Chiraag D. Kapadia, BA^1,2, Matthew Yousefzadeh, PhD^3*, Emily Mitchell^4,5*, Duy Le, BS^2,6, Nicholas Williams, PhD^4,7*, Marcus A. Florez, PhD^2,6, Katherine Y. King, MD, PhD^2,6, Laura Niedernhofer, MD, PhD^3*, Jyoti Nangalia, MBBChir^4,5 and Margaret A. Goodell, PhD^1,2

¹Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX
²Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX
³Institute on the Biology of Aging and Metabolism, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN
⁴Wellcome Sanger Institute, Hinxton, United Kingdom
⁵Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
⁶Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, TX
⁷Wellcome-MRC Cambridge Stem Cell Institute, Department of Haematology, University of Cambridge, Cambridge, United Kingdom

Sergio of Barajas, BS^1,2, Sasidhar Vemula^3*, Sisi Chen, PhD⁴, Hongxia Chen^2*, Wenjie Cai^2,3*, Shiyu Xiao^2*, Stephanie Halene, MD⁵, Omar Abdel-Wahab, MD⁶, Linsey Mayo, PhD^7*, Sharon A. Savage, MD⁸ and Yan Liu, PhD⁹

¹Indiana University School of Medicine, Chicago, IL
²Northwestern University Feinberg School of Medicine, Chicago, IL
³Indiana University School of Medicine, Indianapolis, IN
⁴Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Yale Univ. School of Medicine, New Haven, CT
⁶Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁷Herman D Wells Center, Indianapolis, IN
⁸Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD
⁹Department of Medicine, Hematology Oncology Division, Northwestern University Feinberg School of Medicine, Chicago, IL

Bhavisha A. Patel, MD¹, Fernanda Gutierrez-Rodrigues, PhD², Yael Kusne, MD, PhD³, Jenna A. Fernandez, PhD^4*, Terra L. Lasho, PhD⁴, Ruba Shalhoub, MS^5*, Xiaoyang Ma, MS^5*, Hugh Alessi^6*, Christy Finke, BS^4*, Matthew Koster, MD^7*, Abhishek A. Mangaonkar, MBBS⁴, Kenneth Warrington, MD^7*, Kebede H. Begna, MD⁸, Zhuoer Xie, MD, MS⁹, Amanda Ombrello, MD^10*, David S. Viswanatha, MD¹¹, Marcela Ferrada, MD^12*, Lorena Wilson, NP, PhD^13*, Ronald Go, MD⁴, Taxiarchis Kourelis, MD⁴, Kaaren K. Reichard, MD^14*, Horatiu Olteanu, MD, PhD^15*, Emma M. Groarke, MD¹, Ivana Darden, RN^1*, Dalton Hironaka, BA^16*, Sofia Rosenzweig, BS^13*, Daniel L. Kastner, MD PhD^13*, Katherine R. Calvo, MD, PhD¹⁷, Colin O. Wu, PhD^5*, Peter C. Grayson, MD, Msc^12*, David B. Beck, MD, PhD^18*, Mrinal M. M. Patnaik, MD, MBBS⁴ and Neal S. Young, MD¹

¹Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
²Hematology Branch, National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, MD
³Department of Hematology and Oncology, Mayo Clinic, Phoenix, AZ
⁴Division of Hematology, Mayo Clinic, Rochester, MN
⁵Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
⁶National Institutes of Health, Bethesda, MD
⁷Division of Rheumatology, Mayo Clinic, Rochester, MN
⁸Divison of Hematology, Mayo Clinic, Rochester, MN
⁹Division of Hematology, Mayo Clinic, Lutz, FL
¹⁰National Human Genome Research Institute, NIH, National Institutes of Health, Bethesda, MD
¹¹Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
¹²Vasculitis Translational Research Program, National Institute of Arthritis, Musculoskeletal, and Skin Diseases. National Institutes of Health, Bethesda, MD
¹³Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD
¹⁴Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
¹⁵Mayo Clinic, Rochester, MN
¹⁶Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD
¹⁷Hematology Section, Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD
¹⁸National Institutes of Heath, Bethesda, MD

Ryunosuke Saiki^1*, Ho Namkoong^2*, Ryuya Edahiro^3,4*, Kyuto Sonehara^3,5*, Qingbo S Wang^3,6*, Takanori Hasegawa^7*, Yukihide Momozawa, DVM, Ph.D^8*, Hideki Makishima, MD, PhD⁹, Yasuhito Nannya, M.D., Ph.D.¹, Nobuyuki Kakiuchi, MD, PhD^1*, Chikashi Terao, MD, PhD^10*, Yuichi Shiraishi, PhD^11*, Kenichi Chiba, PhD^11*, Hiroko Tanaka, B.A.^7*, Koichi Matsuda, MD, PhD^12*, Takayuki Morisaki, MD, PhD^13*, Yoshinori Murakami, MD, PhD^13*, Yoichiro Kamatani, MD, Ph.D^10,12*, Michiaki Kubo, MD, Ph.D^14*, Akinori Kimura^15*, Seiya Imoto, PhD^16*, Satoru Miyano, PhD^7*, Takanori Kanai^17*, Koich Fukunaga^18*, Yukinori Okada^3* and Seishi Ogawa, MD, PhD^19,20,21

¹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
²Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan
³Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan
⁴Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan
⁵Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan
⁶Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan
⁷M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan
⁸Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
⁹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, KYO, Japan
¹⁰Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
¹¹Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo, Japan
¹²Department of Computational Biology and Medical Sciences, Graduate school of Frontier Sciences, The University of Tokyo, Tokyo, Japan
¹³Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
¹⁴RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
¹⁵Institute of Research, Tokyo Medical and Dental University, Tokyo, Japan
¹⁶Division of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
¹⁷Division of Gastroenterology and Hepatology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
¹⁸Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
¹⁹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto City, Japan
²⁰Center for Hematology and Regenerative Medicine, Department of Medicine (MedH), Karolinska Institutet, Huddinge, Sweden
²¹Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan

Jamie M Lee^1*, Joshua Zhang^2*, Maeve Flanagan^3*, Julian A Martinez^4,5,6*, Christopher Cunniff^7*, Steve Horvath^8* and Vivian Y. Chang, MD, MS^9,10,11

¹Division of Pediatric Hematology/ Oncology, UCLA, Los Angeles, CA
²Department of Human Genetics, UCLA, Los Angeles, CA
³Department of Pediatrics, Weill Cornell Medical College, New York, NY
⁴Human Genetics, UCLA, Los Angeles, CA
⁵Psychiatry, UCLA, Los Angeles, CA
⁶Division of Medical Genetics, UCLA, Los Angeles, CA
⁷Pediatrics, Weill Cornell Medical College, New York, NY
⁸Altos Labs, San Diego, CA
⁹Jonsson Comprehensive Cancer Center, UCLA, Los Angeles
¹⁰Children’s Discovery and Innovation Institute, UCLA, Los Angeles
¹¹Division of Pediatric Hematology Oncology, University of California, Los Angeles, Los Angeles, CA

Laura Poisa-Beiro, PhD^1,2*, Jonathan JM Landry, Ph.D.^3*, Simon Raffel, MD⁴, Volker Eckstein, Ph.D.^2*, Laura Villacorta, Ph.D.^5*, Anne-Claude Gavin^6,7*, Vladimir Benes, Ph.D.^3* and Anthony D Ho, MD^1,2

¹MMPU (Molecular Medicine Partnership Unit), Heidelberg, Germany
²Department of Medicine V, Heidelberg University, Heidelberg, Germany
³Genomics Core Facility, EMBL, Heidelberg, BW, DEU
⁴Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany
⁵Genomic Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany
⁶European Molecular Biology Laboratory, Heidelberg, DEU
⁷Department for Cell Physiology and Metabolism, Centre Medical Universitaire, University of Geneva, 1211, Switzerland, Geneva, Switzerland

Naser Ansari-Pour, PhD^1*, Verena Körber, PhD^2*, Niels Asger Jakobsen, BM BCh MRCP^3*, Rachel Moore, BA^3*, Nina Claudino^2*, Marlen Metzner, MSc^3*, Batchimeg Usukhbayar^3*, Mirian Angulo Salazar, MSc^3*, Simon Newman^4*, Benjamin Kendrick^4*, Adrian Taylor^4*, Rasheed Afinowi-Luitz^5*, Roger Gundle^4*, Bridget Watkins^4*, Kim Wheway^4*, Debra Beazley^4*, Andrew Carr, ChM DSc FRCS FMedSci^4*, Paresh Vyas, DPhil, FRCP, FRCPath, MRCP, MRCPath¹ and Thomas Höfer, PhD^2*

¹MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
²Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany
³MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
⁴Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom
⁵Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom

Silvia Vicenzi, PhD¹, Lara Avsharian^2*, Fangyuan Gao^3*, Qianlan Xu^3*, Kseniya Malukhina^4*, Dorota Skowronska-Krawczyk^3* and Leslie Crews, PhD⁵

¹UNIVERSITY CALIFORNIA, SAN DIEGO, San Diego, CA
²UNIVERSITY CALIFORNIA, SAN DIEGO, SAN DIEGO, CA
³UC Irvine, Irvine
⁴UCSD, San Diego
⁵Moores Cancer Center, University of California, San Diego, La Jolla, CA

Shyam A Patel, MD, PhD^1*, William K Gerber^2*, Lloyd Hutchinson, PhD^3*, Shrinkhala Khanna, MD¹, Jan Cerny, MD, PhD^3,4, Muthalagu Ramanathan, MD⁵, Andrew Gillis-Smith, MD^6*, Sakiko Suzuki, MD⁷, Gregory A. Abel, MD, MPH^8,9,10,11, Salwa Khedr, MD^12*, William Selove, MD^12*, Bruce Woda, MD¹³, Rena Zheng, MD, PhD¹², Patricia Minehart Miron, PhD^13*, Anne Higgins, PhD^3* and Jonathan M Gerber, MD¹²

¹University of Massachusetts Chan Medical School, Worcester, MA
²New York University Liberal Studies, New York, NY
³University of Massachusetts Medical School, Worcester, MA
⁴UMass Memorial Medical Center, Worcester, MA
⁵Division of Stem Cell Transplantation, UMass Memorial Medical Center University Campus, Worcester, MA
⁶Hematology/Oncology, University of Massachusetts, Worcester, MA
⁷Division of Hematology-Oncology, University of Massachusetts Medical School, Worcester, MA
⁸Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁹Center for Bioethics, Harvard Medical School, Boston, MA
¹⁰DFCI, Boston, MA
¹¹Dana-Farber Cancer Institute, Boston, MA
¹²UMass Chan Medical School, Worcester, MA
¹³Department of Pathology, University of Massachusetts Memorial Medical Center, Worcester, MA

Katherine Hampton, MSc, BSc^1*, Charlotte Hellmich, MBBChair^1,2*, Rebecca S Maynard, MSc^1*, Jamie A Moore, BSc, MSc^1*, Aisha Jibril, BSc^1*, Kristian M Bowles, MBBS, PhD^1,2 and Stuart A Rushworth, PhD¹

¹Norwich Medical School, University of East Anglia, Norwich, United Kingdom
²Department of Haematology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom

Bowen Yan, PhD^1,2*, Guangrong Zheng, PhD^3*, Daohong Zhou, PhD^4,5* and Olga A Guryanova, MD, PhD⁶

¹University of Florida College of Medicine, Department of Pharmacology & Therapeutics, Gainesville
²Department of Pharmacology & Therapeutics, University of Florida, Gainesville, FL
³Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL
⁴Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville
⁵University of Texas Health Science Center at San Antonio, San Antonio
⁶Department Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL

Evelyn L Schmidt^1*, Irenaeus C.C. Chan^2*, Alex Panchot, MSc^1*, Brian Wiley^3*, Jie Liu, MBBS, MPH⁴, Lea Moukarzel^5*, Yiwen Zhang^6*, Daniel C. Link, MD⁷, Konrad Stopsack^6* and Kelly L Bolton, MD⁸

¹Washington University, St Louis, MO
²Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO
³Division of Oncology, Washington University School of Medicine, St Louis, MO
⁴Washington University School of Medicine In St.Louis, University City, MO
⁵Memorial Sloan Kettering, New York, NY
⁶Harvard T.H Chan School of Public Health, Cambridge
⁷Department of Medicine, Division of Oncology, Section of Stem Cell Biology, Washington Univ. Med. School, Saint Louis, MO
⁸Department of Medicine, Division of Oncology, Section of Stem Cell Biology, Washington University School of Medicine, Saint Louis, MO, Washington University In St Louis, St Louis, MO