Hongzhe Li, PhD¹, Sandro Bräunig, MSc^1*, Parashar Dhapola, MSc^2*, Göran Karlsson, PhD², Stefan Lang, PhD^2* and Stefan Scheding, MD^3,4

¹Division of Molecular Hematology / Stem Cell Center, Lund University, Lund, Sweden
²Lund Stem Cell Center/ Division of Molecular Hematology, Lund University, Lund, Sweden
³Lund Stem Cell Center/ Division of Molecular Hematology, University of Lund, Lund, Sweden
⁴Department of Hematology, Skåne University Hospital, Lund, Sweden

Shinya Fujita^1,2*, Takayuki Morikawa, PhD^1*, Keisuke Kataoka, MD, PhD^3,4 and Keiyo Takubo, MD, PhD^1*

¹Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
²Division of Hematology, Department of Medicine, Keio University School of Medicine, Shinjuku-Ku, Japan
³Division of Molecular Oncology, National Cancer Center Research Institute, Tokyo, Japan
⁴Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan

Xiaojing Cui, MS^1*, Bowen Yan, PhD^2*, Cuiping Zhang, MD, PhD^1*, Xinghui Zhao, PhD¹, Jinpeng Liu, PhD^3,4*, Daheng He, PhD^3*, Chi Wang, PhD^3,4*, Daohong Zhou, MD⁵ and Ying Liang, MD, PhD¹

¹Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY
²Department of Pharmacology & Therapeutics, University of Florida, Gainesville, FL
³Markey Cancer Center, University of Kentucky, Lexington, KY
⁴Department of Internal Medicine, University of Kentucky, Lexington, KY
⁵Department of Biochemistry & Structural Biology, University of Texas Health at San Antonio, San Antonio, TX

Karin Prummel^1*, Anna Mathioudaki, MSc^2,3*, Lixiazi He, PhD^4*, Shubhankar Sood, PhD^5*, Rim Moussa^3*, Robert Reinhardt, PhD^6*, Swati Garg, PhD⁷, Simon Haas, PhD^5,8*, Marieke Essers, PhD⁵, Sinem K Saka, PhD^6*, Caroline Pabst, MD^4* and Judith Zaugg, PhD^3*

¹Structural and Computational Biology Unit, EMBL Heidelberg, Heidelberg, Germany
²Department of Medicine V, Hematology, Oncology and Rheumatology,, University Hospital Heidelberg, Heidelberg, Germany
³Structural and Computational Biology Unit, EMBL, Heidelberg, Germany
⁴Department of Medicine V, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany
⁵Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany
⁶Genome Biology Unit, EMBL, Heidelberg, Germany
⁷Department of Medicine V, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, MA, Germany
⁸Berlin Institute of Health (BIH), Charité – Universitätsmedizin Berlin, Berlin, Germany

Yuko Kawano, MD, PhD^1,2*, Hiroki Kawano, MD, PhD^3*, Daniel K. Byun, BS^4*, Dalia Ghoneim, PhD^5*, Thomas J Fountaine, MD⁶, Mark W. LaMere, BA^4*, John M. Ashton, Ph.D^5*, Mitra Azadniv, PhD^7*, Jane L. Liesveld, MD⁸, Youmna Kfoury, PhD⁹, David T. Scadden, MD¹⁰, Michael W. Becker, MD⁸ and Laura M. Calvi, MD^7,11

¹James P. Wilmot Cancer Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA, Rochester, NY
²Division of Endocrinology and Metabolism, University of Rochester Medical Center, Rochester, NY
³Division of Hematology/Oncology, University of Rochester Medical Center, Rochester, NY
⁴University of Rochester Medical Center, Rochester, NY
⁵Department of Biomedical Genetics, Wilmot Cancer Institute, University of Rochester, Rochester, NY
⁶Division of Hematology and Oncology, University of Rochester Medical Center, Rochester, NY
⁷Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY
⁸Wilmot Cancer Institute, Division of Hematology and Oncology, University of Rochester Medical Center, Rochester, NY
⁹Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA
¹⁰Harvard Stem Cell Institute, Cambridge, MA
¹¹Wilmot Cancer Institute, Division of Endocrinology and Metabolism, University of Rochester Medical Center, Rochester, NY

Hidekazu Nishikii, MD, PhD¹, Mizuki Saito^2*, Takaharu Kimura, MD, PhD^3*, Yusuke Kiyoki, MD^2*, Takayasu Kato, MD, PhD^2*, Tatsuhiro Sakamoto, MD, PhD^1*, Mamiko Sakata-Yanagimoto, MD, PhD^1*, Naoshi Obara, MD, PhD^1*, Satoshi Yamazaki, PhD^3* and Shigeru Chiba, MD, PhD¹

¹Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
²Department of Hematology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
³Laboratory of Stem Cell Therapy, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan

Ding-Wen Chen, PhD¹, Tingting Huang^2*, Yuyang Huang^3*, Stephanie N Hurwitz, MD, PhD^1,4*, Julie Schrey^1*, Jian-Meng Fan^1*, Martin Carroll, MD^5*, Peter Kurre, MD^6,7 and Bonnie W Lau, MD PhD^3*

¹Comprehensive Bone Marrow Failure Center, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
²Geisel School of Medicine at Dartmouth College, Lebanon, NH
³Dartmouth Cancer Center, Department of Pediatrics, Geisel School of Medicine at Dartmouth College, Lebanon, NH
⁴Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
⁵Division of Hematology-Oncology/Department of Medicine, University of Pennsylvania, Philadelphia, PA
⁶Perelman School Medicine, University of Pennsylvania, Philadelphia, PA
⁷Comprehensive Bone Marrow Failure Center, Children's hospital of Philadelphia, Philadelphia, PA

Melanie Gadelorge^1*, Frederic Deschaseaux, PhD^1*, Jean-Gerard Descamps^1*, Alexandra Grimaldi^2*, Pierre Layrolle^3*, Agnes Coste, PhD^1*, Wassim El Nemer, PhD², Maria De Grandis, PhD^2* and Nicolas Espagnolle, PhD^1*

¹Geroscience and rejuvenation research center (RESTORE), Flames Team, INSERM 1301, UMR CNRS 5070, Univ. P. Sabatier, EFS / ENVT, Toulouse, France
²Établissement Français du Sang PACA-Corse, Aix Marseille Université, CNRS, UMR 7268 ADES, Marseille, France
³Toulouse Neuroimaging Center, UMR1214, INSERM, Toulouse, France

Seyram Yao Adzraku^1,2,3*, Guozhang Wang^1,2,3*, Can Cao^1,2,3*, Kailin Xu^1,2,3*, Jianlin Qiao, PhD^1,2,3, Wen Ju^1,2,3* and Lingyu Zeng^1,2,3*

¹Key Laboratory of Bone Marrow Stem Cell, Xuzhou, China
²Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
³Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China

Sara Ali, MD^1*, Syed Mian, PhD^1*, William Grey, PhD^1*, Manuel Garcia-Albornoz, PhD^1*, Fatihah Mohamad Nor^1*, Aneesh Sharma^1*, Samantha Atkinson^1*, Linda Ariza McNaughton^1*, John G. Gribben, MD, DSc, FRCP, FRCPath, FMedSci² and Dominique Bonnet, PhD¹

¹Hematopoietic Stem Cell Lab, The Francis Crick Institute, London, United Kingdom
²Center for Hemato-Oncology, Barts Cancer Institute, London, United Kingdom

Joanna A Storer^1,2*, Tim C.P Somervaille, PhD FRCP FRCPath^2,3, Daniel H Wiseman, PhD, MB, ChB, MRCP, FRCPath^1,4* and Kiran Batta, PhD^1*

¹Division of Cancer Sciences, The University of Manchester, Manchester, United Kingdom
²Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom
³Haematology Department, The Christie Hospital NHS Foundation Trust, Manchester, United Kingdom
⁴Haematology, The Christie Hospital NHS Foundation Trust, Manchester, United Kingdom

Sandro Bräunig, MSc^1*, Hongzhe Li, PhD¹, Isak Karmhag^1*, Anne Hultquist, MD^2* and Stefan Scheding, MD³

¹Division of Molecular Hematology / Stem Cell Center, Lund University, Lund, Sweden
²Department of Pathology, Skåne University Hospital, Lund University, Lund, Sweden
³Department of Hematology, Skåne University Hospital, Lund, Sweden