64th ASH Annual Meeting and Exposition: 102. Iron Homeostasis and Biology: Poster II

Symposia: Iron Homeostasis and Biology Oral and Poster Abstracts
Poster

Hall D (Ernest N. Morial Convention Center)

Differential Recovery of Macrophage Iron Deficiency By Oral Iron Formulations Determines Cell Inflammatory Response in Conditions of Iron Deficiency Anemia

Ada Antypiuk¹^*, Richa Sharma¹^*, Elisa Brilli, PhD²^*, Germano Tarantino²^* and Francesca Vinchi, PhD³

¹Iron Research Laboratory, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY
²Pharmanutra S.p.A., Pisa, Italy
³Iron Research Laboratory, New York Blood Center, New York, NY

2338

ALK2 Inhibition and a Modified Activin Receptor Type Iia Ligand Trap Cotherapy Maximized Hematologic Improvements in a Mouse Model of Anemia of Inflammation

Chia-Yu Wang^*, Emiliano Melgar-Bermudez^*, Diana Welch^*, Claire C Tseng, PhD^*, Ffolliott Fisher, PhD^*, Samuel M Cadena, PhD^*, Lorena Lerner, PhD^*, Jasbir Seehra, PhD^* and Jenn Lachey, PhD

Keros Therapeutics, Lexington, MA

2339

DISC-0974, an Anti-Hemojuvelin Antibody, Reduces Hepcidin and Mobilizes Iron in Healthy Volunteers

Natasha Novikov, MD^*, Akshay Buch, PhD^*, Hua Yang, PhD^*, Sarah Tuller, JD, RAC^*, Michelle Andruk, MBA^*, Katherine Chan, PhD, MPH, MBA^*, Min Wu, PhD, Richard Rodriguez, MS^*, Rajiv Panwar, PhD^*, Haley Howell^*, Brian MacDonald, MBChB, PhD^* and Will Savage, MD, PhD

Disc Medicine, Watertown, MA

2340

Genetic Iron Overload Aggravates and Pharmacological Iron Restriction Improves MDS Pathophysiology in a Preclinical Mouse Model

S. Zebulon Vance¹^*, Ada Antypiuk¹^*, Richa Sharma¹^*, Franz Dürrenberger, PhD²^*, Vania Manolova, Ph.D²^* and Francesca Vinchi, PhD³

¹Iron Research Laboratory, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY
²Vifor (International) Ltd., St.Gallen, Switzerland
³Iron Research Laboratory, New York Blood Center, New York, NY

2341

Ferroportin Q248H Mutation Leads to a Moderate Iron Load in Mutant Slc40a1^Q248H/Q248H Mice

Fatemah Alhakami^1,2^*, Asrar Ahmad, PhD³^*, Marina Jerebtsova, PhD⁴ and Sergei Nekhai, PhD⁵

¹Center for Sickle Cell Disease and Department of Human Genetics, Howard University, Arlington, VA
²Department of Medical Laboratory, Jazan Univeristy, Jazan, Saudi Arabia
³Howard University, Howard University, Washington, DC
⁴Department of Microbiology, Howard University, McLean, VA
⁵Center for Sickle Cell Disease and Department of Medicine, Howard University Center for Sickle Cell Disease, Washington, DC

2342

Rusfertide Analog-PN23114 As a Hepcidin Mimetic Provides Efficacy Benefits in Conjunction with Phlebotomy in Mouse Model for Hereditary Hemochromatosis

Roopa Taranath, PhD^*, Celino Dion^*, Ashok Bhandari, PhD^* and David Y Liu, PhD

Protagonist Therapeutics, Newark, CA

2343

Conditional Synthetic Lethality between the Initial Steps of Heme Biosynthesis and Pyridoxine Metabolism during Erythropoiesis

Sarah Ducamp, PhD¹, Anoop Sendamarai, PhD²^* and Mark D. Fleming, MD, DPhil¹

¹Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA
²UW Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI

2344

The Effects of Iron Deficiency on the Gut Microbiota in Young Women

Seug Yun Yoon^*, Min Jung Kim, MS^*, Min Young Lee, MD, PhD^*, Kyoung Ha Kim, MD, PhD, Namsu Lee, MD, PhD^* and Jong Ho Won, MD, PhD

Division of Hematology & Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea, Republic of (South)

2345

During Iron Supplementation, Endogenous Iron Losses Are Increased and Are a Function of the Amount of Iron Absorbed Not of the Dose Given: Stable Iron Isotope Studies

Ambra Giorgetti, MSc¹^*, Michael Bruce Zimmermann, MD^2,3^*, Cornelia Speich, PhD⁴^*, Catalina Netland, BSc⁵^*, Suzane Valentine Nyilima, BSc⁶^*, Nicole Ursula Stoffel, PhD^3,7, Diego Moretti, PhD⁸^*, Edith Mwasi, MD⁹^*, Simon Karanja, PhD¹⁰^*, Christophe Zeder, MSc⁷^* and Gary M. Brittenham, MD¹¹

¹Laboratory of Human Nutrition, ETH Zurich, Zurich, Switzerland
²ETH Zurich, Zurich, Switzerland
³MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
⁴Laboratory of Human Nutrition, ETH, Zürich, Switzerland
⁵Laboratory of Human Nutriton, ETH Zurich, Zurich, Switzerland
⁶Public and Community Health Department, JKUAT, Nairobi, Kenya
⁷Human Nutrition Laboratory, ETH Zurich, Zurich, Switzerland
⁸Swiss Distance University of Applied Sciences, Regendorf, Switzerland
⁹Pediatric Department, Msambweni District Hospital, Kwale, Kenya
¹⁰Public and Community Health Department, Jomo Kenyatta University, Nairobi, Kenya
¹¹Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Morgan Stanley Children’s Hospital, Columbia University Irving Medical Center, New York, NY

2346

Phase 2, Randomized, Open-Label Trial of Bitopertin in Erythropoietic Protoporphyria: Beacon Trial Design

George Mensing^*, Haley Howell^*, Katherine Chan, PhD, MPH, MBA^*, Brian MacDonald, MBChB, PhD^* and Will Savage, MD, PhD

Disc Medicine, Watertown, MA

2347

Regulation of Iron Transport Is Required for Terminal Erythroid Differentiation Even Under Iron-Replete Conditions Sufficient for Hemoglobinization

Yvette Y. Yien, PhD¹, Meilin Chen²^*, Aidan Danoff³^* and Amber Stratman⁴^*

¹University of Pittsburgh School of Medicine, Pittsburgh, PA
²Department of Medicine, University of Pittsburgh, Pittsburgh, PA
³University of Maryland, College Park
⁴Department of Cell Biology and Physiology, Washington University at St. Louis, St. Louis, MO

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^*signifies non-member of ASH