Nidhi Aggarwal, BS¹, Ash Lee Manley^2*, Jichun Chen, PhD¹, Emma M. Groarke, MD¹, Xingmin Feng, PhD¹ and Neal S. Young, MD¹

¹Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
²Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Silver Spring, MD

Carmelo Gurnari, MD^1,2, Pedro H. Prata, MD³, Luiz Fernando Bazzo Catto, MD^4*, Arda Durmaz^2*, Lise Larcher^3*, Marie Sebert, MD, PhD^3,5*, Vincent Allain, MD^6*, Tariq Kewan, MD^2*, Simona Pagliuca, MD, PhD^7,8, Andre Luiz Pinto^4*, Mariana C. B. Inacio, MD^4*, Lucie Hernandez^3*, Nathalie Dhedin, MD^9*, Sophie Caillat-Zucman, MD, PhD^6*, Emmanuelle Clappier, PharmD, PhD^3*, Flore Sicre de Fontbrune, MD, PhD^10,11*, Maria Teresa Voso, MD¹², Valeria Visconte, PhD², Regis Peffault De Latour^10,11*, Jean Soulier, MD, PhD³, Gérard Socié, MD, PhD^13*, Rodrigo T. Calado, MD, PhD⁴ and Jaroslaw P. Maciejewski, MD, PhD, FACP¹⁴

¹Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
³INSERM U944/CNRS UMR7212, Institut de Recherche Saint-Louis, Paris, France
⁴Department of Hematology and Clinical Oncology, University of São Paulo, Riberão Preto, Brazil
⁵Hematology Seniors, Paris, France
⁶Laboratory of Immunology, Saint Louis Hospital, APHP, Paris, France
⁷Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Vandœuvre-lès-Nancy, France, France
⁸Service d'Hématologie Clinique, Hôpital Brabois, CHRU de Nancy, Nancy, France
⁹St-Louis Hospital, APHP, Adolescents and Young Adults Hematology Department, Paris, France
¹⁰Hematology and Transplantation Unit, Hôpital Saint Louis, AP-HP, Paris, France
¹¹French Reference Center for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria, Paris, France
¹²Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, Rome, Italy
¹³Hôpital Saint-Louis, Paris, France
¹⁴Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

Naomi Kawashima, MD, PhD^1*, BEN Ponvilawan, MD^1*, Pat Rayman^2*, Jennifer Powers^3*, Fauzia Ullah, MD^1*, Yasuo Kubota, MD, PhD^1*, Mai Aly, MD, BSc, MS^1*, Li Lily Wang^1*, Simona Pagliuca, MD, PhD⁴, Valeria Visconte, PhD¹, C. Marcela Diaz-Montero, PhD^3*, Jaroslaw P. Maciejewski, MD, PhD, FACP¹ and Carmelo Gurnari, MD^1,5

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
²Center for Immunotherapy and Precision Immuno-Oncology (CITI), Lerner Research Institute, Cleveland Clinic, Cleveland, OH
³LRI Center for Immunotherapy and ImmunoOncology, Cleveland Clinic, Cleveland, OH
⁴Service d'Hématologie Clinique, Hôpital Brabois, CHRU de Nancy, Nancy, France
⁵Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy

Richard Kelly, BSc, MD^1*, Matthew Holt, MBChB^2*, Jennifer Vidler, MBBS, MRCP^3*, Louise Arnold, BSc Hons^2*, Joanna Large, BA, MA^3*, Briony Forrest, BSc^2*, Catherine Barnfield, BSc^2*, Alexandra Pike, MRes^2*, Morag Griffin, FRCPath, MRCP^4*, Talha Munir, MBBS, MRCP, FRCPath, PhD^2*, Petra Muus^2*, Sateesh K. Nagumantry^5*, Roochi Trikha^6*, Austin Kulasekararaj, MD, MBBS, FRCPath, MRCP³, Lindsay Mitchell, MD^7* and Shreyans Ghandi, MD^3*

¹Department of Haematology, St James University Hospital, Leeds, United Kingdom
²St James's University Hospital, Leeds, United Kingdom
³King's College Hospital, London, United Kingdom
⁴St James's University Hospital, Sheffield, United Kingdom
⁵Peterborough City Hospital, Peterborough, United Kingdom
⁶King’s College Hospital, National Institute for Health and Care Research/Wellcome King’s Clinical Research Facility, London, United Kingdom
⁷University Hospital Monklands, Airdrie, United Kingdom

Fauzia Ullah, MD^1*, Danai Dima, MD¹, Carmelo Gurnari, MD^1,2*, Suresh Kumar Balasubramanian, MD³, Olisaemeka Ogbue⁴, Hussein Awada^1*, Naomi Kawashima, MD^1*, Najiullah Omar, MD^1*, Swapna Thota, MD^5,6, Hetty E. Carraway, MD, MBA⁷, Valeria Visconte, PhD¹ and Jaroslaw P. Maciejewski, MD, PhD, FACP¹

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
²Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
³Karmanos Cancer Institute/ Wayne State University, Detroit
⁴Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Rocky River, OH
⁵Roswell Park Comprehensive Cancer Center, Buffalo, NY
⁶St. Jude Research Hospital, The University of Tennessee Health Science Center, Memphis, TN
⁷Department of Hematology and Medical Oncology, Taussig Cancer institute, Leukemia Program, Cleveland Clinic, Cleveland, OH

Luana Marano^1*, Patrizia Ricci^2*, Camilla Frieri, MD^1*, Eleonora Urciuoli^1*, Ada Sanseverino^1*, Fabiana Cacace, MD^3*, Ilenia Manfra, MD^1*, Giovanna De Santis^1*, Selenia Vitiello, MD^1*, Serena Marotta^4* and Antonio M Risitano, MD, PhD^5,6

¹Hematology and Hematopoietic Transplantation, AORN S. Giuseppe Moscati, Avellino, Italy
²Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy
³UOC TCSE e Terapie Cellulari, AORN Santobono-Pausilipon, Naples, Italy
⁴BMT Unit, AORN Cardarelli, Naples, Italy
⁵Hematology and Hematopoietic Transplantation, AORN S. Giuseppe Moscati Avellino, Avellino, Italy
⁶Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy

Simona Pagliuca, MD, PhD^1,2, Austin Kulasekararaj, MD, MBBS, FRCPath, MRCP³, Dirk-Jan Eikema^4*, Brian Piepenbroek^5*, Raheel Iftikhar, FCPS, MBBS^6*, Tariq Mahmood Satti, FCPS^6*, Morag Griffin, FRCPath, MRCP^7*, Marica Laurino, MD^8*, O. Alphan Kupesiz, MD^9*, Yives Bertrand, MD^10*, Bruno Fattizzo, MD^11*, Ibrahim Yakoub-Agha, MD, PhD¹², Mahmoud Aljurf, MD¹³, Paola Corti, MD^14*, Erika Massaccesi, MD^15*, Bruno Lioure, MD^16*, Marisa Calabuig, MD^17*, Matthias Klammer, MD¹⁸, Emel Unal, MD^19*, Depei Wu²⁰, Patrice Chevallier, MD²¹, Edouard Forcade, MD, PhD²², John A. Snowden, MBBS PhD^23*, Hakan Ozdogu, MD^24*, Antonio M Risitano, MD, PhD²⁵ and Regis Peffault De Latour^26,27*

¹Department of Clinical Hematology, CHRU Nancy, Vandœuvre-lès-Nancy, France, France
²CNRS UMR 7365 IMoPa, Biopôle de l’Université de Lorraine, Vandœuvre-lès-Nancy, France
³King’s College Hospital, National Institute for Health and Care Research/Wellcome King’s Clinical Research Facility, London, ENG, United Kingdom
⁴EBMT Statistical Unit, Leiden, Netherlands
⁵EBMT Leiden Study Unit, Leiden, Netherlands
⁶Armed Forces Bone MarrowTransplant Centre, Rawalpindi, Pakistan
⁷St James's University Hospital, Sheffield, United Kingdom
⁸UO ematologia e terapie cellulari, IRCCS Ospedale Policlinico San martino, Genova, Padua, Italy
⁹Hematology Department, Akdeniz University Medical School, Antalya, Turkey
¹⁰Institute of Pediatric Hematology and Oncology, Civil Hospital of Lyon - Claude Bernard University, Lyon, France
¹¹Dipartimento di Oncologia e Emato-Oncologia, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milano, Italy
¹²Centre Hospitalier Universitaire de Lille LIRIC, INSERM U1286, Université de Lille, LILLE, France
¹³Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
¹⁴Pediatric Hemato-Oncolgy, Fondazione MBBM/ASST-Monza, University of Milano-Bicocca, Monza, Italy
¹⁵IRCSS Istituto Giannina Gaslini, Genoa, Italy
¹⁶Centre Hospitalier Universitaire de Strasbourg, Strasbourg, France
¹⁷Hospital Clínico de Valencia, Valencia, Spain
¹⁸St. George's University Hospital, London, United Kingdom, United Kingdom
¹⁹Division of Pediatric Hematology/Oncology, Ankara University Faculty of Medicine, Department of Pediatrics - Division of Pediatric Hematology-Oncology, Ankara, Turkey., Istanbul, Turkey
²⁰National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Institute of Blood and Marrow Transplantation of Soochow University, Suzhou, China
²¹Hematology Department, Nantes University Hospital, Nantes, France
²²Service d'Hématologie Clinique et Thérapie Cellulaire, CHU Bordeaux, Hôpital Haut-Leveque, Bordeaux, France
²³Sheffield University Teaching Hospitals, Sheffield, United Kingdom
²⁴Hematology Division, BMT Unit, Haemaology Reserach Laboratory, Training & Medical, Baskent University Hospital, Adana, Turkey
²⁵Hematology and Hematopoietic Transplantation, AORN S. Giuseppe Moscati Avellino, Avellino, Italy
²⁶Assistance Publique–Hôpitaux de Paris, Saint-Louis Hospital, Université Paris Cité, Paris, France
²⁷French Reference Center for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria, Paris, France

William Pullman, PhD, MBBS, Jane Humphreys, BSc^*, Edward Philpot, MD^* and W. Jason Cummings, PhD^*

Omeros Corporation, Seattle, WA

Antonio M Risitano, MD, PhD^1,2, Regis Peffault De Latour^3,4*, Eng Soo Yap, MBBS, MMed (Int Med), MRCP, FRCPath Haematology^5*, Lily LL Wong, MD^6*, Bor-Sheng Ko, MD, PhD^7,8*, Sung-Soo Yoon, MD, PhD⁹, Alexander Roeth, MD¹⁰, Irina Baltcheva^11*, Julie Milojevic, PhD^12*, Niamh Fagan^13*, Kenneth Kulmatycki^14*, Prasanna K Nidamarthy, PhD^15*, Guido Junge, MD, PhD^12* and Jun Ho Jang, MD, PhD^16,17

¹University of Naples Federico II, Naples, Italy
²AORN Moscati, Avellino, Italy
³Hôpital Saint-Louis, Paris, France
⁴French Référence Center for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria, Paris, France
⁵National University Cancer Institute, Singapore, Singapore
⁶Hematology Unit, Queen Elizabeth Hospital, Kota Kinabalu, Malaysia
⁷National Taiwan University Hospital, Taipei, Taiwan
⁸National Taiwan University Cancer Center, Taipei, Taiwan
⁹Seoul National University Hospital, Seoul, Korea, Republic of (South)
¹⁰West German Cancer Center, University Hospital Essen, Essen, Germany
¹¹Novartis Pharma AG, Basel, Switzerland
¹²Novartis Institutes for BioMedical Research, Basel, Switzerland
¹³Novartis Ireland Limited, Dublin, Ireland
¹⁴Novartis Institutes for BioMedical Research, Cambridge, MA
¹⁵Novartis Healthcare Private Limited, Hyderabad, India
¹⁶Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South)
¹⁷Samsung Medical Center, Seoul, Korea, Republic of (South)

Xin Zhao, MD^1*, Li Zhang^1*, Bing Han, MD^2*, Tiantian Zhang^3*, Xu Liu^1*, Miao Chen^2*, Changping Li^3*, Huijie Huang^3*, Liping Jing, MD^1*, Kang Zhou^1*, Guangxin Peng^1*, Yuan Li^1*, Jianping Li^1*, Lei Ye^1*, Huihui Fan^1*, Wenrui Yang^1*, Yingchang Mi, MD¹ and Fengkui Zhang^1*

¹Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China
²Peking Union Medical College Hospital, Beijing, China
³Department of statistics, Tianjin Medical University, Tianjin, China

Ling Deng^1*, Tian Zhang^2*, Yihui Zhao^2*, Zonghong Shao² and Rong Fu, MD^2*

¹Department of Hematology, Tianjin Medical University General Hospital, Tianjin, NY, China
²Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China

Wenrui Yang^1*, Xin Zhao, MD^1*, Guangsheng He^2*, Hong Chang^3*, Bing Han, MD^4*, Sujun Gao^5*, Shunqing Wang^6*, Tong Chen, MD⁷, Fei Li^8*, Yi Wang, MD^9*, Xiaoyan Ge^10*, Rong Fu, PhD^11*, Zheng Ge^12*, Yingmei Li^13*, Hong Liu, MD^14*, Xinjian Liu^15*, Miao Miao, MD^16*, Liansheng Zhang^17* and Fengkui Zhang^1*

¹Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China
²Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China
³West China Hospital of Sichuan University, Chengdu, China
⁴Peking Union Medical College Hospital, Beijing, China
⁵Jilin University, First Hospital of Bethune Medical, Changchun, China
⁶Guangzhou First People's Hospital, Guangzhou, China
⁷Department of Hematology, Huashan Hospital, Fudan University, Shanghai, China
⁸Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China
⁹Department of Hematology, Shaanxi Provincial People's Hospital, Xi'an, China
¹⁰The Second Hospital of Shanxi Medical University, Taiyuan, China
¹¹Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China
¹²Zhongda Hospital Affiliated to Southeast University, Nanjing, China
¹³The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
¹⁴Department of Hematology, Affiliated Hospital of Nantong University, Nantong, China
¹⁵Henan Cancer Hospital, Zhengzhou, China
¹⁶The First Affiliated Hospital of Suzhou University, Suzhou, China
¹⁷Hematology Department, Lanzhou University Second Hospital, Lanzhou, China, Lanzhou, CHN

Liping Jing, MD^1*, Yingchang Mi, MD^1,2, Huihui Fan^1*, Wenrui Yang^3*, Yuan Li^1*, Jianping Li^1*, Li Zhang^1*, Xin Zhao, MD^4*, Kang Zhou^1*, Lei Ye^1* and Fengkui Zhang^1*

¹Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China
²National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
³Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
⁴Institute of Hematology and Blood Disease Hospital, Chinese Academy Medical Science & Peking Union Medical College, Tianjin, China