Kim-Anh Nguyen-Peyre^1*, Weiqiang Liu^2*, Lazaros Papamanolis^3*, Christian Kassasseya^4*, Nour Belkeziz^5*, Valentin Amar^6*, Gabriel Nahas^2*, Saskia Eckert^7*, Pierre Vedel^8*, Laurène Lenoir^9*, Katy Drémont^10*, Sabine Cleophax^10*, France Pirenne, MD, PhD¹¹, Frédéric Segonds^9*, Suzanne Verlhac, MD^12*, Irène Vignon-Clémentel^6* and Pablo Bartolucci, MD, PhD^13,14*

¹INSERM U955 EQUIPE PIRENNE, EFS, CRETEIL, France
²INRIA Paris, Paris, France
³INRIA Paris, paris, France
⁴IMRB – Inserm U955 Transfusion et maladies du globule rouge (Equipe 2) Etablissement Français du Sang, APHP Hôpital Henri Mondor, Creteil, France, Creteil, France
⁵Team Pirenne IMRB INSERM U955, Paris, AL, France
⁶INRIA, Paris, France
⁷Art et Metier Paris Tech, Paris, France
⁸Arts et Metiers Paris Tech, Paris, France
⁹Arts and Métiers ParisTech, LCPI, Paris, France
¹⁰French Blood establishment, Rungis, France
¹¹IMRB INSERM U955 , GR-Ex (Paris) and Paris-Est-Créteil University, Créteil, France
¹²Medical Imagery Department, Reference Center for Sickle Cell Disease, CHIC and Debré Hospital, Créteil, France
¹³Sickle cell referral center - UMGGR, University Paris-East Créteil, Henri Mondor University Hospitals, APHP, Creteil, France
¹⁴Team 2. GRex, IMRB UPEC, Créteil, France

Ran An, PhD¹, Alireza Avanaki, Ph.D.^2*, Priyaleela Thota, MD^3*, Sai Nemade^4*, Amrish Mehta, M.D.^5* and Umut A. Gurkan, PhD¹

¹Department of Mechanical & Aerospace Engineering, Case Western Reserve University, Cleveland, OH
²Hemex Health, Inc., Portland, OR
³Hemex Health Inc., Portland, OR
⁴Plasma Lab, Jalgaon, Maharashtra, India
⁵Apple Diagnostics Lab in Ghatkopar, Mumbai, India

Marietta Truger^*, Manja Meggendorfer, PhD, Wencke Walter, PhD^*, Stephan Hutter, PhD^*, Constance Baer, PhD, Niroshan Nadarajah^*, Wolfgang Kern, MD, Claudia Haferlach, MD and Torsten Haferlach, MD

MLL Munich Leukemia Laboratory, Munich, Germany

Heiko Mueller, PhD^*, Wencke Walter, PhD^*, Stephan Hutter, PhD^*, Niroshan Nadarajah^*, Frank Dicker, PhD, Manja Meggendorfer, PhD, Wolfgang Kern, MD, Torsten Haferlach, MD and Claudia Haferlach, MD

MLL Munich Leukemia Laboratory, Munich, Germany

Maher Albitar, MD^1*, Hong Zhang, PhD^1*, Andrew Ip, MD, MSc², Jeffrey Justin Estella, BS, MS^1*, Ahmad Charifa, MD^1*, Wanlong Ma^1*, Ipsa Sharma^1*, Andrew L. Pecora, MD^3*, Lori Leslie, MD⁴, Tatyana Feldman, MD⁵ and Andre H. Goy, MD, MS^4*

¹Genomic Testing Cooperative, Irvine, CA
²Hackensack Meridian Health Hackensack University Medical Center, Hackensack, NJ
³John Theurer Cancer Center, Hackensack Meridian Health, Division of Multiple Myeloma, Hackensack, NJ
⁴Hackensack Meridian School of Medicine, Hackensack, NJ
⁵Lymphoma Division, Hackensack Meridian Health, Edison, NJ

Yaochi Yu, MS^1,2*, Mei Wang^3,4*, Lawrence Liu, MD^5,6*, Theodore S. Thomas, MD, MPHS¹, Martin Schoen^7,8*, Kristen M. Sanfilippo, MD^9,10, Graham A Colditz, MD, DrPH^11*, Jr-Shin Li, PhD^12* and Su-Hsin Chang, PhD^13,14*

¹St. Louis Veterans Affairs Medical Center, Saint Louis, MO
²Department of Electrical and Systems Engineering, Washington University in St. Louis, St. Louis, St. Louis, MO
³Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO
⁴Research Service, St. Louis Veterans Affairs Medical Center, St. Louis, MO
⁵St. Louis Veterans Affairs Medical Center, St Louis, MO
⁶City of Hope Comprehensive Cancer Center, Duarte, CA
⁷Division of Hematology and Medical Oncology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO
⁸St. Louis Veterans Affairs Medical Center, St. Louis, MO
⁹St. Louis Veterans Affairs Medical Center Research Service, Saint Louis, MO
¹⁰Division of Hematology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO
¹¹Division of Public Health Sciences, Department of Surgery, Washington University in St. Louis School of Medicine, St Louis, MO
¹²Department of Electrical and Systems Engineering, Washington University in St. Louis, St. Louis, MO
¹³Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, Saint Louis, MO
¹⁴Research Service, St. Louis Veterans Affairs Medical Center, Saint Louis, MO

Sang Mok Park^1*, Yuhyun Ji^1*, Semin Kwon^1*, Andrew RW O'Brien, MD^2,3, Ying Wang, MD, PhD^4* and Young L Kim^1,5*

¹Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN
²Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN
³Indiana University Simon Cancer Center, Indianapolis, IN
⁴Department of Anesthesia, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN
⁵Regenstrief Center for Healthcare Engineering, Purdue University, West Lafayette, IN

Guoliang Li^1*, Hui Wei, MD^2*, Arthur Jiang^1*, Jian Hu^1*, Jun Yan^1*, Linfeng Li^1* and Jianxiang Wang, MD³

¹Yidu Cloud Technology Inc, Beijing, China
²State Key laboratory of Experimental Hematolog, National Clinical Research Center for Blood Disease, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China

Siba El Hussein, MD^1*, Pingjun Chen, PhD^2*, Morteza Salehjahromi, PhD^2*, Hong Fang, MD^3*, Wei Wang, MD, PhD^3*, Sanam Loghavi, MD³, Patrick M. Reagan, MD⁴, Jonathan W. Friedberg, MD, MMSc⁵, Richard Burack, MD, PhD⁶, Andrew G Evans, MD, PhD⁷, L. Jeffrey Medeiros, MD³, Jia Wu, PhD^2* and Joseph D. Khoury, MD, FCAP⁸

¹Department of Pathology, University of Rochester Medical Center, Rochester, NY
²Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴James P. Wilmot Cancer Center, University of Rochester Medical Center, Fairport, NY
⁵James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY
⁶Department of Pathology and Laboratory Medicine/Hematopathology, University of Rochester Medical Center, Rochester, NY
⁷University of Rochester Medical Center, Rochester, NY
⁸University of Nebraska Medical Center, Omaha, NE

Vibhu Agarwal^1*, Jacob Aptekar, MD, PhD^2*, David C Fajgenbaum, MD, MBA, MSc^3,4 and Penelope Lafeuille, MS^5*

¹Medidata Solutions, New York, NY
²Medidata Acorn AI, a Dassault Systèmes Company, New York
³Center for Cytokine Storm Treatment & Laboratory, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
⁴Castleman Disease Collaborative Network, Philadelphia, PA
⁵Medidata Solutions, NY

Noor Rashidha Binte Meera Sahib^1*, Jen Wei Ying, MA (Oxon), BM BCh (Distinction), M.Med (Internal Medicine), MRCP (UK), FRCPath (UK)^2*, Melissa Ooi, MB Bch, BAO, MRCP(I), FRCPath, PhD^3*, Yen Lin Chee, MBChB PhD², Masturah Rashid, PhD^4*, Jayalakshmi Jayalakshmi^5* and Edward KH Chow^6*

¹Yong Loo Lin School of Medicine, National University of Singapore, Singapore, AL, Singapore
²Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore, Singapore
³Department of Haematology Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore, Singapore
⁴KYAN Therapeutics, Singapore, Singapore
⁵National University Health System, Singapore, Singapore
⁶Cancer Science Institute of Singapore, National University of Singapore, Singapore, SGP

Alexander J Ryu, MD^1*, Shaji K Kumar, MD², Angela Dispenzieri, MD³, Robert A. Kyle, MD⁴, S. Vincent Rajkumar, MD⁵ and Thomas C Kingsley, MD, MPH^6*

¹Division of Hospital Internal Medicine, Mayo Clinic, Rochester, MN
²Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN
³Division of Hematology, Mayo Clinic, Rochester, MN
⁴Division of Hematology, Mayo Clinic, Stabile 6-28, Rochester, MN
⁵Mayo Clinic College of Medicine, Rochester, MN
⁶Division of Hospital Internal Medicine, Division of Qualitative Health Sciences, Mayo Clinic, Rochester, MN

Hui Yang, MD, PhD¹, Guillermo Garcia-Manero, MD², Yue Wei, PhD¹, Koji Sasaki, MD¹, Kelly S. Chien, MD¹, Zhenya Tang, MD, PhD^3*, Guillermo Montalban-Bravo, MD¹, Awdesh Kalia^4*, Rajyalakshmi Luthra, PhD^5*, L. Jeffrey Medeiros, MD⁵ and Rashmi Kanagal-Shamanna, MD⁶

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX
⁴MD Anderson Cancer Center, Houston, TX
⁵Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX

Adam Stanford-Moore^1*, Yi Liu, PhD^1*, Chandan Akiti^1*, Ali Behrooz, PhD^1*, Bahar Rahsepar, PhD^1*, Benjamin Glass^1*, Aditee Shrotre^2*, Jeremy A. Ross, PhD^2* and Dorothy French, PhD^2*

¹PathAI, Boston, MA
²AbbVie, Inc., North Chicago, IL

Evelyn Kendall Williams^1*, Dan Y. Zhang, MS², Ryan J Summers, MD^3,4, Jamie Oakley, MD^3,4, Melissa L. Kemp, PhD^1*, Christopher C. Porter, MD^3,5 and Wilbur A. Lam, MD, PhD^1,3,4

¹Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA
²George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA
³Department of Pediatrics, Division of Pediatric Hematology/Oncology, Emory University School of Medicine, Atlanta, GA
⁴Aflac Cancer and Blood Disorders Center of Children’s Healthcare of Atlanta, Atlanta, GA
⁵Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Atlanta, GA

Rula Green Gladden, MD¹, Shruti Bhise^2*, Sami B Kanaan, PhD^3*, Olivia Waltner^4*, Jeffrey Stevens, BA^5*, Colleen Annesley, MD⁶ and Scott N Furlan, MD^1*

¹Fred Hutchinson Cancer Center, Seattle, WA
²Fred Hutchinson Cancer Center, Seattle
³Fred Hutchinson Cancer Research Center, Seattle, WA
⁴Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁵Seattle Children's Hospital, Seattle, WA
⁶Division of Hematology-Oncology, Seattle Children's Hospital, Seattle, WA

Hussam Al-Kateb, PhD, MSc¹, Tomi Jun, M.D.^1*, Jim Hayes, PhD^1*, Michael Rossi, PhD^1*, Feras Hantash, MS, DPhil^1*, William K. Oh, M.D.^2,3 and Kenan Onel, M.D., Ph.D.¹

¹Sema4, Stamford, CT
²medical, Sema4, Stamford, CT
³Icahn School of Medicine at Mount Sinai, New York, NY

Vikram Dhillon, DO^1* and Suresh Kumar Balasubramanian, MD²

¹Department of Internal Medicine, Wayne State University, Detroit, MI
²Department of Oncology, Wayne State University/ Karmanos Cancer Institute, Detroit, MI

Ehsan Malek, MD¹, Jeries Kort, MD², Gi-Ming Wang, PhD^3*, Curtis Tatsuoka, PhD^3* and James J. Driscoll, MD, PhD⁴

¹Division of Hematology and Oncology, Case Western Reserve University, Cleveland, OH
²Department of Hematology and Oncology, University Hospitals Seidman Cancer Center, Cleveland, OH
³Department of Population and Quantitative Health Sciences, Case Western Reserve University, School of Medicine, Cleveland, OH
⁴Case Comprehensive Cancer Center, Cleveland, OH