Bruno Paiva^1*, Bonny Gaffney^2*, Kelven Burnett^2*, Paola Castiglioni^2*, Michael Angelo^2*, Daniel W. Pierce^3* and Isaac W. Boss, PhD^4*

¹Clinica Universidad de Navarra, Cancer Center Universidad de Navarra (CCUN), Centro de Investigación Medica Aplicada (CIMA), Instituto de Investigación Sanitaria de Navarra (IDISNA), Navarra, Spain
²Bristol Myers Squibb, San Diego, CA
³Bristol Myers Squibb, San Francisco, CA
⁴Translational Research, Bristol Myers Squibb, Seattle, WA

Erin Meermeier^1*, Caleb K Stein, PhD^1*, Meaghen E Sharik, BS^1*, Yuan Xiao Zhu, Ph.D.^1*, Megan T Du, B.S.^1*, Seth J Welsh, PhD^1*, Chang-Xin Shi, Ph.D.^1*, Matthew L Wheeler, Ph.D.^2*, P. Leif Bergsagel, MD¹ and Marta Chesi, PhD¹

¹Division of Hematology and Oncology, Mayo Clinic, Scottsdale, AZ
²Tumor Microenvironment Thematic Research Center, Bristol Myers Squibb, Redwood City, CA

Rudra Prasad Dutta, PhD^1,2*, Rohit Kumar, PhD^1,3*, Prashant R. Tembhare, MD⁴, Bhausaheb Bagal, MD, DM^5*, Rajeeb Kumar Swain, PhD^6* and Syed Khizer Hasan, PhD^7,8*

¹Hasan Lab, ACTREC Tata Memorial Centre, Mumbai, India
²Hematology-Oncology, The Mount Sinai Medical center, New York, NY
³Department of Medicine, Baylor College of Medicine, Houston, TX
⁴Hematopathology Laboratory, ACTREC, Tata Memorial Centre, Mumbai, India
⁵Adult Hematolymphoid Disease Management Group, Department of Medical Oncology, Tata Memorial Centre, Mumbai, India
⁶Developmental Biology, Institute of Life Sciences, Bhubaneswar, Bhubaneswar, India
⁷Hasan Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Navi Mumbai, Navi Mumbai, India
⁸Homi Bhabha National Institute, Mumbai, India

Moutaz Helal^1*, Mara John^2*, Emilia Stanojkovska^3*, Greta Mattavelli^1*, Lars Grundheber^1*, Alexander Leipold^1*, Nazia Afrin^1*, Christine Riedhammer^4*, Johannes Duell, MD^5,6*, Max Johannes Steinhardt^7*, Julia Mersi, MD^7*, Hermann Einsele, MD⁷, Kai Kretzschmar^8*, K. Martin Kortuem^7,9*, Angela Riedel^10* and Leo Rasche, MD^7,11*

¹Mildred Scheel Early Career Center (MSNZ), University Hospital Würzburg, Würzburg, Germany
²Mildred Scheel Early Career Center (MSNZ), University Hospital Wuerzburg, Wuerzburg, DEU
³Mildred Scheel Early Career Center (MSNZ), University Hospital Würzburg, Würzburg, DEU
⁴University Hospital of Würzburg, Würzburg, DEU
⁵Medizinische Klinik und Poliklinik II, Universitätsklinik Würzburg, Würzburg, Bavaria, Germany
⁶Department of Internal Medicine II, University Hospital Würzburg, University of Würzburg, Würzburg, Germany
⁷Department of Internal Medicine II, University Hospital Wuerzburg, Wuerzburg, Germany
⁸Mildred Scheel Early Career Center (MSNZ), University Hospital of Würzburg, Würzburg, Germany
⁹Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany
¹⁰University Hospital Wuerzburg, Wuerzburg, DEU
¹¹Department of Internal Medicine II, University Hospital Wuerzburg, Wuerzburg, Bayern, Germany

Thomas C. Smits^1,2*, Anil Aktas-Samur, PhD^3*, Romain Lannes^1*, Mariateresa Fulciniti, PhD⁴, Masood A. Shammas, PhD^5*, Jill Corre^6*, Giovanni Parmigiani, PhD^4*, Herve Avet-Loiseau, MD, PhD^7*, Nikhil C Munshi, MD, PhD⁸ and Mehmet K. Samur, PhD⁴

¹Department of Data Science, Dana Farber Cancer Institute, Boston, MA
²Department of Biomedical Informatics, Harvard Medical School, Boston
³Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
⁴Dana-Farber Cancer Institute, Boston, MA
⁵Harvard Medical School At VAMC, West Roxbury, MA
⁶Toulouse, and CRCT, Toulouse, France, Toulouse, France
⁷Unite de Genomique du Myelome, IUC-Oncopole, Toulouse, France
⁸Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Boston, MA

Elisa Gelli, PhD^1*, Antonella Laudisi^2*, Claudia Martinuzzi^3*, Debora Soncini, PhD^4*, Pamela Becherini^3*, Fabio Guolo, MD^4*, Concetta Conticello, MD, PhD^5*, Daniele Derudas^6*, Francesco Di Raimondo, MD⁷, Antonia Cagnetta, MD^4*, Domenico Coviello, MD^8*, Roberto Massimo Lemoli, MD⁹ and Michele Cea^4*

¹DIMI, University of Genoa, Genova, Italy
²dimi, University of Genoa, Genoa, ITA
³University of Genoa, Genoa, ITA
⁴Clinic of Hematology, Department of Internal Medicine (DiMI), IRCCS Ospedale Policlinico San Martino, Genova, Italy
⁵Division of Hematology, Azienda Policlinico - OVE, University of Catania, Catania, Italy
⁶Ospedale Oncologico "A. Businco", Struttura Complessa di Ematologia e Centro Trapianto Cellule Staminali Emopoieti, Cagliari, Italy
⁷Divisione di Ematologia, Ospedale Ferrarotto, A.O.U. Policlinico-OVE, Università di Catania, Catania, Italy
⁸Unit of Genetic, IRCCS-Istituto Gainnina Gaslini, GEnova, Italy
⁹Clinic of Hematology, Department of Internal Medicine (DiMI),IRCCS per l’Oncologia, University of Genoa, Genoa, Italy

Tianjiao Wang¹, Mark A Fiala, PhD^2*, Julie M Fortier, PhD^3*, Ruiyang Liu, BS^4*, Reyka G. Jayasinghe, PhD^5*, Ravi Vij, MD⁶ and Li Ding, PhD^7*

¹Washington University School of Medicine, SAINT LOUIS, MO
²Washington University School of Medicine, St. Louis, MO
³Department of Medicine, Division of Hematology & Oncology, Washington University School of Medicine, St. Louis, MO
⁴Department of Medicine, Washington University School of Medicine, Saint Louis, MO
⁵Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO
⁶Department of Medicine, Oncology Division, Washington University School of Medicine, St. Louis, MO
⁷Siteman Cancer Center, Washington University School of Medicine, Saint Louis, MO

Liang Lin, PhD^1*, Hao-Ming Chang, PhD^1*, Ben Titz, MSc, PhD^2*, Dennis Wu, PhD^2*, Amy Chen, BS^2*, Marshall Chao Ma, PhD^1*, Preeti Ashok^1*, David Zou, PhD^1*, Armand Bensussan, PhD^3*, Jean Kadouche, PhD^1*, Elisabetta Burchi^4*, ARMIN RATH^5*, Daniel Teper, PharmD^1*, Wei Li, PhD^1*, Antonio Arulanandam, DVM, PhD^1*, Nejmi Dilmac^1*, Chorom Pak, PhD^2* and Stanley Frankel, MD, FACP¹

¹Cytovia Therapeutics, Natick, MA
²Lynx Biosciences INC, San Diego, CA
³Paris University, INSERM, UMR-976, Institut de Recherche Saint-Louis, Paris, France
⁴Cytovia Therapeutics, Adventura, FL
⁵Cytovia Therapeutics, Aventura, FL

Danny V Jeyaraju, PhD^1*, Maryam Alapa^1*, Aimee O’Donohue^1*, Ross La Motte-Mohs^1*, Isaac W. Boss, PhD^2*, Patrick Hagner, PhD^3*, Michael Pourdehnad^4*, Michael R. Burgess, MD, PhD^5*, William E. Pierceall, PhD¹ and Anjan Thakurta, PhD^1*

¹Translational Development and Diagnostics, Bristol Myers Squibb, Summit, NJ
²Immuno Oncology and Cell Therapy, Bristol Myers Squibb, Seattle, WA
³Translational Medicine Hematology, Bristol Myers Squibb, Summit, NJ
⁴Hematology/Oncology and Cell Therapy Early Clinical Development, Bristol Myers Squibb, San Francisco, CA
⁵Bristol Myers Squibb, Princeton, NJ

Tommaso Perini, MD, PhD^1,2*, Laura Oliva, PhD^3*, Maria Materozzi, PhD^3*, Rossella Del Pizzo^3*, Laura Cassina, PhD^4*, Mehmet K. Samur, PhD⁵, Ugo Orfanelli^3*, Enrico Milan, PhD^3*, Alessandra Boletta, PhD^4*, Nikhil C Munshi, MD, PhD⁶ and Simone Cenci, MD³

¹Hematology and Bone Marrow Transplantation Unit, IRCCS Ospedale San Raffaele, Milan, Italy
²Laboratory of Age Related Diseases, Division of Genetics and Cell Biology, IRCCS Ospedale San Raffaele, Milan, Milano, Italy
³Laboratory of Age Related Diseases, Division of Genetics and Cell Biology, IRCCS Ospedale San Raffaele, Milan, Italy
⁴Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy
⁵Department of Data Science, Harvard TH Chan School of Public Health, Dana-Farber Cancer Institute, Boston, MA
⁶Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Boston, MA

Tal Zvida^1,2*, Eli Muchtar, MD³, Mali Salmon-Divon^1,4*, Angela Dispenzieri, MD⁵, Hila Fishov^1,2*, Claudio Schneider, MD^6*, Benjamin Bender, MD^6*, Adrian Duek, MD^7*, Merav Leiba, MD^7*, Ofer Shpilberg, MD, MPH^2,4,8* and Oshrat Hershkovitz-Rokah, PhD^1,2*

¹Department of Molecular Biology, Faculty of Natural Sciences, Ariel University, Ariel, Israel
²Translational Research Lab, Assuta Medical Centers, Tel-Aviv, Israel
³Associate Professor of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN
⁴Adelson School of Medicine, Ariel University, Ariel, Israel
⁵Division of Hematology, Mayo Clinic, Rochester, MN
⁶Orthopedic Department, Assuta Medical Centers, Tel-Aviv, Israel
⁷Institute of Hematology, Faculty of Health Science, Ben-Gurion University of the Negev, Assuta Ashdod University Hospital,, Ashdod, Israel
⁸Institute of Hematology, Assuta Medical Centers, Tel-Aviv, Israel

Pooja Shah^1*, Thorsten Stuehmer, PhD^2*, Larissa Haertle^3,4*, Daniela Bruennert, PhD^5*, Umair Munawar, PhD^6*, Ellen Leich, PhD^7*, Sabrina Kraus, MD^1*, Michael Hudecek, MD^6*, Manik Chatterjee, MD^8*, Andreas Schlosser, PhD^9*, Martin Kortuem^6*, Ralf C Bargou, MD^8*, Hermann Einsele, MD¹, Friederike Berberich-Siebelt, PhD^7* and Torsten Steinbrunn, MD, PhD^1,10*

¹Department of Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany
²Comprehensive Cancer Center Mainfranken, University Hospital of Würzburg, Wurzburg, Germany
³Department of Internal Medicine II, University Hospital WüRzburg, W, WüRzburg, DEU
⁴H12O-CNIO Hematological Malignancies Group, Clinical Research Unit. CNIO, Madrid, Spain
⁵Department of Obstetrics and Gynecology, University Hospital of Wuerzburg, Wuerzburg, Germany
⁶Department of Internal Medicine II, University Hospital Wuerzburg, Wuerzburg, Germany
⁷Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany
⁸Comprehensive Cancer Center Mainfranken, University Hospital of Wuerzburg, Wuerzburg, Germany
⁹Rudolf Virchow Center for Experimental Biomedicine, University of Wuerzburg, Wuerzburg, Germany
¹⁰Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

Inge Oudaert, MSc^1*, Arne Van der Vreken, MSc^1*, Gamze Ates, PhD^2*, Sylvia Faict, MD, PhD^1,3*, Philip Vlummens, MD^1,4*, Hatice Satilmis, MSc^1*, Rong Fan, MSc^1*, Anke Maes, PhD^1*, Elke De Bruyne, PhD^1*, Kim De Veirman, PhD^1*, Ann Massie, PhD^2*, Karin Vanderkerken, PhD¹ and Eline Menu, PhD^1*

¹Department of Hematology and Immunology, Myeloma Center Brussels, Vrije Universiteit Brussel, Brussels, Belgium
²Center for Neurosciences, Neuro-Aging & Viro-Immunotherapy, Vrije Universiteit Brussel, Brussels, Belgium
³Department of Hematology, UZ Brussel, Brussels, Belgium
⁴Ghent University Hospital, Ghent, Belgium

Antonia Reale, MD^1*, Irena Carmichael, PhD^2*, Rong Xu, PhD^3*, Haoyun Fang^4*, Jaynish S Shah, PhD^1*, Tiffany Khong, BSc, PhD¹, Nicholas Bingham, BSc, MBBS^5,6*, Malarmathy Ramachandran^5*, Maoshan Chen, PhD^1*, David W Greening, PhD^4* and Andrew Spencer^7,8

¹Myeloma Research Group, Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia
²Monash Micro Imaging-AMREP, Monash University, Melbourne, VIC, Australia
³NanoBiotechnology Group, Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
⁴Baker Heart and Diabetes Institute, Melbourne, Australia
⁵Myeloma Research Group, Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
⁶Malignant Haematology & Stem Cell Transplantation Services, Alfred Health, Melbourne, Australia
⁷Monash University, Melbourne, Australia
⁸Malignant Haematology & Stem Cell Transplantation Service, Alfred Health, Melbourne, VIC, Australia

Caleb K Stein, PhD^1*, Erin Meermeier^1*, Seth J Welsh, PhD^1*, Marta Chesi, PhD² and P. Leif Bergsagel, MD³

¹Division of Hematology and Oncology, Mayo Clinic, Scottsdale, AZ
²Mayo Clinic, Scottsdale, AZ
³Division of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ

Mun Yee Koh, BSc^1*, Phaik Ju Teoh, PhD^1,2, Tae-Hoon Chung, PhD^1*, Leilei Chen, PhD^1,3* and Wee Joo Chng, MBChB PhD^1,2,4

¹Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
²Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
³Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⁴National University Cancer Institute, Singapore, Singapore

Yuxin Liu, MD¹, Sabrina L. Browning, MD¹, Jennifer VanOudenhove, PhD^2*, Giulia Biancon, PhD², Noffar Bar, MD¹, Terri L. Parker, MD², Tara Anderson, PA-C^3*, Madhav Dhodapkar, MBBS⁴, Stuart Seropian, MD², Stephanie Halene, MD², Mina L Xu, MD^5*, Elan Gorshein, DO, JD, MPH^6*, Ashita Talsania, MCRP, MBBS⁷, Wajih Zaheer Kidwai, MD⁶, David H. Witt, MD^8*, Victor Chang, MD^9*, Francesca Montanari, MD¹⁰, Andrew Lischuk, MD^11*, Andrew Haims, MD^11*, Wei Wei, MD^12* and Natalia Neparidze, MD²

¹Department of Internal Medicine, Section of Hematology, Yale University School of Medicine and Yale Cancer Center, New Haven, CT
²Section of Hematology, Department of Internal Medicine, Yale University School of Medicine and Yale Cancer Center, New Haven, CT
³Yale-New Haven Hospital and Yale Cancer Center, New Haven, CT
⁴Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA
⁵Yale University School of Medicine and Yale Cancer Center, New Haven, CT
⁶Smilow Cancer Hospital Care Center- Guilford, Yale University School of Medicine and Yale Cancer Center, Guilford, CT
⁷Smilow Cancer Hospital Care Center- Torrington, Yale University School of Medicine and Yale Cancer Center, Torrington, CT
⁸Smilow Cancer Hospital Care Center- Trumbull, Yale University School of Medicine and Yale Cancer Center, Trumbull, CT
⁹Smilow Cancer Hospital Care Center-Waterbury, Yale University School of Medicine and Yale Cancer Center, Waterbury, CT
¹⁰Smilow Cancer Hospital - Greenwich, Yale School of Medicine and Yale Cancer Center, Greenwich, CT
¹¹Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT
¹²Department of Biostatistics, Yale School of Public Health, New Haven, CT

Christina Pfeiffer, MSc^1*, Alexander Michael Grandits, PhD^2,3*, Hélène Asnagli, PhD^4*, Anja Schneller, MSc^1*, Julia Huber, MSc^1*, Niklas Zojer, MD^1*, Martin Schreder, MD^1*, Andrew Parker, PhD^4*, Arnold Bolomsky, PhD^1,5*, Philip Beer, MD, PhD^4* and Heinz Ludwig, MD¹

¹Wilhelminen Cancer Research Institute, Clinic Ottakring, Department of Medicine I, Vienna, Austria
²Department of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria
³Comprehensive Cancer Center, Vienna, Austria
⁴Step Pharma, Saint-Genis-Pouilly, France
⁵Center for Cancer Research, Lymphoid Malignancies Branch, National Institutes of Health, National Cancer Institute, Bethesda, MD

Reyka G. Jayasinghe, PhD^1,2*, George Mulligan, PhD^1*, April Cook, PhD^1*, Mark Hamilton, PhD^1*, Sacha Gnjatic, PhD^3,4*, Seunghee Kim-Schulze, PhD^4,5*, Hearn J. Cho, MD, PhD^1,6 and Shaji K Kumar, MD⁷

¹Multiple Myeloma Research Foundation, Norwalk, CT
²Department of Medicine, Washington University in St. Louis, St. Louis, MO
³Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY
⁴Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
⁵Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY
⁶Department of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
⁷Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN

Metin Gunes, PhD^1*, Jessica Dang^2*, Yate-Ching Yuan, PhD^3*, Idit Shachar, PhD^4*, Murali Janakiram, MD, MS⁵, Mingye Feng, PhD^2*, Steven T. Rosen, MD^1,6 and Emine Gulsen Gunes, PhD^1,6

¹Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
²Department of Immuno-Oncology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
³Translational Bioinformatics, City of Hope National Medical Center, Duarte, CA
⁴Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel
⁵Division of Myeloma, Department of Hematology, City of Hope National Medical Center, Duarte, CA
⁶Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope National Medical Center, Duarte, CA

Alexis Talbot, MD^1,2,3*, Solène Weill^4*, Eléonore Fox, PhD^4*, Léa Meunier^4*, Guillaume Appé^4*, Camille Marijon, PhD^4*, Abdelkader Behdenna, PhD^4*, Arun P Wiita, MD, PhD⁵, Akpéli Nordor, PharmD, PhD^4* and Justin Eyquem, PhD^1,2,3

¹Department of Medicine, University of California, San Francisco, San Francisco, CA
²Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA
³Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA
⁴Epigene Labs, Paris, France
⁵Department of Laboratory Medicine, UCSF, San Francisco, CA

Xiaoyan Qu^1*, Jianyong Li, MD², Zhengxu Sun, PhD^1*, Jiamei Ji^1*, Yating Li^1* and Yunqi Cui^1*

¹Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China, Nanjing, China
²Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

Alana Keller¹, Olivia Perez De Acha, MD^1*, Lauren T Reiman, BSc^1*, Zachary J Walker, BS, MS^1*, David S Jayabalan, MSc^2*, Ruben Niesvizky, MD³, Peter A Forsberg⁴, Peter Kim, PhD^5*, Kamlesh Bisht, PhD^5*, Hongfang Wang^5*, Helgi van de Velde, MD, PhD⁶ and Daniel W. Sherbenou, MD, PhD¹

¹Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO
²Department of Pathology & Laboratory Medicine, Weill Cornell Medical College, New York, NY
³Division of Hematology & Medical Oncology, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY
⁴University of Colorado School of Medicine, Aurora, CO
⁵Sanofi R&D, Cambridge, MA
⁶Oncology Development, Sanofi, Brussels, MA, Belgium

Danai Dima, MD^1,2, Metis Hasipek, PhD^1*, Divya Jyoti Singh, PhD^1*, Dongxu Jiang, PhD^1*, Anand D. Tiwari, PhD^1*, Dale Grabowski, BS^1*, Yvonne Parker^1*, Daniel J. Lindner, MD, PhD^1*, Jianjun Zhao, MD³, Kenneth H. Shain, MD, PhD⁴, Jack Khouri, MD², Jaroslaw P. Maciejewski, MD, PhD, FACP¹ and Babal K. Jha, PhD, MPhil, MSc, BSc^1,5*

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
²Department of Hematology and Medical Oncology, Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH
³Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH
⁴Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
⁵Center for Immunotherapy & Precision Immuno-Oncology, Cleveland Clinic, Lerner Research Institute, Cleveland, OH

Cesarina Giallongo, PhD^1*, Grazia Scandura^2*, Alessandro Barbato^3*, Enrico La Spina^2*, Lucia Longhitano, Ph.D^4*, Tatiana Zuppelli^5*, Ilaria Dulcamare, Research Fellow^6*, Nunziatina Laura Parrinello, PhD^7*, Sebastiano Giallongo^5*, Francesca Polito^8*, Rosaria Oteri^8*, Mohammed Aguennouz^8*, Giuseppe A. Palumbo, MD, PhD^9*, Marco Lolicato^10*, Giovanni Li Volti, MD, PhD^11*, Francesco Di Raimondo, MD^12,13, Daniele Tibullo, PhD^14* and Alessandra Romano, MD, PhD^3,15

¹Department of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, Catania, CT, Italy
²Division of Hematology, University of Catania, Catania, Italy
³Division of Hematology, Azienda Policlinico - OVE, University of Catania, Catania, Italy
⁴Section of Biochemistry, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
⁵CHIRMED- Università degli Studi di Catania, CATANIA, Italy
⁶University of Catania, Catania, Italy
⁷A.O.U. Policlinico "Vittorio Emanuele", University of Catania, Catania, CA, ITA
⁸University of Messina, Messina, Italy
⁹Department of Medical, Surgical and Advanced Technology "G.F. Ingrassia", University of Catania, Catania, Italy
¹⁰Università di Pavia, Pavia, Italy
¹¹Department of Biomedical and Biotechnological Sciences, Univeristy of Catania, Catania, Italy
¹²Azienda Ospedaliero Universitaria Policlinico "G.Rodolico-San Marco", Catania, Italy
¹³Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy
¹⁴Biometec - Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
¹⁵CHIRMED - Department of General Surgery and Medical-Surgical Specialties - Hematology Section, University of Catania, Tremestieri Etneo, Cantania, Italy

Attaya Suvannasankha¹, Colin D. Crean, BS^2*, David Halladay, PhD^3*, David G. Roodman, MD, PhD⁴ and John Chirgwin, PhD^2*

¹Indiana University Simon Cancer Center, Indiana University and Roudebush VAMC, Indianapolis, IN
²Medicine/Hematology and Oncology, Indiana University School of Medicine, Indianapolis, IN
³Indiana University School of Medicine, Indianapolis, IN
⁴Department of Medicine, Indiana University School of Medicine, Indianapolis, IN

Xiaojing Wei^1*, Zhen Yu, MD^1*, Hao Sun, PhD^1*, Lixin Gong^2*, Lanting Liu^1*, Teng Fang, PhD^1*, Yi He^1*, Tingyu Wang^1*, Weiwei Sui^3*, Yan Xu^3*, Gang An, MD^4*, Xiaoke Ma^5*, Lugui Qiu³ and Mu Hao, PhD^1*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical Colleg, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁵School of Computer Science and Technology, Xidian University, Xi'an, China, xian, China

Bonny Gaffney^1*, Yu Shi^1*, Petrus de Jong, MD, Ph D^2*, Manuel Sanchez^1*, Celia Fontanillo^1*, Antonia Lopez-Girona^1*, Isaac W. Boss, PhD^1*, Antonina Kurtova^1*, Soraya Carrancio^1*, Lilly Wong^2* and Daniel W. Pierce^1*

¹Bristol Myers Squibb, Princeton, NJ
²Bristol Myers Squibb at the time of the study, Princeton, NJ

Phaik Ju Teoh, PhD^1,2, Ricardo De Matos Simoes, PhD^3*, Tae-Hoon Chung^4*, Mick Lee^5*, Olga Dashevsky, PhD^6*, Shizuka Yamano^7*, Roger Foo, Assoc Prof^8,9*, Wee Joo Chng, MBChB PhD^4,10,11,12 and Constantine S. Mitsiades, MD, PhD^6,7

¹Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
²Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
³Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
⁴Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
⁵Genome Institute of Singapore, Singapore, Singapore
⁶Broad Institute of MIT and Harvard, Cambridge, MA
⁷Dept. of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
⁸National University Heart Centre, National University Healthcare System, Singapore, Singapore
⁹Genomic Institute of Singapore, Singapore, Singapore
¹⁰Department of Haematology-Oncology, National University Heath System, Singapore, Singapore
¹¹National University Cancer Institute of Singapore, Singapore, Singapore
¹²National University Cancer Institute, Singapore, Singapore

Natalia Kreiniz, MD, MSc candidate^1,2*, Nasreen Eiza, PhD^2,3*, Tamar Tadmor, MD^2,4*, Adi Sabag, PhD^2,3*, Sarah Matarasso Greenfeld, MD^1*, Ilana Levy, MD^1,2*, Celia Surio, MD^5,6*, Ekaterina Votinov, MD^7*, Raeda Mubariki, MSc, PhD candidate^2,8*, Aaron Polliack, MD⁹, Elias Toubi, MD, PhD^2,10* and Zahava Vadasz, MD, PhD^2,3,11*

¹Hematology Unit, Bnai Zion Medical Center, Haifa, Israel
²The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
³The Proteomic Unit, Bnai Zion Medical Centre, Haifa, Israel
⁴Bnai Zion Medical Center, Haifa, Israel
⁵Hematology, Galilee Medical Center, Nahariya, Israel
⁶Faculty of Medicine, Bar Ilan University, Safed, Israel
⁷Hematology, Kaplan Medical Center,affiliated with Hadassah and Hebrew University Medical School, Rehovot, Israel
⁸Microbiology, Bnai Zion Medical Center, Haifa, Israel
⁹Hadassah Medical Organization, Eln Karem, Jerusalem, Israel
¹⁰Bnai-Zion Medical Center, Haifa, Israel
¹¹Division of Clinical Immunology, Bnai Zion Medical Centre, Haifa, Israel

Annamaria Gulla, MD¹, Eugenio Morelli, MD¹, Mehmet K. Samur, PhD^1,2, Megan Johnstone^3*, Cirino Botta, MD, PhD⁴, Delaney Vinaixa^5*, Marcello Turi^5,6*, Mariateresa Fulciniti, PhD⁷, Kenneth Wen^5*, Selma Cifric^8*, Srikanth Talluri, PhD^9,10*, Giada Bianchi, MD^11,12, Rao Prabhala, PhD^9,10, Paul G. Richardson, MD^11,13, Dharminder Chauhan, PhD^14*, Ruben D. Carrasco, MD, PhD^11,15,16*, Teru Hideshima, MD, PhD¹, Nikhil C Munshi, MD, PhD^17,18 and Kenneth C. Anderson, MD^11,19

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston
²Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
³Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁴Department of Health Promotion, Mother and Child Care,Internal Medicine and Medical Specialties, University of Palermo, Italy, Palermo, Italy
⁵Medical Oncology, Dana-Farber Cancer Institute, Boston
⁶University Hospital Ostrava, Ostrava, CZE
⁷Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
⁸Medical Oncology, Dana-Farber Cancer institute, Boston
⁹Dana-Farber Cancer Institute, Boston, MA
¹⁰VA Boston Healthcare System, Boston, MA
¹¹Harvard Medical School, Boston, MA
¹²Division of hematology, Brigham and Women's Hospital, Boston
¹³Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Boston, MA
¹⁴Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
¹⁵Department of Pathology, Dana-Farber Cancer Institute, Boston, MA
¹⁶Department of Pathology, Brigham and Women's Hospital, Boston, MA
¹⁷Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
¹⁸VA Boston Healthcare System, Boston
¹⁹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

Isaac W. Boss, PhD^1*, Ethan Thompson, PhD^2*, Allison M. Gaudy, PhD^3*, Minh Diem Vu, PhD^4*, Colin D. Godwin, MD, MPhil⁵, Michael R. Burgess, MD, PhD⁶, Sandy W. Wong, MD⁷ and Luciano J. Megala Costa, MD, PhD⁸

¹Translational Research, Bristol Myers Squibb, Seattle, WA
²Informatics and Predictive Sciences, Bristol Myers Squibb, Seattle, WA
³Clinical Pharmacology and Pharmacometrics, Bristol Myers Squibb, Summit, NJ
⁴Early Asset Development, Bristol Myers Squibb, Boudry, Switzerland
⁵Early Clinical Development, Bristol Myers Squibb, Seattle, WA
⁶Early Clinical Development, Bristol Myers Squibb, Princeton, NJ
⁷Department of Medicine, University of California San Francisco, San Francisco, CA
⁸Department of Medicine, Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL

Tina Bagratuni, PhD^1*, Foteini Aktypi, MSc^2*, Nefeli Mavrianou-Koutsoukou^3*, Dimitrios Patseas^4*, Christine Ivy Liacos, MSc^2*, Stamatia Skourti^5*, Alexandra Papadimou^5*, Foteini Theodorakakou, MD^6*, Ioannis Ntanasis-Stathopoulos, MD^2*, Maria Gavriatopoulou, MD^6*, Evangelos Terpos, MD, PhD⁷, Meletios A. Dimopoulos, MD⁸ and Efstathios Kastritis, MD^9*

¹Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Athens, Attiki, Greece
²Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
³NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS, ATHENS, GRC
⁴NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS, ATHENS, Greece
⁵Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Athens, Greece
⁶Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
⁷Department of Therapeutics, National and Kapodistrian University of Athens, Alexandra Hospital, Drosia, Attiki, Greece
⁸Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece
⁹Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, ATHENS, Greece

Jeremy M. Kinder, PhD^1*, Chanel Athena-Estrada^2*, Danyal Malik^2*, Xiaomeng Hu, PhD^3*, Meghan Lamba^3*, Chi Young^3*, Neal Van Hoeven^2*, Brian Granger^4*, Vandana Chaturvedi^2*, Ouwen Liang^4*, Jesus Moreno^2*, Aaron Lampano^2*, Garrett Zipp^2*, Adam Johnson, PhD^4*, Terry Fry^5*, Sonja Schrepfer^6* and Aaron Foster⁴

¹T cell Therapeutics, Sana Biotechnology, Seattle, WA
²Sana Biotechnology, Seattle
³Sana Biotechnology, San Francisco, CA
⁴Sana Biotechnology, Seattle, WA
⁵Sana Biotechnology Inc, South San Francisco
⁶Sana Biotechnology Inc, San Mateo, CA

Minghao Dang, PhD^1*, Li Qin, PhD^2*, Wei Tan^3*, Liping Dong^3*, Hans C. Lee, MD⁴, Krina Patel, MD, MSc², Luz Yurany Moreno Rueda, Ph.D., M.Sc.^2*, Pei Lin, MD, DM, MDPC⁵, Hima Bansal, PhD^3*, David Berrios, MD^3*, Sheeba K Thomas, MD², Donna M. Weber, MD², David E. Symer, M.D., Ph.D.^3*, Linghua Wang, PhD¹, Elisabet E. Manasanch, MD² and Robert Z. Orlowski, MD, PhD^6,7

¹Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Lymphoma/Myeloma, MD Anderson Cancer Center, Houston, TX
⁵Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Lymphoma and Myeloma, MD Anderson Cancer Center, Houston, TX
⁷Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX

Benjamin Diamond, MD¹, Alexandra M Poos, PhD^2*, Bachisio Ziccheddu, PhD^1*, Kylee H Maclachlan, MBBCh, PhD³, Yanming Zhang, MD⁴, Saad Usmani, MD⁵, Eileen M Boyle, MD, MSc⁶, Faith E Davies, MD⁶, Gareth J. Morgan, MD⁶, Ola Landgren, MD⁷, Marc S Raab, MD^8*, Francesco Maura, MD⁹ and Niels Weinhold, PhD^2*

¹Myeloma Service, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
²Multiple Myeloma Research Group, Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany
³Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Department of Pathology and Laboratory Medicine, Cytogenetics Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Myeloma Service, Memorial Sloan Kettering Cancer Center, New York
⁶Myeloma Research Program, Perlmutter Cancer Center, NYU Langone Health, New York, NY
⁷Myeloma Division, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
⁸German Cancer Research Center, Heidelberg, Germany
⁹Myeloma Program, Department of Medicine, University of Miami, Sylvester Comprehensive Cancer Center, PALMETTO BAY, FL

Camille V Edwards, MD^1,2, Richard Giadone, PhD^1*, Sabrina Ghosh^1*, Gareth Morgan, PhD², Vaishali Sanchorawala, MD² and George J Murphy, PhD¹

¹Center for Regenerative Medicine (CReM), Boston University School of Medicine, Boston, MA
²Amyloidosis Center, Boston University School of Medicine, Boston, MA

Rodrigo Fonseca, MD^1*, Yuan Xiao Zhu, Ph.D.^1*, P. Leif Bergsagel, MD^1,2, Marta Chesi, PhD³, Akhilesh Pandey, MD, PhD^4*, Kiran Mangalaparthi, Ph.D.^5*, Yi Chen, PhD^6*, Felai Tan, PhD, MD^7*, Stephen P. Anthony, DO⁶, Yu Chen, MD, PhD^6*, Yue Shen, PhD^6*, Bing Dai, Ph.D.^6*, Esteban Braggio, PhD¹ and Rafael Fonseca, MD²

¹Division of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ
²Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ
³Division of Hematology and Oncology, Mayo Clinic, Scottsdale, AZ
⁴Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁵Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁶Newave Pharmaceutical Inc., Pleasanton, CA
⁷Newave Pharmaceuticals Inc., Pleasanton, CA