Tariq Kewan, MD^1,2*, Arda Durmaz^3,4*, Waled Bahaj, MD^4,5, Carmelo Gurnari, MD^4,6, Hussein Awada^4*, Olisaemeka Ogbue⁷, Ramsha Ahmed, MD^4*, Simona Pagliuca, MD, PhD^8,9, Hassan Awada, MD^10*, Yasuo Kubota, MD, PhD^4*, Minako Mori, MD, PhD^4,11*, BEN Ponvilawan, MD^4*, Bayan Al-Share, MD¹², Bhumika J. Patel, MD⁴, Hetty E. Carraway, MD, MBA¹³, Jacob Scott^4*, Suresh Kumar Balasubramanian, MD¹⁴, Taha Bat, MD¹⁵, Yazan F. Madanat, MD^16,17, Mikkael A. Sekeres, MD^18,19, Torsten Haferlach, MD²⁰, Valeria Visconte, PhD⁴ and Jaroslaw P. Maciejewski, MD, PhD, FACP⁴

¹Smilow Cancer Center, Yale New Haven Hospital, New Haven, CT
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
³Case Western Reserve University, Systems Biology and Bioinformatics Department, School of Medicine, Cleveland, OH
⁴Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
⁵Brown Cancer Center, University of Louisville, Louisville, KY
⁶Department of Biomedicine and Prevention, Ph.D. in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Rome, Italy
⁷Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Rocky River, OH
⁸Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Vandœuvre-lès-Nancy, France, France
⁹Hematology Department, University Hospital of Nancy, Vandoeuvre, France
¹⁰Roswell Park Comprehensive Cancer Center, Buffalo, NY
¹¹Department of Hematology and Oncology, Kyoto University, Kyoto, Japan
¹²Karmanos Cancer Center, Detroit, MI
¹³Department of Hematology and Medical Oncology, Taussig Cancer institute, Leukemia Program, Cleveland Clinic, Cleveland, OH
¹⁴Department of Oncology, Wayne State University/ Karmanos Cancer Institute, Detroit, MI
¹⁵Division of Hematology and Oncology, UT Southwestern Medical Center, Dallas, TX
¹⁶Division of Hematology/Oncology, Department of Internal Medicine, University of Texas Southwestern, Dallas, TX
¹⁷Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX
¹⁸University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL
¹⁹Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
²⁰MLL Munich Leukemia Laboratory, Munich, Germany

Yue Wei, PhD¹, Rashmi Kanagal-Shamanna, MD², Hong Zheng^1*, Pamela Lockyer, MS^1*, Faezeh Darbaniyan, PhD^3*, Ziyi Li, PhD^3*, Kim-Anh Do, PhD^3* and Guillermo Garcia-Manero, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX
³Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX

Valeria Visconte, PhD¹, Arda Durmaz^1*, Hussein Awada^1*, Ishani Nautiyal^1*, Tariq Kewan, MD^1*, Waled Bahaj, MD¹, Anjali Advani, MD², Caroline Astbury, PhD^3*, Heesun J. Rogers, MD³, Jaroslaw P. Maciejewski, MD, PhD, FACP¹ and Carmelo Gurnari, MD^1,4

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
²Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
³Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH
⁴Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy

Emily C Wheeler, PhD^1*, Benjamin Martin^2*, William Doyle^1*, Rebecca Gorelov, BS^3*, Melanie Donahue, BS^3*, Johann-Christoph Jann, MD^1*, Omar Abdel-Wahab, MD⁴, Justin Taylor, MD⁵, Michael Seiler, PhD^6*, Silvia Buonamici, PhD⁷, Roger Belizaire, MD, PhD⁸, Karen Adelman, PhD^9* and Zuzana Tothova, MD, PhD¹⁰

¹Dana Farber Cancer Institute, Boston
²Harvard Medical School, Boston
³Broad Institute, Cambridge, MA
⁴Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁵University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL
⁶H3 Biomedicine, Inc., Cambridge, MA
⁷H3 Biomedicine, Cambridge, MA
⁸Department of Pathology, Division of Transfusion Medicine, Dana Farber/Brigham & Women's/Massachusetts General Hospital, Boston, MA
⁹Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA
¹⁰Dana Farber Cancer Institute, Boston, MA

Carmelo Gurnari, MD¹, Arda Durmaz^1*, Hussein Awada^1*, Olisaemeka Ogbue^1,2, Yasuo Kubota, MD, PhD^1*, Tariq Kewan, MD^1*, Waled Bahaj, MD¹, Chao-Yie Yang, PhD³, Jacob Scott^1*, Torsten Haferlach, MD⁴, Jaroslaw P. Maciejewski, MD, PhD, FACP¹ and Valeria Visconte, PhD¹

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Rocky River, OH
³Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN
⁴MLL Munich Leukemia Laboratory, Munich, Germany

Bianca L Rivera, PhD¹, Samarpana Chakraborty², Yang Shi, MD, PhD^3*, Hui Zhang^4*, Gaurav S Choudhary, PhD^5*, Shanisha Gordon, MS^6*, Kith Pradhan, PhD^7*, Bowen Fu^2*, Isidora Tosic^8*, Rongbao Zhao^2*, Mendel Goldfinger, MD⁹, Ioannis Mantzaris, MD¹⁰, Milagros Carbajal^4*, Nandini Ramachandra, MS^6*, Marina Konopleva, MD, PhD², David Frank, MD, PhD¹¹, Yogenthiran Saunthararajah, MD¹², Amit Verma, MD⁹ and Aditi Shastri, MD¹³

¹Department of Oncology, Albert Einstein College of Medicine, Bronx, NY
²Albert Einstein College of Medicine, Bronx, NY
³Department of Pathology, Montefiore Medical Center Center for Cancer Care, Bronx, NY
⁴Cancer Center, Albert Einstein College of Medicine, Bronx, NY
⁵Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY
⁶Department of Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY
⁷Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
⁸Harvard University, Boston, MA
⁹Department of Hematology and Medical Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
¹⁰Hematology/Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
¹¹Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA
¹²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
¹³Department of Medicine, Albert Einstein College of Medicine, Bronx, NY

Lingxu Jiang^1*, Xinping Zhou^2*, Chao Hu^3*, Chen Mei^2*, Gaixiang Xu, MD^4*, Liya Ma, M.D.^5*, Yanling Ren, M.D.^2*, Li Ye^2*, Lu Wang^6*, Yingwan Luo, Ph.D^7*, Jie Jin, PhD⁸, Jie Sun, PhD^9* and Hongyan Tong, MD, PhD^5*

¹Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
²Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
³Department of Hematology, The First Affiliated Hospital Zhejiang University, Hangzhou, China
⁴Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁵Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China, Hangzhou, China
⁶Department of Hematology, The first affiliated hospital, Zhejiang university school of medicine, Hangzhou, China
⁷Department of Hematology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
⁸Department of Hematology, The First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China
⁹Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

Xingchen Yang^1*, Xiaoying Zhang^1*, Yicheng Zhang, MD, PhD^1,2 and JIA Wei, MD, PhD^1,2,3*

¹Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
²Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China
³Department of Hematology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Shanxi Medical University; Shanxi Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Taiyuan, China

Pedro Luis Moura, PhD^1*, Isabel Juliana F Hofman, PhD^1*, Yasuhito Nannya, MD, PhD^2,3, Affaf Aliouat, PhD^4*, Teresa Mortera-Blanco, PhD^5*, Tetsuichi Yoshizato, MD, PhD^1,6, Ryunosuke Saiki^3*, Masahiro Marshall Nakagawa, MD, PhD³, Ann-Charlotte Björklund^1*, Gunilla Walldin^5*, Indira Barbosa, BMA^1*, Monika Jansson^5*, Francesca Grasso, PhD^1*, Maria Creignou, MD^5,7*, Edda Maria Elvarsdottir, PhD^1*, Petter S Woll, PhD^1,6*, Sten Eirik Waelgaard Jacobsen, MD, PhD^1,4,6*, Seishi Ogawa, MD, PhD^1,8,9 and Eva Hellström-Lindberg, MD, PhD^5,7

¹Center for Hematology and Regenerative Medicine, Department of Medicine (MedH), Karolinska Institutet, Huddinge, Sweden
²Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Kyoto City, Japan
³Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⁴Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
⁵Center for Hematology and Regenerative Medicine (HERM), Department of Medicine (MedH), Karolinska Institutet, Huddinge, Sweden
⁶Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden
⁷Department of Hematology, Karolinska University Hospital, Huddinge, Sweden
⁸Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto City, Japan
⁹Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan

Qi Xingxing, PhD^1* and Seishi Ogawa, MD, PhD^2,3,4

¹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
²Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto City, Japan
³Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto, Japan
⁴Center for Hematology and Regenerative Medicine, Department of Medicine (MedH), Karolinska Institutet, Huddinge, Sweden

Rurika Okuda, MSc, BS^1*, Yotaro Ochi, MD, PhD^1*, Kazuhisa Chonabayashi, MD, PhD^2,3*, Nobuhiro Hiramoto, M.D.^4*, Masashi Sanada, MD, PhD^1,5, Hiroshi Handa, MD, PhD⁶, Senji Kasahara⁷, Shinya Sato, MD^8*, Nobuhiro Kanemura, MD, PhD⁹, Toshiyuki Kitano, MD, PhD^10*, Mizuki Watanabe, MD^3*, Wolfgang Kern, MD¹¹, Maria Creignou^12*, Yuichi Shiraishi, PhD^13*, Mitsumasa Watanabe, MD, PhD^14*, Kensuke Usuki, MD, PhD¹⁵, Shinsaku Imashuku, MD, PhD^16*, Eva Hellström-Lindberg, MD, PhD¹², Torsten Haferlach, MD¹¹, Shigeru Chiba, MD, PhD¹⁷, Nobuo Sezaki^18*, Lee-Yung Shih, MD¹⁹, Yasushi Miyazaki, MD⁸, Yoshinori Yoshida, MD, PhD^2*, Takayuki Ishikawa⁴, Kazuma Ohyashiki, MD, PhD²⁰, Yoshiko Atsuta^21*, Yusuke Shiozawa, MD, PhD^1*, Satoru Miyano, PhD^13,22*, Hideki Makishima, MD, PhD¹, Yasuhito Nannya, M.D., Ph.D.¹ and Seishi Ogawa, MD, PhD^1,12,23

¹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto City, Japan
²Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan
³Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⁴Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan
⁵Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
⁶Department of Hematology, Gunma University Hospital, Maebashi, Japan
⁷Department of Hematology, Gifu Pharmaceutical University, Gifu, Japan
⁸Japan Adult Leukemia Study Group, Tokyo, Japan
⁹Department of Internal Medicine, Gifu University, Gifu, Japan
¹⁰Department of Hematology, Kitano Hospital, Osaka, Japan
¹¹MLL Munich Leukemia Laboratory, Munich, Germany
¹²Center for Hematology and Regenerative Medicine, Department of Medicine (MedH), Karolinska Institutet, Huddinge, Sweden
¹³Laboratory of Sequence Data Analysis, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
¹⁴Department of Hematology, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Japan
¹⁵Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan
¹⁶Department of Laboratory Medicine, Uji-Tokushukai Medical Center, Uji, Japan
¹⁷Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
¹⁸Department of Hematology, Chugoku Central Hospital, Fukuyama, Japan
¹⁹Division of Hematology-Oncology, Chang Gung University, Chang Gung Memorial Hospital-Linkou, Taoyuan, Taiwan
²⁰Department of Hematology, Tokyo Medical University, Tokyo, Japan
²¹Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan
²²Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
²³Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan

Matilde Y Follo, PhD^1*, Alessia De Stefano, BSc^1*, Sara Mongiorgi, PhD^1*, Irene Casalin, BSc^1*, Alessandra Cappellini, PhD^1*, Stefano Ratti, MD, PhD^1*, Andrea Pellagatti, PhD^2*, Miriam Fogli, PhD^3*, Michele Cavo, MD^4*, Lucia Manzoli, MD^1*, Lucio Cocco, MD^1*, Jacqueline Boultwood, PhD², Sarah Parisi, MD, PhD⁵, Stefania Paolini, MD, PhD^3*, Antonio Curti, MD, PhD⁶ and Carlo Finelli, MD^7*

¹Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
²Blood Cancer UK, University of Oxford, Oxford, United Kingdom
³IRCCS Azienda Ospedaliero-Universitaria di Bologna - Istituto di Ematologia “Seràgnoli”, Bologna, Italy, Bologna, Italy
⁴IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
⁵IRCCS Azienda ospedaliero-universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
⁶IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy
⁷IRCCS Azienda Ospedaliero-Universitaria di Bologna Institute of Hematology “Seràgnoli”, Bologna, Italy

Claudia Cabrera, BS^1*, Sridhar Nonavinkere Srivatsan, MS^2*, Abigael Cheruiyot^3*, Tanzir Ahmed, PhD¹, Zheng Yang^4*, Jin J Shao^2*, Monique Chavez, BS², Julie Bailis, PhD^5*, Zhongsheng You, PhD^6* and Matthew J Walter, MD²

¹Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO
²Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO
³Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO
⁴Department of Cell Biology and Physiology, Washington University School of Medicine, St.Louis, MO
⁵Oncology Research, Amgen Inc, South Francisco, California, South San Francisco, CA
⁶Department of Cell Biology and Physiology, Washington University School of Medicine, St.Louis