Helen Fogarty, MBBCHBAO^1,2,3, Soracha Ward^4*, Ellie Karampini, PhD^4*, Azaz Ahmad, PhD^5*, Gemma Leon, PhD^3*, Aisling Rehill, PhD^6*, Rosena Geoghegan^1*, Helena Conroy^1*, Noel Ngwenya^7*, Mary Byrne^8*, Ulrich Budde, MD, PhD⁹, Sonja Schneppenheim, MD, PhD^10*, Emma Tuohy, MD^7*, Corrina McMahon, MD, PhD^11* and James O'Donnell, MD, PhD^2,12,13*

¹Department of Haematology, Children’s Health Ireland (CHI) at Crumlin, Dublin, Ireland
²National Children’s Research Centre, Children’s Health Ireland (CHI) at Crumlin, Dublin, Ireland
³Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland, Dublin, Ireland
⁴Department of Vascular Biology, Royal College of Surgeons in Ireland, Dublin, Ireland
⁵Irish Centre for Vascular Biology, Royal College of Surgeons In Ireland, Dublin 2, IRL
⁶Irish Centre for Vascular Biology, Royal College of Surgeons In Ireland, Dublin, IRL
⁷Department of Haematology, St James's Hospital, Dublin, Ireland
⁸National Coagulation Centre, St James's Hospital, Dublin 8, Ireland
⁹MEDILYS Labor Gesellschaft, Hamburg, DEU
¹⁰Medilys Laborgesellschaft Mbh, Hamburg, DEU
¹¹Department of Haematology, Children’s Health Ireland at Crumlin, Crumlin, Ireland
¹²Irish Centre for Vascular Biology, Royal College of Surgons in Ireland, Dublin, Ireland
¹³National Coagulation Centre, St James’s Hospital, Dublin, Ireland

Kobina Dufu, PhD^1*, Donna Oksenberg, PhD^1*, Brian E Cathers, PhD^1*, Carlos J Munoz, MS^2*, Cynthia R Muller, PhD^2* and Pedro Pedro Cabrales, PhD^2*

¹Global Blood Therapeutics, South San Francisco, CA
²University of California, San Diego, La Jolla, CA

Kobina Dufu, PhD^1*, Donna Oksenberg, PhD^1*, Brian E Cathers, PhD^1*, Carlos J Munoz, MS^2*, Cynthia R Muller, PhD^2* and Pedro Pedro Cabrales, PhD^2*

¹Global Blood Therapeutics, South San Francisco, CA
²University of California, San Diego, La Jolla, CA

Fabio H Silva^1*, Carolina Oliveira Splendore^1*, Fabiano B Calmasini, PhD^2* and Fernando Ferreira Costa, M.D., Ph.D.³

¹Sao Francisco University, Braganca Paulista, Brazil
²University of Campinas, Campinas, Brazil
³Hematology and Hemotherapy Center, University of Campinas, Campinas, SP, Brazil

Stephen C Rogers, PhD^1*, Parikshit Moitra, PhD^2*, Mary Brummet^1*, Zohreh Safari, PhD^1*, Qihong Wang, MD^1*, Joy Okhuevbie, BS^1*, Nancy Anabaraonye^3*, Osheiza Y. Abdulmalik, DVM^4*, Martin K. Safo, PhD^5*, Nicole Glynn-Cunningham, RN^6*, Jennie Y. Law, MD⁷, Maria R. Baer, MD⁸, Dipanjan Pan, PhD^9* and Allan Doctor, MD¹

¹Center for Blood Oxygen Transport and Hemostasis, University of Maryland School of Medicine, Baltimore, MD
²Department of Bioengineering, Pennsylvania State University School of Engineering, University Park, PA
³Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA
⁴Division of Hematology, The Children’s Hospital of Philadelphia, Philadelphia, PA
⁵Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, VA
⁶Department of Hematology, University of Maryland Medical Center, Baltimore, MD
⁷Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
⁸University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD
⁹School of Engineering; Huck Institutes for the Life Sciences, Pennsylvania State University, University Park, PA

Kunhua Qin^1*, Peng Huang, PhD^1*, Xianjiang Lan, PhD^2,3*, Megan S. Saari, BS^1*, Eugene Khandros, MD, PhD¹, Osheiza Y. Abdulmalik, DVM^1*, Cheryl A. Keller, PhD^4*, Belinda M. Giardine^4*, Ross C. Hardison, PhD^4*, Junwei Shi, PhD^5* and Gerd A. Blobel, MD, PhD^1,6

¹Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA
²Department of Systems Biology for Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China
³Liver Cancer Institute, Zhongshan Hospital, Shanghai, China
⁴Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA
⁵Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
⁶Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

Ruben Yiqi Luo, PhD^1*, Carolyn Wong, CLS^2*, James Qiangwei Xia, PhD^3*, Bert Glader, MD, PhD⁴, Run-Zhang Shi, PhD^1* and James L Zehnder, MD⁵

¹Pathology, Stanford University, Palo Alto, CA
²Stanford Health Care, Palo Alto, CA
³CMP Scientific, Brooklyn, NY
⁴Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA
⁵Department of Pathology, Stanford University School of Medicine, Stanford, CA

Namita Kumari, PhD^1*, Asrar Ahmad, PhD^2,3*, Clemilson Berto-Junior, PhD^4*, Andrey Ivanov, PhD^5*, Fayuan Wen, Ph.D^4*, Sharmin Diaz, NP^6*, James G. Taylor, MD⁴, Marina Jerebtsova, PhD⁷ and Sergei Nekhai, PhD⁸

¹Sickle Cell Center, Howard University, Washington, DC
²Howard University, Washington DC, DC
³Howard University, Center for Sickle Cell Disease, Washington DC, DC
⁴Center for Sickle Cell Disease, Howard University, Washington, DC
⁵Center for Sickle Cell Disease, Howard University, Washington DC, DC
⁶Medicine, Howard University, Washington DC, DC
⁷Department of Microbiology, Howard University, McLean, VA
⁸Center for Sickle Cell Disease and Department of Medicine, Howard University Center for Sickle Cell Disease, Washington, DC

Nirupama Ramadas, PhD^1*, Kailyn Lowder^1*, Laurent O. Mosnier, PhD², Rafal Pawlinski, PhD³ and Erica Sparkenbaugh, PhD¹

¹Blood Research Center, Division of Hematology, University of North Carolina Chapel Hill, Chapel Hill, NC
²Department of Molecular Medicine, The Scripps Research Inst., La Jolla, CA
³Blood Research Center, Division of Hematology, University of North Carolina, Chapel Hill, NC

Malini Sharma, BA^1*, Timothy Lequang, MSc², Brian J Philips, PhD^2*, Fabliha A Chowdhury, MSc^2,3*, Katherine C Wood, PhD², Adam C Straub, PhD^2,3* and Julia Z Xu, MD, MS^2,4

¹University of Pittsburgh School of Medicine, Pittsburgh, PA
²Heart, Lung, Blood and Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
³Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA
⁴Department of Medicine, University of Pittsburgh, Pittsburgh, PA

Celeste K. Kanne, MS^1*, Christina Liu^1*, Britney N. Hernandez^1*, Erica N. Evans¹, Mira P. Pochron, PhD^2*, Kobina Dufu, PhD^2* and Vivien A. Sheehan, MD, PhD¹

¹Aflac Blood and Cancer Center, Children’s Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
²Global Blood Therapeutics, South San Francisco, CA

Kang Le, PhD^1*, Xunde Wang, PhD^1*, Maureen Lundt, MSc^1*, Anna Conrey, NP^1*, Ingrid Frey, RN, BSN, MS^1*, Silvia Giannini, PhD², Penelope A. Kosinski, MS^3*, John A. Hausman^4*, Philip S. Low, PhD^4*, Neal Jeffries, PhD^5* and Swee Lay Thein, MBBS, DSc, FRCP, FRCPath, MRCP, MRCPath¹

¹Sickle Cell Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
²Agios Pharmaceuticals, Inc., Brookline, MA
³Agios Pharmaceuticals, Inc., Cambridge, MA
⁴Purdue University, West Lafayette, IN
⁵National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD

Miguel Brito, PhD^1*, Catarina Ginete, MSc^2*, Joana Ferreira, BSc^2*, Manuela Mendes^3*, Jocelyne Vasconcelos, MSc^4*, Mariana Delgadinho, MSc^2*, Cruz Santos, PhD^4*, Francisco Quinto, MD^3*, Fernanda Simão, MD^3*, Anabela Mateus, BSc^4* and Filipe Fernandes^2*

¹Escola Superior de Tecnologia da Saúde de Lisboa, Lisbon, AL, Portugal
²Escola Superior de Tecnologia da Saúde de Lisboa, Lisbon, Portugal
³Maternidade Lucrécia Paím, Luanda, Angola
⁴Centro de Investigação em Saúde de Angola, Luanda, Angola

Alessandro Mattè^1*, Antonio Recchiuti^2*, Enrica Federti^1*, Filippo Mazzi^1*, Jacopo Ceolan^1*, Annamaria Porreca^2*, Marta Di Nicola^2*, Sofia Menotti^1*, Stefano Alivernini^3*, Carlo Brugnara, MD⁴ and Lucia De Franceschi, MD¹

¹University of Verona and AOUI Verona, Verona, Italy
²"G. D'Annunzio" University of Chieti - Pescara, Chieti, ITA
³Institute of Rheumatology, Università Cattolica del Sacro Cuore & Fondazione Policlinico Gemelli, Rome, Italy
⁴Department of Laboratory Medicine, Harvard Medical School, Boston Children's Hospital, Boston, MA

Zoe Sekyonda, BS^1*, Utku Goreke, MSc^2*, Ran An, PhD², Solomon Oshabaheebwa, MSc^1*, Yuncheng Man, PhD^2* and Umut A. Gurkan, PhD^1,2,3

¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH
²Department of Mechanical & Aerospace Engineering, Case Western Reserve University, Cleveland, OH
³Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH

Alka A. Potdar, PhD^1*, Michael Caponegro, PhD^2*, Onuralp Soylemez, PhD^1*, Anupama Reddy, PhD^2* and Karen Yu, PhD^1*

¹Global Blood Therapeutics, South San Francisco, CA
²Vindhya Data Science, Morrisville, NC

Carlos J Munoz, MS^1*, Cynthia R Muller, PhD^1*, Daniela Lucas, BS^1*, Ivan Susin Pires, BS^2*, Andre F Palmer, PhD^2*, Srila Gopal, MD³ and Pedro Cabrales, PhD^1*

¹Department of Bioengineering, University of California San Diego, La Jolla, CA
²William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH
³University of California San Diego, La Jolla, CA