauren A Jeffers^6*, Ryan Philip Jajosky, MD^7*, Connie M. Arthur, PhD⁸, Michael Koval, PhD^6*, Clinton H. Joiner, MD, PhD⁹, David R. Archer, PhD¹⁰ and Sean R. Stowell, MD, PhD^11,12

¹Emory University, Aflac Cancer & Blood Disorders Center of Children’s Healthcare of Atlanta, Atlanta, GA
²Department of Pediatrics, Emory University, Atlanta, GA
³Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, GA
⁴Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta/Emory University School of Medicine, Atlanta, GA
⁵Department of Laboratory Medicine and Pathology, Emory University School of Medicine, Atlanta, GA
⁶Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA
⁷Department of Pathology, Brigham and Women's Hospital, Boston, MA
⁸Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
⁹Aflac Cancer & Blood Disorders Center of Children’s Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
¹⁰Aflac Cancer & Blood Disorders Center of Children’s Healthcare of Atlanta and the Department of Pediatrics, Emory University, Atlanta, GA
¹¹Harvard University, Boston, MA
¹²Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Boston, MA

Ran An, PhD¹, Yuncheng Man, PhD^1*, Kevin Cheng^2*, Tianyi Zhang^2*, Chunsheng Chen, PhD^3*, Erdem Kucukal^2*, William Wulftange^2*, Utku Goreke, MSc^1*, Allison Bode, BS^1*, Lalitha Nayak, MD⁴, Gregory M. Vercellotti, MD⁵, John D Belcher, PhD³, Jane Alison Little, MD⁶ and Umut A. Gurkan, PhD¹

¹Department of Mechanical & Aerospace Engineering, Case Western Reserve University, Cleveland, OH
²Case Western Reserve University, Cleveland, OH
³Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN
⁴Department of Medicine, Division of Hematology and Oncology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH
⁵Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN
⁶Department of Medicine, UNC Adult Sickle Cell Program, Chapel Hill, NC

Hemanth M Cherukury, MS¹, Donovan A Argueta, PhD², Natalie Garcia, BS^3*, Raghda Fouda, MD/PhD^4*, Stacy B Kiven, BSc^5*, Graham Velasco^6* and Kalpna Gupta, PhD^3,7,8,9,10

¹University of California Irvine, Irvine, CA
²Department of Medicine, Division of Hematology/Oncology, University of California, Irvine, Los Angeles, CA
³Department of Medicine, Division of Hematology/Oncology, University of California, Irvine, Irvine, CA
⁴University of California, Irvine, Orange, CA
⁵University of California, Irvine, Irvine, CA
⁶VA Long Beach Medical Center, Long Beach, CA
⁷SCIRE, Long Beach VA Medical Center, Long Beach, CA
⁸asD, asd, MN
⁹Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN
¹⁰Division of Hematology/Oncology, Department of Medicine, University of California, Irvine, Irvine, CA

Reilly L. Allison^1*, Anthony Burand, PhD^2*, Amanda M. Brandow, DO, MS³, Cheryl Stucky, PhD^2* and Allison D. Ebert, PhD^2*

¹Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Wauwatosa, WI
²Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI
³Pediatric Hematology/Oncology, Medical College of Wisconsin and Children’s Research Institute of the Children’s Hospital of Wisconsin, Milwaukee, WI

Erica M.F. Gotardo, Ph.D.^1*, Lidiane S. Torres, PhD^2,3*, Lucas F.S. Gushiken, Ph.D.^1*, Pamela L. Brito, M.Sc.^1*, Flavia C. Leonardo, Ph.D.^1*, Sergei Agoulnik, Ph.D.^4*, Jiri Kovarik, Ph.D.^5*, Andreas Bruederle^6*, John Millholland, Ph.D.^7*, Alessandra Vitaliti, Ph.D.^8*, Irmgard Förster, Ph.D.^9*, Fernando Ferreira Costa, M.D., Ph.D.¹ and Nicola Conran, PhD¹

¹Hematology Center, University of Campinas - UNICAMP, Campinas - São Paulo, Brazil
²Ruth L. and David Gottesman Institute for Stem cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY
³Hematology Center, University of Campinas - UNICAMP, Campinas, Brazil
⁴Novartis Precision Medicine (former affiliation), Cambridge, MA
⁵Novartis Institutes for BioMedical Research, Basel, Switzerland
⁶Novartis Pharma AG, Basel, Switzerland
⁷Novartis Precision Medicine, Cambridge, MA
⁸Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
⁹Immunology and Environment, University of Bonn, Bonn, Germany

Ali San, BS^1,2, Gowtham K Annarapu, PhD³, Lynda Little-Ihrig^4*, Enrico M. Novelli, MD, MS⁵ and Sruti Shiva, PhD^3,6

¹Vascular Medicine Institute, University of Pittsburgh, Kansas City, MO
²Kansas City University College of Osteopathic Medicine, Kansas City, MO
³Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
⁴Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
⁵Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
⁶Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA

Myrthe J. van Dijk^1,2*, Marissa J.M. Traets^1*, Brigitte A. van Oirschot^1*, Jonathan R.A. de Wilde^1*, Jennifer Bos^1*, Wouter W. van Solinge^1*, Margaret J. Koziel^3*, Revati Wani^3,4*, Eduard J. Van Beers, MD, PhD^2*, Richard van Wijk^1* and Minke A.E. Rab, MD, PhD^1,5*

¹Central Diagnostic Laboratory - Research, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
²Center for Benign Hematology, Thrombosis and Hemostasis - Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
³Axcella Therapeutics, Cambridge, MA
⁴Boehringer Ingelheim Pharmaceuticals, Cambridge, MA
⁵Department of Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands

Ravi Vats, PhD^1,2, Rikesh K Dubey, PhD¹, Gabriel Njikang, PhD^3*, John Paderi, PhD^4* and Prithu Sundd, PhD^2,5,6

¹Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA
²Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA
³IHP Therapeutics, San Francisco, CA
⁴IHP Therapeutics, San Carlos, CA
⁵Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA
⁶Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA

Anne Gallivan, BS^1*, Amarachi Kanu^1*, Mikail Alejandro, BS^1*, Nebeyat Zekaryas^1*, Hart Horneman, BS^1*, Jagadeesh Ramasamy, PhD^2*, Lenny Hong^2*, Donald Lavelle, PhD^2,3, Alan Diamond, Ph.D.^2*, Robert E. Molokie, MD², Elliott P. Vichinsky, MD¹ and Angela Rivers, MD¹

¹UCSF Benioff Children's Hospital Oakland, Oakland, CA
²University of Illinois at Chicago, Chicago, IL
³Jesse Brown VA Medical Center, Chicago, IL

Stephen C Rogers, PhD^1*, Zohreh Safari, PhD^2*, Mary Brummet^1*, Qihong Wang, MD^1*, Joy Okhuevbie, BS^1*, Nicole Glynn-Cunningham, RN^3*, Jennie Y. Law, MD⁴, Maria R. Baer, MD⁴ and Allan Doctor, MD⁵

¹Center for Blood Oxygen Transport and Hemostasis, University of Maryland School of Medicine, Baltimore, MD
²Center for Blood Oxygen and Hemostasis, University of Maryland, Baltimore, Baltimore, MD
³Department of Hematology, University of Maryland Medical Center, Baltimore, MD
⁴Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
⁵Director, Center for Blood Oxygen Transport and Hemostasis, University of Maryland School of Medicine, Baltimore, MD

James Fan, MD^1*, Joanna Gemel, PhD^2*, Theodore Lang, BA³, Eric C. Beyer, MD, PhD^2* and Gabrielle Lapping-Carr, MD²

¹Department of Internal Medicine, The University of Chicago Medical Center, Chicago, IL
²Department of Pediatrics, Section of Hematology and Oncology, The University of Chicago, Comer Children's Hospital, Chicago, IL
³The University of Chicago Pritzker School of Medicine, Chicago, IL

Nicolas Hebert^1,2,3*, Laurent Kiger, PhD^1,3*, Alexis Chenneviere, PhD^4*, Anne-Laure Pham Hung D'Alexandry D'Orengiani, PhD^3*, France Pirenne, MD, PhD^2,5, Orsolya Czakke^6*, Bela Farago^6*, Lionel Porcar^6*, Stephane Longeville, PhD^4* and Pablo Bartolucci, MD, PhD^1,3*

¹Université Paris-Est Créteil, INSERM, IMRB, Laboratory of excellence LABEX GRex, Créteil, France
²Etablissement Français du Sang, Creteil, France
³Sickle Cell Referral Center - UMGGR, Henri Mondor Hospital, AP-HP, Creteil, France
⁴Laboratoire Léon Brillouin, CEA-CNRS, Université de Paris-Saclay, Gif-sur-Yvette, France
⁵IMRB INSERM U955 , GR-Ex (Paris) and Paris-Est-Créteil University, Créteil, France
⁶Institut Laue-Langevin (ILL), Grenoble, France

Jasmin Martin, MD^1*, Lily C. Wain, BA^1*, Elisabeth F Heuston, PhD^1*, Ilya Gertsman, PhD^2* and David M Bodine, PhD¹

¹NHGRI, National Institutes of Health, Bethesda, MD
²Clarus Analytical, San Diego, CA

Utku Goreke, MSc^1*, Allison Bode, BS^1*, Ran An, PhD¹, Jane Alison Little, MD² and Umut A. Gurkan, PhD¹

¹Department of Mechanical & Aerospace Engineering, Case Western Reserve University, Cleveland, OH
²Department of Medicine, UNC Adult Sickle Cell Program, Chapel Hill, NC

Omika Katoch, PhD^1*, Ziming Li^2*, Ravi Vats, PhD¹, Rikesh K K. Dubey, PhD¹, Tomasz W. Kaminski, PharmD¹, Tomasz Brzoska, PhD¹, Prithu Sundd, PhD¹, Enrico M. Novelli, MD³ and Tirthadipa Pradhan-Sundd, PhD⁴

¹Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA
²University of Pittsburgh, Pittsburgh, PA
³Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
⁴Hematology-Oncology, University of Pittsburgh, Pittsburgh, PA

Nassima Djouder^1,2,3*, Nicolas Hebert^1,3,4*, Stephane Moutereau, MD^1,5*, Emmanuel Adu^1,3*, Steeve Lowenski^1,3*, Anne-Laure Pham Hung D'Alexandry D'Orengiani, PhD^3*, France Pirenne, MD, PhD^4,6, Carlosse Keumeugni^2*, Corinne Duguet, MD² and Pablo Bartolucci, MD, PhD^1,3*

¹Université Paris-Est Créteil, INSERM, IMRB, Laboratory of excellence LABEX GRex, Créteil, France
²ADDMEDICA, Paris, France
³Sickle Cell Referral Center - UMGGR, Henri Mondor Hospital, AP-HP, Creteil, France
⁴Etablissement Français du Sang, Creteil, France
⁵Département de Biochimie-Biologie Moléculaire-Pharmacologie-Génétique Médicale, Hôpital Henri Mondor, AP-HP, Creteil, France
⁶INSERM-U955, Equipe 2, Laboratoire D'Excellence, GRex, Institut Mondor, Créteil, France

Ioannis Papassotiriou, PhD¹, Anastasia Bartzeliotou, PhD^2*, Pagona Flevari, MD^3*, Maria Dimopoulou, MD^3*, Charalambos Kapogiannis, MD^1*, Vassiliki Kappou, MSc^1*, Veroniki Komninaka, MD^3*, Konstantina Repa, MD^3*, Aimilia Mantzou, PhD^1*, Alexandra Margeli, PhD^2*, Eleni Pergantou, MD, PhD^4*, Christos Poziopoulos, MD^5* and Ersi Voskaridou, MD^3*

¹First Department of Pediatrics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
²Department of Clinical Biochemistry, "Aghia Sophia" Children's Hospital, Athens, Greece
³Centre of Excellence in Rare Hematological Disease-Hemoglobinopathies, "Laiko" General Hospital, Athens, Greece
⁴Haemophilia Centre/Haemostasis and Thrombosis Unit, Aghia Sophia Children's Hospital, Athens, AL, Greece
⁵Department of Hematology, METROPOLITAN Hospital, Athens, Greece