Patrice Chevallier, MD¹, Thibault Leguay^2*, Rathana KIM, PharmD^3*, Marc Delord^4*, Michael Doubek, MD, PhD⁵, Francoise Huguet, MD^6*, Aurelie Cabannes-Hamy, MD^7*, Ulla Wartiovaara-Kautto, MD, PhD⁸, Colombe Saillard, MD^9*, Emmanuel Raffoux^10*, Thomas Cluzeau, MD, PhD¹¹, Stephane Lepretre, MD^12*, Marie Balsat^13*, Anna Berceanu, MD^14*, Nicolas Boissel, MD, PhD¹⁵, Claude Gardin, MD^16*, Emmanuelle Clappier^17*, Herve Dombret, MD PhD¹⁸ and Philippe Rousselot, MD, PhD^19*

¹Hematology Department, Nantes University Hospital, Nantes, France
²Bordeaux University Hospital, Pessac, FRA
³Hematology laboratory, Assistance Publique Des Hopitaux De Paris (AP-HP) - Universite Paris Descartes -, Paris, Ile-de-France, France
⁴Direction à la recherche clinique et à l'innovation, Centre hospitalier de Versailles, Le Chesnay, France
⁵Department of Internal Medicine - Hematology and Oncology, University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic
⁶Service d'Hematologie, CHU de Toulouse- Institut Universitaire de Cancérologie de Toulouse Oncopole, Toulouse, France
⁷Hematology Unit, Versailles Hospital, Le Chesnay, France
⁸Department of Hematology, University of Helsinki, Helsinki, Finland
⁹Institut Paoli Calmettes, Marseille, France
¹⁰Department of Hematology, Université de Paris, Saint-Louis Hospital, Paris, France
¹¹Département d'Hématologie Clinique, Université Côte d'Azur, CHU Nice, Nice, Provence Alpes Cote d'Azur, France
¹²Centre Henri Becquerel, Rouen, Rouen, FRA
¹³Clinical hematology service, Hospices Civils de Lyon, Lyon, France
¹⁴Clinical Hematology, Besançon University Hospital, Besançon, France
¹⁵Hematology Adolescent and Young Adult Unit, France, Paris Cedex 10, France
¹⁶Hematology Department, Avicenne Hospital, Bobigny, France
¹⁷Hematology Laboratory and INSERM U944, Université de Paris, Saint-Louis Hospital, Paris, France
¹⁸Hopital Saint-Louis, Assistance Publique - Hopitaux De Paris (AP-HP), Paris, FRA
¹⁹Hematology Department, Centre Hospitalier de Versailles, LE CHESNAY CEDEX, France

Sarah K Tasian, MD^1,2, Deborah S Hunter, PhD^3*, I-Ming L Chen⁴, Richard C Harvey, PhD⁴, Andrew J. Carroll, PhD⁵, Elizabeth Wagner^6*, Shalini C Reshmi, PhD⁶, Michael J Borowitz, MD PhD⁷, Brent L. Wood, MD PhD⁸, Jeannie Daniel, PhD^3*, Meenakshi Devidas, PhD, MBA⁹, Elizabeth A. Raetz, MD¹⁰, Stephen P. Hunger, MD¹¹, Albert Assad, MD^3* and Mignon L. Loh, MD¹²

¹Department of Pediatrics and Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
²Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
³Incyte Corporation, Wilmington, DE
⁴University of New Mexico Cancer Center, Albuquerque, NM
⁵Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
⁶Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH
⁷Departments of Pathology and Oncology, Johns Hopkins Hospital, Baltimore, MD
⁸Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA
⁹Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN
¹⁰Division of Pediatric Hematology and Oncology, Stephen D. Hassenfeld Children's Center for Cancer and Blood Disorders, NYU Langone Health, New York, NY
¹¹Department of Pediatrics and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia and the Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA
¹²Division of Hematology, Oncology, BMT, and Cellular Therapies, Seattle Children's Hospital, Seattle, WA

Giovanni Marconi, MD¹, Alfonso Piciocchi, MS^2*, Sabina Chiaretti, MD, PhD³, Cristina Papayannidis, MD, PhD⁴, Monia Lunghi, MD^5*, Prassede Salutari, MD^6*, Patrizia Zappasodi^7*, Alessandro Rambaldi, MD⁸, Attilio Olivieri, MD⁹, Maurizio Cavallari, MD^10*, Stefano Soddu^2*, Nicola S Fracchiolla, MD^11*, Federica Gigli, MD^12*, Chiara Cattaneo, MD^13*, Daniele Giovanni Mattei, MD¹⁴, Anna Candoni, MD^15*, Giovanni Grillo, MD^16*, Maria Chiara Abbenante, MD^17*, Ernesta Audisio^18*, Massimiliano Bonifacio, MD^19*, Albana Lico, MD^20*, Roberto Massimo Lemoli, MD^21,22*, Paolo De Fabritiis, MD^23*, Felicetto Ferrara, MD^24*, Martina Rachele Marino^25*, Monica Messina^26*, Anna Ferrari, PhD^27*, Valentina Robustelli, PhD^28,29*, Jacopo Nanni, MD^30*, Irene Della Starza, PhD^31*, Giorgia Simonetti^32*, Maria Stefania De Propris, PhD^31*, Maria Teresa Bochicchio^32*, Marco Vignetti^33*, Paola Fazi, MD^2* and Giovanni Martinelli, MD³⁴

¹IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori “Dino Amadori”(IRST),, Meldola, Italy
²GIMEMA Foundation, Rome, Italy
³Umberto I - Rome, AOU Policlinico, Rome, Italy
⁴IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy, Bologna, Italy
⁵Division of Hematology Department of Translational Medicine , AOU Maggiore della Carità, Università del Piemonte Orientale, Novara, ITA
⁶Dipartimento Oncologia Ematologia, Ospedale Civile Spirito Santo, Pescara, Italy
⁷Department of Hematology Oncology, Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
⁸Hematology, ASST Papa Giovanni XXIII, Bergamo, Italy
⁹Hematology, Università Politecnica Delle Marche-AOU Ospedali Riuniti, Ancona, Ancona, ITA
¹⁰Mestre, Ospedale serenissima, Mestre, Italy
¹¹Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, MILANO, Italy
¹²European Institute of Oncology, Milan, Italy
¹³Department of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy
¹⁴Azienda Ospedaliera S. Croce e Carle, Cuneo, Italy
¹⁵Division of Hematology and Bone Marrow Transplantation, Clinica Di Ematologia E Unità Di Terapie Cellulari 'carlo Melzi'-Azienda, Udine, Italy
¹⁶Department of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy, Italy
¹⁷university of Bologna, Istituto di Oncoematologia L. e A. Seragnoli, Bologna, Italy
¹⁸TORINO CITTÀ DELLA SALUTE E DELLA SCIENZA, Torino, Italy
¹⁹Department of Medicine, Section of Hematology, University of Verona and Azienda Ospedaliera Universitaria Integrata, Verona, Italy
²⁰Hematology and Clinical Immunology, Department of Medicine, AULSS 8 BERICA - OSPEDALE DI VICENZA, Vicenza, Italy
²¹IRCCS San Martino Hospital, Genoa, Italy
²²University of Genoa, Clinic of Hematology, Department of Internal Medicine (DiMI), Genoa, Italy
²³Department of Hematology S. Eugenio Hospital, Rome, Italy, Roma, Italy
²⁴+390817472241, Napoli, Italy
²⁵GIMEMA Foundation, ROMA, Italy
²⁶Hematology, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy
²⁷Istituto Scientifico Romagnolo per lo Studio e Cura dei Tumori (IRST) IRCCS, Meldola, Italy
²⁸Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
²⁹Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy
³⁰Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università di Bologna, Bologna, Italy
³¹Hematology, Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy
³²Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola (FC), Italy
³³GIMEMA Foundation, Roma, ITA
³⁴IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori", Meldola, Italy

Pilar Martínez Sánchez, M.D.^1*, Gerhard Zugmaier, M.D., PhD², Paul Gordon, M.D.^3*, Elias Jabbour, MD⁴, José J. Rifón Roca, M.D.^5*, Stefan Schwartz, M.D.^6*, Erika Borlenghi, M.D.^7*, Francoise Huguet, MD^8*, Jesús María Hernández-Rivas, MD, PhD⁹, Federico Lussana, MD, PhD^10*, Céline Berthon, M.D.^11*, Priti Kadu, MSc^12*, Hansen Wong, PhD^13*, Ana Markovic, PhD^3*, Yuliya Katlinskaya, PhD^13* and Alessandro Rambaldi, MD^14,15

¹Hematology Department, Hospital Universitario 12 de Octubre, CNIO, Complutense University, Madrid, Spain
²Amgen Research GmbH, Munich, Germany
³Amgen Inc., Thousand Oaks, CA
⁴Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Hematology and Cell Therapy Department, Clínica Universidad de Navarra, Pamplona, Spain
⁶Hematology, Oncology and Tumor Immunology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
⁷Department of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy
⁸Department of Hematology, Institut Universitaire du Cancer-Oncopole CHU de Toulouse, Toulouse, France
⁹Cancer Research Center of Salamanca (USAL-CSIC), Salamanca, Spain
¹⁰Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Please Choose A State, Italy
¹¹Cancer Heterogeneity, Plasticity and Resistance to Therapies, Univ. Lille, Lille, France
¹²IQVIA RDS (India) Private Limited, Bangalore, India
¹³Amgen Inc., South San Francisco, CA
¹⁴Hematology, ASST Papa Giovanni XXIII, Bergamo, Italy
¹⁵Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII Piazza OMS, Bergamo, Italy

Bela Patel Wrench, MD^1*, Amy A. Kirkwood, MSc^2*, Krisztina Zuborne Alapi, MSc^3*, Laura Clifton-Hadley, BSc, PhD^2*, SooWah Lee, MSc^3*, David I. Marks, MD, PhD^4*, Anthony V. Moorman⁵, Nicholas J. Morley, MBBS PhD^6*, Pip Patrick, PhD, MSc, MA^2*, Zaynab Rana, MSc^7*, Clare J. Rowntree, MBBS PhD^8*, John A. Snowden, MBBS PhD^6* and Adele K. Fielding, MBBS, PhD³

¹CRUK Barts Centre, Queen Mary University of London, London, United Kingdom
²Cancer Research UK & UCL Cancer Trials Centre, University College London, London, United Kingdom
³UCL Cancer Institute, London, United Kingdom
⁴Bristol University Hospitals, Bristol, United Kingdom
⁵Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle, United Kingdom
⁶Sheffield University Teaching Hospitals, Sheffield, United Kingdom
⁷Cancer Research UK & UCL Cancer Trials Centre, London, United Kingdom
⁸Department of Haematology, University Hospital of Wales, Cardiff, United Kingdom

Daniel Nguyen, MD, PhD¹, Elias Jabbour, MD², Nicholas Short, MD³, Ghayas C. Issa, MD⁴, Musa Yilmaz, MD⁵, Naval Daver, MD², Naveen Pemmaraju, MD², Kelly S. Chien, MD², Lucia Masarova, MD², Farhad Ravandi, MD², Nitin Jain, MD⁵, Wuliamatu Deen, BSN, RN^2*, Min Zhao^2*, Christopher Loiselle, BS^2*, Lourdes Waller^2*, Glenda Banks^2*, Rebecca Garris^2* and Hagop Kantarjian, MD⁶

¹Department of Medicine, The University of Texas Health Science Center at Houston, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, Universit Y of Texas At Houston, Houston, TX
⁵Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Juliëtte Schmidt^1*, Peter M. Hoogerbrugge, MD, PhD^1,2, Caroline Lindemans, MD, PhD^1,3*, Stefan Nierkens, PhD^1,4,5*, Robert S. Van Binnendijk, PhD^6*, Louis J Bont, MD, PhD^7* and Wim J.E. Tissing, MD, PhD^1,8*

¹Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
²Dutch Childhood Oncology Group, Utrecht, Netherlands
³Utrecht University, Utrecht, Netherlands
⁴Center for Translational Immunology, University Medical Center, Utrecht, Netherlands
⁵Pediatric Blood and Marrow Transplantation Program, University Medical Center Utrecht, Utrecht, Netherlands
⁶Centre for Immunology of Infectious Diseases and Vaccines, National Institute for Public Health and the Environment, Bilthoven, Netherlands
⁷Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, Utrecht, Netherlands
⁸Pediatric Oncology/Hematology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

Yajaira Valentine Jimenez-Antolinez, MD^1*, Samantha Fierro Sáenz, MD², Lilia Edith Carrizales Torres, MD^1*, Julia Esther Colunga Pedraza, MD^1*, Hernan Ramirez-Duran^1*, Andres Gomez-De Leon, MD², David Gómez-Almaguer, MD² and Oscar Gonzalez, MD^1*

¹Pediatric Hematology, Universidad Autónoma de Nuevo León. Facultad de Medicina y Hospital Universitario "Dr. José Eleuterio González, Monterrey, Mexico
²Universidad Autónoma de Nuevo León. Facultad de Medicina y Hospital Universitario "Dr. José Eleuterio González, Monterrey, Mexico

Elias Jabbour, MD¹, Ibrahim Aldoss, MD², Shaun Fleming, FRACP FRCPA^3*, Ashish Bajel, MBBS, DM⁴, Paul Cannell, MBBS, FRACP, FRCPA⁵, Monika Brüggemann, MD^6*, Gerhard Zugmaier, M.D., PhD⁷, Joan Morris, MD^8*, Yuqi Chen, PhD^8*, Sonny Powar, MBChB, MSc^9*, Hansen Wong, PhD^10*, Björn Steffen, MD^11*, Hagop Kantarjian, MD¹ and Nicola Goekbuget, MD¹²

¹MD Anderson Cancer Center, Houston, TX
²City of Hope, Duarte, CA
³The Alfred, Melbourne, VIC, Australia
⁴Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, VIC, Australia
⁵Fiona Stanley Hospital, Murdoch, Western Australia, Australia
⁶University Medical Center Schleswig-Holstein, Kiel, Germany
⁷Amgen Research GmbH, Munich, Germany
⁸Amgen Inc., Thousand Oaks, CA
⁹Amgen Inc., Uxbridge, United Kingdom
¹⁰Amgen Inc., South San Francisco, CA
¹¹Department of Medicine II, Hematology/Oncology, Goethe University Hospital, Frankfurt, Germany
¹²Department of Medicine II, Goethe University, University Hospital, Frankfurt, Germany

Xiaoyan Zhang^1*, Xiaofan Zhu, MD², Ju Gao, PhD^3*, Jie Yu^4*, Shaoyan Hu, MD, PhD⁵, Hua Jiang, MD^6*, Xin Tian, PhD^7*, Ningling Wang, PhD^8*, Aiguo Liu^9*, Runming Jin, MD^10* and Lirong SUN, PhD^11*

¹Division of Pediatric Blood Diseases Center, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China, Tianjin, China
²Department of Pediatric Blood Diseases Center, Institute of Hematology & Blood Diseases Hospital, Tianjin, China
³West China Second University Hospital, Sichuan University; Key Laboratory of Chronobiology (Sichuan University), National Health Commission of China, Chengdu, China
⁴Chongqing Medical University, Chongqing, China
⁵Department of Pediatric Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, China
⁶hematology and oncology, Guangzhou Women and Children's Medical Center, Guangzhou, CHN
⁷Kunming Children's Hospital, Kunming, China
⁸Anhui medical university second affiliated hospital, Hefei, Anhui, CHN
⁹Tongji Medical College of Huazhong University of Science & Technology, Wuhan, China
¹⁰Union Hospital Affiliated To Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
¹¹Department of Pediatrics, Affiliated Hospital of Qingdao University, Qingdao, CHN

Jessica C Hochberg, MD^1*, Javier Oesterheld, MD^2*, Aliza Gardenswartz, MD^3*, Liana Klejmont, Pharm D^4*, Jaclyn Basso, RN, MSN, PNP^4*, Elizabeth Mintzer^5*, Lauren Harrison, RN, MSN^3*, Michael J Borowitz, MD PhD⁶, Michael R. Loken, PhD^7* and Mitchell S Cairo⁸

¹Department of Pediatrics, New York Medical College, Hawthorne, NY
²Levine Children's Hosp., Charlotte, NC
³Department of Pediatrics, New York Medical College, Valhalla, NY
⁴Pediatrics, New York Medical College, Valhalla, NY
⁵New York Medical College, Valhalla, NY
⁶Departments of Pathology and Oncology, Johns Hopkins Hospital, Baltimore, MD
⁷Hematologics, Inc., Seattle, WA
⁸New York Medical College, Departments of Pediatrics, Medicine, Pathology, Microbiology and Immunology, and Cell Biology and Anatomy, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, NY