Agnieszka Wierzbowska, MD, PhD¹, Agnieszka Pluta, MD, PhD^1*, Anna Czyz, MD, PhD^2*, Marta Antonina Libura, MD, PhD^3*, Sebastian Giebel, MD, PhD^4*, Piotr Stelmach, MD, PhD^5*, Magdalena Czemerska^1*, Piotr Strzałka, MD^1*, Anna Kopinska, MD, PhD^6*, Krzysztof Wozniczka, MD, PhD^7*, Grzegorz Helbig, MD, PhD^6*, Karol Wojcik, MD^8*, Malgorzata Razny, MD, PhD^8*, Marta Anna Sobas, MD, PhD^2*, Tomasz Wróbel², Andrzej Szczepaniak, MD, PhD^9*, Lidia Gil, MD, PhD¹⁰, Magdalena Dutka, MD, PhD^11*, Maria Bieniaszewska, MD, PhD^11*, Tomasz Gromek, MD, PhD^12*, Marek Hus, MD, PhD^13*, Edyta Cichocka, MD^14*, Janusz Halka, MD, PhD^15*, Elzbieta Patkowska, MD, PhD^16*, Marzena Watek, MD PhD^16*, Jolanta Wozniak, PhD^17*, Ewa Lech-Marańda, MD, PhD^18*, Agnieszka Kopacz, MD, PhD^19*, Katarzyna Dulik, MD^4*, Jerzy Holowiecki, MD, PhD^4*, Michal Soin^1*, Damian Mikulski, MD^20*, Ewelina Perdas, PhD^20*, Wojciech Fendler, MD, PhD^20*, Ameenah Sukkur^21*, Andi Rustani^22*, Nuria Mencia Trinchant, PhD^21*, Pinkal Desai, MD, MPH²¹, Sangmin Lee²¹, Michael Samuel, MD^21*, Justin D. Kaner, MD²³, Ellen Ritchie, MD²¹, Monica L. Guzman, PhD²⁴ and Gail J. Roboz, MD²¹

¹Department of Hematology Medical University of Lodz, Provincial Multi-specialist Oncology and Traumatology Center, Lodz, Poland
²Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland
³Department of Hematology, Transplantology and Internal Diseases, Warsaw Medical University, Warsaw, Poland
⁴Department of Hematology and Bone Marrow Transplantation, Maria Sklodowska-Curie Institute of Oncology, Gliwice, Poland
⁵Provincial Multi-specialist Oncology and Traumatology Center, Lodz, Poland
⁶Medical University of Silesia, Katowice, Poland
⁷Department of Hematology and Bone Marrow Transplantation, Medical University of Silesia, Katowice, Poland
⁸Department of Hematology, Rydygier Specialist Hospital, Cracow, Poland
⁹Department of Hematology and Bone Marrow Transplantation, Medical University, Poznan, Poland
¹⁰Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznan, Poland
¹¹Department of Hematology, Medical University of Gdansk, Gdansk, Poland
¹²Department of Hematooncology and Bone Marrow Transplantation, Medical University, Lublin, Poland
¹³Department of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin, Poland
¹⁴Department of Hematology and Bone Marrow Transplantation, Copernicus Memorial Hospital, Torun, Poland
¹⁵Department of Hematology, Warmian-Masurian Cancer Center of The Ministry of the Interior and Administration’s Hospital, Olsztyn, Poland
¹⁶Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
¹⁷Division of Hematological Diagnostics, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
¹⁸Hematology Department, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
¹⁹Department of Hematology, Medical University of Rzeszow, Rzeszow, Poland
²⁰Department of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland
²¹Division of Hematology and Oncology, Weill Cornell Medicine and The New York-Presbyterian Hospital, New York, NY
²²Division of Hematology and Oncology, Weill Cornell Medicine and The New York-Presbyterian Hospital, New York
²³Department of Medicine, Division of Hematology and Medical Oncology, Leukemia Program, Weill-Cornell Medicine, Syosset, NY
²⁴Division of Hematology and Oncology, Department of Medicine, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY

Nadeen Anabtawi^1*, Jessica Kohlschmidt, PhD^2,3, Daelynn Buelow, PhD^4*, Shelley Orwick, BS^1*, Kennedy Coleman^1*, Krzysztof Mrózek, MD, PhD⁵, Jonathan E. Kolitz, MD^6,7, Bayard L. Powell, MD⁸, William G. Blum, MD⁹, Maria R. Baer, MD¹⁰, John C. Byrd, MD¹¹, Wendy Stock, MD¹², Geoffrey L. Uy, MD¹³, Ann-Kathrin Eisfeld, MD^14,15, Sharyn Baker, PharmD PhD⁴ and James S. Blachly, MD^16,17

¹The Ohio State University Comprehensive Cancer Center, Columbus, OH
²Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus
³Alliance Statistics and Data Management Center, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁴Division of Pharmaceutics and Pharmacology, College of Pharmacy, Comprehensive Cancer Center, The Ohio State University, Columbus
⁵Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁶Monter Cancer Center, Zucker School of Medicine at Hofstra/Northwell, Lake Success, NY
⁷Monter Cancer Center, North Shore University Hospital and Long Island Jewish Medical Center, Northwell Health, New Hyde Park, NY
⁸Wake Forest Baptist Comprehensive Cancer Center, Winston Salem, NC
⁹Department of Hematology and Oncology, Winship Cancer Institute of Emory University, Atlanta, GA
¹⁰University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD
¹¹University of Cincinnati College of Medicine, Cincinnati, OH
¹²University of Chicago, Chicago, IL
¹³Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO
¹⁴Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH
¹⁵Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University, Columbus, OH
¹⁶James Comprehensive Cancer Center, The Ohio State University, Columbus, OH
¹⁷The Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH

Jan Philipp Bewersdorf, MD^1,2, Vanessa Hasle^3*, Rory M. Shallis, MD⁴, Ethan G. Thompson, PhD^3*, Daniel Lopes de Menezes, PhD^3*, Shelonitda Rose, MD^5*, Isaac W. Boss, PhD^6*, Stephanie Halene, MD⁷, Torsten Haferlach, MD⁸, Brian Fox^9* and Amer M. Zeidan, MD⁴

¹Department of Internal Medicine, YALE UNIVERSITY SCHOOL OF MEDICINE, New Haven, CT
²Department of Medicine; Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
³Bristol Myers Squibb, Princeton, NJ
⁴Department of Internal Medicine, Section of Hematology, Yale University School of Medicine, New Haven, CT
⁵Bristol-Myers Squibb, Princeton, NJ
⁶Immuno Oncology and Cell Therapy, Bristol Myers Squibb, Seattle, WA
⁷Section of Hematology, Department of Internal Medicine, Yale University School of Medicine and Yale Cancer Center, New Haven, CT
⁸MLL Munich Leukemia Laboratory, Munich, Germany
⁹Bristol-Myers Squibb Company, Princeton, NJ

Anthi Bouchla, MD^1*, Theodoros Loupis, PhD^2*, Georgia Delikonstantinos, PhD^1*, Frieda Kontsioti, PhD^1*, Vassiliki Mpakou, PhD^1*, Maria Dellatola, MD^3*, Maria Pagoni, MD, PhD^3*, Konstantinos Theodorakopoulos^1*, Sotirios Papageorgiou, MD, PhD^1*, Argiris Symeonidis, MD, PhD⁴ and Vassiliki Pappa, MD^1*

¹Second Department of Internal Medicine and Research Institute, Attikon University General Hospital, Athens, Greece
²Haematology Research Lab, Clinical, Experimental and Translational Research Center, Biomedical Research Foundation, Academy of Athens, Athens, Greece
³Hematology-Lymphomas Department and BMT Unit, Evangelismos General Hospital, Athens, Greece
⁴University General Hospital of Patras, Department of Hematology, Patras, Greece

Magdalena Czemerska^1*, Aneta Wisnik^2*, Dariusz Jarych^3*, Izabela Zawlik^4*, Piotr Strzałka, MD^5*, Kinga Krawiec, MD^6*, Barbara Cebula-Obrzut^7*, Agata Majchrzak^8*, Kamil Brzozowski^9*, Marcin Kozlowski^9*, Agnieszka Pluta, MD, PhD^10* and Agnieszka Wierzbowska, MD, PhD¹¹

¹Department of Hematology, Medical University of Lodz, Multidisciplinary Provincial Centre of Traumatology and Oncology Nicolas Copernicus in Lodz, Lódz, Poland
²Copernicus Memorial Hospital, Lodz, Poland
³Medical University of Lodz, Copernicus Memorial Hospital, Lodz, Poland
⁴Copernicus Memorial Hospital of Lodz, Department of Medical Genetics University of Rzeszow, Rzeszow, Poland
⁵Department of Hematology, Medical University of Lodz, Copernicus Memorial Hospital, Lodz, Poland
⁶Department of Hematology Medical University of Lodz, Department of Hematology Medical University of Lodz, Provincial Multi-specialist Oncology and Traumatology Center, Lodz, Poland
⁷Department of Experimental Hematology, Medical University of Lodz, Copernicus Memorial Hospital, Lodz, Lodz, Poland
⁸Department of Experimental Hematology,Copernicus Memorial Hospital, Lodz, Poland
⁹Department of Hematology, Copernicus Memorial Hospital, Lodz, Poland
¹⁰Department of Hematology Medical University of Lodz, Provincial Multi-specialist Oncology and Traumatology Center, Lodz, Poland
¹¹Department of Hematology, Medical University of Lodz, Multidisciplinary Provincial Centre of Traumatology and Oncology Nicolas Copernicus in Lodz, Lodz, Lodzkie, Poland

Rabea Mecklenbrauck^1*, Nora Borchert^1*, Carolin Funke^1*, Maximilian Brandes^1*, Louisa-Kristin Dallmann^1*, Piroska Klement, MD^1*, Walter Fiedler, MD², Jürgen Krauter, MD, PhD^3*, Arne Trummer, MD^3*, Bernd Hertenstein, MD^4*, Andreas Voss, MD^5*, Michael Lübbert, MD⁶, Verena I. Gaidzik, MD⁷, Konstanze Döhner, MD⁸, Hartmut Döhner, MD⁷, Arnold Ganser, MD^9*, Felicitas R. Thol, MD¹ and Michael Heuser, MD¹

¹Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
²Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, University Cancer Center Hamburg, University Hospital Eppendorf, Hamburg, Germany
³Department of Internal Medicine III, Braunschweig Municipal Hospital, Braunschweig, Germany
⁴Klinikum Bremen Mitte, Bremen, Germany
⁵Department of Oncology and Hematology, University Hospital, Oldenburg, Germany
⁶Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Freiburg, Germany
⁷Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
⁸Division of Hematology and Oncology, University Hospital Ulm, Ulm, Germany
⁹Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hanover, Germany

Jiani Chai, MD, PhD^1*, Jui Choudhuri, MD^1*, Qing Wang, MD, PhD^1*, Yanan Fang, MD, PhD^1*, Yang Shi, MD, PhD^2*, Wa Shen, BS^1*, Swati Goel, MD^3*, Ioannis Mantzaris, MD⁴, Aditi Shastri, MD⁵, R. Alejandro Sica, MD⁶, Nishi Shah, MD, MPH⁷, Kira Gritsman, MD, PhD⁴, Marina Konopleva, MD, PhD⁸, Noah Kornblum, MD^9*, Amit Verma, MD⁶, Mendel Goldfinger, MD⁴, Yanhua Wang, MD, PhD^2* and Xuejun Tian, MD, PhD^1*

¹Department of Pathology, Montefiore Medical Center, Bronx, NY
²Department of Pathology, Montefiore Medical Center Center for Cancer Care, Bronx, NY
³Montefiore Medical Center, Bronx, NY
⁴Hematology/Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
⁵Oncology, Hematology/Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
⁶Department of Hematology and Medical Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
⁷Oncology, Montefiore Medical Center Center for Cancer Care, Bronx, NY
⁸Albert Einstein College of Medicine, Bronx, NY
⁹Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY

Ing S Tiong, FRACP, FRCPA, MPhil^1,2,3, Adam Ivey, BSc, MSc, PhD^4*, Katherine Fielding, MBBS⁵, Chun Yew Fong, MBBS, PhD, FRACP, FRCPA⁶ and Andrew H Wei, MBBS, PhD^2,7

¹Peter MacCallum Cancer Centre and the Royal Melbourne Hospital, Melbourne, VIC, Australia
²The Alfred Hospital and Monash University, Melbourne, VIC, Australia
³Austin Health and Olivia Newton John Cancer Research Institute, Melbourne, Australia
⁴The Alfred Hospital and Monash University, Melbourne, Australia
⁵Department of Clinical Haematology, Austin Hospital, Melbourne, Australia
⁶Austin Health and Olivia Newton John Cancer Research Institute, Melbourne, VIC, Australia
⁷Department of Clinical Haematology, Peter MacCallum Cancer Centre and the Royal Melbourne Hospital, Melbourne, VIC, Australia

Stefan Hubner^1*, Marina Konopleva, MD, PhD², Zhihong Zeng, MD^1*, Fieke W Hoff, MD, PhD³, Yihua Qiu^1*, Vivian Ruvolo, MS^4*, Terzah M. Horton, MD, PhD⁵ and Steven M. Kornblau, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Albert Einstein College of Medicine, Bronx, NY
³UT Southwestern Medical Center, Dallas, TX
⁴Department of Leukemia and Section of Molecular Hematology and Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Baylor College of Medicine, Houston, TX

Julia-Annabell Georgi, MD^1*, Sebastian Stasik, PhD^1*, Sven Zukunft^2*, Marita Hartwig^1*, Christoph Röllig^3*, Uta Oelschlaegel, PhD^1*, Utz Krug, MD⁴, Tim Sauer, MD^5*, Sebastian Scholl, MD^6*, Andreas Hochhaus, MD⁶, Tim H Brümmendorf, MD^7*, Ralph Naumann, MD⁸, Björn Steffen, MD^9*, Hermann Einsele, MD¹⁰, Markus Schaich, MD^11*, Andreas Burchert, MD¹², Andreas Neubauer, MD¹², Kerstin Schaefer-Eckart, MD¹³, Christoph Schliemann, MD^14*, Stefan W. Krause, MD^15*, Mathias Haenel, MD^16*, Richard Noppeney, MD^17*, Ulrich Kaiser, MD^18*, Claudia D. Baldus, MD^19*, Martin Kaufmann, MD²⁰, Carsten Müller-Tidow, MD^21*, Uwe Platzbecker, MD²², Wolfgang E. Berdel, MD²³, Hubert Serve, MD²⁴, Gerhard Ehninger, M.D.²⁵, Martin Bornhaeuser, MD^1,26, Johannes Schetelig, MD, MSc^1,27, Frank P. Kroschinsky, MD, MBA¹ and Christian Thiede, MD^2,28

¹Department of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany
²Department of Internal Medicine I, University Hospital Dresden, Dresden, Germany
³Department of Internal Medicine I, Department of Internal Medicine I, University Hospital Dresden, TU Dresden, Dres, Dresden, Germany
⁴Department of Medicine III, Hospital Leverkusen, Leverkusen, Germany
⁵Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany
⁶Department of Internal Medicine II, Hematology and Oncology, University Hospital Jena, Jena, Germany
⁷Department of Internal Medicine 4, RWTH Aachen University, Aachen, Germany
⁸Department for Internal Medicine 3, St. Marien-Krankenhaus Siegen, Siegen, Germany
⁹Department of Medicine II, Hematology/Oncology, Goethe University Hospital, Frankfurt, Germany
¹⁰Department of Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany
¹¹Department of Hematology, Oncology and Palliative Care, Rems-Murr-Klinikum Winnenden, Germany, Winnenden, Germany
¹²Department of Hematology and Oncology, University Hospital Giessen and Marburg, Marburg, Germany
¹³Med. Clinic 5, BMT Unit, Nuremberg Hospital, Paracelsus Medizinische Privatuniversität, Nuremberg, Germany
¹⁴Department of Hematology, Oncolog and Pneumology, University of Münster, Münster, Germany
¹⁵Department of Hematology and Medical Oncology, University Hospital Erlangen, Erlangen, Germany
¹⁶Department of Internal Medicine III, Chemnitz Hospital, Chemnitz, Germany
¹⁷Department of Hematology and Stem Cell Transplantation, University Hospital of Essen, Essen, Germany
¹⁸Department of Hematology and Oncology, St. Bernward Hospital, Hildesheim, Germany
¹⁹Department of Internal Medicine II, University Hospital Schleswig-Holstein, Kiel, Kiel, Germany
²⁰2nd Department of Internal Medicine, Oncology and Hematology, Robert Bosch Hospital, Stuttgart, Germany
²¹Internal Medicine V - Hematology, Oncology & Rheumatology, University Hospital Heidelberg, Heidelberg, Germany
²²Medical Clinical and Policlinic 1, Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany
²³Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, Muenster, Germany
²⁴Department of Medicine II, Hematology and Oncology, University Hospital Frankfurt, Frankfurt, Germany
²⁵AvenCell Europe GmbH, Dresden, Germany
²⁶National Center for Tumor Diseases (NCT), Dresden, Dresden, Germany
²⁷Clinical Trials Unit, DKMS gGmbH, Dresden, Germany
²⁸AgenDix GmbH, Dresden, Germany

Diego Pereira-Martins, PhD^1*, Noortje van Dijk, BSc^2*, Isabel Weinhaeuser, PhD^3*, Douglas RA Silveira, MD^4,5*, Juan Coelho Da Silva, PhD^6*, Thiago M Bianco, PhD^7,8*, César Alexander Ortiz, BSc^9*, Fabiola Traina, MD, PhD^10,11, Lorena L Figueiredo-Pontes, MD, PhD^12*, Emanuele Ammatuna, MD. PhD^13*, Lynn Quek, MD PhD^14*, Gerwin A. Huls, MD, PhD¹⁵, Antonio R. Lucena-Araujo, Prof. PhD^16*, Eduardo M Rego, MD, PhD^{8,17,18,19,20} and Jan Jacob Schuringa, PhD¹³

¹Experimental Hematology, University Medical Center Groningen, Groningen, Netherlands
²Department of Experimental Hematology, University Medical Center Groningen, Groningen, Netherlands
³Experimental Hematology, University Medical Center Groningen, Groningen, AL, Netherlands
⁴School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
⁵School of Cancer and Pharmaceutical Sciences, King's College London, London, ENG, United Kingdom
⁶Department of Medical Images, Haematology, and Clinical Oncology, Ribeirão Preto Medical School, University of Sao Paulo, Medical School of Ribeirao Preto, Ribeirao Preto, Brazil
⁷Hematology Division of Medical Images, Hematology, and Clinical Oncology, University of Sao Paulo at Ribeirao Preto Medical School, Ribeirao Preto, MG, Brazil
⁸Center for Cell-based Therapy and Regional Hemotherapy Center, University of Sao Paulo at Ribeirao Preto Medical School, Ribeirao Preto, Sao Paulo, Brazil
⁹Center of Cell-based Therapy, University of Sao Paulo, Medical School of Ribeirao Preto, RIBEIRAO PRETO, BRA
¹⁰Hematology Division, Department of Medical Imaging, Hematology, and Oncology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brasil, Brazil
¹¹Center for Cell Based Therapy, Fundação Hemocentro de Ribeirão Preto, Ribeirao Preto, Brazil, Ribeirao Preto, Brazil
¹²Hematology Division, Department of Medical Images, Hematology, and Clinical Oncology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil
¹³Department of Hematology, Cancer Research Centre Groningen, University Medical Centre Groningen, University of Groningen, Groningen, Netherlands
¹⁴School of Cancer and Pharmaceutical Sciences, King's College Hospital, London, United Kingdom
¹⁵University Medical Center, University Groningen, Groningen, GZ, Netherlands
¹⁶Department of Genetic, Federal University of Pernambuco, Recife - PE, AC, BRA
¹⁷Division of Hematology, Transfusion Medicine and Cell Therapy, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
¹⁸Medical Research Laboratory on Molecular Hematology (LIM-31), University of São Paulo, São Paulo, São Paulo, Brazil
¹⁹University of Sao Paulo, Sao Paulo, Brazil
²⁰University of São Paulo Medical School, Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, Brazil

Ghayas C. Issa, MD¹, Aram Bidikian^1*, Edward Ayoub, PhD^2*, Feng Wang, PhD^3*, Vakul Mohanty, PhD^4*, Jake Leighton^5*, Xiaogang Wu, PhD^3*, Tallie Patsilevas, BS^1*, Zoe Alaniz, BS^1*, Jabra Zarka, MD^1*, Rashmi Kanagal-Shamanna, MD⁶, Naval Daver, MD¹, Andy Futreal, PhD^3*, Marina Konopleva, MD, PhD¹, Nicholas Navin, PhD^5*, Jianhua Zhang, PhD^3*, Ken Chen, PhD^4* and Michael Andreeff, MD, PhD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX

Maher Albitar, MD^1*, Andrew Ip, MD, MSc², Andre H. Goy, MD, MS^3*, Katherine Linder, MD^4*, Jeffrey Justin Estella, BS, MS^1*, Ahmad Charifa, MD^1*, Wanlong Ma^1*, Andrew L. Pecora, MD^5*, Jamie Koprivnikar, MD^6* and James McCloskey, MD^7*

¹Genomic Testing Cooperative, Irvine, CA
²Hackensack Meridian Health Hackensack University Medical Center, Hackensack, NJ
³Hackensack Meridian School of Medicine, Hackensack, NJ
⁴John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ
⁵John Theurer Cancer Center, Hackensack Meridian Health, Division of Multiple Myeloma, Hackensack, NJ
⁶Division of Leukemia, John Thuerer Cancer Center at Hackensack University Medical Center, Hackensack, NJ
⁷John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ

Bofei Wang, PhD^1*, Fatima Zahra Jelloul, MD^2*, Pamella Borges^3*, Poonam Desai, MSc^1*, Guilin Tang, MD, PhD^2*, Marina Konopleva, MD, PhD¹, Natalia Baran, MD, PhD¹, Michael R. Green, PhD⁴, Qing Deng, PhD^5*, Naval Daver, MD³, Andy Futreal, PhD^6*, Dapeng Hao^7* and Hussein A Abbas, MD, PhD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
³The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Friendswood, TX
⁵Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Pathology, Harbin Medical University, Harbin, China

Amanda C. Winters, MD, PhD¹, Mohd Minhajuddin, PhD², Brett M. Stevens, PhD³, Ajay Major, MD, MBA^4*, Nicholas Miltgen, BS^5*, Ji Yuan^6*, Amy Treece, MD^7*, Jonathan A. Gutman, MD⁸, Craig T Jordan, PhD⁹ and Daniel A. Pollyea, MD¹⁰

¹Center for Cancer and Blood Disorders, Children's Hospital Colorado, University of Colorado Anschutz, Aurora, CO
²Division of Hematology, University of Colorado, Anschutz Medical Campus, RC2; 10th floor; Room# 10440D, CO
³Anschutz Medical Campus, Division of Hematology, University of Colorado School of Medicine, Aurora, CO
⁴Department of Medicine, Division of Hematology, University of Colorado, Denver, CO
⁵Department of Pediatrics, University of Colorado, Aurora, CO
⁶Children's Hospital Colorado, Aurora, CO
⁷Pathology, Children's Hospital Colorado, Aurora, CO
⁸Division of Hematology, Department of Medicine, University of Colorado, Aurora, CO
⁹University of Colorado, Aurora, CO
¹⁰Anschutz Medical Campus, Division of Hematology, University of Colorado School of Medicine, Denver, CO

Shyam A Patel, MD, PhD^1*, Jan Cerny, MD, PhD², William K Gerber^3*, Andrew Gillis-Smith, MD^4*, Muthalagu Ramanathan, MD⁵, Sakiko Suzuki, MD⁶, Lloyd Hutchinson, PhD^7*, Anne Higgins, PhD^7*, Patricia Minehart Miron, PhD^8*, Ryan Horgan, NP^2*, Andrea Milano, NP^2*, Christie Perron, NP^2*, Rachel Pransky, NP^2*, Lindsey Shanahan, PA^9*, Karl Simin, PhD^10*, Alyssa Tonelli, DNP^2* and Jonathan M Gerber, MD¹¹

¹University of Massachusetts Chan Medical School, Worcester, MA
²UMass Memorial Medical Center, Worcester, MA
³New York University Liberal Studies, New York, NY
⁴Hematology/Oncology, University of Massachusetts, Worcester, MA
⁵Division of Stem Cell Transplantation, UMass Memorial Medical Center University Campus, Worcester, MA
⁶Division of Hematology-Oncology, University of Massachusetts Medical School, Worcester, MA
⁷University of Massachusetts Medical School, Worcester, MA
⁸Department of Pathology, University of Massachusetts Memorial Medical Center, Worcester, MA
⁹Division of Stem Cell Transplantation, UMass Memorial Medical Center, Worcester, MA
¹⁰Department of Molecular, Cell & Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA
¹¹UMass Chan Medical School, Worcester, MA

Adriana Plesa^1,2*, Florent Dumezy, PharmD^3*, Stéphanie Mathis, PharmD^4*, Anne-Catherine Lhoumeau, PhD, PharmD^5*, Valerie Bardet, MD, PharmD^6*, Véronique Saada, PharmD^7*, Isabelle Arnoux, PharmD^8*, Bouchra Badaoui, PharmD^9*, Edouard Cornet, MD^10*, Jennifer Osman, PharmD^11*, Estelle Guerin, PharmD^12*, Nicolas Chapuis, PharmD, PhD^13*, Franck Genevieve, PharmD^14*, Rémi Letestu, MD^15*, Delphine Manzoni, PharmD^16*, Anne Roggy, PharmD^17*, Mikael Roussel^18*, Véronique Harrivel, MD^19*, Elsa Bera, MD^20*, Caroline Mayeur-Rousse, MD^21*, Hélène Lapillonne, MD, PhD^22*, Richard Veyrat-Masson, MD^23*, Lydia Campos, MD, PhD²⁴, Magali Le Garff-Tavernier^25*, Tatiana Raskovalova, PharmD^26*, Francois Vergez, DVM, Ph.D.^27*, Julien Guy, MD^28*, Agnes Charpentier, PharmD^29*, Claire Hemar, PharmD^30*, Valerie Goncalves Monteiro, PharmD^31*, Frederic Fegier, PharmD^32*, Karine Celli-Lebras, CRA^33*, Raphael Itzykson, MD, PhD³⁴, Herve Dombret, MD, PhD^35,36,37, Claude Preudhomme, PharmD, PhD^36,38,39 and Christophe Roumier, PharmD^3,40*

¹Lyon University Hospital, CHU-HCL, Lyon Sud, Pierre Benite, France
²Coordinator of the AML MRDflow & LSC - ALFA French Intergroup, CHU-CHLS-HCL Lyon, France
³Laboratory of Hematology, Lille University Hospital, Lille, France
⁴Laboratory of Hematology, Saint Louis Hospital, APHP, Paris, France
⁵Cancer Biology department, Biological Hematology, Paoli-Calmettes Institut, Marseille, France
⁶Ambroise Pare Hospital, Paris, France
⁷Département de Biologie et Pathologie Médicales, Gustave Roussy, Université Paris-Saclay, Villejuif, France
⁸Laboratory of Haematology-- APHM, Hôpital de la Timone, Marseille, France
⁹Département d'Hématologie et Immunologie biologiques, APHP Hôpitaux universitaires Henri Mondor, Créteil, France
¹⁰CHU de Caen, Caen Cedex9, FRA
¹¹Centre Hospitalier De Versailles, Le Chesnay, France
¹²Hematology Laboratory Limoges, Limoges, France
¹³Assistance Publique-Hôpitaux de Paris.Centre-Université Paris Cité, Hôpital Cochin, Laboratory of Hematology, Paris, France
¹⁴Hematology Laboratory, Angers University Hospital, Angers, France
¹⁵Hematology Laboratory, Avicenne Hospital, APHP, Bobigny, France
¹⁶Lyon Sud University Hospital, Pierre Benite, France
¹⁷Univ. Bourgogne Franche-comté, INSERM, EFS BFC, UMR1098, Interactions H, Besancon, France
¹⁸CHU Rennes, Rennes, France
¹⁹Laboratoire d'Hématologie, CHU Amiens, Amiens, France
²⁰Centre Hospitalier Universitaire de Rouen, Rouen, France
²¹Laboratoire d'hematologie, Hopital Hautepierre, STRASBOURG, France
²²Pediatric Hematology and Oncology Department, Hôpital Armand Trousseau, Paris, France
²³Hospital University Clermont Ferrand, Clermont Ferrand, France
²⁴Laboratoire d'Hématologie, CHU de Saint-Etienne, Saint-Priest-en-Jarez, France
²⁵APHP Hôpital de la Pitié Salpétrière, PARIS, France
²⁶Hospital University Grenoble, Grenoble, France
²⁷Laboratoire d'Hématologie, CHU de Toulouse - Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France
²⁸Laboratoire d'Hématologie, Centre Hospitalier Universitaire de Dijon, DIJON, France
²⁹Hematology Laboratory, St Vincent de Paul Hospital, Lille, France
³⁰Hospital Vallenciennes, Vallenciennes, France
³¹Hospital University Reims, Reims, France
³²Hospital University Saint Antoine, APHP, Paris, Paris, France
³³ALFA coordination, Saint-Louis University Hospital, Paris, France
³⁴Department of Hematology, Hôpital Saint-Louis, Paris, France
³⁵Hematology, University Hôpital Saint-Louis, Paris, France
³⁶ALFA Group, Paris, France
³⁷IRSL, EA3518 Leukemia Translational Laboratory, Paris, France
³⁸Institut de Recherche contre le Cancer de Lille, UMR-S1172, Lille, France
³⁹Laboratory of Hematology, CHU Lille, Lille, France
⁴⁰Coordinator of the AML MRDflow & LSC - ALFA French Intergroup, CHU-Lille, France

Somedeb Ball, MD¹, Akriti G Jain, MD², Parth C. Patel, DO, MS³, Chen Wang, MD^4*, Luis E. E. Aguirre, MD², Mohammad O Hussaini, MD^5*, Onyee Chan, MD¹, Seongseok Yun, MD, PhD⁶, Andrew Kuykendall, MD⁷, Eric Padron, MD⁶, Kendra Sweet, MD⁸, Jeffrey E. Lancet, MD¹, Rami S. Komrokji, MD¹ and David A. Sallman, MD⁹

¹Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
²Division of Hematology and Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
³Department of Internal Medicine, University of South Floirda, Riverview, FL
⁴Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL
⁵Department of Hematopathology and Lab Medicine, Moffitt Cancer Center, Tampa, FL
⁶Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL
⁷Department of Malignant Hematology, H. Lee Mofitt Cancer Center, Tampa, FL
⁸Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
⁹Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL

Eric S. Winer, MD¹, Yael Flamand, MS^2*, Rory M. Shallis, MD³, Jessica M. Stempel, MD⁴, Aaron D Goldberg, MD, PhD⁵, Maximilian F. Stahl, MD⁶, Anand Ashwin Patel, MD⁷, Adam S Duvall, MD⁸, Yasmin Abaza, MD⁹, Timothy Seijung Oh, MD^10*, Karen Ma, MD^11*, Talha Badar, MD¹², Mark R. Litzow, MD¹³, Vamsi Kota, MD¹⁴, Danielle Bradshaw, MD^15*, Hari S. Raman, MD^16*, Marlise R. Luskin, MD¹, Richard M. Stone, MD¹⁷ and Daniel J. DeAngelo, MD, PhD^18*

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
³Yale University School of Medicine, New Haven, CT
⁴Department of Internal Medicine, Hematology/Oncology, Yale University School of Medicine, New Haven, CT
⁵Memorial Sloan Kettering Cancer Center, New York, NY
⁶Department of Medical Oncology, Dana-Farber Institute, Boston, MA
⁷Department of Medicine, Section of Hematology/Oncology, University of Chicago Medical Center, Chicago, IL
⁸Department of Medicine, University of Chicago, Chicago, IL
⁹Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL
¹⁰Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL
¹¹Memorial-Sloan Kettering Cancer Center, New York, NY
¹²Division of Hematology and Oncology, Mayo Clinic Florida, Jacksonville, FL
¹³Division of Hematology, Mayo Clinic, Rochester, MN
¹⁴Department of Medicine: Hematology and Oncology, Medical College of Georgia, Augusta University, Augusta, GA
¹⁵Division of Hematology/Oncology, Georgia Cancer Center at Augusta University, Augusta, GA
¹⁶Department of Medicine, Brigham and Women's Hospital, Brookline, MA
¹⁷Center for Leukemia, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
¹⁸Dana-Farber Cancer Institute, Boston, MA

Timothy James Keyes, BA^1*, Astraea Jager, B.S.^2*, Michael Krueger^3*, Sylvia Plevritis^4*, Robert Tibshirani^5*, Richard Aplenc, MD, PhD⁶, Garry P. Nolan, PhD^7*, Michele S. Redell, MD PhD⁸ and Kara L. Davis, D.O.²

¹Stanford University, Stanford
²Department of Pediatrics, Hematology, Oncology, and Stem Cell Transplant and Regenerative Medicine, Stanford University, Stanford, CA
³Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX
⁴Stanford University, Stanford, CA
⁵Department of Statistics, Stanford University, Stanford, CA
⁶Children's Hospital of Philadelphia, Philadelphia, PA
⁷Baxter Laboratory for Stem Cell Biology, Stanford University School of Medicine, Stanford, CA
⁸Texas Children's Cancer Center, Houston, TX

Nona Struyf^1*, Cornelia Arnroth^2*, Stephanie Sunandar^3*, Anna Bohlin^4*, Sofia Bengtzén^4*, Sören Lehmann^4,5, Olli Kallioniemi^2,6*, Päivi Östling^2*, Brinton Seashore-Ludlow, PhD^3* and Tom Erkers^3*

¹Oncology-Pathology, SciLifeLab, Karolinska Institute, Solna, Sweden
²Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden
³Oncology-Pathology, SciLifeLab, Karolinska Institute, Stockholm, Sweden
⁴Center for Hematology and Regenerative Medicine (HERM), Karolinska Institute, Huddinge, Sweden
⁵Uppsala University Hospital, Uppsala, Sweden
⁶Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland

Laurene Pousse, MSc^1*, Bruno C. Medeiros, MD², Koorosh Korfi, PhD^3*, Marco Berrera, PhD^3*, Nadine Kumpesa^3*, Vera Griesser^3*, Jan Eckmann^4*, Vaios Karanikas, PhD^5*, Christian Klein, PhD⁵ and Maria Amann, PhD^5*

¹Roche Innovation Center Zurich, Roche Pharma Research and Early Development, Schlieren, PA, Switzerland
²Oncology Early Development, Abbvie Pharmaceuticals, South San Francisco, CA
³Roche Innovation Center Basel, Roche Pharma Research and Early Development, Basel, Switzerland
⁴Roche Innovation Center Munich, Roche Pharma Research and Early Development, Penzberg, Germany
⁵Roche Innovation Center Zurich, Roche Pharma Research and Early Development, Schlieren, Switzerland

Konstanze Döhner, MD¹, Hartmut Döhner, MD¹, Daniela Weber, MSc^1*, Silke Kapp-Schwoerer, MD^1*, Amanda Gilkes^2*, Ian Thomas^3*, Sean Johnson^3*, Nicola Potter, PhD^4*, Yana Bevan^5*, Jad Othman, MBBS⁴, Nigel H. Russell, MD⁶, Christoph Röllig, MD, MSc^7*, Christian Thiede, MD⁸, Martin Bornhaeuser, MD⁷, Thomas Oellerich, MD^9*, Jenna Elder, PhD^10*, Luis A. Carvajal, PhD^11*, Zung To^11*, Jorge DiMartino, MD¹¹ and Richard Dillon, MA PhD MRCP FRCPath⁵

¹Ulm University Hospital, Ulm, Germany
²Division of Cancer and Genetics, Cardiff University, Cardiff, United Kingdom
³Centre for Trials Research, Cardiff University, Cardiff, United Kingdom
⁴Department of Medical and Molecular Genetics, King's College London, London, United Kingdom
⁵King’s College London, London, United Kingdom
⁶Guy's Hospital, London, United Kingdom
⁷University Hospital TU Dresden, Dresden, Germany
⁸Medical Dept. 1, University Hospital TU Dresden, Dresden, Germany
⁹Frankfurt Cancer Institute, Goethe University, Frankfurt, Germany
¹⁰PharPoint Research, Inc., Durham, NC
¹¹Kronos Bio, Inc., San Mateo, CA

Richard J Marrero, PharmD¹, Xueyuan Cao, PhD^2*, Huiyun Wu, PhD^3*, Hiroto Inaba, MD, PhD⁴, Susana C. Raimondi, PhD⁵, Ching-Hon Pui, MD⁶, Raul C. Ribeiro, MD⁷, Jeffrey E. Rubnitz, MD⁴, Stanley B. Pounds, PhD^3* and Jatinder K. Lamba, PhD⁸

¹Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, GAINESVILLE, FL
²Department of Health Promotion and Disease Prevention, University of Tennessee Health Science Center, Memphis, TN
³Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
⁴Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
⁵Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁶Department of Oncology, St. Jude Children's Rsch./Hosp., Memphis, TN
⁷St. Jude Children's Research Hospital, Memphis, TN
⁸Department of Pharmacotherapy and Translational Research, University of Florida, College of Pharmacy, Pharmacotherapy and Translational Re, Gainesville, FL

Adam J. Lamble, MD¹, Rhonda E. Ries, MA^2*, Alice Dang, Ph.D.^3*, Todd A. Alonzo, PhD^3,4*, Karen Chisholm^5*, Pandurang Kolekar, Ph.D^6*, Yanling Liu, PhD^6*, Quang Tran, PhD⁷, Todd M. Cooper, DO¹, Richard Aplenc, MD, PhD⁸, Alan S. Gamis, MD, MPH⁹, Edward A. Kolb, MD¹⁰, Xiaotu Ma, PhD^7* and Soheil Meshinchi, M.D., Ph.D.¹¹

¹Seattle Children's Hospital, Seattle, WA
²Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA
³Children's Oncology Group, Monrovia, CA
⁴Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA
⁵Department of Laboratories, Seattle Children's Hospital, Seattle, WA
⁶Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN
⁷St. Jude Children's Research Hospital, Memphis, TN
⁸Division of Oncology and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA
⁹Hematology/Oncology, Children's Mercy Hospitals and Clinics, Kansas City, MO
¹⁰Division of Oncology, Nemours Alfed I. duPont Hospital For Children, Wilmington, DE
¹¹Fred Hutchinson Cancer Center, Seattle, WA

Tom Erkers^1*, Francesco Marabita^1*, Nona Struyf^1*, Mattias Vesterlund^1*, Tojo James^1*, Cornelia Arnroth^1*, Anna Bohlin^2*, Sofia Bengtzén^2*, Albin Österroos^3*, Matthias Stahl^1*, Rozbeh Jafari^1*, Lukas Orre^1*, Yudi Pawitan^4*, Brinton Seashore-Ludlow^1*, Janne Lehtiö^1*, Sören Lehmann^2,5, Päivi Östling^1* and Olli Kallioniemi^1*

¹Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden
²Center for Hematology and Regenerative Medicine (HERM), Karolinska Institute, Huddinge, Sweden
³Department of Medical Sciences, Haematology, Uppsala University, Uppsala, Sweden
⁴Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
⁵Uppsala University Hospital, Uppsala, Sweden

Shuzhao Chen^1*, Yun Wang, MD, PhD^1*, Peidong Chi^2*, Runcong Nie^3*, Robert Peter Gale^4*, Hanying Huang^1*, Zhigang Chen^5*, Yanyu Cai^6*, Enping Yan^7*, Na Zhong^8*, Xinmei Zhang^8* and Yang Liang, MD, PhD¹

¹State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine; Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China
²Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, CHN
³Department of Gastric Surgery,, Sun Yat-sen University Cancer Center, guangzhou, China
⁴Centre For Haematology Research, Department of Immunology and Inflammation, Impe, London, GBR
⁵Department of Medical Oncology, State Key Laboratory of Oncology In South China, Collaborative Innovation Center, Guangzhou, CHN
⁶Sun Yat-sen University Cancer Center, guangzhou, China
⁷SUN YAT-SEN UNIVERSITY CANCER CENTER, Guangzhou, China
⁸Becton Dickinson Medical Devices (Shanghai) Co., Ltd, Guangzhou, China

Loïc Vasseur^1*, Laurène Fenwarth, MD, MSc^2,3*, Xavier Thomas, MD, PhD⁴, Jérôme Lambert, MD, PhD^5*, Stéphane de Botton, MD, PhD^6*, Martin Figeac, PhD^7*, Céline Villenet^7*, Pierre-Yves Dumas, MD, PhD^8*, Christian Recher, MD⁹, Céline Berthon, MD, PhD^10*, Emilie Lemasle, MD^11*, Delphine Lebon, MD^12*, Juliette Lambert, MD, PhD^13*, Christine Terré, PharmD, PhD^14*, Karine Celli-Lebras, CRA^15*, Hervé Dombret, MD, PhD¹⁶, Claude Preudhomme, PharmD, PhD^2,3, Meyling Cheok, BSPharm, PhD^2*, Raphael Itzykson, MD, PhD¹⁷ and Nicolas Duployez, PharmD, PhD^2,3*

¹Adolescents and Young Adults Hematology Department, St-Louis University Hospital, AP-HP, Paris, France
²UMR9020-U1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, Univ. Lille, CNRS, Inserm, CHU Lille, Lille, France
³Laboratory of Hematology, CHU Lille, Lille, France
⁴Hematology Department, Lyon-Sud University Hospital, Hospices Civils de Lyon, Pierre-Benite, France
⁵Biostatistical Department, Hôpital Saint Louis, Paris, France
⁶Département d’hématologie et Département d’innovation thérapeutique, Gustave Roussy, Villejuif, France
⁷University of Lille, Plate-Forme De GéNomique Fonctionnelle Et Structural, Lille, France
⁸Department of Clinical Hematology, Bordeaux University Hospital, PESSAC, France
⁹Service d'Hématologie, CHU de Toulouse - Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France
¹⁰Hematology Department, Lille University Hospital, Lille, France
¹¹Hematology Department, Henri-Becquerel Cancer Center, Rouen, France
¹²Service d’Hématologie Clinique et Thérapie cellulaire, Centre Hospitalier Universitaire d’Amiens, Amiens, France
¹³Service d'Hématologie et Oncologie, Centre Hospitalier de Versailles, Le Chesnay, France
¹⁴Laboratory of Hematology, Centre hospitalier de Versailles, Le Chesnay, France
¹⁵ALFA coordination, Saint-Louis University Hospital, Paris, France
¹⁶Division of Hematology, EA3518 Saint-Louis Institute for Research, Hôpital Saint-Louis, APHP, University of Paris, Paris, France, Paris, France
¹⁷Department of Hematology, Hôpital Saint-Louis, Paris, France

Sanam Loghavi, MD¹, Patrick K Reville, MD, MPH², Curtis A Lachowiez, MD^3*, Mark Routbort, MD, PhD^4*, Keyur Patel, MD, PhD^1*, Rashmi Kanagal-Shamanna, MD⁵, Chi Young Ok, MD¹, Joseph D. Khoury, MD, FCAP⁶, Guilin Tang, MD, PhD^1*, Sa A Wang, MD^1*, Tapan M. Kadia, MD², Naval Daver, MD², Koichi Takahashi, MD, PhD⁷, Guillermo Garcia-Manero, MD⁸, Sherry A. Pierce, BSN, BA^2*, Marina Konopleva, MD, PhD^9,10, L. Jeffrey Medeiros, MD¹, Hagop Kantarjian, MD¹¹, Farhad Ravandi, MD², Nicholas Short, MD⁷ and Courtney D. DiNardo, MD, MSCE²

¹Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Medicine, Oregon Health and Science University, Portland, OR
⁴Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX
⁶University of Nebraska Medical Center, Omaha, NE
⁷Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁸Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
⁹Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX
¹⁰Albert Einstein College of Medicine, Bronx, NY
¹¹Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Carl T. Shultz, DO¹, Aref Al-Kali, MD¹, Anmol Baranwal, MBBS^1*, Rakchha Chhetri, MBBS MHID Grad Cert. Biostat.^2*, Elizabeth Ngoc Hoa Tran, PhD^3*, Arini Arsana^1*, Hassan B. Alkhateeb, MD^1*, Bradley Stish, MD^4*, Ayalew Tefferi, MD¹, Mrinal M. M. Patnaik, MD, MBBS¹, Naseema Gangat, MBBS¹, Devendra Hiwase, MD, MBBS, PhD, FRACP, FRCPA² and Mithun V. Shah, MD, PhD¹

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Department of Haematology, Royal Adelaide Hospital, Adelaide, SA, Australia
³University of Adelaide, Adelaide, SA, Australia
⁴Division of Radiation Oncology, Mayo Clinic, Rochester, MN

Eduardo Sabino de Camargo Magalhaes, MD^1*, Brandon D Brown, MD^2*, Stefan Hubner^3*, Yihua Qiu^3* and Steven M. Kornblau, MD^3,4

¹Department of Ageing Biology/ERIBA, University Medical Center Groningen, Groningen, Netherlands
²Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Joseph Rimando, MD¹, Leslie Cope, PhD^1*, Karen McKinnon, PhD^2*, Benjamin G. Vincent, MD², Sergio Rutella, MD, PhD, FRCPath, FRSB³, Joshua F. Zeidner, MD⁴, Jonathan S. Serody, MD⁵, Ivana Gojo, MD¹ and Leo Luznik, MD¹

¹Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
²Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC
³John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, ENG, United Kingdom
⁴UNC - Lineberger Comprehensive Cancer Center, Chapel Hill, NC
⁵Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC

Louis Theret^1*, Marie-Eve Bordeleau, Ph.D.^1*, Azadeh Hajmirza, PhD^1*, Arnaud Metois, MSc^1*, Ossama Moujaber, PhD^1*, Eric Audemard, PhD^1*, Jean-Francois Spinella, Ph.D.^1*, Jalila Chagraoui, PhD^1*, Léo Aubert, PhD^1*, Azer Farah^1*, Véronique Lisi, PhD^1*, Eric Bonneil^1*, Isabel Boivin^2*, Nadine Mayotte^1*, Tara MacRae^1*, Pierre Thibault, Ph.D.^1,3*, Sébastien Lemieux, Ph.D.^1,4*, Vincent-Philippe Lavallée, MD^1,5*, Josee Hebert, MD^1,6,7,8, Guy Sauvageau, MD, PhD^1,7,8,9 and Philippe P Roux, PhD^1,10*

¹The Leucegene Project at the Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, QC, Canada
²Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, QC, Canada
³Department of Chemistry, Université de Montréal, Montréal, QC, Canada
⁴Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC, Canada
⁵Department of Pediatric Hematology Oncology, CHU Sainte-Justine Research Center, Montréal, QC, Canada
⁶Department of Medicine, Université de Montréal, Montreal, QC, Canada
⁷Quebec Leukemia Cell Bank, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada
⁸Division of Hematology-Oncology, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada
⁹Département de Médecine, Université de Montréal, Montreal, QC, Canada
¹⁰Department of Pathology and Cell Biology, Université de Montréal, Montréal, QC, Canada

Krzysztof Mrózek, MD, PhD^1,2, Jessica Kohlschmidt, PhD^3,4, James S. Blachly, MD⁵, Deedra Nicolet, MS^3,6, Andrew J. Carroll, PhD⁷, Kellie J. Archer, PhD^8*, Alice S. Mims, MD⁵, Karilyn T. Larkin, MD⁹, Shelley Orwick, BS^10*, Christopher C. Oakes, PhD⁴, Jonathan E. Kolitz, MD¹¹, Bayard L. Powell, MD¹², William G. Blum, MD¹³, Guido Marcucci, MD¹⁴, Maria R. Baer, MD¹⁵, Geoffrey L. Uy, MD¹⁶, Wendy Stock, MD¹⁷, John C. Byrd, MD¹⁸ and Ann-Kathrin Eisfeld, MD^6,10

¹The Ohio State University, Comprehensive Cancer Center, Columbus, OH
²Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH
³Alliance Statistics and Data Management Center, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁴Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus
⁵Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
⁶Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University, Columbus, OH
⁷Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
⁸Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH
⁹Department of Internal Medicine, Division of Hematology, The Ohio State University, Columbus, OH
¹⁰Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH
¹¹Monter Cancer Center, North Shore University Hospital and Long Island Jewish Medical Center, Northwell Health, New Hyde Park, NY
¹²Wake Forest Baptist Comprehensive Cancer Center, Winston Salem, NC
¹³Department of Hematology and Oncology, Winship Cancer Institute of Emory University, Atlanta, GA
¹⁴Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA
¹⁵University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD
¹⁶Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO
¹⁷University of Chicago, Chicago, IL
¹⁸University of Cincinnati College of Medicine, Cincinnati, OH

Maryam Kazerani, PhD^1,2*, Lucas Wange^3*, Benjamin Tast^1,2*, Maria Solovey, PhD^4*, Daniel Nixdorf^1,2*, Lisa Rohrbacher, MSc^1,2*, Christina Heitmüller, Ph.D.^1,2*, Thomas Koehnke, MD, PhD^1,2,5, Frauke Schnorfeil, PhD^1,2*, Victoria V Grunwald, MD^2*, Karsten Spiekermann^2,6,7, Klaus H Metzeler, MD^2,8, Karl-Peter Hopfner, Prof. Dr.^9*, Wolfgang Enard^3*, Veit L Buecklein, MD^1,2* and Marion Subklewe, MD^1,7,10

¹Laboratory for Translational Cancer Immunology, Gene Center, LMU, Munich, Germany
²Department of Medicine III, University Hospital, LMU Munich, Munich, Germany
³Anthropology and Human Genomics, Faculty of Biology, LMU Munich, Martinsried, Germany
⁴Institute of Physiological Chemistry, BMC, Ludwig Maximilian University, Martinsried, Germany
⁵Department of Medicine, Division of Hematology, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA
⁶Experimental Leukemia and Lymphoma Research, Department of Medicine III, University Hospital, LMU Munich, Munich, Germany
⁷German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany
⁸Department of Hematology and Cell Therapy, University Hospital Leipzig, Leipzig, Germany
⁹Department of Biochemistry, Gene Center, LMU, Munich, Germany
¹⁰Department of Medicine III (Hematology/Oncology), LMU University Hospital Munich, Muenchen, Germany

Ghayas C. Issa, MD¹, Vakul Mohanty, PhD^2*, Edward Ayoub, PhD^3*, Feng Wang, PhD^4*, Jake Leighton^5*, Xiaogang Wu, PhD^4*, Aram Bidikian^1*, Tallie Patsilevas, BS^1*, Zoe Alaniz, BS^1*, Jabra Zarka, MD^1*, Rashmi Kanagal-Shamanna, MD⁶, Andy Futreal, PhD^4*, Naval Daver, MD¹, Marina Konopleva, MD, PhD¹, Nicholas Navin, PhD^5*, Jianhua Zhang, PhD^4*, Ken Chen, PhD^2* and Michael Andreeff, MD, PhD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX
³Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX

Katharina Waack^1,2*, Katharina Andernacht^3*, Christiane Walter, PhD^4*, Markus Schneider, PhD^4*, Nils Von Neuhoff, PhD^3*, Sophia Hahn^5*, Amani Awada^6* and Dirk Reinhardt, MD⁴

¹Pediatric Research Network, Essen, Germany
²Pediatric Hematology/Oncology, University Hospital Essen, Essen, DEU
³Department of Pediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany
⁴Department of Pediatrics III, University Children’s Hospital Essen, University Duisburg-Essen, Essen, Germany
⁵Department of Pediatrics III, University Children's Hospital Essen, University Duisburg-Essen, Essen, Germany
⁶Department of Pediatrics III, University Hospital Essen, Essen, Germany

Sangeetha Venugopal, MD, MS¹, Sanam Loghavi, MD², Mark Routbort, MD, PhD^3*, Fatima Zahra Jelloul, MD^2*, Rashmi Kanagal-Shamanna, MD⁴, Sherry A. Pierce, BSN, BA^1*, Ghayas C. Issa, MD⁵, Hussein A Abbas, MD, PhD¹, Koji Sasaki, MD¹, Koichi Takahashi, MD, PhD⁵, Naval Daver, MD¹, Farhad Ravandi, MD¹, Hagop Kantarjian, MD⁶ and Courtney D. DiNardo, MD, MSCE¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Eduardo Sabino de Camargo Magalhaes, MD^1*, Yihua Qiu^2* and Steven M. Kornblau, MD²

¹Department of Ageing Biology/ERIBA, University Medical Center Groningen, Groningen, Netherlands
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Guillaume Richard-Carpentier, MD, FRCPC^1,2,3, Francois Beliveau, Ph.D.^3,4*, Sandrine Lacoste^3,4*, Jean-Francois Spinella, Ph.D.^3*, Michael Vladovsky^3,5,6*, Patrick Gendron^3*, Sébastien Lemieux, Ph.D.^3,7,8*, Vincent-Philippe Lavallee, MD^3,5,6, Guy Sauvageau, MD, PhD^3,4,9,10 and Josee Hebert, MD^3,4,9,10

¹Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
²Department of Medicine, Division of Medical Oncology and Hematology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada
³The Leucegene Project at the Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada
⁴Quebec Leukemia Cell Bank, Hôpital Maisonneuve-Rosemont Research Centre, Montréal, QC, Canada
⁵Division of Pediatric Hematology and Oncology, Centre Hospitalier Universitaire Sainte-Justine, Montréal, QC, Canada
⁶Department of Pediatrics, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada
⁷Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, QC, Canada
⁸Department of Computer Science and Operations Research, Université de Montréal, Montreal, QC, Canada
⁹Hôpital Maisonneuve-Rosemont, Département d’Hématologie-Oncologie, Montréal, QC, Canada
¹⁰Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada

Ian M. Bouligny, MD¹, Graeme Murray^2*, Valerie Tran, MD^1*, Juhi Gor, MD^3*, Yiwei Hang^1*, Yanal Alnimer, MD^1*, Kyle Zacholski, PharmD^1*, Chad Venn, PharmD^1* and Keri Maher, DO⁴

¹Massey Cancer Center, Virginia Commonwealth University, Richmond, VA
²Massey Cancer Center, Viriginia Commonwealth University, Richmond, VA
³Virginia Commonwealth University, Richmond, VA
⁴Massey Cancer Center, Virginia Commonwealth University, Tucson, AZ