Clemence Aldebert^1*, Emily Duan^2*, Sylwia Jasinski, MD^2*, Talia H Ostrow^2*, Isaiah Gonzalez^2*, Aristotelis Tsirigos, PhD^3*, Elizabeth A. Raetz, MD^4,5, Nikki Ann Evensen, PhD, BS² and William L. Carroll, MD^2,4

¹Laura and Isaac Perlmutter Cancer Center, NYU Langone health, New York, NY
²Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY
³Department of Applied Bioinformatics, New York University Langone Health, New York, NY
⁴Division of Pediatric Hematology and Oncology, Stephen D. Hassenfeld Children's Center for Cancer and Blood Disorders, NYU Langone Health, New York, NY
⁵Laura and Isaac Perlmutter Cancer Center, NYU langone Health, New York, NY

Irina Pushel, PhD^1*, Midhat S. Farooqi, MD, PhD^1,2*, Byunggil Yoo, MS^1*, Kai Tan, PhD^3,4, Kathrin M. Bernt, MD⁵ and Erin Guest, MD^6,7

¹Genomic Medicine Center, Children's Mercy Research Institute, Kansas City, MO
²Department of Pathology, University of Missouri - Kansas City School of Medicine, Kansas City, MO
³Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
⁴Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA
⁵Pediatric Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
⁶Department of Pediatrics, University of Missouri - Kansas City School of Medicine, Kansas City, MO
⁷Children's Mercy Kansas City, Kansas City, MO

Sean I. Tracy, MD, PhD¹, Hrishi Venkatesh^1*, Miriam Arroyo, B.S.^1*, Todd Knutson^2*, Ashenafi Tilahun^1*, Bartosz Grzywacz, MD³ and Michael Farrar, PhD⁴

¹University of Minnesota, Minneapolis, MN
²Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN
³Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN
⁴Center for Immunology, University of Minnesota, Minneapolis, MN

Trisha Tee^1*, Titine Ruiter^1*, Danique Wajon^1*, Shuiyan Wu, MD, PhD^1,2*, Ahmed Dahaoui^1*, Dorette S van Ingen Schenau^1*, Laurens T van der Meer, PhD¹ and Frank N van Leeuwen, PhD¹

¹Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
²Department of Pediatric Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, China

Jordi Ribera^1*, Isabel Granada, PhD^2*, Teresa González, PhD^3*, Mireia Morgades^4*, Olga Garcia^5*, Ricardo Sanchez^6,7,8*, Esperanza Such, PhD^9*, Susana Barrena, PhD^10*, Juana Ciudad, PhD^11*, Beatriz Soriano^12*, Rocio Benito, PhD^13*, Gayane Avetisyan^14*, Eva Lumbreras^3*, Cristina Miguel-García, BSc^15*, Sandra Santos-Mínguez^3*, Lurdes Zamora, PhD^1,16*, Mar Mallo, Ph.D.^17*, Celia González-Gil^18*, Eulàlia Genescà, PhD^18*, Thaysa Lopes^1*, Jesús María Hernández-Rivas, MD, PhD^{19,20,21,22,23}, Alberto Orfao, MD, PhD^11,24,25 and Josep-Maria Ribera, MD, PhD⁴

¹Institut de Recerca contra la Leucèmia Josep Carreras, Badalona, Spain
²ICO-Hospital Germans Trias i Pujol. Josep Carreras Research Institute. Universitat Autònoma de Barcelona, Badalona, Spain
³Unidad de Diagnóstico Molecular y Celular del Cáncer, Centro de Investigación del Cáncer-Universidad de Salamanca (IBMCC, USAL-CSIC); Genética Molecular en Oncohematología, Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain
⁴Hematology Department, ICO Badalona, Germans Trias i Pujol University Hospital. Universitat Autònoma de Barcelona. Josep Carreras Leukemia Research Institute, Badalona, Spain
⁵Department of Hematology, ICO-Hospital Germans Trias i Pujol, Josep Carreras Leukaemia Research Institute (IJC), Institut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona, Badalona, Spain
⁶Hematology, Hospital Universitario 12 de Octurbe, Madrid, Spain
⁷Hematology Department Hospital 12 de Octubre, Complutense University, H12O-CNIO Clinical research unit, CIBERONC, Madrid, Spain
⁸Altum sequencing Co., Madrid, Spain
⁹Hematology Department., Hospital Universitario y Politécnico La Fe, Valencia, Spain
¹⁰Cytometry Service (NUCLEUS), Department of Medicine and IBSAL, Cancer Research Center (IBMCC, University of Salamanca-CSIC), Salamanca, Spain and Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Salamanca, Spain
¹¹IBSAL, IBMCC, Centro de Investigación del Cáncer, CIBERONC, Universidad de Salamanca-CSIC, Hospital Universitario, Salamanca, Spain
¹²Servicio General de Citometría/Universidad de Salamanca (Nucleus), Centro de Investigación del Cáncer/IBMCC (CSIC), Salamanca, Salamanca, Spain
¹³Servicio de Hematología, Hospital Universitario de Salamanca (HUSAL/IBSAL), and IBMCC (USAL-CSIC), Salamanca, Spain
¹⁴Servicio de Hematología. Hospital La Fe, Valencia, Spain
¹⁵Universidad de Salamanca, IBSAL, Centro de Investigación del Cáncer, IBMCC-CSIC, Servicio de Hematología, Hospital Universitario de Salamanca, Salamanca, Spain
¹⁶Hematology Department, ICO - Hospital Germans Trias i Pujol, Badalona, Spain
¹⁷Josep Carreras Leukemia Research Institute (IJC), ICO-Hospital GermansTrias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain
¹⁸Institut de Recerca Contra la Leucèmia Josep Carreras (IJC), ICO-Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain
¹⁹HARMONY Alliance Chair, Salamanca, Spain
²⁰Department of Hematology, University Hospital of Salamanca, IBSAL, Salamanca, Spain
²¹Department of Hematology, University Hospital of Salamanca, Institute of Biomedical Research of Salamanca (IBSAL), Cancer Research Center, Salamanca, Spain
²²Cancer Research Center (IBMCC) CSIC, University of Salamanca, Salamanca, Spain
²³IBSAL, IBMCC, CIC, Universidad de Salamanca-CSIC, Salamanca, Spain
²⁴Cancer Research Center (IBMCC, USAL-CSIC), Department of Medicine and Cytometry Service (NUCLEUS), University of Salamanca; Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain
²⁵Cancer Research Centre (IBMCC, USAL-CSIC), Department of Medicine and Cytometry Service (NUCLEUS), University of Salamanca and IBSAL, Salamanca, Spain

Heiko Mueller, PhD^1*, Wencke Walter, PhD^1*, Stephan Hutter, PhD^1*, Niroshan Nadarajah^1*, Frank Dicker, PhD¹, Manja Meggendorfer, PhD¹, Qingsong Gao^2*, Ilaria Iacobucci, PhD³, Charles G. Mullighan, MBBS, MD², Wolfgang Kern, MD¹, Torsten Haferlach, MD¹ and Claudia Haferlach, MD¹

¹MLL Munich Leukemia Laboratory, Munich, Germany
²St. Jude Children's Research Hospital, Memphis, TN
³Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN

Deborah Cardinali, PhD student^1*, Irene Della Starza, PhD^1,2*, Vittorio Bellomarino, Bs^1*, Marco Beldinanzi, PhD student^1*, Mariangela Di Trani, Bs^1*, Felicetto Ferrara, MD^3*, Monica Bocchia, MD^4*, Prassede Salutari, MD^5*, Monia Lunghi, MD, PhD^6*, Erika Borlenghi, M.D.^7*, Matteo Piccini^8*, Catello Califano, MD^9*, Alfonso Piciocchi, MS^2*, Maria Stefania De Propris, PhD^1*, Robin Foà, Full professor^1* and Sabina Chiaretti, MD, PhD¹

¹Hematology, Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy
²GIMEMA Foundation, Rome, Italy
³+390817472241, Napoli, Italy
⁴Hematology, University of Siena, Azienda Ospedaliera Universitaria Senese, Siena, Italy, Siena, Italy
⁵Dipartimento Oncologia Ematologia, Ospedale Civile Spirito Santo, Pescara, Italy
⁶Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
⁷Department of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy
⁸SOD Ematologia, SOD Ematologia, Università Di Firenze, AOU Careggi, Firenze, Italy, Firenze, Italy
⁹Onco-Ematologia Ospedale Pagani, Salerno, Italy

Fieke W Hoff, MD, PhD¹, Lourdes Sriraja^2*, Yihua Qiu^3*, Gaye Jenkins, BS^4*, Andrew Ligeralde^5*, David T. Teachey, MD⁶, Brent L. Wood, MD PhD⁷, Meenakshi Devidas, PhD, MBA⁸, Mignon L. Loh, MD⁹, Todd A. Alonzo, PhD^10*, Amina A Qutub, PhD^11*, Evangelia Petsalaki^12*, Steven M. Kornblau, MD³ and Terzah M. Horton, MD, PhD⁴

¹UT Southwestern Medical Center, Dallas, TX
²2European Molecular Biology Laboratory, Hinxton, United Kingdom
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Baylor College of Medicine, Houston, TX
⁵University of California, Berkeley, CA
⁶Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Rutledge, PA
⁷Children's Hospital Los Angeles, Los Angeles, CA
⁸Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN
⁹Department of Pediatrics, Benioff Children's Hospital, University of California San Francisco, San Francisco, CA
¹⁰Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA
¹¹The University of Texas at San Antonio, San Antonio
¹²European Molecular Biology Laboratory, Hinxton, United Kingdom

Ruimin Hong^1*, Linghui Zhou, MD^2*, Ye Meng^2*, Mingming Zhang^2*, Houli Zhao, MD^2*, Jiazhen Cui^2,3,4*, Simao Huang^2,3,4,5*, Yongxian Hu^6* and He Huang^2,5,7,8

¹Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang Province, AL, China
²Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
³Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China
⁴Institute of Hematology, Zhejiang University, Hangzhou, China
⁵Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China
⁶Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, AL, China
⁷Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
⁸Liangzhu Laboratory, Zhejiang University Medical Center, 1369 West Wenyi Road, Hangzhou 311121, China, Hangzhou, China

Daniel Leongamornlert, PhD^1*, Jesús Gutiérrez-Abril^2*, SooWah Lee, MSc^3*, Emilio Barretta^4*, Thomas Creasey^4*, Krisztina Zuborne Alapi, MSc^3*, Max F. Levine, MS^2*, Juan E Arango-Ossa^2*, Juan S Medina-Martinez^2*, Amy A. Kirkwood, MSc^5*, Laura Clifton-Hadley, BSc, PhD^5*, Pip Patrick, PhD, MSc, MA^5*, David Jones^1*, Adam P Butler^1*, Christine J. Harrison, PhD, FRCPath⁴, Peter J. Campbell^1*, Bela Patel Wrench, MD^6*, Anthony V. Moorman⁴, Adele K. Fielding, MBBS, PhD³ and Elli Papaemmanuil, PhD²

¹Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, United Kingdom
²Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
³UCL Cancer Institute, London, United Kingdom
⁴Leukaemia Research Cytogenetics Group, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
⁵Cancer Research UK & UCL Cancer Trials Centre, University College London, London, United Kingdom
⁶Department of Haemato-Oncology, Queen Mary University of London, London, United Kingdom

Alexandra Niedermayer^1*, Stefanie Enzenmüller^1*, Felix Seyfried^1*, Daniel Tews^1*, Pamela Fischer-Posovszky^1*, Ulrich Rupp^2*, Paul Walther^2*, Klaus-Michael Debatin¹ and Lüder Hinrich Meyer^1*

¹Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany
²Central Facility for Electron Microscopy, Ulm University, Ulm, Germany

Matthew M Klairmont, MD¹, William L. Carroll, MD², Iannis Aifantis, PhD³ and Christopher Y. Park, MD, PhD¹

¹Pathology, New York University School of Medicine, New York, NY
²NYU School of Medicine, New York, NY
³Department of Pathology, New York University School of Medicine, New York, NY

Xiaojie Liang^1*, Bingqing Tang^1*, Cai Zihong^1*, Zicong Huang^1*, Baiwei Luo^2*, Bingyu Lin^2*, Yunong Yang^2*, Qifa Liu, MD¹ and Hongsheng Zhou^1*

¹Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
²The First Clinical Medical College, Guangdong Medical University, Zhanjiang, China

Carol Fries Simpson, MD¹, Janice M Spence^2*, Cameron Baker, MS^3*, Aayush Poudel^4*, John P Spence, PhD^5*, Philip J Rock^6*, Hongyue Wang, PhD^7*, Diana G Adlowitz, PhD^2*, Helene R McMurray, PhD^8*, Andrew McDavid, PhD^9* and Richard Burack, MD, PhD⁶

¹Department of Pediatrics, Pediatric Hematology & Oncology, University of Rochester, Rochester, NY
²Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY
³Biostatistics, Genomics Research Center, University of Rochester, Rochester, NY
⁴School of Medicine and Dentistry, University of Rochester, Rochester, NY
⁵NGS Tech, Albany, NY
⁶Department of Pathology and Laboratory Medicine/Hematopathology, University of Rochester Medical Center, Rochester, NY
⁷Biostatistics, University of Rochester, Rochester, NY
⁸Department of Pathology and Laboratory Medicine, Department of Biomedical Genetics, University of Rochester, Rochester, NY
⁹Department of Biostatistics and Computational Biology, University of Rochester, Rochester, NY

Diego Alberto Barcenas-Lopez, MSc^1,2, Juan Carlos Nuñez-Enriquez, PhD^3*, Laura Lucila Gomez-Romero, PhD^4*, Hugo Antonio Tovar-Romero, PhD^4*, Elva Jimenez-Hernandez, PhD^5*, Aurora Medina-Sanson, MD^6*, Jose Gabriel Peñaloza-Gonzalez, MD^7*, Luz Victoria Flores Villegas, MD, Hematology^8*, Minerva Mata-Rocha, PhD^9*, Haydee Rosas-Vargas, PhD^9*, Alfredo Hidalgo-Miranda, PhD^2*, Juan Manuel Mejia-Arangure, PhD² and Silvia Jimenez-Morales, PhD^2*

¹Biological Sciences Graduate Studies Program, National Autonomous University of Mexico, Coyoacan, Mexico City, Mexico
²Cancer Genomics Laboratory, National Institute of Genomic Medicine, Tlalpan, DF, Mexico
³Clinical Epidemiology Division. National Medical Center “Siglo XXI”, Mexican Institute of Social Security, Cuauhtemoc, DF, Mexico
⁴Computational Genomics Department, National Institute of Genomic Medicine, Tlalpan, DF, Mexico
⁵Pediatric Hematology Department. National Medical Center “La Raza”, Mexican Institute of Social Security, Azcapotzalco, DF, Mexico
⁶Hematological Oncology Department, Children’s Hospital of Mexico “Federico Gomez”, Cuauhtemoc, DF, Mexico
⁷Pediatric Oncology Department, Juarez Hospital of Mexico, Gustavo A Madero, DF, Mexico
⁸Pediatric Hematology, National Medical Center "20 de Noviembre" ISSSTE, Mexico City, MEX
⁹Human Genetics Research Department. National Medical Center “Siglo XXI”, Mexican Institute of Social Security, Cuauhtemoc, DF, Mexico

Chiara Palmi, PhD^1*, Silvia Bresolin, PhD^2*, Stefanie V. Junk^3*, Grazia Fazio, PhD^4*, Daniela Silvestri, Dr^5*, Marketa Zaliova⁶, Athanasios Oikonomou^4*, Katerina Scharov^7*, Martin Stanulla, MD, MSc^8*, Anja Moericke^9*, Martin Zimmermann, PhD^10*, Martin Schrappe, MD¹¹, Barbara Buldini^12*, Claudia Saitta, PhD^4*, Marta Galbiati^13*, Michela Bardini, PhD^1*, Sanil Bhatia, PhD^14*, Arndt Borkhardt, MD⁷, Luca Lo Nigro, PhD, MD¹⁵, Valentino Conter, MD^16*, Maria Grazia Valsecchi, PhD^5,17*, Andrea Biondi, MD⁴, Geertruij Te Kronnie^18*, Gunnar Cario^19* and Giovanni Cazzaniga, PhD^20,21*

¹Tettamanti Research Center, Pediatrics, Department of Medicine, University of Milano-Bicocca, Monza, Italy
²SDB Department, Pediatric Hemato-Oncology, University of Padova, Padova, Italy
³Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany
⁴Tettamanti Research Center, Dept. Pediatrics, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy
⁵Centro Operativo di Ricerca Statistica, Fondazione Tettamanti, Monza, Italy
⁶CLIP - Childhood Leukemia Investigation Prague, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
⁷Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
⁸Pediatric Hematology and Oncology, Hannover Medical School (MHH), Hanover, Germany
⁹Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
¹⁰Department of Pediatric Hematology and Oncology, Medical School Hannover, Hannover, Germany
¹¹University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany
¹²Women's and children's health department, onco-hematology lab and clinic, University-Hospital of Padova, Padova, Italy
¹³Centro Ricerca Tettamanti, University of Milano Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy
¹⁴Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
¹⁵Center of Pediatric Hematology and Oncology, Azienda Policlinico-San Marco, Catania, Italy
¹⁶Department of Pediatrics, Pediatric Hematology-Oncology Unit, Fondazione MBBM/San Gerardo Hospital, Monza, Italy
¹⁷Statistics, University of Milan Bicocca, Monza, Italy
¹⁸Woman and Child Health Department, OncoHematology Lab, University of Padua, Padua, Italy
¹⁹Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany, Kiel, Germany
²⁰Medical Genetics, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy
²¹Tettamanti Research Center, Pediatrics, University of Milano-Bicocca / Fondazione Tettamanti, Monza, Italy

Amir Enshaei, PhD^1*, Javier Martinez Martínez Elicegui^2*, Esther Anguiano^3*, Jude Gibson^4*, Mirella Ampatzidou^5*, Michael Doubek, MD, PhD⁶, Adele K. Fielding, MBBS, PhD⁷, Edoardo La Sala, MSc^8*, Elizabeth Middleton^9*, Anita W. Rijneveld, MD, PhD^10*, Amin T. Turki, MD¹¹, Ajay Vora, MD¹², Martin Zimmermann, PhD^13* and Anthony V. Moorman¹⁴

¹Translational and Clinical Research Institute, Newcastle University, Newcastle-upon-Tyne, United Kingdom
²Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain
³Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain
⁴Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
⁵Department of Pediatric Hematology-Oncology, "Aghia Sophia” Children’s Hospital, Athens, Greece
⁶Department of Internal Medicine - Hematology and Oncology, University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic
⁷Cancer Institute, University College London, London, United Kingdom
⁸Italian Group for Adult Hematologic Diseases (GIMEMA), Data Center and Health Outcomes Research Unit, Rome, Italy
⁹Translational and Clinical Research Institute, Newcastle University, Newcastle, United Kingdom
¹⁰Erasmus University Medical Center Cancer Institute, Rotterdam, Netherlands
¹¹Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany
¹²Department of Haematology, The Children's Hospital, London, United Kingdom
¹³Department of Pediatric Hematology/Oncology, Hannover Medical School, Hannover, Germany
¹⁴Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle, United Kingdom