Liqin Liu, PhD^*, Gene Li, PhD^*, Ling Wang^*, Poonam Yakkundi, PhD^*, Paul R. Hinton^*, Deepal Pandya^*, Manal Amoury, PhD^*, Keerthana Sekar^*, Chian Liu^*, Rodnie Rosete^*, Nardeen Hanna^*, Maya F. Kotturi, PhD^*, Liz Bogaert, Ph.D^*, Jiyoung Hong, PhD^*, Christina Tsai, PhD^*, Bruce A. Keyt, PhD and Angus M. Sinclair, PhD

IGM Biosciences, Inc., Mountain View, CA

Qiang Liu, PhD, BSc¹, Alex Murison, PhD^2*, Andy G.X. Zeng, BSc², Changjiang Xu^3,4*, Veronique Voisin, PhD^5*, Faith Yeung^2*, Amit Subedi, PhD⁶, Steven M. Chan, MD, PhD⁷, Brian Raught, PhD^2*, Gary D Bader^8*, John E. Dick, PhD^9,10 and Jean C.Y. Wang, MD, PhD^2,11,12

¹Princess Margaret, University Health Network, Toronto, ON, Canada
²Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
³Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
⁴The Donnelly Centre, University of Toronto, Toronto, Canada
⁵Terrence Donnelly Centre for Cellular and Biomedical Research, University of Toronto, Toronto, ON, Canada
⁶Princess Margaret Cancer Centre; University Health Network, Toronto, ON, Canada
⁷Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁸The Donnelly Centre, University of Toronto, Toronto, ON, Canada
⁹Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
¹⁰University Health Network, Toronto, ON, Canada
¹¹Department of Medicine, University of Toronto, Toronto, ON, Canada
¹²Division of Medical Oncology and Hematology, University Health Network, Toronto, ON, Canada

Anagha Inguva, BSc¹, Krysta L. Engel, PhD^1*, Hunter Tolison, BS^1*, Mark J Althoff, PhD¹, Shanshan Pei, PhD^2*, Maria L. Amaya, MD, PhD¹, Anna Krug, BS^1*, Mohammad Minhajuddin, PhD^1*, Courtney L Jones, PhD^3,4, Austin E. Gillen, PhD^1*, Monica Ransom, PhD^1*, Sarah Staggs, PhD^1*, Daniel A. Pollyea, MD⁵, Clayton Smith, MD^1*, Brett M. Stevens, PhD¹ and Craig T. Jordan, PhD¹

¹Anschutz Medical Campus, Division of Hematology, University of Colorado School of Medicine, Aurora, CO
²Liangzhu Laboratory, Bone Marrow Transplantation Center, Zhejiang University School of Medicine, Hangzhou, China
³Princess Margaret Cancer Centre; University Health Network, Toronto, ON, Canada
⁴University of Toronto, Toronto, ON, Canada
⁵Anschutz Medical Campus, Division of Hematology, University of Colorado School of Medicine, Denver, CO

Bo Dai^1*, Feng Wang^2*, Ying Wang^1*, Jiayan Zhu^3*, Yunxuan Li^4*, Tingting Zhang^4*, Luyao Zhao^4*, Li-Ling Wang^5*, Wenhui GAO^6*, Junmin Li^7*, Aibin Liang, MD, PhD^8*, Hong-hu Zhu, M.D., Ph.D.^9*, Ke Li^10* and Jiong Hu, MD¹¹

¹Shanghai Institute of Hematology, Blood and Marrow Transplantation Center, Collaborative Innovation Center of Hematology, Department of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai,China, Shanghai, China
²NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Beijing, China
³Shanghai Institute of Hematology, Blood and Marrow Transplantation Center, Collaborative Innovation Center of Hematology, Department of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai,China, Shanghai, CHN
⁴NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Beijing, CHN
⁵Ruijin Hospital, Shanghai, CHN
⁶Shanghai Institut of Hematology, Ruijin Hospital Affiliated To Shanghai Jiao Ton, Shanghai, CHN
⁷Department of hematology, Rui Jin Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, Shanghai, China
⁸School of Medicine, Tongji Hospital of Tongji University, Shanghai, China
⁹Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China, Hangzhou, China
¹⁰Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
¹¹Department of Hematology, RuiJin Hospital, Shanghai Jiao Tong University, Shanghai, China

Guo Qiu^1*, Xi Xu^2* and Qifa Liu, MD³

¹Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, CA, China
²Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
³Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China

Min Chul Kwon¹, Olivier Querolle, PhD^2*, Xuedong Dai^3*, Jan Willem Thuring^4*, Tinne Verhulst^5*, Ann Marien^5*, Dries Goffin^5*, Wei Cai^3*, Vikki Keersmaekers^6*, Filmon Eyassu^5*, Karin Verstraeten^5*, Sara El Ashkar, PhD⁷, Shanna M Hogeling, MSc^8*, Frank Jacob^9*, Petra Vinken^9*, Nicolas Darville^9*, Vineet Pande^9*, Daniel Krosky^10*, Gregor Urbanietz^9*, Bie Verbist^11*, Lucille A. Ferrante, MD¹², Christina Diane Drenberg, PhD¹³, David Wilson^9*, Ricardo M. Attar¹⁴, Jan Jacob Schuringa, PhD⁸, Nikki Daskalakis, MD¹⁵, Kathryn Packman^14*, Christine Pietsch, PhD¹⁶, Yusri Elsayed, MD, MMSc, PhD¹⁷ and Ulrike Philippar, PhD⁴

¹Discovery Oncology,, Janssen R&D, Beerse, Belgium
²Discovery Product Development & Supply, Janssen R&D, Val De Reuil Cedex, AL, FRA
³Discovery Product Development & Supply, Janssen R&D, Shanghai, China
⁴Janssen Research & Development, Beerse, Belgium
⁵Discovery Oncology, Janssen R&D, Beerse, Belgium
⁶Janssen R&D, Beerse, BEL
⁷Discovery Oncology, Janssen R&D, Beerse, BEL
⁸Department of Hematology, Cancer Research Centre Groningen, University Medical Centre Groningen, University of Groningen, Groningen, Netherlands
⁹Discovery Product Development & Supply, Janssen R&D, Beerse, Belgium
¹⁰Discovery Oncology, Janssen R&D, Spring House
¹¹Johnson&Johnson, Beerse, BEL
¹²Janssen Pharmaceuticals, Inc., Horsham, PA
¹³Translational Research, Janssen R&D, Spring House
¹⁴Janssen Research and Development, Spring House, PA
¹⁵Janssen R&D, Horsham, PA
¹⁶Janssen Research & Development, Springhouse, PA
¹⁷Janssen R&D, Spring House, PA

Bing Z Carter, PhD¹, Po Yee Mak^1*, Wenjing Tao^1*, Lauren B Ostermann^1*, Yuki Nishida, MD, PhD¹, Naveen Pemmaraju, MD², Steffen Boettcher^3*, Elizabeth J Shpall, MD⁴, Gabriela Chiosis, PhD^5*, Georgios Karras, PhD^6*, Barbara Wallner, PhD^7*, Robert A Morgan^8* and Michael Andreeff, MD, PhD¹

¹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Medical Oncology and Hematology, University of Zurich and University Hospital of Zurich, Zurich, Switzerland
⁴Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Memorial Sloan Kettering Cancer Center, New York, NY
⁶The University of Texas MD Anderson Cancer Center, Department of Genetics, Houston, TX
⁷Samus Therapeutics, Topsfield, MA
⁸Samus Therapeutics Inc, Topsfield, MA

Luis A. Carvajal, PhD^*, Michael McKeown, PhD^*, Tressa Hood, MS^*, Pavan Kumar, PhD^*, Douglas C. Saffran, PhD^* and Jorge DiMartino, MD

Kronos Bio, Inc., San Mateo, CA

Kristyna Pimkova^*, Lubomir Minařík, MD^*, Juraj Kokavec, PhD^* and Tomas Stopka, MD, PhD

BIOCEV, First Faculty of Medicine, Charles University, Prague, Czech Republic

Sara Elgamal, PhD^1*, Tracy Clevenger, PhD^2*, Michael Gulrajani^2*, Jean Cheung, MS^2*, Erin G. Jeremy, MS^3*, Sydney Fobare^3*, Shelley Orwick, BS^4*, Ellen J. Sass^3*, Erin Hertlein, PhD^1*, Karilyn T. Larkin, MD¹, Todd Covey^2*, Wayne P. Rothbaum^2* and John C. Byrd, MD¹

¹Department of Internal Medicine, Division of Hematology, University of Cincinnati, Cincinnati, OH
²Kartos Therapeutics, Redwood City, CA
³Department of Internal Medicine, Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁴The Ohio State University Comprehensive Cancer Center, Columbus, OH

Tomasz Rzymski, PhD^1*, Agnieszka Sroka-Porada Sr.^1*, Magdalena Kozakowska, PhD^1*, Urszula Głowniak-Kwitek^1*, Karolina Bukowska-Strakova, PhD^2*, Marta Obacz^1*, Peter Littlewood, BSc^3*, Kamil Kuś, PhD^1*, Kristina Goller^1*, Kinga Kęska^1*, Urszula Pakulska, PhD^1*, Kamila Kozłowska-Tomczyk^1*, Monika Madej, PhD^1*, Milena Mazan, PhD^1*, Przemyslaw Juszczynski, MD, PhD^4*, Jan M. Zaucha, MD, PhD^5*, Agnieszka Zarzycka, MD^6*, Noemi Angelosanto, MD¹, Hendrik Nogai^1* and Krzysztof Brzózka, PhD⁷

¹Ryvu Therapeutics, Cracow, Poland
²Department of Clinical Immunology, Jagiellonian University Medical College, Crakow, Poland
³Ryvu Therapeutics, Krakow, Poland
⁴Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
⁵Early Phase Clinical Trial Unit, University Clinical Center, Gdansk, Poland
⁶Medical University of Gdansk, Gdansk, Poland
⁷Ryvu Therapeutics S.A., Cracow, Poland

Edward Ayoub, PhD^1*, Akhil Marupudi^2*, Yuki Nishida, MD, PhD³, Rafael Heinz Montoya, BS^1*, Vakul Mohanty, PhD^4*, Wencke Walter, PhD^5*, Mark R Bray^6*, Tallie Patsilevas, BS^7*, Steffen Boettcher^8*, Ghayas C. Issa, MD⁹, Ken Chen, PhD^4*, Torsten Haferlach, MD⁵, Gautam Borthakur, MD⁷ and Michael Andreeff, MD, PhD⁷

¹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²The University of Texas MD Anderson Cancer Center, Houston
³Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁴Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵MLL Munich Leukemia Laboratory, Munich, Germany
⁶Treadwell Therapeutics Canada, Inc, Toronto, ON, Canada
⁷Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁸Department of Medical Oncology and Hematology, University of Zurich and University Hospital of Zurich, Zurich, Switzerland
⁹Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX

Jaclyn Rosenzweig, MD, Diego Ferreira Coutinho, PhD^*, Matthew Long^*, Katie Souto^*, Glorymar Ibanez Sanchez^*, Raina Fishkin^*, Kristina Guillan^*, Armaan Siddiquee^*, Paul Calder^*, Daoqi You^*, Andrew L. Kung, MD, PhD and Filemon Dela Cruz, MD^*

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY

James J. Yoon, MD¹, Hongzhi Miao^2*, Trupta Purohit^2*, Dong Chen, PhD^2*, Tomasz Cierpicki, PhD^2* and Jolanta Grembecka, PhD^2*

¹Division of Hematology/Oncology, Department of Medicine, University of Michigan, Ann Arbor, MI
²Department of Pathology, University of Michigan, Ann Arbor, MI

Nam H.K. Nguyen, MS, PharmD¹, Abderrahmane Tagmount, PhD^2*, Jeffrey E. Rubnitz, MD³, Raul C. Ribeiro, MD⁴, Xueyuan Cao, PhD^5*, Stanley B. Pounds, PhD^5*, Chris D. Vulpe, MD, PhD^6* and Jatinder K. Lamba, PhD⁷

¹Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL
²University of Florida, Gainesville, FL
³Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
⁴St. Jude Children's Research Hospital, Memphis, TN
⁵Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
⁶Physiological Sciences, University of Florida, Gainesville, FL
⁷Department of Pharmacotherapy and Translational Research, University of Florida, College of Pharmacy, Pharmacotherapy and Translational Re, Gainesville, FL

Jan S Rosenbaum, PhD^1*, Scott B. Hoyt, Ph.D.^2*, Amal S. Kolt, MS^3*, Daniel A Luedtke, PhD³, Craig J. Thomas, PhD^4,5* and Daniel T. Starczynowski, PhD^6,7,8,9

¹Kurome Therapeutics, Cincinnati, OH
²Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD
³Kurome Therapeutics Inc., Cincinnati, OH
⁴Division of Pre-Clinical Innovation Chemistry Technologies, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD
⁵Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD
⁶Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁷Department of Pediatrics, University of Cincinnati, Cincinnati, OH
⁸Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁹Department of Cancer Biology, College of Medicine, University of Cincinnati, Cincinnati, OH

Kader Cicek, BS^1,2*, Joshua R. Faust, MS^3*, Meredith Tavenner, MS^3*, E. Anders Kolb, MD¹, Sonali P. Barwe, PhD, MSc^1,2 and Anilkumar Gopalakrishnapillai, PhD, MSc^1,2

¹Nemours Center for Cancer and Blood Disorders, Nemours Children's Health, Wilmington, DE
²University of Delaware, Newark, DE
³Nemours Center for Cancer and Blood Disorders, Nemours Children’s Health, Wilmington, DE

Katharina Wohlan, PhD¹, Dandan Fan^2,3,4*, Anna Guzman^1*, Jianzhong Su, PhD^2,3,4*, Margaret A. Goodell, PhD^5,6,7 and Rachel E. Rau, MD^7,8

¹Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston
²Institute of Biomedical Big Data, Wenzhou Medical University, Wenzhou, China
³School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, China
⁴School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China
⁵Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX
⁶Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX
⁷Department of Pediatrics, Baylor College of Medicine, Houston
⁸Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston

Beatrix Stelte-Ludwig, PhD^1*, George Clemens, PhD^2*, Tibor Schomber, PhD^1*, Melanie M. Frigault, PhD², Amy J. Johnson, PhD², Hans-Georg Lerchen, PhD^1*, Raquel Izumi, PhD² and Ahmed Hamdy, MD²

¹Vincerx Pharma GmbH, Monheim, Germany
²Vincerx Pharma Inc, Palo Alto, CA

Samin Houshyar, MD^1*, Betul Gok Yavuz, MD, PhD^2*, Pritesh Patel³, Nadim Mahmud, MBBS, PhD³, Karen Sweiss, PharmD⁴, Irum Khan, MBBS⁵, Santosh L. Saraf, MD^3,6, Damiano Rondelli, MD³, Anwar Khan, PhD^6* and John G. Quigley, MD, FRCP (C)³

¹Department of Medicine, University of Illinois Chicago, Chicago, IL
²Division of Hematology and Oncology, University of Illinois College of Medicine, Chicago, IL
³Division of Hematology and Oncology, University of Illinois at Chicago, Chicago, IL
⁴Department of Pharmacy Practice, University of Illinois at Chicago, Hinsdale, IL
⁵Division of Hematology and Oncology, University of Illinois, Chicago, IL
⁶University of Illinois at Chicago, Chicago, IL

Haley E. Ramsey, PhD, MSc¹, Benjamin J. Reisman, M.D., PhD^2,3, Maria P. Arrate, MSc^1*, Agnieszka E. Gorska, MSc^1*, Londa Fuller, LVMT^1*, Brian O. Bachmann, PhD^3* and Michael R. Savona, MD^1,4

¹Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
²Medical Scientist Training Program, Vanderbilt University, Nashville, TN
³Department of Chemistry, Vanderbilt University, Nashville, TN
⁴Cancer Biology Program, Vanderbilt University, Nashville, TN

Lyuben Tsvetkov^1*, Janét Pittsenbarger, BA^2*, Christian Atsriku^1*, Paul Devine, PhD^1*, Karen Dingley, PhD^1*, Adam Levinson^1*, Sayan Mondal, PhD^1*, Joseph Piccotti^3*, Roman Shimanovich, PhD^1*, Lin Tang^3*, Daniel Weiss, MD, PhD^1*, Jacky Woo^1*, Min Ye, PhD^1*, Wu Yin, PhD¹, Karen Akinsanya, PhD^1*, Wayne Tang, PhD^1*, Hamish Wright, PhD^1*, Elie Traer, MD, PhD⁴ and Kristian Jensen, PhD^1*

¹Schrodinger, Inc., New York
²Knight Cancer Institute, Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Sciences University, Portland, OR
³Schrodinger, Inc., San Diego, CA
⁴Knight Cancer Institute, Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR

Kara Lehner^1,2*, Anilkumar Gopalakrishnapillai, PhD, MSc^1,2, E. Anders Kolb, MD¹ and Sonali P. Barwe, PhD, MSc^1,2

¹Nemours Center for Cancer and Blood Disorders, Nemours Children's Health, Wilmington, DE
²University of Delaware, Newark, DE

Keli Lima, BSc^1,2*, Diego A Pereira-Martins, MD^2,3*, Lívia Bassani Lins de Miranda, BSc^1*, Juan L Coelho-Silva, PhD^4*, Giovana da Silva Leandro, PhD^5*, Isabel Weinhäuser, PhD^2,3*, Rita de Cassia Cavaglieri, PhD^2*, Wellington F Silva Jr., MD PhD⁶, Aline Medeiros Leal, PhD^2*, Ana Paula Alencar de Lima Lange, PhD^2*, Elvira Deolinda Rodrigues Pereira Velloso, MD, PhD², Emmanuel Griessinger, PhD^3*, Jacobien R Hilberink, PhD^3*, Gerwin A. Huls, MD, PhD³, Jan Jacob Schuringa, PhD⁷, João Agostinho Machado-Neto, PhD^1* and Eduardo M Rego, MD, PhD⁸

¹Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
²Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil
³Department of Experimental Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
⁴Department of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil
⁵Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
⁶Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Division of Hematology, Transfusion Medicine and Cell Therapy, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (HCFMUSP), São Paulo, Brazil
⁷Department of Hematology, Cancer Research Centre Groningen, University Medical Centre Groningen, University of Groningen, Groningen, Netherlands
⁸Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, Medical School of the University of São Paulo, Sao Paulo, Brazil

Adam Yuh Lin, MD, PhD¹, Jonathan Scott Rink, PhD^1*, Eva Yang, BS^1*, Sara Small, MD, PhD², Fransheska Serrano^3*, Yasmin Abaza, MD², Jessica K. Altman, MD¹, Leonidas C. Platanias, MD, PhD⁴, Colby Shad Thaxton, MD, PhD^5* and Leo I. Gordon, MD¹

¹Department of Medicine, Division of Hematology/Oncology and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Northwestern University Feinberg School of Medicine, Chicago, IL
²Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL
³University of Buffalo, Buffalo
⁴Division of Hematology-Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL
⁵International Institute for Nanotechnology, Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL