Emmanuel Olivier, PhD^1*, Zi Yan^2* and Eric E. Bouhassira, PhD¹

¹Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY
²Dept. of Cell Biology, Albert Einstein College of Medicine, Bronx, NY

Jayme L. Olsen, PhD¹, Kathleen E. McGrath, PhD², Kristin Murphy, PhD^2*, Taylor Schofield^2*, Michael Getman, MS^2*, Mohandas Narla, DSc³, Lionel Blanc, PhD⁴, Vincent P Schulz, PhD^5*, Patrick G. Gallagher, MD⁶, Laurie A. Steiner, MD² and James Palis, MD²

¹Department of Biomedical Genetics, University of Rochester, Rochester, NY
²Department of Pediatrics, University of Rochester, Rochester, NY
³New York Blood Center, New York, NY
⁴The Feinstein Institutes for Medical Research, Manhasset, NY
⁵Department of Pediatrics, Yale University School of Medicine, New Haven, CT
⁶Pediatrics, Pathology, Genetics, Yale School of Medicine, Hamden, CT

Min Wu, PhD¹, Kathryn Wang, PhD^2* and Brian MacDonald, MBChB, PhD^2*

¹DISC Medicine, Cambridge, MA
²Disc Medicine, Watertown, MA

Greggory Myers^1*, Lei Yu^2*, Ginette Balbin-Cuesta, MD, PhD^3,4, Ayse Bilge Ozel, PhD^5*, James Douglas Engel^1* and Rami Khoriaty, MD^1,6,7,8

¹Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI
²Department of Internal Medicine, University of Michigan, Ann Arbor, MI
³Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI
⁴Medical Scientist Training Program, University of Michigan, Ann Arbor, MI
⁵Department of Human Genetics, University of Michigan, Ann Arbor, MI
⁶Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI
⁷Rogel Cancer Center, University of Michigan, Ann Arbor, MI
⁸Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI

Valéna Karaghiannis^1,2*, Darko Maric^3,4*, Céline Garrec^5*, Nada Maaziz^6*, Alexandre Buffet^7*, Vincent Antunes^8*, Amandine le Roy^9*, Fabrice Airaud^10*, Bernard Aral^11*, Loic Schmitt^12*, Sébastien Corbineau^9*, Lamisse Mansour-Hendili^13*, Valentine Lesieur^9*, Antoine Rimbert^14*, Fabien Laporte^15*, Marine Delamare^16*, Stephane Bezieau^5*, Bruno Cassinat, PharmD, PhD¹⁷, Frédéric Galactéros, MD, PhD^18*, Anne-Paule Gimenez-Roqueplo^19*, Nelly Burnichon^20*, Holger Cario, MD, PhD²¹, Richard van Wijk^22*, Celeste Bento, MSc^23*, Anaise Blouet, MD^24*, Juliette Bouteloup, MD^25*, Françoise Boyer perrard^26*, Aisha Aiko Bruce, MD²⁷, Emilie Cayssials, MD^28*, Nicole Casadevall, MD²⁹, Brieuc Cherel^30*, Marielaure Couec, MD^15*, Louis Drevon, MD^31*, Cecile Dumesnil, MD^32*, Thierry Lamy De La Chapelle, MD, PhD^33*, Marion Gambart, MD^34*, Loic Garcon, MD PhD^35*, Brigitte Granel^36*, Pierre Hirsch, MD-PhD^37*, Agnès Lahary^38*, Amira Mejri^39*, Sandrine Meunier, MD^40*, Franck E. Nicolini, MD, PhD⁴¹, Emmanuel Raffoux^42*, Dana Ranta, MD^43*, Nicolas Schleinitz^44*, Jean Baptiste Valentin, MD^45*, Mathieu Wemeau, MD^46*, Francois Girodon, MD, PhD ⁴⁷, David Hoogewijs^48*, Betty Gardie, PhD^49* and Olivier Hermine, MD, PhD^50,51,52

¹Ecole Pratique des Hautes Etudes, EPHE, Université Paris Sciences et Lettres, France, Paris, France
²Université de Nantes, CNRS, INSERM, l’institut du thorax, F-44000 Nantes, Nantes, France
³Section of Medicine, Department of Endocrinology, Metabolism and Cardiovascular System, University of Fribourg, CH-1700 Fribourg, Switzerland, Fribourg, Switzerland
⁴National Center of Competence in Research “Kidney.CH”, Switzerland, Fribourg, Switzerland
⁵Centre Hospitalier Universitaire De Nantes, Nantes, FRA
⁶Service d’Hématologie Biologique, Pôle Biologie, CHU de Dijon, Dijon, France, Dijon, France
⁷INSERM, UMR970, Paris-Centre De Recherche Cardiovasculaire, Paris, FRA
⁸ch, zurich, France
⁹2 Université de Nantes, CNRS, INSERM, l’institut du thorax, F-44000 Nantes, France, nantes, France
¹⁰CHU De NANTES, NANTES, FRA
¹¹Chu Dijon Bourgogne, Dijon, France
¹²Ch rennes, rennes, France
¹³APHP, Paris, France
¹⁴Chu NAntes, nantes, France
¹⁵Chu Nantes, Nantes, France
¹⁶Chu nantes, Nantes, France
¹⁷INSERM UMR 1131, Institut de Recherche Saint-Louis, Paris, France
¹⁸Unité des Maladies Génétiques du Globule Rouge, CHU Henri Mondor, Créteil, France
¹⁹Assistance Publique Hôpitaux De Paris, Paris, FRA
²⁰INSERM U970, Paris, FRA
²¹Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
²²Central Diagnostic Laboratory - Research, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
²³Hospital Pediatrico De Coimbra, Coimbra, Coimbra, PRT
²⁴Service oncologie-hématologie, Centre Hospitalier, Cholet, Cholet, France
²⁵Hematology Department, Chalon Center Hospital, Chalon-sur-Saone, France
²⁶Ch Angers, Angers, France
²⁷University of Alberta, Edmonton, AB, Canada
²⁸Poitiers University Hospital, Poitiers, France
²⁹AP-HP, Laboratoire d’hématologie biologique, Hôpital Saint-Antoine, Paris, France, Paris, France
³⁰Chu Rennes, rennes, France
³¹ApHP, paris, France
³²Pediatric Oncology and Hematology Unit, Charles Nicolle Rouen University Hospital, Rouen, France
³³Clinical hematology, University Hospital of Rennes, Rennes, France
³⁴CHU de Toulouse, Toulouse, France
³⁵Laboratoire d'Hématologie, CHU Amiens, Amiens, France
³⁶Ch marseille, marseille, France
³⁷Université Pierre et Marie Curie, Paris, France
³⁸ch rouens, rouens, France
³⁹Service hématologie clinique -GHRMSA Ch Mulhouse, Mulhouse, France
⁴⁰Chu Lyon, Lyon Cedex, FRA
⁴¹Centre Hospitalier Lyon Sud, LYON Cedex 03, France
⁴²Department of Hematology, Université de Paris, Saint-Louis Hospital, Paris, France
⁴³Centre Hospitalier Universitaire, Nancy, France
⁴⁴Service De Medecine Interne, CHU Conception, AP-HM, Marseille, FRA
⁴⁵Chu Tours, Chambray Les Tours, FRA
⁴⁶CHRU Lille, Paris, FRA
⁴⁷Laboratorie D'Hematologie CHU Dijon, Dijon, France
⁴⁸University of ZüRich, ZüRich, CHE
⁴⁹Université de Nantes, CNRS, INSERM, l’institut du thorax, F-44000 Nantes, France, Nantes, FRA
⁵⁰INSERM U1163 and CNRS 8254, Imagine Institute, Université Sorbonne Paris Cité, Paris, France
⁵¹Laboratory of Excellence GR-Ex, Paris, France
⁵²Necker–Enfants Malades Hospital and Imagine Institute, CEREMAST, Paris, France

Hanny Al-Samkari, MD¹, Rachael F. Grace, MD², Eduard J. van Beers, MD, PhD^3*, Feng Tai, PhD^4*, Jaime Morales-Arias, MD^4*, Vanessa Beynon, MD^4* and Andreas Glenthøj, MD, PhD⁵

¹Division of Hematology Oncology, Massachusetts General Hospital, Cambridge, MA
²Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA
³Benign Hematology Center, Van Creveldkliniek, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands
⁴Agios Pharmaceuticals, Inc., Cambridge, MA
⁵Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark

Amit Choudhury, PhD^1*, Wim Noël, PhD^2*, Tarek Ebrahim, MD^3*, Cathye Shu, PhD^4*, Leona E Ling, PhD^5* and Bruno Fattizzo, MD^6*

¹Janssen Research & Development, LLC, Cambridge, PA
²Janssen Scientific Affairs, LLC, Immunology, Brussels, Belgium
³Janssen Pharmaceutical Companies of Johnson & Johnson, Cambridge, MA
⁴Janssen Research & Development, LLC, Spring House, PA
⁵Janssen Research & Development, LLC, Cambridge, MA
⁶Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico and University of Milan, Milan, Italy

Daniel Kuppers, PhD^1*, Yong Peng, PhD^2*, Sonali Arora, MS^3*, Cindy Wladyka, BS^3*, Anne Wilhite^3*, Derek Stirewalt³, Beverly Torok-Storb, PhD^4*, Andrew Hsieh, MD^3*, Chuan He, PhD^5,6,7* and Patrick Paddison, PhD^8*

¹Human Biology Division, Fred Hutchinson Cancer Center, Seattle
²The University of Chicago, Chicago
³Fred Hutchinson Cancer Center, Seattle
⁴FHCRC D1-100, Seattle, WA
⁵Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL
⁶Howard Hughes Medical Institute, University of Chicago, Chicago, IL
⁷Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL
⁸Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA

Seong Juyong^1,2*, Dong-Yeop Shin, MD, PhD^3*, Ja Min Byun, MD, PhD⁴, Youngil Koh, MD, PhD³, Junshik Hong, MD⁵, Inho Kim, MD, PhD^6* and Sung-Soo Yoon, MD, PhD⁷

¹Hematology, Seoul national univerity hospital, Seoul, Korea, Republic of (South)
²Seoul national university hospital, Seoul, South Korea
³Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South)
⁴Seoul National University, Seoul, Korea, Republic of (South)
⁵Department of Internal Medicine, Gachon University Gil Hospital, Seoul, Korea, Republic of (South)
⁶Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South)
⁷Division of Hematology/Medical Oncology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South)

Tomasz M. Grzywa, PhD^1,2*, Magdalena Justyniarska^1*, Anna Sosnowska, PhD^1*, Patrycja Szpak, MSc.^3*, Karol Czubak^4*, Klaudyna Fidyt, MSc^1*, Ilona Kalaszczynska, PhD^3*, Milena Małecka-Giełdowska, MSc^5*, Olga Ciepiela, PhD^5*, Agnieszka Tomaszewska, MD, PhD^6*, Grzegorz W Basak, MD, PhD^7*, Jakub Golab, MD, PhD^1* and Dominika Nowis, MD, PhD^2*

¹Department of Immunology, Medical University of Warsaw, Warsaw, Poland
²Laboratory of Experimental Medicine, Medical University of Warsaw, Warsaw, Poland
³Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland
⁴Laboratory of Experimental Medicine, Medical University of Warsaw, Warszawa, Poland
⁵Department of Laboratory Medicine, Medical University of Warsaw, Warsaw, Poland
⁶Medical University of Warsaw, Warsaw, Poland
⁷Department of Hematology, Transplantation, and Internal Diseases, Medical University of Warsaw, Warsaw, Poland

Min Dong^1,2*, Angela Good, angela.good@cchmc.org^1*, Alexander A. Vinks, PharmD, PhD, FCP^1,2*, Russell E. Ware^2,3 and Patrick T. McGann, MD, PhD^4,5

¹Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH
³Division of Hematology, Children's Hospital Medical Center, Cincinnati, OH
⁴Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, RI
⁵Lifespan Comprehensive Sickle Cell Center, Providence, RI

Ginette Balbin-Cuesta, MD, PhD^1,2, Katherine Rybkin^3*, Greggory Myers^4* and Rami Khoriaty, MD^4,5,6,7

¹Medical Scientist Training Program, University of Michigan, Ann Arbor, MI
²Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI
³College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI
⁴Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI
⁵Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI
⁶Rogel Cancer Center, University of Michigan, Ann Arbor, MI
⁷Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI

Jun Ho Jang, MD, PhD¹, Raymond Wong, MBChB, MD², Rodrigo Pavani, MD, PhD^3*, Lisa Aurand, MD³, Bradley Dain, PhD^3*, Lorah Perlee, PhD^3*, Amal Souttou, MD^3*, Jonathan Weyne, MD^3* and Richard Kelly, BSc, MD^4*

¹Samsung Medical Center, Seoul, South Korea
²Sir YK Pao Centre for Cancer & Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Hong Kong
³Regeneron Pharmaceuticals, Inc., Tarrytown, NY
⁴Department of Haematology, St James University Hospital, Leeds, United Kingdom

Richard Kelly, BSc, MD^1*, Nicola Houghton^2*, Talha Munir, MBBS, MRCP, FRCPath, PhD^3*, Petra Muus^4*, Nora Youngs, BSc^2*, Lisa Aurand, MD⁵, Bradley Dain, PhD^5*, Rodrigo Pavani, MD, PhD^5*, Lorah Perlee, PhD^5*, Amal Souttou, MD^5* and Morag Griffin, FRCPath, MRCP^6*

¹Department of Haematology, St James University Hospital, Leeds, United Kingdom
²St James’s University Hospital, Leeds, GBR
³Department of Haematology, St James’s University Hospital, Leeds, United Kingdom
⁴St James’s University Hospital, Leeds, United Kingdom
⁵Regeneron Pharmaceuticals, Inc., Tarrytown, NY
⁶St James's University Hospital, Sheffield, United Kingdom

Julien Maquet, MD, MSc^1,2*, Margaux Lafaurie, PharmD, PhD^2,3*, Marc Michel, MD^4*, Maryse Lapeyre-Mestre, MD, PhD^2,3* and Guillaume Moulis, MD, PhD^2,5*

¹Department of Internal Medicine, Toulouse University Hospital, Toulouse, France
²Clinical Investigation Center 1436, Toulouse University Hospital, Toulouse, France
³Department of Clinical Pharmacology, Toulouse University Hospital, Toulouse, France
⁴Henri-Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, UPEC, Créteil, France
⁵Department of Internal medicine, Toulouse University Hospital, Toulouse, France