Jorge Gonzalez-Puelma, MSc^1*, Julieta Sepulveda-Yanez, MSc^2*, Jorge Torres-Almonacid^3*, Diego Alvarez-Saravia^4*, Maria Elena Marquez, PhD^5*, Hermy Alvarez-Ojeda^6*, Daniela Cardemil, MD^7*, Roberto Uribe-Paredes^8*, Pablo Oppezzo, PhD^5* and Marcelo Navarrete, MD²

¹School of Medicien, University of Magallanes, Punta Arenas, Chile
²School of Medicine, University of Magallanes, Punta Arenas, Chile
³Deparment of Computer Engineering, University of Magallanes, Punta Arenas, Chile
⁴Department of Computer Engineering, University of Magallanes, Punta Arenas, DC, Chile
⁵Institut Pasteur de Montevideo, Montevideo, Uruguay
⁶Laboratory of Molecular Medicine, University of Magallanes, Punta Arenas, Chile
⁷Hospital de Punta Arenas, Punta Arenas, Chile
⁸Department of Computer Engineering, University of Magallanes, Punta Arenas, CHL

Aishath S Naeem, PhD^1,2, Filippo Utro, PhD^3*, Qing Wang^4*, Justin Cha^1*, Mauno Vihinen, PhD^5*, Stephen P. Martindale^6*, Yinglu Zhou^7*, Svitlana Tyekucheva, PhD^8*, Annette S. Kim, MD, PhD⁹, Stacey M. Fernandes, BS^10*, Rayan Fardoun, BS^6*, Gordon Saksena, PhD^11*, Kahn Rhrissorrakrai, PhD^3*, Chaya Levovitz, MD, PhD^3*, Brian P Danysh, PhD^12*, Kara Slowik^13*, Raquel Jacobs^12*, Matthew S. Davids, MD^14,15, Rula Zain, PhD^16,17*, Edvard CI Smith, MD, PhD^18*, Ignaty Leshchiner, PhD^12*, Laxmi Parida, PhD^3*, Gad Getz, PhD^1,19,20* and Jennifer R. Brown, MD, PhD^1,6,21

¹Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA
²Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
³IBM T.J. Watson Research Center, Yorktown Heights, NY
⁴Department of Laboratory Medicine (LABMED), Karolinska Institutet, Stockholm, Sweden
⁵Department of Experimental Medical Science, Lund University, Lund, Sweden
⁶Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁷Department of Data Sciences, Dana-Farber Cancer Institute, Harvard T.H Chan School of Public Health, Boston, MA
⁸Department of Data Sciences, Department of Biostatistics, Dana-Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, MA
⁹Department of Pathology, Brigham and Women's Hospital, Boston, MA
¹⁰Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
¹¹Broad Institute of MIT and Harvard, Cambridge
¹²Broad Institute of MIT and Harvard, Cambridge, MA
¹³Broad Institute of Harvard and MIT, Cambridge, MA
¹⁴Department of Medical Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Ctr, Boston, MA
¹⁵Department of Medicine, Brigham and Women’s Hospital, Boston, MA
¹⁶Centre for Rare Diseases, Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden
¹⁷Department of Laboratory Medicine (LABMED), Karolinska Institutet, Stockholm, AL
¹⁸Department of Laboratory Medicine (LABMED), Laboratory Medicine, Huddinge, Sweden
¹⁹Department of Medicine, Harvard Medical School, Boston, MA
²⁰Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, MA
²¹Harvard Medical School, Boston, MA

Salma Parvin, PhD^1*, Binyamin A. Knisbacher, PhD^2*, Aditi Aryal, BA^3*, Stacey M. Fernandes, BS^3*, Donna S. Neuberg, ScD⁴, Catherine J. Wu, MD^2,5,6,7, Jennifer R. Brown³, Gad Getz, PhD^2,8,9,10* and Anthony G. Letai, MD, PhD^3,7

¹Department of Medical Oncology, Dana Farber Cancer Institute, Jamaica Plain, MA
²Broad Institute of MIT and Harvard, Cambridge, MA
³Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
⁴Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
⁵Department of Medicine, Brigham and Women's Hospital, Boston, MA
⁶Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁷Harvard Medical School, Boston, MA
⁸Center for Cancer Research, Massachusetts General Hospital, Boston, MA
⁹Department of Medicine, Harvard Medical School, Boston, MA
¹⁰Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, MA

Huayuan Zhu^1,2,3*, Yeqin Sha^1,2,3*, Yi Miao^1,2,3*, Shuchao Qin^1,2,3, Rui Jiang^1,2,3*, Wei Wu^1,2,3*, Yi Xia^1,2,3*, Tonglu Qiu^1,2,3*, Li Wang^1,2,3*, Lei Fan^1,2,3*, Wei Xu^1,2,3, Hui Jin^1,2,3* and Jianyong Li, MD^1,2,3

¹Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China
²Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, China
³Pukou CLL Center, Pukou division of Jiangsu Province Hospital, Nanjing, China

Angimar Uriepero, M.D.^1*, Melanie Mediavilla-Varela, PhD^1*, Kamira Maharaj, PhD¹, Wael Gamal^1,2, Maria Elena Marquez, PhD^3*, John J. Powers, BS^1*, Vishaal Kunta^1*, Eva Sahakian, PhD^1,4*, Pablo Oppezzo, PhD^3* and Javier Pinilla Ibarz, MD^1,4

¹Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
²Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL
³Institut Pasteur de Montevideo, Montevideo, Uruguay
⁴Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL

Mariana T. Mendez, BS^1*, Murali Mamidi^2*, Sara K. Vesely, PhD, MPH³, Jennifer Holter-Chakrabarty, MD^4* and Asish K Ghosh, PhD^5,6

¹Stephenson Cancer Center, Oklahoma City, OK
²University of Oklahoma Health Sciences Center, Oklahoma City, OK
³Biostatistics and Epidemiology, Hudson College of Public Health, The Univ. of OK Health Sciences Ctr., Oklahoma City, OK
⁴Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK
⁵Stephenson Cancer Center/Department of Pathology, University Oklahoma Health Sciences Center, Oklahoma City, OK
⁶Stephenson Cancer Center/Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK

Md Kamrul Hasan, PhD¹, George F. Widhopf II, PhD¹ and Thomas J. Kipps, MD, PhD^2*

¹Center for Novel Therapeutics, Moores Cancer Center, University of California, San Diego, La Jolla, CA
²Center for Novel Therapeutics, Moores Cancer Center, University of California San Diego, La Jolla, CA

Yeqin Sha^1,2,3*, Shuchao Qin^1,2,3, Yi Miao^1,2,3*, Rui Jiang^1,2,3*, Wei Wu^1,2,3*, Yi Xia^1,2,3*, Tonglu Qiu^1,2,3*, Li Wang^1,2,3*, Lei Fan^1,2,3*, Wei Xu^1,2,3, Hui Jin^1,2,3*, Jianyong Li, MD^1,2,3 and Huayuan Zhu^1,2,3*

¹Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China
²Pukou CLL Center, Pukou division of Jiangsu Province Hospital, Nanjing, China
³Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, China

Wael Gamal^1,2, Melanie Mediavilla-Varela, PhD^2*, Kamira Maharaj, PhD², Angimar Uriepero, M.D.^2*, Vishaal Kunta^2*, Eva Sahakian, PhD^2,3* and Javier Pinilla Ibarz, MD^2,3

¹Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL
²Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
³Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL

Gregory Lazarian, PharmD^1,2,3*, Jordan Ferreira^1,3*, Ian Morilla^3,4*, Emeline Saindoy^2*, Valeria Bisio, PhD^5*, Nicolas Dulphy, PhD^5*, Karl Balabanian, PhD^5*, Catherine Thieblemont, MD, PhD⁶, Nadine Varin-Blank, PhD^1,3*, Dominique Ledoux, PhD^1,3*, Fanny Baran-Marszak, MD, PhD^1,2,3* and Laura Gardano, PhD^1,3*

¹INSERM U978, Bobigny, France
²Hematology Laboratory, Avivenne Hospital, GHUPSSD, Bobigny, France
³Université Sorbonne Paris Nord, Bobigny, France
⁴LAGA, CNRS, UMR 7539, Laboratoire d’excellence Inflamex, Villetaneuse, France
⁵Université Paris-Cité, Institut de Recherche Saint-Louis, INSERM U1160, Paris, France
⁶APHP, Hôpital Saint-Louis, Hemato-Oncology, Paris, France; Diderot University, Sorbonne Paris-Cité, Paris, France

Chaja Feige Jacobs, MD^1,2,3,4*, Fleur Peters^1,2,3,4*, Gaspard Cretenet, PhD^1,2,3,4*, Eric Eldering, PhD^1,3,4,5*, Noam Zelcer, PhD^6*, Arnon P. Kater, MD, PhD^2,3,4,5 and Helga Simon-Molas^1,2,3,4*

¹Experimental Immunology, Amsterdam UMC, location University of Amsterdam, Amsterdam, Netherlands
²Hematology, Amsterdam UMC, location University of Amsterdam, Amsterdam, Netherlands
³Cancer Immunology, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands
⁴Cancer Immunology, Cancer Center Amsterdam, Amsterdam, Netherlands
⁵Lymphoma and Myeloma Center Amsterdam, Amsterdam, Netherlands
⁶Medical Biochemistry, Amsterdam UMC location University of Amsterdam, Amsterdam, Netherlands

Cristina Paraschivescu, PhD^1*, Shivani Chhabra, PhD^1*, Rukhsana Aslam, MD^1*, Byeongho Jung, BS^2*, Gerardo Ferrer, PhD^3*, Jacqueline C. Barrientos, MD, MS⁴, Joanna M. Rhodes, MD, MSCE⁵, Jonathan E. Kolitz, MD⁴, Steven L Allen, MD⁵, Kanti R Rai, MD⁵, Barbara Sherry, PhD^6,7 and Nicholas Chiorazzi, MD^1,6

¹Karches Center for Oncology Research, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY
²Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY
³Cancer Epigenetics, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain
⁴Department of Medicine, North Shore University Hospital and Long Island Jewish Medical Center, Northwell Health, Manhasset
⁵Department of Medicine, North Shore University Hospital and Long Island Jewish Medical Center, Northwell Health, Manhasset, NY
⁶Departments of Medicine and of Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY
⁷Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, Northwell Health System, Manhasset, NY

Ozren Jaksic, MD, PhD^1,2, Marija Ivic, MD^1*, Branimir Gizdic, PhD^3*, Zdravko Mitrovic, MD, PhD^1,2*, Ena Soric, MD^1*, Ozana Jaksic^2*, Anamarija Vrkljan Vuk, MD^1*, Mario Pirsic, MD^1*, Vlatko Pejsa, MD, PhD^1,2*, Branimir Jaksic, MD, PhD^4* and Rajko Kusec, MD, PhD^1,2*

¹Department of Hematology, Dubrava University Hospital, Zagreb, Croatia
²Medical School, University of Zagreb, Zagreb, Croatia
³Department of Pathology and Cytology, Dubrava University Hospital, Zagreb, Croatia
⁴University of Zagreb, Zagreb, Croatia