Luis E. E. Aguirre, MD¹, Najla Al Ali, MS², Somedeb Ball, MD^1*, Avani M Singh, MD¹, Akriti G Jain, MD³, Onyee Chan, MD^1*, Zaker I. Schwabkey, MD¹, Sara M Tinsley-Vance, PhD, ANP¹, Andrew Kuykendall, MD¹, Kendra Sweet, MD¹, Jeffrey E. Lancet, MD¹, Eric Padron, MD¹, David A. Sallman, MD² and Rami S. Komrokji, MD¹

¹Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
²Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
³Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, WESLEY CHAPEL, FL

Mark Gurney, MB BCh BAO^1*, Ismahene Chekkaf, MD^1*, Rong He, MD², David S. Viswanatha, MD³, Patricia Greipp, DO², Abhishek A. Mangaonkar, MBBS¹, Kebede Begna, MD⁴, Naseema Gangat, MBBS¹, Mrinal M. M. Patnaik, MD¹, Mark R. Litzow, MD¹, James M. Foran, MD⁵, Talha Badar, MD⁶, Mithun V. Shah, MD, PhD¹, Hassan B. Alkhateeb, MD^1* and Aref Al-Kali, MD¹

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
³Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁴Divison of Hematology, Mayo Clinic, Rochester, MN
⁵Division of Hematology/Oncology and Blood and Marrow Transplanation and Cellular Therapy, Mayo Clinic, Jacksonville, FL
⁶Division of Hematology and Oncology, Mayo Clinic Florida, Jacksonville, FL

Christina K Ferrone, BSc¹, Amy JM McNaughton, PhD^1*, Iran Rashedi, MD PhD^2*, Rena Buckstein³, Hubert Tsui, MD, PhD, FRCPC³ and Michael J Rauh, MD PhD¹

¹Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada
²Sunnybrook Health Sciences Centre, Toronto, ON, Canada
³Division of Hematological Pathology, Precision Diagnostics and Therapeutics Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Rami S. Komrokji, MD¹, Luis E. E. Aguirre, MD¹, Najla Al Ali, MS¹, Onyee Chan, MD^2*, Andrew Kuykendall, MD³, Kendra Sweet, MD¹, Jeffrey E. Lancet, MD¹, Eric Padron, MD¹ and David A. Sallman, MD¹

¹Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
²Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, TAMPA, FL
³Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL

Jose F. Falantes, MD^1*, Francisco J. Márquez-Malaver, RN^2*, Estrella Carrillo-Cruz, MD^3*, Rosario M Morales-Camacho, PhD, MD^2*, Concepción Prats-Martín, MD^4*, Teresa Caballero, PhD^5*, Eduardo Rodriguez Arbolí, MD^4*, Ildefonso Espigado, MD, PhD⁶ and Jose A. Perez-Simon, MD, PhD⁴

¹Hematology, Department of Hematology, Hospital Universitario Virgen del Rocío; Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Seville, Spain
²Department of Hematology, Hospital Universitario Virgen del Rocío; Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Seville, Spain
³Hematology Department, Hospital Vírgen del Rocío, Instituto de Biomedicina (IBIS / CSIC / CIBERONC), Universidad de Sevilla, Seville, Spain
⁴Instituto de Biomedicina de Sevilla (IBiS), UGC-Hematología, Hospital Universitario Virgen del Rocío/ CSIC/ CIBERONC, Universidad de Sevilla, Sevilla, Spain
⁵Department of Hematology, Hospital Universitario Virgen del Rocio; Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla,Spain, Sevilla, Spain
⁶Hematology Department, Hospital Universitario Virgen del Rocio, Sevilla, Spain

Dorela Lame^1*, Marianeve Caprino^2*, Elena Marinelli Busilacchi, PhD^3*, Nadia Viola^4*, Erika Morsia, MD^5,6*, Michelangelo Pianelli, MD^1*, Shahram Kordasti, MD, PhD^7,8,9,10, Attilio Olivieri, MD^6,11,12* and Antonella Poloni, PhD, MD^13,14*

¹Hematology, Università Politecnica Marche-Ospedali Riuniti Ancona Italy, Ancona, Italy
²Università Politecnica delle Marche, Ancona, Italy
³Hematology Clinic, Università Politecnica delle Marche, Ancona, Italy
⁴Ospedali Riuniti Ancona, Ancona, Italy
⁵Hematology, Clinic of Hematology, Rochester, MN
⁶Ospedali Riuniti di Ancona, Clinic of Hematology, Ancona, Italy
⁷Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College, London, United Kingdom
⁸Haematology Department, Guy's and St Thomas' NHS Trust, London, United Kingdom
⁹Department of Haematological Medicine, King's College Hospital NHS Foundation Trust, London, United Kingdom
¹⁰Department of Haematological Medicine, King's College London, London, United Kingdom
¹¹Università Politecnica Delle Marche, Ancona, Italy
¹²Azienda Ospedali Riuniti di Ancona, Ancona University, Ancona, Italy
¹³Hematology, Università Politecnica delle Marche - AOU Ospedali Riuniti, Ancona, ITA
¹⁴Dipartimento di Medicina Interna, AOU Ospedali Riuniti, Ancona, Italy

Alessandro Bosi^1*, Bruno Fattizzo, MD^2,3*, Lorenzo Rizzo, MD^4*, Silvia Ferrari, MD^5*, Federico Lussana, MD, PhD^6*, Lorenza Maria Borin^7*, Andrea Castelli, MD^8*, Paola Bianchi, PhD, BSc⁹, Wilma Barcellini, MD^10*, Roberto Cairoli^4*, Alfredo Molteni, MD^11* and Marta Riva, MD^12*

¹Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy, Department of Oncology and Haemato-oncology, University of Milan, Milan, Italy, Segrate (milan), LA, Italy
²Haematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Milano, Italy
³Department of Oncology and Oncohaematology, University of Milan, Milan, Italy
⁴Department of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy
⁵Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy
⁶Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Please Choose A State, Italy
⁷Department of Hematology, San Gerardo Hospital, Monza, Italy
⁸Division of Hematology, Ospedale degli Infermi, Biella, Italy
⁹Hematology Unit, Pathophysiology of Anemias Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
¹⁰Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
¹¹Division of Hematology, ASST Cremona, Cremona, Italy
¹²Dipartimento di Ematologia, Oncologia e Medicina Molecolare, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy

John E. Pimanda, MBBS, FRACP, FRCPA, PhD^1,2,3, Julie A.I. Thoms^4*, Henry R. Hampton, PhD^1*, Sarah Davidson^5*, Swapna Joshi, MSc^3*, Chowdhury H. Sarowar, PhD^3*, Xin Ying Lim, PhD^3*, Andrea C. Nunez, PhD^3*, Purvi M. Kakadia, PhD^6*, Russell Pickford, PhD^7*, Mark Raftery, PhD^8*, Sally Hough^5*, Griselda Buckland^5*, Michelle Bailey^5*, Yuvaraj Ghodke^5*, Noorul Absar^5*, Lachlin Vaughan, MBBS, BSc, FRACP, FRCPA^9*, Leonardo Pasalic, MBBS, PhD^10*, Chun Yew Fong, MBBS, PhD, FRACP, FRCPA¹¹, Melita Kenealy, MBBS, FRACP, FRCPA^12*, Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA¹³, Rohanna Stoddart^14*, Soma Mohammed^9*, Linda Lee, PhD^15*, Freda H. Passam, MD, PhD¹⁶, Kevin Spring, PhD^17*, Kristy K. Skarratt^18*, Patricia Rebeiro, MD^19*, Stephen R Larsen, MBBS PhD FRACP FRCPA²⁰, Peter Presgrave, MBBS, FRACP, FRCPA^21*, William S Stevenson, MBBS, PhD, FRACP, FRCPA²², Silvia Ling, MBBS, PhD²³, Campbell Tiley, MBBS FRACP FRCPA²⁴, Stephen Fuller, MBBS, PhD^18*, Fernando Roncolato^25*, Anoop Kumar Enjeti, MBBS, FRCPA, MD, MRCP²⁶, Dirk Hoenemann, MD^27*, Charlotte Lemech, MD, FRACP^28*, Stefan K. Bohlander, MD⁶, Jake Olivier, PhD^29*, Mark Hertzberg, MD³⁰, Ashwin Unnikrishnan, PhD³ and Mark N. Polizzotto, MBBS, FRACP, FRCPA^31*

¹School of Medical Sciences, University of New South Wales, Sydney, Australia
²Haematology Department, Prince of Wales Hospital, Sydney, Australia
³School of Clinical Medicine, University of New South Wales, Sydney, Australia
⁴School of Medical Sciences, University of New South Wales, Randwick, Australia
⁵Kirby Institute, University of New South Wales, Sydney, Australia
⁶Leukaemia & Blood Cancer Research Unit, Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
⁷Bioanalytical Mass Spectrometry Facility, University of New South Wales, Sydney, Australia
⁸Bioanalytical Mass Spectrometry Facility, UNSW, Sydney, Australia
⁹Westmead Hospital, Sydney, Australia
¹⁰ICPMR, Department of Haematology, Westmead Hospital, Sydney, Australia
¹¹Department of Haematology, Austin Health, Melbourne, Australia
¹²Cabrini Hospital, Melbourne, Australia
¹³Department of Haematology, Royal Adelaide Hospital, Adelaide, SA, Australia
¹⁴University of New South Wales, Sydney, Australia
¹⁵Royal North Shore Hospital, Sydney, Australia
¹⁶Haematology Research Group, Heart Research Institute, Sydney, NSW, Australia
¹⁷Liverpool Clinical School, Western Sydney University, Sydney, Australia
¹⁸Nepean Hospital, Sydney, Australia
¹⁹Blacktown Hospital, Sydney, Australia
²⁰Institute of Haematology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
²¹Wollongong Hospital, Wollongong, Australia
²²Department of Haematology, Royal North Shore Hospital, Sydney, NSW, Australia
²³Liverpool Hospital, Sydney, Australia
²⁴Central Coast Health, Gosford Hospital, Gosford, Australia
²⁵St. George Hospital, Sydney, Australia
²⁶Department of Haematology, Calvary Mater Hospital, Waratah, NSW, Australia
²⁷Otway Pharmaceutical Development and Consulting Pty Ltd, Forrest, Australia
²⁸Scientia Clinical Research, Medical Oncology, Prince of Wales Hospital, Sydney, Australia
²⁹School of Mathematics and Statistics, University of New South Wales, Sydney, Australia
³⁰Department of Clinical Haematology, Prince of Wales Hospital, Sydney, Australia
³¹ANU Clinical Hub for Interventional Research (CHOIR), John Curtin School of Medical Research, Canberra, Australia

Jing Dong, PhD¹, Christopher Staffi Buradagunta^2*, Tao Zhang, PhD^3*, Stephen R. Spellman^4*, Yung-Tsi Bolon, PhD^4*, Paul Auer, phD^5* and Wael Saber, MD, MS⁶

¹Division of Hematology Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
²MEDICAL COLLEGE OF WISCONSIN, Milwaukee, WI
³Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, MN
⁴CIBMTR® (Center for International Blood and Marrow Transplant Research), National Marrow Donor Program/Be The Match, Minneapolis, MN
⁵Division of Biostatistics, Institute for Health & Equity, and Cancer Center, MEDICAL COLLEGE OF WISCONSIN, Milwaukee, WI
⁶CIBMTR® (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI

Wan Hsuan Lee^1,2,3*, Chien-Chin Lin, MD, PhD^4,5*, Cheng-Hong Tsai, MD, PhD^5,6*, Mei-Hsuan Tseng, M.Sc.^5*, Yuan-Yeh Kuo, Ph.D.^5*, Ming-Chih Liu^5*, Jih-Luh Tang, M.D., Ph.D.^5,7, Hsun-I Sun^8*, Yi-Kuang Chuang^8*, Wen-Chien Chou, MD, PhD^4,5, Hsin-An Hou, MD, PhD^5* and Hwei-Fang Tien, MD, PhD⁵

¹Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan
²Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
³Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan
⁴Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan
⁵Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
⁶Department of Medical Education and Research, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan
⁷Department of Hematological Oncology, National Taiwan University Cancer Center, Taipei, Taiwan
⁸Tai-Cheng Stem Cell Therapy Center, National Taiwan University, Taipei, Taiwan

Lisa Johnson, PhD^1*, Yajia Zhang^1*, Biao Li^1*, Lisa Aviles^1*, Indu Lal^1*, Giri Ramsingh^2*, Naval Daver, MD³, Paresh Vyas, DPhil, FRCP, FRCPath, MRCP, MRCPath⁴ and David A. Sallman, MD⁵

¹Gilead Sciences Inc, Foster City, CA
²Gilead Sciences, Inc., Foster City, CA
³The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Oxford University, Oxford, United Kingdom
⁵Moffitt Cancer Center, University of South Florida, Tampa, FL

Chen Wang, MD^1*, Onyee Chan, MD², Najla Al Ali, MS³, Andrew Kuykendall, MD², Eric Padron, MD⁴, Kendra Sweet, MD², Jeffrey E. Lancet, MD², Rami S. Komrokji² and David A. Sallman, MD³

¹Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL
²Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
³Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁴Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL

Roger M. Lyons, MD¹, Wei-Han Cheng, PhD^2*, Laura Moore-Schiltz^3*, Ping Shi^3*, Anders Svensson, MD^2*, Cat N. Bui, PharmD^2*, Jessica E. Hutti, PhD^2*, Ann Marie McNeill, PhD^2*, Elizabeth S. Mearns, PharmD^4*, Archibong Yellow-Duke^4* and Ira Zackon, MD¹

¹The US Oncology Network, The Woodlands, TX
²AbbVie, North Chicago, IL
³Ontada, The Woodlands, TX
⁴Genentech, A Member of the Roche Group, San Francisco, CA

Farah Fleti, MD^1*, Amritpal Singh, MD^1*, Aref Al-Kali, MD², James M. Foran, MD³, Michelle A Elliott, MD², Kebede Begna, MD⁴, Talha Badar, MD⁵, Nandita Khera, MD, MPH⁶, Mithun V. Shah, MD, PhD², Hassan B. Alkhateeb, MD^2*, Maymona Abdelmagid^1*, Kaaren K. Reichard, MD^7*, Rhett P. Ketterling, MD^7*, Animesh Pardanani, MBBS, PhD ², Naseema Gangat, MBBS² and Ayalew Tefferi, MD²

¹Mayo Clinic, Rochester, MN
²Division of Hematology, Mayo Clinic, Rochester, MN
³Division of Hematology/Oncology and Blood and Marrow Transplanation and Cellular Therapy, Mayo Clinic, Jacksonville, FL
⁴Divison of Hematology, Mayo Clinic, Rochester, MN
⁵Division of Hematology and Oncology, Mayo Clinic Florida, Jacksonville, FL
⁶Division of Hematology/Oncology, Mayo Clinic, Phoenix, AZ
⁷Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

Tariq Kewan, MD^1,2*, Waled Bahaj, MD^3,4, Mai Aly, MD, BSc, MS^5,6*, Arda Durmaz^6,7*, Olisaemeka Ogbue⁸, Hetty E. Carraway, MD, MBA⁹, Abhay Singh, MD, MPH¹⁰, Suresh Kumar Balasubramanian, MD^11,12, Mikkael A. Sekeres, MD¹³, Valeria Visconte, PhD¹⁴, Carmelo Gurnari, MD^6,15 and Jaroslaw P. Maciejewski, MD, PhD, FACP⁶

¹Smilow Cancer Center, Yale New Haven Hospital, New Haven, CT
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
³Brown Cancer Center, University of Louisville, Louisville, KY
⁴Cleveland Clinic Foundation, Cleveland, OH
⁵Assiut University, Clinical Hematology unit, Faculty of Medicine, Assiut, Egypt
⁶Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
⁷Case Western Reserve University, Systems Biology and Bioinformatics Department, School of Medicine, Cleveland, OH
⁸Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Rocky River, OH
⁹Department of Hematology and Medical Oncology, Taussig Cancer institute, Leukemia Program, Cleveland Clinic, Cleveland, OH
¹⁰Department of Hematology and Medical Oncology, Taussig Cancer Institute, Leukemia Program, Cleveland Clinic Foundation, Cleveland, OH
¹¹Wayne State University, Detroit, MI
¹²Karmanos Cancer Institute/ Wayne State University, Detroit
¹³University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL
¹⁴Taussig Cancer Institute, Cleveland, OH
¹⁵Department of Biomedicine and Prevention, Ph.D. in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Rome, Italy

Luca Lanino^1*, Prassede Salutari, MD^2*, Alessandra Perego, MD^3*, Bruno Fattizzo, MD^4*, Marta Riva, MD^5*, Marta Ubezio, MD^1*, Pellegrino Musto, MD⁶, Daniela Cilloni, MD^7*, Esther Natalie Oliva, MD⁸, Maria Teresa Voso, MD⁹, Anna Maria Pelizzari, MD^10*, Antonella Poloni, PhD, MD^11*, Isabella Capodanno, MD^12*, Chiara Elena, MD^13*, Claudio Fozza, MD^14*, Fabrizio Pane, MD¹⁵, Massimo Breccia, MD^16*, Marco De Gobbi, MD, PhD^17*, Francesco Di Bassiano, MD^18*, Daniela Barraco, MD^19*, Elena Crisà, MD^20*, Dario Ferrero, MD^21*, Chiara Frairia, MD^22*, Antonella Vaccarino, MD^23*, Davide Griguolo, MD^24*, Stefania Paolini, MD, PhD^25*, Martina Quintini, MD^26*, Mariarosaria Sessa, MD^27*, Mauro Turrini, MD^28*, Monica Bocchia, MD^29*, Nicola Di Renzo, MD^30*, Elisa Diral, MD^31*, Cristina Foli, MD^32*, Alfredo Molteni, MD^33*, Ubaldo Occhini, MD^34*, Giulia Rivoli, MD^35*, Carmine Selleri, MD³⁶, Roberto Bono, MD^37*, Anna Calvisi, MD^38*, Andrea Castelli, MD^39*, Eros Di Bona, MD^40*, Ambra Di Veroli, MD^41*, Luana Fianchi, MD^42*, Sara Galimberti, MD^43*, Daniele Grimaldi, MD^44*, Monia Marchetti^45*, Marianna Norata, MD^46*, Alessandro Rambaldi, MD⁴⁷, Ilaria Tanasi, MD^48*, Patrizia Tosi, MD^49*, Ilaria Naldi, PhD^50*, Valeria Santini, MD, PhD^51* and Matteo G. Della Porta, MD^1*

¹Cancer Center, IRCCS Humanitas Research Hospital & Humanitas University, Rozzano - Milan, Italy
²Dipartimento Oncologia Ematologia, Ospedale Civile Spirito Santo, Pescara, Italy
³Ospedale San Gerardo, Monza, Italy
⁴Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico and University of Milan, Milan, Italy
⁵Dipartimento di Ematologia, Oncologia e Medicina Molecolare, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy
⁶“Aldo Moro” University School of Medicine and AOU Consorziale Policlinico, Bari, Italy
⁷A.O. Ordine Mauriziano di Torino, Turin, Italy
⁸Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Reggio Calabria, Italy
⁹Policlinico Tor Vergata & Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy
¹⁰UOC Ematologia, ASST Spedali Civili di Brescia, Brescia, Italy
¹¹Dipartimento di Medicina Interna, AOU Ospedali Riuniti, Ancona, Italy
¹²Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, RE, Italy
¹³Divisione di Ematologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
¹⁴Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy
¹⁵Azienda Ospedaliera Universitaria Federico II, Naples, Italy
¹⁶Division of Hematology, Department of Translational and Precision Medicine, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy
¹⁷University of Turin and San Luigi University Hospital, Orbassano, Italy
¹⁸Ospedali Riuniti Villa Sofia - Cervello, Palermo, Italy
¹⁹Ospedale di Circolo, ASST Sette Laghi, Varese, Italy
²⁰Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale Amedeo Avogadro, AOU Maggiore della Carità, Novara, Italy
²¹University of Turin/University Hospital A.O.U. “Città della Salute e della Scienza”, Turin, Italy
²²AOU Città della Salute e della Scienza, Torino, Italy
²³Ospedale San Giovanni Bosco, ASL Città di Torino, Torino, Italy
²⁴Ospedale Maggiore, ASU GI, Trieste, Italy
²⁵IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
²⁶AO Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy
²⁷Dipartimento di Scienze Mediche, Azienda Ospedaliero Universitaria di Ferrara, Ferrara, Italy
²⁸Dep. of Internal Medicine, Valduce Hospital, Como, Italy
²⁹Hematology, University of Siena, Azienda Ospedaliera Universitaria Senese, Siena, Italy, Siena, Italy
³⁰UOC Ematologia e Trapianto di Cellule Staminali, PO Vito Fazzi, Lecce, Italy
³¹IRCCS Ospedale San Raffaele, Milan, Italy
³²SSD Ematologia, ASL TO4, Chivasso - Ivrea, Italy
³³Division of Hematology, ASST Cremona, Cremona, Italy
³⁴Ospedale San Donato, USL Toscana Sud Est, Arezzo, Italy
³⁵Ospedale Policlinico San Martino, UO Ematologia e Terapie Cellulari, Genova, Italy
³⁶Hematology and Transplant Center, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy
³⁷Unità Trapianti di Midollo Osseo, Ospedali Riuniti Villa Sofia - Cervello, Palermo, Italy
³⁸UOC Ematologia and CTMO, Ospedale "San Francesco", ASL Nuoro, Nuoro, Italy
³⁹Division of Hematology, Ospedale degli Infermi, Biella, Italy
⁴⁰UOC Oncoematologia, AULSS7 Pedemontana, Bassano del Grappa (VI), Vicenza, Italy
⁴¹Hematology, Belcolle Hospital, Viterbo, Italy
⁴²Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
⁴³UO Ematologia, AOU Santa Chiara, Pisa, Italy
⁴⁴Ematologia, AO Santa Croce e Carle, Cuneo, Italy
⁴⁵Division of Hematology, Hospital Antonio e Biagio and Cesare Arrigo, Alessandria, Italy
⁴⁶IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy
⁴⁷Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII and University of Milan, Bergamo, Italy
⁴⁸Section of Hematology, Department of Medicine, Verona University Hospital, Verona, Italy
⁴⁹Hematology Unit, Infermi Hospital Rimini, Rimini, Italy
⁵⁰Fondazione Italiana Sindromi Mielodisplastiche FISiM-ETS, Firenze, Italy
⁵¹Department of Experimental and Clinical Medicine, MDS Unit, Hematology, AOU Careggi - University of Florence, Firenze, Italy

Maria Julia Montoro Gómez, MD, PhD^1*, Laura Palomo, PhD^1*, Pablo Vidal^2*, Francisco Fuster-Tormo^3*, Esperanza Such, PhD^4*, Margarita Ortega, PhD^1*, Teresa González^5*, Felix Lopez-Cadenas, MD^6*, Sara Garcia-Avila, MD^6*, Nieves Garcia-Gisbert^6*, Elvira Mora Casterá, MD^7*, Eugenia Rivero, MD^8*, Francesc Bosch, MD, PhD¹, Andrés Jerez, MD, PhD^9*, Maria Diez-Campelo, MD^10*, Francesc Solé, PhD¹¹ and David Valcárcel, MD, PhD¹

¹Department of Hematology, University Hospital Vall d’Hebron, Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
²Salamanca Universitu Hospital, Salamanca, Spain
³Cancer Genomics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain
⁴Hematology Department., Hospital Universitario y Politécnico La Fe, Valencia, Spain
⁵Department of Hematology, University Hospital of Salamanca, Salamanca, Spain
⁶Group of Applied Clinical Research in Hematology, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain
⁷Department of Hematology, University Hospital La Fe, Valencia, Spain
⁸Department of Hematology, University Hospital Arnau de Vilanova, Lleida, Spain
⁹Hematology and Medical Oncology Department, Hospital Morales Meseguer, IMIB, Murcia, Spain, MURCIA, Spain
¹⁰Hematology Department, Hospital Universitario de Salamanca-IBSAL, Salamanca, Spain
¹¹MDS Group. Institut de Recerca Contra la Leucèmia Josep Carreras (IJC), ICO-Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain

Samuel Urrutia, MD¹, Koji Sasaki, MD², Rashmi Kanagal-Shamanna, MD³, Alex Bataller, MD, PhD^2*, Guillermo Montalban-Bravo, MD², Irene Ganan-Gomez, PhD², Yue Wei, PhD², Hui Yang, MD, PhD², Kelly S. Chien, MD², Danielle Hammond, MD², Carlos E. Bueso-Ramos, MD, PhD⁴, Sherry A. Pierce, BSN, BA^2*, Hagop Kantarjian, MD⁵ and Guillermo Garcia-Manero, MD⁶

¹MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX
⁴Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX

Vishesh Khanna, MD¹, Rong Lu, PhD^2*, Jyoti Kumar, MD, MS^3*, Henning Stehr, PhD^4*, Michael A Spinner, MD⁵, Oscar Silva, MD, PhD^4*, Sebastian Fernandez-Pol, MD, PhD^4*, Jean S Oak, MD, PhD^4*, Brent Tan, MD, PhD^4* and Peter L Greenberg, MD⁵

¹Division of Hematology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA
²Department of Medicine, Quantitative Sciences Unit, Stanford University School of Medicine, Stanford, CA
³Department of Pathology, Stanford University School of Medicine, Palo Alto, CA
⁴Department of Pathology, Stanford University School of Medicine, Stanford, CA
⁵Division of Hematology, Department of Medicine, Stanford University Medical Center, Stanford, CA

Christina-Nefeli Kontandreopoulou^1*, Stavroula Syriopoulou^1*, Panagiotis T Diamantopoulos, MD, PhD^1*, Nefeli Giannakopoulou^1*, Dimitra Vlachopoulou^1*, Panagiota Katsiampoura^1*, Christos Stafylidis^1*, Maria Dimou², Athanasios Galanopoulos^3*, Sotirios Papageorgiou, MD, PhD^4*, Eleftheria Hatzimichael^5*, Vassiliki Pappa, MD^6*, Kotsianidis Ioannis^7*, Argiris Symeonidis, MD, PhD⁸, Panayiotis Panayiotidis, MD² and Nora-Athina Viniou, MD, PhD¹

¹Hematology Unit, First Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece
²First Propedeutic Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Greece,, Athens, Greece
³Department of Clinical Hematology, G. Gennimatas Hospital, Athens, GRC
⁴Second Department of Internal Medicine, Hematology Unit, Attikon University General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
⁵Department of Haematology, University Hospital of Ioannina, Ioannina, Greece
⁶Second Department of Internal Medicine and Research Institute, Attikon University General Hospital, Athens, Greece
⁷Department of Hematology, Democritus University of Thrace Medical School, Alexandroupolis, Greece
⁸Hematology Division, Department of Internal Medicine, University of Patras, Patras, Greece

Marie Solange Flores-Moran, MD^1*, Leonor Arenillas, MD, PhD^2,3*, Ana Ferrer, MD, PhD^2,3*, Felix Lopez-Cadenas, MD^4*, Sara Garcia-Avila, MD^4*, Concepción Fernández, PhD^3,5*, Antonio Salar, MD, PhD^4* and Xavier Calvo, MD, PhD^2,3*

¹Hematology Department, Hospital del Mar, Barcelona, Cataluña, Spain
²Group of Translational Research on Hematological Neoplasms, Hospital del Mar-IMIM, Barcelona, Spain
³Pathology Department, Hospital del Mar, Barcelona, Spain
⁴Hematology Department, Hospital del Mar, Barcelona, Spain
⁵Group of Applied Clinical Research in Hematology. Cancer research program-IMIM, Barcelona, Spain

Chung Hoow Kok, PhD, BSc^1,2, Elizabeth Ngoc Hoa Tran, PhD^2,3*, Dariusz Ladon^4*, Rakchha Chhetri, MBBS MHID Grad Cert. Biostat.^2,5*, Anmol Baranwal, MBBS^6*, Kirsty M Sharplin, MBBS⁵, Hassan B. Alkhateeb, MD^6*, Deepak Singhal, MBBS, MD, FRACP, FRCPA^1,5, Aref Al-Kali, MD⁶, Naseema Gangat, MBBS⁶, David T Yeung, MBBS, PhD, BSc, FRACP, FRCPA^5,7, Mark R. Litzow, MD⁶, David M Ross, MBBS, PhD, FRACP, FRCPA^2,5*, William J. Hogan, MB, BCh⁶, Ashanka Begna Kebede^6*, Abhishek A. Mangaonkar, MBBS⁶, Mrinal M. M. Patnaik, MD⁶, Ayalew Tefferi, MD⁶, Naranie Shanmuganathan, MBBS, FRACP, FRCPA^2,5, Sharad Kumar^8*, Daniel Thomas, MD, PhD^1,2, Mithun V. Shah, MD, PhD⁶ and Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA^1,2,5

¹Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia
²Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia
³The University of Adelaide, Adelaide, Australia
⁴Genetic and Molecular Pathology, SA Pathology, Adelaide, Australia
⁵Department of Haematology, Royal Adelaide Hospital, Adelaide, SA, Australia
⁶Division of Hematology, Mayo Clinic, Rochester, MN
⁷Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia
⁸Centre For Cancer Biology, SA Pathology, Adelaide, SA, AUS

Mithun V. Shah, MD, PhD¹, Christopher N Hahn, PhD², Rakchha Chhetri, MBBS MHID Grad Cert. Biostat.^3,4*, Elizabeth Ngoc Hoa Tran, PhD^3,5*, Deepak Singhal, MBBS, MD, FRACP, FRCPA^4,6, William J. Hogan, MB, BCh¹, Monika M Kutyna, MSc^3,4,6*, Hassan B. Alkhateeb, MD^1*, Aref Al-Kali, MD¹, Naseema Gangat, MBBS¹, Mark R. Litzow, MD¹, Begna Kebede, MD^1*, Abhishek A. Mangaonkar, MBBS¹, Mrinal M. M. Patnaik, MD¹, Ayalew Tefferi, MD¹, Anmol Baranwal, MBBS^1*, Naranie Shanmuganathan, MBBS, FRACP, FRCPA^3,4, Sharad Kumar, PhD^2*, Daniel Thomas, MD, PhD^3,6, Chung Hoow Kok, PhD, BSc^3,6 and Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA^3,4,6

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, Australia
³Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia
⁴Department of Haematology, Royal Adelaide Hospital, Adelaide, SA, Australia
⁵The University of Adelaide, Adelaide, Australia
⁶Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia

Sandra Novoa Jáuregui, MD^1*, Laura Palomo, PhD^2*, Ana Pérez, MD^3*, Bárbara Tazón, PhD^1*, Maria Julia Montoro, MD, PhD^4*, Adoracion Blanco^5*, Silvia Saumell, MD, PhD^3*, Laura Gallur, MD^3*, Eugenia Rivero, MD^6*, Sara Garrido, MD^1*, Marc Bosch Schips, MD^1*, Sofia Laura Muzio, MD^3*, Margarita Ortega, PhD^1*, Antonieta Molero Yordi, MD^1*, Francesc Bosch, MD, PhD³ and David Valcárcel, MD, PhD³

¹Department of Hematology, University Hospital Vall d’Hebron, Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
²Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
³Department of Hematology, University Hospital Vall d’Hebron, Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), University Autonoma of Barcelona (UAB), Barcelona, Spain
⁴Department of Hematology, University Hospital Vall d’Hebron, Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), University Autonoma of Barcelona (UAB), BARCELONA, Spain
⁵Department of Hematology, University Hospital Vall d’Hebron, Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), University Autonoma of Barcelona (UAB), Barcelona, AL, Spain
⁶Department of Hematology, University Hospital Arnau de Vilanova, Lleida, Spain

Maria Creignou, MD^1,2*, Elsa Bernard, PhD^3*, Michael Crowther, PhD^4*, Anna Tranberg, MD^1,2*, Elisabeth Ejerblad, MD^5*, Lars Nilsson, MD, PhD^6*, Hege Garelius, MD, PhD^7*, Petar Antunovic, MD^8*, Bengt Erik Holger Rasmussen, MD, PhD^9*, Fryderyk Lorenz, MD^10*, Gabriele Todisco, MD^1*, Gunilla Walldin^1*, Teresa Mortera-Blanco, PhD^1*, Monika Jansson^1*, Magnus Tobiasson, MD, PhD^1,2*, Gustaf Edgren, MD PhD^11,12*, Martin Jadersten, MD, PhD^1,2*, Elli Papaemmanuil, PhD³ and Eva Hellström-Lindberg, MD, PhD^1,2

¹Center for Hematology and Regenerative Medicine (HERM), Department of Medicine (MedH), Karolinska Institutet, Huddinge, Sweden
²Department of Hematology, Karolinska University Hospital, Huddinge, Sweden
³Center for Molecular Oncology, Center for Heme Malignancies and Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA, New York, NY
⁴Red Door Analytics, Stockholm, Sweden
⁵Unit of Haematology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
⁶Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden
⁷Department of Medicine, Section of Hematology and Coagulation, Sahlgrenska University Hospital, Göteborg, Sweden
⁸Department of Hematology, University Hospital in Linköping, Linköping, Sweden
⁹Department of Hematology, Örebro University Hospital, Örebro, Sweden
¹⁰Department of Hematology, University Hospital of Umeå, Umeå, Sweden
¹¹Department of Cardiology, Södersjukhuset, Stockholm, Sweden
¹²Department of Medicine (MedS), Karolinska Institutet, Solna, Sweden

Uwe Platzbecker, MD¹, Valeria Santini, MD, PhD^2*, Rami S. Komrokji³, Amer M. Zeidan, MD⁴, Guillermo Garcia-Manero, MD⁵, Rena Buckstein⁶, Esther Natalie Oliva, MD⁷, Veronika Pozharskaya^8*, Xianwei Ha^8*, Jose Alberto Nadal, PhD, MSc^9*, Dimana Miteva^9* and Pierre Fenaux¹⁰

¹Department for Hematology, Cell Therapy and Hemostaseology, University of Leipzig Medical Center, Leipzig, Germany
²University of Florence, Florence, Italy
³Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁴Department of Internal Medicine, Yale School of Medicine and Yale Cancer Center, New Haven, CT
⁵The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
⁷Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Reggio Calabria, Italy
⁸Bristol Myers Squibb, Princeton, NJ
⁹Celgene International Sàrl, a Bristol-Myers Squibb Company, Boudry, Switzerland
¹⁰Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France

Zaker I. Schwabkey, MD¹, Amin Azem, MD^2*, Najla Al Ali, MS², Somedeb Ball, MD^3*, Luis E. E. Aguirre, MD², Akriti G Jain, MD⁴, Avani M Singh, MD⁵, Sara M Tinsley-Vance, PhD, ANP³, Onyee Chan, MD², Jeffrey E. Lancet, MD², Kendra Sweet, MD³, Andrew Kuykendall, MD³, Eric Padron, MD², David A. Sallman, MD² and Rami S. Komrokji⁶

¹Division of Hematology and Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
²Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
³Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁴Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, WESLEY CHAPEL, FL
⁵Division of Hematology and Oncology, USF / Moffitt Cancer Center & Research Institute, Tampa, FL
⁶H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL

Michael Pfeilstocker, Univ.-Prof., MD, MBA^1,2, Heinz Tuechler^3*, Lionel Ades⁴, Jaroslav Cermak, MD, PhD⁵, Fatiha Chermat^6*, Matteo G. Della Porta, MD^7*, Pierre Fenaux⁸, Guillermo Garcia-Manero, MD⁹, Ulrich Germing^10*, Detlef Haase, MD, PhD^11*, Andrea Kuendgen, MD^12*, Michael Luebbert, MD¹³, Silvia Maria Meira Magalhaes, MD, PhD ¹⁴, Luca Malcovati, MD^15,16, Yasushi Miyazaki, MD¹⁷, Guillermo Sanz, MD, PhD^18,19,20,21, Valeria Santini, MD²², Mikkael A. Sekeres, MD²³, Matthew J Walter, MD^24,25, Peter Valent, MD^2,26 and Peter L Greenberg, MD²⁷

¹3rd Medical Department, Hematology & Oncology, Hanuschkrankenhaus, Vienna, Austria
²Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria
³3rd Med Dept, Hanusch Hospital, Vienna, Austria
⁴Department of Hematology and Bone Marrow Transplantation, Hôpital Saint-Louis, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France
⁵Dep. of Clinical Hematology, Inst. of Hematology & Blood Transfusion, Prague, Czech Republic
⁶Service d'Hématologie Séniors, Hôpital Saint-Louis, Paris, France
⁷Department of Biomedical Sciences, Humanitas University, Milan, Italy
⁸Université de Paris, Hematology department, Saint-Louis hospital, APHP, Paris, France
⁹University of Texas, MD Anderson Cancer Center, Houston, TX
¹⁰Dept. of Hematology, Oncology and Clinical Immunology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
¹¹Clinics of Hematology and Medical Oncology, University Medicine Göttingen, Göttingen, Germany
¹²Heinrich Heine University, Department of Hematology, Oncology, and Clinical Immunology, Duesseldorf, Germany
¹³Clinic of Internal Medicine I, University Hospital Freiburg, Freiburg, Germany
¹⁴Department of Clinical Medicine; Cancer Cytogenomics Laboratory, Drug Research and Development Center, Universidade Federal do Ceará, Fortaleza, Brazil
¹⁵Department of Hematology Oncology, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy
¹⁶Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Pavia, Italy
¹⁷Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
¹⁸CIBERONC, Instituto Carlos III, Madrid, Spain
¹⁹Istituto de Investigación Sanitaria La Fe, Valencia, Spain
²⁰Hematology Deparment, Health Research Institute La Fe, Valencia, Spain
²¹Hematology Department, Hospital Universitario i Politècnic La Fe, Valencia, Spain
²²DMSC, MDS Unit, AOU Careggi, University of Florence, Firenze, Italy
²³Hematologic Oncology and Blood Disorders, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²⁴Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO
²⁵Washington University in St. Louis, St. Louis, MO
²⁶Department of Medicine I, Division of Hematology and Hemostaseology, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria
²⁷Division of Hematology, Department of Medicine, Stanford University Medical Center, Stanford, CA